Difference between revisions of "LEAK state"
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{{MitoPedia | {{MitoPedia | ||
|abbr=L | |abbr=''L'' | ||
|description= | |description=The '''LEAK state''', ''L'', is the non-phosphorylating resting state of intrinsic [[uncoupled]] or [[dyscoupled]] respiration when oxygen flux is maintained mainly to compensate for the [[proton leak]] when ATP synthase is not active. | ||
*[[LEAK state with ATP]]: L<sub>T</sub> | *[[LEAK state with ATP]]: ''L''<sub>T</sub> | ||
*[[LEAK state with Omy]]: L<sub>Omy</sub> | *[[LEAK state with Omy]]: ''L''<sub>Omy</sub> | ||
*[[LEAK state without adenylates]]: L<sub>N</sub> | *[[LEAK state without adenylates]]: ''L''<sub>N</sub> | ||
|info=[[MiPNet12.15]] | |info=[[MiPNet12.15]] | ||
|type=Respiration | |type=Respiration | ||
}} | }} | ||
{{Labeling}} | {{Labeling | ||
|discipline=Mitochondrial Physiology | |||
|topics=Respiration; OXPHOS; ETS Capacity, Coupling; Membrane Potential | |||
|type=Respiration | |||
}} | |||
==LEAK== | |||
* Not [[State 2]] in the classical sense, but frequently called 'State 2', State 4, State 4o, basal state, or inactive state of respiration. | |||
Respiration compensating for the [[proton leak]] is the main component of [[LEAK respiration]]. If proton leak were the only component involved, it would make sense to simply write leak respiration for the compensatory oxygen flux. Proton slip and cation cycling, however, are also involved to a larger or smaller extent to stimulate LEAK respiration. The upper case 'LEAK', therefore, should make us aware that this is more accurately considered as an acronym, and cannot be taken as a definitive delineation of the stimulatory mechanism in the LEAK state of respiration. | |||
Revision as of 11:07, 19 October 2010
- high-resolution terminology - matching measurements at high-resolution
LEAK state
Description
The LEAK state, L, is the non-phosphorylating resting state of intrinsic uncoupled or dyscoupled respiration when oxygen flux is maintained mainly to compensate for the proton leak when ATP synthase is not active.
Abbreviation: L
Reference: MiPNet12.15
Labels:
Regulation: Respiration; OXPHOS; ETS Capacity"Respiration; OXPHOS; ETS Capacity" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property., Coupling; Membrane Potential"Coupling; Membrane Potential" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property.
LEAK
- Not State 2 in the classical sense, but frequently called 'State 2', State 4, State 4o, basal state, or inactive state of respiration.
Respiration compensating for the proton leak is the main component of LEAK respiration. If proton leak were the only component involved, it would make sense to simply write leak respiration for the compensatory oxygen flux. Proton slip and cation cycling, however, are also involved to a larger or smaller extent to stimulate LEAK respiration. The upper case 'LEAK', therefore, should make us aware that this is more accurately considered as an acronym, and cannot be taken as a definitive delineation of the stimulatory mechanism in the LEAK state of respiration.
