LEAK respiration

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LEAK respiration

Description

L.jpg EAK respiration or LEAK oxygen flux L compensating for proton leak, proton slip, cation cycling and electron leak, is a dissipative component of respiration which is not available for performing biochemical work and thus related to heat production. LEAK respiration is measured in the LEAK state, in the presence of reducing substrate(s), but absence of ADP - abbreviated as L(n) (theoretically, absence of inorganic phosphate presents an alternative), or after enzymatic inhibition of the phosphorylation system, which can be reached with the use of oligomycin - abbreviated as L(Omy). The LEAK state is the non-phosphorylating resting state of intrinsic uncoupled or dyscoupled respiration when oxygen flux is maintained mainly to compensate for the proton leak at a high chemiosmotic potential, when ATP synthase is not active. In this non-phosphorylating resting state, the electrochemical proton gradient is increased to a maximum, exerting feedback control by depressing oxygen flux to a level determined mainly by the proton leak and the H+/O2 ratio. In this state of maximum protonmotive force, LEAK respiration, L, is higher than the LEAK component of OXPHOS capacity, P. The conditions for measurement and expression of respiration vary (oxygen flux in the LEAK state, JO2L, or oxygen flow, IO2L). If these conditions are defined and remain consistent within a given context, then the simple symbol L for respiratory rate can be used as a substitute for the more explicit expression for respiratory activity. » MiPNet article

Abbreviation: L

Reference: BEC 2020.1, Gnaiger 2020 BEC MitoPathways, Gnaiger 2009 Int J Biochem Cell Biol

LEAK respiration: concept-linked terminology of respiratory states

LEAK respiration corresponds to resting, non-phosphorylating electron transfer with a shortcircuit of the proton cycle across the inner mt-membrane due to intrinsic uncoupling or dyscoupling. 2[H] indicates the reduced hydrogen equivalents of CHO substrates and electron transfer to oxygen. H+out are protons pumped out of the matrix phase. Proton leaks (a property of the inner mt-membrane) dissipate energy of translocated protons, and proton slip prevents full translocation of protons across the inner mt-membrane (a property of the proton pumps). Measurement of LEAK respiration is possible in living cells by inhibition of the phosphorylation system and in mt-preparations supported by an ET-pathway competent substrate state, exemplifed as the NS-pathway (CI&II-linked substrate supply) (Gnaiger 2020 BEC MitoPathways).
Publications in the MiPMap
Gnaiger E (2019) LEAK respiration: concept-linked terminology of respiratory states. Mitochondr Physiol Network 2019-01-24.

» Gnaiger 2020 BEC MitoPathways

Oroboros (2019) MiPNet

Abstract: L.jpg Mitochondrial respiratory states have been defined originally by Chance and Williams (1955) as a sequence (from 1 to 5) of titrations and transitions in a respiratory protocol, including State 4 as a LEAK state of respiration obtained after exhaustion of the added ADP. The second state (State 2) is induced by addition of 'high ADP'. Confusion persists in the current literature as to the meaning of State 2, which can be resolved by a transition from a specific protocol-linked to a generalized concept-linked terminology.


O2k-Network Lab: AT Innsbruck Gnaiger E


The LEAK state

LEAK states of respiration are frequently called State 4, State 4o, basal state, or inactive state. Importantly, State 2 is not a LEAK state according to the classical definition.
Respiration compensating for the proton leak is the main component of LEAK respiration. If proton leak were the only component involved, it would make sense to simply write leak respiration for the compensatory oxygen flux. Proton slip and cation cycling, however, are also involved to a larger or smaller extent to stimulate LEAK respiration. The upper case 'LEAK', therefore, should make us aware that this is more accurately considered as an acronym, and cannot be taken as a definitive delineation of the stimulatory mechanism in the LEAK state of respiration.
  • Note: The distinction between LEAK- and ET capacity helps to clarify the important difference between physiologically uncoupled or pathologically dyscoupled respiration (LEAK) in contrast to noncoupled respiration (ET capacity).


Protocols for measurement of LEAK respiration

The LEAK state can be induced experimentally in various ways, which may yield idential estimates of LEAK respiration, or may show deviations that help to critically assess the proper protocol to be applied in specific cases:

a) LEAK state with ATP

LEAK respiration in the presence of ATP, L(T), and absence of ATPase activity.

LEAK state with ATP: classical State 4 in isolated mitochondria), LEAK respiration L(T) after phosphorylation of ADP to ATP is completed, or when a high concentration of ATP is added in the absence of ADP (Gnaiger 2000 Proc Natl Acad Sci U S A).

In contradiction to the original definition of State 2 (ROX), yet with reference to Chance and Williams (1956), 'State 2' has later been used for describing this functionally different LEAK state:
State 2: substrate added, respiration low due to lack of ADP. .. the controlled respiration prior to addition of ADP, which is strictly termed “state 2”, is functionally the same as state 4, and the latter term is usually used for both states’ (Nicholls & Ferguson 1992).
Thus State 2 was re-defined as functionally the same as State 4. State 2 (Chance and Williams 1955, 1956), however, is substrate-limited residual oxygen consumption at high ADP (ROXD), whereas L(n) and L(T) (State 4) are LEAK respiration in the absence of adenylates, L(n) (no ADP, no ATP) or presence of ATP, L(T).
To overcome the termonological confusion persisting in the scientific literature, the respiratory coupling states of LEAK respiration, OXPHOS capacity and ET capacity are distinguished from residual oxygen consumption (ROX; Gnaiger 2009).



b) LEAK state with oligomycin

LEAK respiration induced by inhibition of ATP synthase by oligomycin, L(Omy).

LEAK state with oligomycin: rate L(Omy) (in isolated mitochondria or other mitochondrial preparations, and non-permeabilized cells).








c) LEAK state without adenylates

LEAK respiration without adenylates, L(n).
LEAK state without adenylates: rate L(n) (in isolated mitochondria or other mitochondrial preparations, using a protocol different from the classical State 2-3-4 sequence).
Sequential addition of (1) mitochondria, (2) ADP, and (3) reduced substrates is the basis of the original State 1-2-3 definitions of respiratory states (Chance and Williams 1955 part III, 1956), where State 2 is zero respiration or residual oxygen consumption in the absence of substrate. An alternative protocol is well established, as shown, e.g., by the classical Fig. 5A (Chance and Williams 1955 part I): 600 µM ADP is added after a state described as ‘Aerobic mitochondria plus succinate’. That state was never defined as ‘State 2’ by Brit Chance. Later Estabrook (1967) made this protocol more popular, with addition of substrate before any ADP or ATP was added.
In this alternative protocol, a respiratory LEAK state is induced in isolated mitochondria, permeabilized tissues, or permeabilized cells, adding the mitochondrial preparation to respiration medium containing inorganic phosphate (State 1), then adding reduced substrate (no external adenylates). This second state (Estabrook 1967) is a non-phosphorylating LEAK state, with respiration L(n) (n for no adenylates; Gnaiger 2009), when substrate-saturated respiration compensates for the proton leak (mainly) in the absence of ADP.


State 4 versus State 2

Static head

State 4 is frequently referred to as 'static head' of isolated mitochondria. Equivalence requires testing, if at State 4 (in a protocol defined by Chance and Williams 1955) ATPase activity is actually zero, such that respiration at State 4 is not partially stimulated by partial recycling of ATP to ADP. In the latter case, State 4 respiration would be higher than LEAK respiration and thus higher than respiration at static head.

Keywords


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Mitochondrial and cellular respiratory rates in coupling-control states

OXPHOS-coupled energy cycles. Source: The Blue Book
» Baseline state
Respiratory rate Definition Icon
OXPHOS capacity P = -Rox P.jpg mt-preparations
ROUTINE respiration R = -Rox R.jpg living cells
ET capacity E = -Rox E.jpg » Level flow
» Noncoupled respiration - Uncoupler
LEAK respiration L = -Rox L.jpg » Static head
» LEAK state with ATP
» LEAK state with oligomycin
» LEAK state without adenylates
Residual oxygen consumption Rox L = -Rox ROX.jpg
  • Chance and Williams nomenclature: respiratory states
» State 1 —» State 2 —» State 3 —» State 4 —» State 5

Flux control ratios related to coupling in mt-preparations and living cells

» Flux control ratio
» Coupling-control ratio
» Coupling-control protocol
FCR Definition Icon
L/P coupling-control ratio L/P L/P coupling-control ratio » Respiratory acceptor control ratio, RCR = P/L
L/R coupling-control ratio L/R L/R coupling-control ratio
L/E coupling-control ratio L/E L/E coupling-control ratio » Uncoupling-control ratio, UCR = E/L
P/E control ratio P/E P/E control ratio
R/E control ratio R/E R/E control ratio
net P/E control ratio (P-L)/E net P/E control ratio
net R/E control ratio (R-L)/E net R/E control ratio

Net, excess, and reserve capacities of respiration

Respiratory net rate Definition Icon
P-L net OXPHOS capacity P-L P-L net OXPHOS capacity
R-L net ROUTINE capacity R-L R-L net ROUTINE capacity
E-L net ET capacity E-L E-L net ET capacity
E-P excess capacity E-P E-P excess capacity
E-R reserve capacity E-R E-R reserve capacity

Flux control efficiencies related to coupling-control ratios

» Flux control efficiency jZ-Y
» Background state
» Reference state
» Metabolic control variable
Coupling-control efficiency Definition Icon Canonical term
P-L control efficiency jP-L = (P-L)/P = 1-L/P P-L control efficiency P-L OXPHOS-flux control efficiency
R-L control efficiency jR-L = (R-L)/R = 1-L/R R-L control efficiency R-L ROUTINE-flux control efficiency
E-L coupling efficiency jE-L = (E-L)/E = 1-L/E E-L coupling efficiency E-L ET-coupling efficiency » Biochemical coupling efficiency
E-P control efficiency jE-P = (E-P)/E = 1-P/E E-P control efficiency E-P ET-excess flux control efficiency
E-R control efficiency jE-R = (E-R)/E = 1-R/E E-R control efficiency E-R ET-reserve flux control efficiency

General

» Basal respiration
» Cell ergometry
» Dyscoupled respiration
» Dyscoupling
» Electron leak
» Electron-transfer-pathway state
» Hyphenation
» Oxidative phosphorylation
» Oxygen flow
» Oxygen flux
» Permeabilized cells
» Phosphorylation system
» Proton leak
» Proton slip
» Respiratory state
» Uncoupling



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References

Bioblast linkReferenceYear
Chance B, Williams GR (1955) Respiratory enzymes in oxidative phosphorylation: III. The steady state. J Biol Chem 217:409-27.1955
Chance B, Williams GR (1955) Respiratory enzymes in oxidative phosphorylation. I. Kinetics of oxygen utilization. J Biol Chem 217:383-93.1955
Chance B, Williams GR (1956) The respiratory chain and oxidative phosphorylation. Adv Enzymol Relat Subj Biochem 17:65-134.1956
Estabrook RW (1967) Mitochondrial respiratory control and the polarographic measurement of ADP:O ratios. Methods Enzymol 10:41-7.1967
Gnaiger E (1993) Efficiency and power strategies under hypoxia. Is low efficiency at high glycolytic ATP production a paradox? In: Surviving hypoxia: Mechanisms of control and adaptation. Hochachka PW, Lutz PL, Sick T, Rosenthal M, Van den Thillart G (eds) CRC Press, Boca Raton, Ann Arbor, London, Tokyo:77-109.1993
Gnaiger E (1993) Nonequilibrium thermodynamics of energy transformations. Pure Appl Chem 65:1983-2002.1993
Gnaiger E (2009) Capacity of oxidative phosphorylation in human skeletal muscle. New perspectives of mitochondrial physiology. Int J Biochem Cell Biol 41:1837-45.2009
Gnaiger Erich et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenerg Commun 2020.1:44 pp. doi:10.26124/bec:2020-0001.v12020
  • Caplan SR, Essig A (1983) Bioenergetics and linear nonequilibrium thermodynamics. The steady state. Harvard Univ. Press, Cambridge:435 pp.
  • Nicholls DG, Ferguson SJ (2002) Bioenergetics 3. Academic Press, London:287 pp.
  • Bioblast alert 2014(04)
Publications in the MiPMap


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» List of publications: LEAK
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Default sorting: chronological. Empty fields appear first in ascending order. 
 YearReferenceCouplingPathwayPreparationOrganismTissue;cell
Komlodi 2021 MitoFit Q2021-05-06Komlodi T, Cardoso LHD, Doerrier C, Moore AL, Rich PR, Gnaiger E (2021) Coupling and pathway control of coenzyme Q redox state and respiration in isolated mitochondria. MitoFit Preprints 2021.2.v2. doi:10.26124/mitofit:2021-0002.v2LEAK
OXPHOS
ET
N
S
NS
Isolated mitochondriaMouseHeart
Nervous system
Cardoso 2021 MitoFit MgG2021-01-29Cardoso LHD, Doerrier C, Gnaiger E (2021) Magnesium Green for fluorometric measurement of ATP production does not interfere with mitochondrial respiration. MitoFit Preprints 2021.1. doi:10.26124/mitofit:2021-0001LEAK
OXPHOS
ET
N
S
ROX
Isolated mitochondriaMouseHeart
Cardoso 2021 BEC MgG2021-006-30Cardoso LHD, Doerrier C, Gnaiger E (2021) Magnesium Green for fluorometric measurement of ATP production does not interfere with mitochondrial respiration. Bioenerg Commun 2021.1. doi:10.26124/bec:2021-0001LEAK
OXPHOS
ET
N
S
ROX
Isolated mitochondriaMouseHeart
Cecatto 2021 CaG2021-##-##Cecatto C, Gnaiger E (2021) CaG ManuscriptLEAKNIsolated mitochondriaMouseLiver
Correia 2021 Hum Mutat2021Correia SP, Moedas MF, Naess K, Bruhn H, Maffezzini C, Calvo-Garrido J, Lesko N, Wibom R, Schober FA, Jemt A, Stranneheim H, Freyer C, Wedell A, Wredenberg A (2021) Severe congenital lactic acidosis and hypertrophic cardiomyopathy caused by an intronic variant in NDUFB7. Hum Mutat [Epub ahead of print].LEAK
OXPHOS
N
S
NS
Permeabilized cellsHumanFibroblast
Jensen 2021 Free Radic Biol Med2021Jensen BS, Pardue S, Duffy B, Kevil CG, Staples JF, Fago A (2021) Suppression of mitochondrial respiration by hydrogen sulfide in hibernating 13-lined ground squirrels. Free Radic Biol Med 169:181-86.LEAKSIsolated mitochondriaOther mammalsLiver
Mendham 2021 Diabetologia2021Mendham AE, Goedecke JH, Zeng Y, Larsen S, George C, Hauksson J, Fortuin-de Smidt MC, Chibalin AV, Olsson T, Chorell E (2021) Exercise training improves mitochondrial respiration and is associated with an altered intramuscular phospholipid signature in women with obesity. Diabetologia 64:1642-59.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Intact cellsHumanSkeletal muscle
Amoedo 2021 J Clin Invest2021Amoedo ND, Sarlak S, Obre E, Esteves P, Bégueret H, Kieffer Y, Rousseau B, Dupis A, Izotte J, Bellance N, Dard L, Redonnet-Vernhet I, Punzi G, Rodrigues MF, Dumon E, Mafhouf W, Guyonnet-Dupérat V, Gales L, Palama T, Bellvert F, Dugot-Senan N, Claverol S, Baste JM, Lacombe D, Rezvani HR, Pierri CL, Mechta-Grigoriou F, Thumerel M, Rossignol R (2021) Targeting the mitochondrial trifunctional protein restrains tumor growth in oxidative lung carcinomas. J Clin Invest 131:e133081.LEAK
ROUTINE
F
CIV
Intact cellsHumanLung;gill
Axelrod 2021 EMBO Mol Med2021Axelrod CL, King WT, Davuluri G, Noland RC, Hall J, Hull M, Dantas WS, Zunica ER, Alexopoulos SJ, Hoehn KL, Langohr I, Stadler K, Doyle H, Schmidt E, Nieuwoudt S, Fitzgerald K, Pergola K, Fujioka H, Mey JT, Fealy C, Mulya A, Beyl R, Hoppel CL, Kirwan JP (2021) BAM15-mediated mitochondrial uncoupling protects against obesity and improves glycemic control. EMBO Mol Med 12:12088.ROUTINE
OXPHOS
ET
LEAK
F
N
S
NS
ROX
DQ
Intact cells
Permeabilized tissue
MouseSkeletal muscle
Flouda 2021 Free Radic Biol Med2021Flouda K, Mercer J, Davies MJ, Hawkins CL (2021) Role of myeloperoxidase-derived oxidants in the induction of vascular smooth muscle cell damage. Free Radic Biol Med [Epub ahead of print].LEAK
ROUTINE
ET
ROXIntact cellsHumanOther cell lines
Fang 2021 Cell Rep2021Fang H, Ye X, Xie J, Li Y, Li H, Bao X, Yang Y, Lin Z, Jia M, Han Q, Zhu J, Li X, Zhao Q, Yang Y, Lyu J (2021) A membrane arm of mitochondrial complex I sufficient to promote respirasome formation. Cell Rep 35:108963.LEAK
ROUTINE
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ET
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S
Permeabilized cells
Intact cells
Schumann 2021 Commun Biol2021Schumann T, Koenig J, von Loeffelholz C, Vatner DF, Zhang D, Perry RJ, Bernier M, Chami J, Henke C, Kurzbach A, El-Agroudy NN, Willmes DM, Pesta D, de Cabo R, O Sullivan JF, Simon E, Shulman GI, Hamilton BS, Birkenfeld AL (2021) Deletion of the diabetes candidate gene Slc16a13 in mice attenuates diet-induced ectopic lipid accumulation and insulin resistance. Commun Biol 4:826.LEAK
ROUTINE
OXPHOS
ET
F
N
NS
ROX
Intact cellsMouseLiver
Seefeldt 2021 Sci Rep2021Seefeldt JM, Lassen TR, Vognstoft Hjortbak M, Jespersen NR, Kvist F, Hansen J, Boetker HE (2021) Cardioprotective effects of empagliflozin after ischemia and reperfusion in rats. Sci Rep 11:9544.LEAK
OXPHOS
N
S
NS
ROX
Permeabilized tissueRatHeart
Furihata 2021 Commun Biol2021Furihata T, Takada S, Kakutani N, Maekawa S, Tsuda M, Matsumoto J, Mizushima W, Fukushima A, Yokota T, Enzan N, Matsushima S, Handa H, Fumoto Y, Nio-Kobayashi J, Iwanaga T, Tanaka S, Tsutsui H, Sabe H, Kinugawa S (2021) Cardiac-specific loss of mitoNEET expression is linked with age-related heart failure. Commun Biol 4:138.LEAK
OXPHOS
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N
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ROX
Isolated mitochondriaMouseHeart
Lei 2021 Ecotoxicol Environ Saf2021Lei C, Liao J, Li Q, Shi J, Zhang H, Guo J, Han Q, Hu L, Li Y, Pan J, Tang Z (2021) Copper induces mitochondria-mediated apoptosis via AMPK-mTOR pathway in hypothalamus of pigs. Ecotoxicol Environ Saf 220:112395.LEAK
OXPHOS
ET
N
S
ROX
PigNervous system
Baldini 2021 Life Sci2021Baldini F, Fabbri R, Eberhagen C, Voci A, Portincasa P, Zischka H, Vergani L (2021) Adipocyte hypertrophy parallels alterations of mitochondrial status in a cell model for adipose tissue dysfunction in obesity. Life Sci 265:118812.LEAK
OXPHOS
ET
N
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ROX
Permeabilized cellsMouseFibroblast
Willis 2021 Sci Rep2021Willis JR, Hickey AJR, Devaux JBL (2021) Thermally tolerant intertidal triplefin fish (Tripterygiidae) sustain ATP dynamics better than subtidal species under acute heat stress. Sci Rep 11:11074.LEAK
OXPHOS
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ROUTINE
N
ROX
NS
HomogenateFishesNervous system
Figueira 2021 Arch Biochem Biophys2021Figueira TR, Francisco A, Ronchi JA, Dos Santos GRRM, Santos WD, Treberg JR, Castilho RF (2021) NADPH supply and the contribution of NAD(P)+ transhydrogenase (NNT) to H2O2 balance in skeletal muscle mitochondria. Arch Biochem Biophys 707:108934.LEAK
OXPHOS
ET
N
F
Isolated mitochondriaMouseSkeletal muscle
Whitehead 2021 Nat Commun2021Whitehead A, Krause FN, Moran A, MacCannell ADV, Scragg JL, McNally BD, Boateng E, Murfitt SA, Virtue S, Wright J, Garnham J, Davies GR, Dodgson J, Schneider JE, Murray AJ, Church C, Vidal-Puig A, Witte KK, Griffin JL, Roberts LD (2021) Brown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis. Nat Commun 12:1905.LEAK
OXPHOS
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F
N
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Permeabilized cellsHumanSkeletal muscle
Schmidt 2021 Cancer Metab2021Schmidt CA, McLaughlin KL, Boykov IN, Mojalagbe R, Ranganathan A, Buddo KA, Lin CT, Fisher-Wellman KH, Neufer PD (2021) Aglycemic growth enhances carbohydrate metabolism and induces sensitivity to menadione in cultured tumor-derived cells. Cancer Metab 9:3.LEAK
OXPHOS
ET
N
S
Gp
CIV
ROX
Isolated mitochondriaHumanLiver
Dubinin 2021 Free Radic Biol Med2021Dubinin MV, Semenova AA, Ilzorkina AI, Penkov NV, Nedopekina DA, Sharapov VA, Khoroshavina EI, Davletshin EV, Belosludtseva NV, Spivak AY, Belosludtsev KN (2021) Mitochondria-targeted prooxidant effects of betulinic acid conjugated with delocalized lipophilic cation F16. Free Radic Biol Med 168:55-69.LEAK
OXPHOS
ET
N
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Isolated mitochondriaRatLiver
Moon 2021 J Lipid Res2021Moon SH, Dilthey BG, Liu X, Guan S, Sims HF, Gross RW (2021) High-Fat diet activates liver iPLA2γ generating eicosanoids that mediate metabolic stress. J Lipid Res 62: 100052. [Epub ahead of print].LEAK
OXPHOS
ET
N
S
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Isolated mitochondriaMouseLiver
Goldberg 2021 Biochem J2021Goldberg EJ, Buddo KA, McLaughlin KL, Fernandez RF, Pereyra AS, Psaltis CE, Lin CT, Hagen JT, Boykov IN, Nguyen TK, Gowdy KM, Ellis JM, Neufer PD, McClung JM, Fisher-Wellman KH (2021) Tissue-specific characterization of mitochondrial branched-chain keto acid oxidation using a multiplexed assay platform. Biochem J 476:1521-37.LEAK
OXPHOS
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N
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ROX
F
Isolated mitochondriaMouseHeart
Skeletal muscle
Liver
Connell 2021 J Nutr2021Connell NJ, Grevendonk L, Fealy CE, Moonen-Kornips E, Bruls YMH, Schrauwen-Hinderling VB, de Vogel J, Hageman R, Geurts J, Zapata-Perez R, Houtkooper RH, Havekes B, Hoeks J, Schrauwen P (2021) NAD+-precursor supplementation with L-tryptophan, nicotinic acid, and nicotinamide does not affect mitochondrial function or skeletal muscle function in physically compromised older adults. J Nutr [Epub ahead of print].LEAK
OXPHOS
ET
F
N
NS
Permeabilized tissueHumanSkeletal muscle
Giovarelli 2021 Pharmacol Res2021Giovarelli M, Zecchini S, Catarinella G, Moscheni C, Sartori P, Barbieri C, Roux-Biejat P, Napoli A, Vantaggiato C, Cervia D, Perrotta C, Clementi E, Latella L, De Palma C (2021) Givinostat as metabolic enhancer reverting mitochondrial biogenesis deficit in Duchenne Muscular Dystrophy. Pharmacol Res [Epub ahead of print].LEAK
OXPHOS
N
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CIV
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Salin 2021 Mar Environ Res2021Salin K, Mathieu-Resuge M, Graziano N, Dubillot E, Le Grand F, Soudant P, Vagner M (2021) The relationship between membrane fatty acid content and mitochondrial efficiency differs within- and between- omega-3 dietary treatments. Mar Environ Res [Epub ahead of print].LEAK
OXPHOS
N
NS
Isolated mitochondriaFishesSkeletal muscle
Pereyra 2021 J Lipid Res2021Pereyra AS, Harris KL, Soepriatna AH, Waterbury QA, Bharathi SS, Zhang Y, Fisher-Wellman KH, Goergen CJ, Goetzman ES, Ellis JM (2021) Octanoate is differentially metabolized in liver and muscle and fails to rescue cardiomyopathy in CPT2 deficiency. J Lipid Res 62:100069 [Epub ahead of print].LEAK
OXPHOS
F
N
Homogenate
Isolated mitochondria
MouseHeart
Skeletal muscle
Liver
Terwilliger 2021 Vasc Med2021Terwilliger ZS, Ryan TE, Goldberg EJ, Schmidt CA, Yamaguchi DJ, Karnekar R, Brophy P, Green TD, Zeczycki TN, Mac Gabhann F, Annex BH, McClung JM (2021) Racial differences in the limb skeletal muscle transcriptional programs of patients with critical limb ischemia. Vasc Med 26:247-58.OXPHOS
LEAK
N
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CIV
ROX
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Permeabilized tissueHumanSkeletal muscle
Fink 2021 Pharmacol Res Perspect2021Fink BD, Yu L, Coppey L, Obrosov A, Shevalye H, Kerns RJ, Yorek MA, Sivitz WI (2021) Effect of mitoquinone on liver metabolism and steatosis in obese and diabetic rats. Pharmacol Res Perspect 9:e00701.LEAK
OXPHOS
NSIsolated mitochondriaRatLiver
Brodnanova 2021 Eur J Pharmacol2021Brodnanova M, Hatokova Z, Evinova A, Cibulka M, Racay P (2021) Differential impact of imipramine on thapsigargin- and tunicamycin-induced endoplasmic reticulum stress and mitochondrial dysfunction in neuroblastoma SH-SY5Y cells. Eur J Pharmacol 902:174073.LEAK
ROUTINE
ET
N
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Permeabilized cells
Intact cells
HumanNeuroblastoma
Hoppel 2021 Front Physiol2021Hoppel F, Calabria E, Pesta DH, Kantner-Rumplmair W, Gnaiger E, Burtscher M (2021) Effects of ultramarathon running on mitochondrial function of platelets and oxidative stress parameters: a pilot study. Front Physiol 12:632664.LEAK
ROUTINE
OXPHOS
ET
N
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ROX
Permeabilized cells
Intact cells
HumanPlatelet
Friederich 2021 Mol Genet Metab2021Friederich MW, Geddes GC, Wortmann SB, Punnoose A, Wartchow E, Knight KM, Prokisch H, Creadon-Swindell G, Mayr JA, Van Hove JLK (2021) Pathogenic variants in MRPL44 cause infantile cardiomyopathy due to a mitochondrial translation defect. Mol Genet Metab 133:362-71.LEAK
OXPHOS
ET
NHumanFibroblast
Matsumoto 2021 Circ Heart Fail2021Matsumoto J, Takada S, Furihata T, Nambu H, Kakutani N, Maekawa S, Mizushima W, Nakano I, Fukushima A, Yokota T, Tanaka S, Handa H, Sabe H, Kinugawa S (2021) Brain-derived neurotrophic factor improves impaired fatty acid oxidation via the activation of adenosine monophosphate-activated protein kinase-ɑ - proliferator-activated receptor-r coactivator-1ɑ signaling in skeletal muscle of mice with heart failure. Circ Heart Fail 14: e005890.LEAK
OXPHOS
Permeabilized tissueMouseSkeletal muscle
Davis 2021 J Appl Physiol2021Davis MS, Barrett MR (2021) Effect of conditioning and physiology hyperthermia on canine skeletal muscle mitochondrial oxygen consumption. J Appl Physiol. 130:1317-1325LEAK
OXPHOS
N
S
NS
Permeabilized cellsDogSkeletal muscle
Avram 2021 Int J Mol Sci2021Avram VF, Chamkha I, Åsander-Frostner E, Ehinger JK, Timar RZ, Hansson MJ, Muntean DM, Elmér E (2021) Cell-permeable succinate rescues mitochondrial respiration in cellular models of statin toxicity. Int J Mol Sci 22:424.ROUTINE
ET
LEAK
ROXIntact cellsHumanPlatelet
Weiss 2021 Crit Care Explor2021Weiss SL, Bittinger K, Lee JJ, Friedman ES, Mattei LM, Graham K, Zhang D, Bush J, Balamuth F, McGowan FX Jr, Bushman FD, Baldassano RN, Wu GD, Wallace DC, Collman RG (2021) Decreased intestinal microbiome diversity in pediatric sepsis: a conceptual framework for intestinal dysbiosis to influence immunometabolic function. Crit Care Explor 3:0360.LEAK
ROUTINE
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ROXIntact cellsHumanLymphocyte
Roy Chowdhury 2021 Cancers (Basel)2021Roy Chowdhury S, Peltier C, Hou S, Singh A, Johnston JB, Gibson SB, Marshall A, Banerji V (2021) Ex vivo mitochondrial respiration parallels biochemical response to ibrutinib in CLL cells. Cancers (Basel) 13:E354.LEAK
ROUTINE
ET
ROXIntact cellsHumanLymphocyte
Saura-Esteller 2021 Int J Mol Sci2021Saura-Esteller J, Sánchez-Vera I, Núñez-Vázquez S, Cosialls AM, Gama-Pérez P, Bhosale G, Mendive-Tapia L, Lavilla R, Pons G, Garcia-Roves PM, Duchen MR, Iglesias-Serret D, Gil J (2021) Activation of the integrated stress response and ER stress protect from fluorizoline-induced apoptosis in HEK293T and U2OS cell lines. Int J Mol Sci 22:6117.LEAK
ROUTINE
ET
ROXIntact cellsHumanLymphocyte
Vidimce 2021 Front Pharmacol2021Vidimce J, Pillay J, Shrestha N, Dong LF, Neuzil J, Wagner KH, Holland OJ, Bulmer AC (2021) Mitochondrial function, fatty acid metabolism, and body composition in the hyperbilirubinemic gunn rat. Front Pharmacol 12:586715.LEAK
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ET
N
S
NS
ROX
Permeabilized tissue
Homogenate
RatSkeletal muscle
Liver
Deline 2021 Biochim Biophys Acta Bioenerg2021Deline ML, Grashei M, van Heijster FHA, Schilling F, Straub J, Fromme T (2021) Adenylate kinase derived ATP shapes respiration and calcium storage of isolated mitochondria. Biochim Biophys Acta Bioenerg 1862:148409.OXPHOS
LEAK
SIsolated mitochondriaMouseLiver
Yardeni 2021 Proc Natl Acad Sci U S A2021Yardeni T, Cristancho AG, McCoy AJ, Schaefer PM, McManus MJ, Marsh ED, Wallace DC (2021) An mtDNA mutant mouse demonstrates that mitochondrial deficiency can result in autism endophenotypes. Proc Natl Acad Sci U S A 118:e2021429118.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateMouseNervous system
Cai 2021 Free Radic Biol Med2021Cai H, Bian X, Chen L, Zhang N, Li L, Tang W, Liu X, Li Z (2021) Selective intra-arterial brain cooling induces cerebral protection against ischemia/reperfusion injury through SENP1-Sirt3 signaling. Free Radic Biol Med 171:272-83.LEAK
OXPHOS
NIsolated mitochondriaMouseNervous system
Tonnesen 2021 Mol Cell Biochem2021Tonnesen PT, Hjortbak MV, Lassen TR, Seefeldt JM, Bøtker HE, Jespersen NR (2021) Myocardial salvage by succinate dehydrogenase inhibition in ischemia-reperfusion injury depends on diabetes stage in rats. Mol Cell Biochem [Epub ahead of print].LEAK
OXPHOS
F
N
Permeabilized tissueRatHeart
Krako 2021 Int J Mol Sci2021Krako Jakovljevic N, Pavlovic K, Jotic A, Lalic K, Stoiljkovic M, Lukic L, Milicic T, Macesic M, Stanarcic Gajovic J, Lalic NM (2021) Targeting mitochondria in diabetes. Int J Mol Sci 22:6642.LEAK
OXPHOS
ET
F
N
S
Permeabilized tissueHumanSkeletal muscle
Liver
Blood cells
Nambu 2021 Cardiovasc Res2021Nambu H, Takada S, Maekawa S, Matsumoto J, Kakutani N, Furihata T, Shirakawa R, Katayama T, Nakajima T, Yamanashi K, Obata Y, Nakano I, Tsuda M, Saito A, Fukushima A, Yokota T, Nio-Kobayashi J, Yasui H, Higashikawa K, Kuge Y, Anzai T, Sabe H, Kinugawa S (2021) Inhibition of xanthine oxidase in the acute phase of myocardial infarction prevents skeletal muscle abnormalities and exercise intolerance. Cardiovasc Res 117:805-19.LEAK
OXPHOS
Permeabilized tissueMouseSkeletal muscle
Knapp-Wilson 2021 bioRxiv2021Knapp-Wilson A, Pereira GC, Buzzard E, Richardson A, Corey RA, Neal C, Verkade P, Halestrap AP, Gold VAM, Kuwabara P, Collinson I (2021) Maintenance of complex I and respiratory super-complexes by NDUF-11 is essential for respiratory function, mitochondrial structure and health in C. elegans. bioRxiv doi: https://doi.org/10.1101/2021.01.06.425530.LEAK
OXPHOS
N
S
Isolated mitochondriaCaenorhabditis elegans
Klepinina 2021 PLoS One2021Klepinina L, Klepinin A, Truu L, Chekulayev V, Vija H, Kuus K, Teino I, Pook M, Maimets T, Kaambre T (2021) Colon cancer cell differentiation by sodium butyrate modulates metabolic plasticity of Caco-2 cells via alteration of phosphotransfer network. PLoS One 16:e0245348.LEAK
ROUTINE
OXPHOS
ET
N
NS
ROX
Permeabilized cells
Intact cells
HumanEndothelial;epithelial;mesothelial cell
Sanchez-de-Diego 2021 Redox Biol2021Sánchez-de-Diego C, Pedrazza L, Pimenta-Lopes C, Martinez-Martinez A, Dahdah N, Valer JA, Garcia-Roves P, Rosa JL, Ventura F (2021) NRF2 function in osteocytes is required for bone homeostasis and drives osteocytic gene expression. Redox Biol 40:101845.LEAK
ROUTINE
ET
ROXIntact cellsMouseOther cell lines
Braga 2021 Sci Rep2021Braga RR, Crisol BM, Brícola RS, Sant'ana MR, Nakandakari SCBR, Costa SO, Prada PO, da Silva ASR, Moura LP, Pauli JR, Cintra DE, Ropelle ER (2021) Exercise alters the mitochondrial proteostasis and induces the mitonuclear imbalance and UPRmt in the hypothalamus of mice. Sci Rep 11:3813.LEAK
OXPHOS
ET
N
NS
Isolated mitochondriaMouseNervous system
Bastos Sant'Anna Silva 2021 Cancers2021Bastos Sant'Anna Silva AC, Perez Valencia JA, Sciacovelli M, Lalou C, Sarlak S, Tronci L, Nikitopoulou E, Meszaros AT, Frezza C, Rossignol R, Gnaiger E, Klocker H (2021) Succinate anaplerosis has an onco-driving potential in prostate cancer cells. Cancers 13:1727.LEAK
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OXPHOS
S
ROX
Permeabilized cells
Intact cells
HumanGenital
Ko 2021 Biomolecules2021Ko HJ, Tsai CY, Chiou SJ, Lai YL, Wang CH, Cheng JT, Chuang TH, Huang CF, Kwan AL, Loh JK, Hong YR (2021) The phosphorylation status of Drp1-Ser637 by PKA in mitochondrial fission modulates mitophagy via PINK1/Parkin to exert multipolar spindles assembly during mitosis. Biomolecules 11:424.LEAK
ROUTINE
ET
ROXIntact cellsHumanHeLa
Morgan 2021 Resuscitation2021Morgan RW, Sutton RM, Himebauch AS, Roberts AL, Landis WP, Lin Y, Starr J, Ranganathan A, Delso N, Mavroudis CD, Volk L, Slovis J, Marquez AM, Nadkarni VM, Hefti M, Berg RA, Kilbaugh TJ (2021) A randomized and blinded trial of inhaled nitric oxide in a piglet model of pediatric cardiopulmonary resuscitation. Resuscitation 162:274-83 .LEAK
OXPHOS
N
NS
HomogenatePigNervous system
Giordano 2021 Gene Ther2021Giordano L, Aneja MK, Sommer N, Alebrahimdehkordi N, Seraji A, Weissmann N, Rudolph C, Plank C, Jacobs HT, Szibor M (2021) Alternative oxidase encoded by sequence-optimized and chemically-modified RNA transfected into mammalian cells is catalytically active. Gene Ther [Epub ahead of print].LEAK
ROUTINE
OXPHOS
N
S
CIV
ROX
Permeabilized cells
Intact cells
MouseFibroblast
Christiansen 2021 Sci Rep2021Christiansen LB, Dohlmann TL, Ludvigsen TP, Parfieniuk E, Ciborowski M, Szczerbinski L, Kretowski A, Desler C, Tiano L, Orlando P, Martinussen T, Olsen LH, Larsen S (2021) Atorvastatin impairs liver mitochondrial function in obese Göttingen Minipigs but heart and skeletal muscle are not affected. Sci Rep 11:2167.LEAK
OXPHOS
ET
F
N
S
CIV
NS
Permeabilized tissuePigHeart
Skeletal muscle
Liver
Honecker 2021 Int J Obes (Lond)2021Honecker J, Weidlich D, Heisz S, Lindgren CM, Karampinos DC, Claussnitzer M, Hauner H (2021) A distribution-centered approach for analyzing human adipocyte size estimates and their association with obesity-related traits and mitochondrial function. Int J Obes (Lond) [Ephub ahead of print].LEAK
ROUTINE
OXPHOS
ET
Intact cellsHumanFat
Mazzoli 2021 Antioxidants (Basel)2021Mazzoli A, Spagnuolo MS, Nazzaro M, Gatto C, Iossa S, Cigliano L (2021) Fructose removal from the diet reverses inflammation, mitochondrial dysfunction, and oxidative stress in hippocampus. Antioxidants (Basel) 10:487.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateRatNervous system
Meng 2021 FEBS Open Bio2021Meng L, Chen D, Meng G, Lu L, Han C (2021) Dysregulation of the Sirt5/IDH2 axis contributes to sunitinib resistance in human renal cancer cells. FEBS Open Bio [Epub ahead of print].LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cellsHumanKidney
Wall 2021 Dis Model Mech2021Wall JM, Basu A, Zunica ERM, Dubuisson OS, Pergola K, Broussard JP, Kirwan JP, Axelrod CL, Johnson AE (2021) CRISPR/Cas9-engineered Drosophila knock-in models to study VCP diseases. Dis Model Mech 14:dmm048603.LEAK
OXPHOS
ET
N
S
Gp
CIV
NS
ROX
Permeabilized tissueDrosophilaSkeletal muscle
Wigner 2021 Sci Rep2021Wigner P, Zielinski K, Labieniec-Watala M, Marczak A, Szwed M (2021) Doxorubicin-transferrin conjugate alters mitochondrial homeostasis and energy metabolism in human breast cancer cells. Sci Rep 11:4544.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
HumanOther cell lines
Xiao 2021 PLoS Genet2021Xiao L, Liu J, Sun Z, Yin Y, Mao Y, Xu D, Liu L, Xu Z, Guo Q, Ding C, Sun W, Yang L, Zhou Z, Zhou D, Fu T, Zhou W, Zhu Y, Chen XW, Li JZ, Chen S, Xie X, Gan Z (2021) AMPK-dependent and -independent coordination of mitochondrial function and muscle fiber type by FNIP1. PLoS Genet 17:e1009488.LEAK
OXPHOS
N
S
Permeabilized tissueMouseSkeletal muscle
Lefranc 2021 Int J Mol Sci2021Lefranc C, Friederich-Persson M, Foufelle F, Nguyen Dinh Cat A, Jaisser F (2021) Adipocyte-mineralocorticoid receptor alters mitochondrial quality control leading to mitochondrial dysfunction and senescence of visceral adipose tissue. Int J Mol Sci 22:2881.LEAK
OXPHOS
ET
NIsolated mitochondriaMouseFat
Dos Santos Escaliante 2021 Int J Biol Macromol2021Dos Santos Escaliante LA, Busato B, de Oliveira Petkowicz CL, Suter Correia Cadena SM, Rodrigues Noleto G (2021) Cytotoxic effect of xyloglucan and oxovanadium (IV/V) xyloglucan complex in HepG2 cells. Int J Biol Macromol 185:40-48.LEAK
OXPHOS
N
S
CIV
ROX
Permeabilized cellsHumanLiver
Thoral 2021 Biol Lett2021Thoral E, Roussel D, Chinopoulos C, Teulier L, Salin K (2021) Low oxygen levels can help to prevent the detrimental effect of acute warming on mitochondrial efficiency in fish. Biol Lett 17:20200759.LEAK
OXPHOS
N
CIV
NS
ROX
HomogenateFishesSkeletal muscle
Holody 2021 Mitochondrion2021Holody C, Anfray A, Mast H, Lessard M, Han WH, Carpenter R, Bourque S, Sauvé Y, Lemieux H (2021) Differences in relative capacities of oxidative phosphorylation pathways may explain sex- and tissue-specific susceptibility to vision defects due to mitochondrial dysfunction. Mitochondrion 56:102-10.LEAK
OXPHOS
N
S
CIV
NS
ROX
HomogenateRatNervous system
Garcia 2021 J Steroid Biochem Mol Biol2021Garcia AM, Bishop EL, Li D, Jeffery LE, Garten A, Thakker A, Certo M, Mauro C, Tennant DA, Dimeloe S, Evelo CT, Coort SL, Hewison M (2021) Tolerogenic effects of 1,25-dihydroxyvitamin D on dendritic cells involve induction of fatty acid synthesis. J Steroid Biochem Mol Biol 211:105891.LEAK
ET
ROXIntact cellsHumanNervous system
MiPNet21.17 BloodCellsIsolation2020-10-22
O2k-Protocols
O2k-Protocols: Isolation of blood cells for HRR.
LEAK
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OXPHOS
ET
F
N
S
Gp
CIV
NS
ROX
Intact cells
Permeabilized cells
HumanBlood cells
Platelet
Hassan 2020 MitoFit Preprint Arch2020-04-30Hassan Hazirah, Gnaiger Erich, Zakaria Fazaine, Makpol Suzana, Abdul Karim Norwahidah (2020) Alterations in mitochondrial respiratory capacity and membrane potential: a link between mitochondrial dysregulation and autism. MitoFit Preprint Arch 2020.3 doi:10.26124/mitofit:200003.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cellsHuman
McLaughlin 2020 Sci Rep2020McLaughlin KL, Kew KA, McClung JM, Fisher-Wellman KH (2020) Subcellular proteomics combined with bioenergetic phenotyping reveals protein biomarkers of respiratory insufficiency in the setting of proofreading-deficient mitochondrial polymerase. Sci Rep 10:3603.LEAKF
N
S
Isolated mitochondriaMouseHeart
Skeletal muscle
Zussman 2020 J Autoimmun2020Zussman R, Xu LY, Damani T, Groom KM, Chen Q, Seers B, Viall CA, Chamley LW, Hickey A (2020) Antiphospholipid antibodies can specifically target placental mitochondria and induce ROS production. J Autoimmun 111:102437.LEAK
ET
N
S
Gp
CIV
NS
ROX
Permeabilized tissueHumanGenital
Jespersen 2020 Sci Rep2020Jespersen NR, Hjortbak MV, Lassen TR, Støttrup NB, Johnsen J, Tonnesen PT, Larsen S, Kimose HH, Bøtker HE (2020) Cardioprotective effect of succinate dehydrogenase inhibition in rat hearts and human myocardium with and without diabetes mellitus. Sci Rep 10:10344.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueRatHeart
Chen 2020 Chem Biol Interact2020Chen HY, Ho YJ, Chou HC, Liao EC, Tsai YT, Wei YS, Lin LH, Lin MW, Wang YS, Ko ML, Chan H (2020) TGF-β1 signaling protects retinal ganglion cells from oxidative stress via modulation of the HO-1/Nrf2 pathway. Chem Biol Interact 331:109249.LEAK
ROUTINE
ET
ROXIntact cellsMouseNervous system
Khamoui 2020 Physiol Genomics2020Khamoui AV, Tokmina-Roszyk D, Rossiter HB, Fields GB, Visavadiya NP (2020) Hepatic proteome analysis reveals altered mitochondrial metabolism and suppressed acyl-CoA synthetase-1 in colon-26 tumor-induced cachexia. Physiol Genomics 52:203-16.LEAK
OXPHOS
ET
N
NS
Intact cellsMouseLiver
Lozano 2020 Part Fibre Toxicol2020Lozano O, Silva-Platas C, Chapoy-Villanueva H, Pérez BE, Lees JG, Ramachandra CJA, Contreras-Torres FF, Lázaro-Alfaro A, Luna-Figueroa E, Bernal-Ramírez J, Gordillo-Galeano A, Benitez A, Oropeza-Almazán Y, Castillo EC, Koh PL, Hausenloy DJ, Lim SY, García-Rivas G (2020) Amorphous SiO2 nanoparticles promote cardiac dysfunction via the opening of the mitochondrial permeability transition pore in rat heart and human cardiomyocytes. Part Fibre Toxicol 17:15.LEAK
OXPHOS
ET
SIsolated mitochondriaRatHeart
Mayoral-Varo 2020 PLoS One2020Mayoral-Varo V, Calcabrini A, Sánchez-Bailón MP, Martínez-Costa ÓH, González-Páramos C, Ciordia S, Hardisson D, Aragón JJ, Fernández-Moreno MÁ, Martín-Pérez J (2020) c-Src functionality controls self-renewal and glucose metabolism in MCF7 breast cancer stem cells . PLoS One 15:e0235850.LEAK
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ET
Intact cellsHumanEndothelial;epithelial;mesothelial cell
Skemiene 2020 Biomolecules2020Skemiene K, Rekuviene E, Jekabsone A, Cizas P, Morkuniene R, Borutaite V (2020) Comparison of effects of metformin, phenformin, and inhibitors of mitochondrial complex I on mitochondrial permeability transition and ischemic brain injury. Biomolecules 10:E1400.LEAK
OXPHOS
NIsolated mitochondriaRatNervous system
Duong 2020 Mitochondrion2020Duong QV, Hoffman A, Zhong K, Dessinger MJ, Zhang Y, Bazil JN (2020) Calcium overload decreases net free radical emission in cardiac mitochondria. Mitochondrion 51:126-39.LEAK
OXPHOS
ET
F
N
S
Isolated mitochondriaGuinea pigHeart
Cubizolle 2020 J Cell Mol Med2020Cubizolle A, Cia D, Moine E, Jacquemot N, Guillou L, Rosell M, Angebault-Prouteau C, Lenaers G, Meunier I, Vercauteren J, Durand T, Crauste C, Brabet P (2020) Isopropyl-phloroglucinol-DHA protects outer retinal cells against lethal dose of all-trans-retinal. J Cell Mol Med 24:5057-69.LEAK
OXPHOS
ET
N
S
CIV
NS
Permeabilized cellsRatEndothelial;epithelial;mesothelial cell
Battaglia 2020 Cell Death Dis2020Battaglia CR, Cursano S, Calzia E, Catanese A, Boeckers TM (2020) Corticotropin-releasing hormone (CRH) alters mitochondrial morphology and function by activating the NF-kB-DRP1 axis in hippocampal neurons. Cell Death Dis 11:1004.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Intact cellsRatNervous system
Alston 2020 Am J Hum Genet2020Alston CL, Veling MT, Heidler J, Taylor LS, Alaimo JT, Sung AY, He L, Hopton S, Broomfield A, Pavaine J, Diaz J, Leon E, Wolf P, McFarland R, Prokisch H, Wortmann SB, Bonnen PE, Wittig I, Pagliarini DJ, Taylor RW (2020) Pathogenic bi-allelic mutations in NDUFAF8 cause Leigh syndrome with an isolated complex I deficiency. Am J Hum Genet 106:92-101.LEAK
ROUTINE
OXPHOS
ET
N
NS
Permeabilized cells
Intact cells
HumanFibroblast
Romeiro 2020 bioRxiv2020Romeiro NC, Ferreira CM, Oliveira MF (2020) Assessment of mitochondrial physiology of murine white adipose tissue by mechanical permeabilization and lipid depletion. bioRxiv doi: https://doi.org/10.1101/2020.02.19.956870.LEAK
OXPHOS
ET
S
ROX
Permeabilized tissueMouseFat
Song 2020 Life Sci2020Song K, Zhang Y, Ga Q, Bai Z, Ge RL (2020) High-altitude chronic hypoxia ameliorates obesity-induced non-alcoholic fatty liver disease in mice by regulating mitochondrial and AMPK signaling. Life Sci 252:117633.LEAK
OXPHOS
ET
F
N
NS
HomogenateMouseLiver
Zhou 2020 Biomed Pharmacother2020Zhou J, Zhang Y, Li S, Zhou Q, Lu Y, Shi J, Liu J, Wu Q, Zhou S (2020) Dendrobium nobile Lindl. alkaloids-mediated protection against CCl4-induced liver mitochondrial oxidative damage is dependent on the activation of Nrf2 signaling pathway. Biomed Pharmacother 129:110351.LEAK
OXPHOS
NIsolated mitochondriaMouseLiver
Mahalingam 2020 J Physiol2020Mahalingam S, Cheviron ZA, Storz JF, McClelland GB, Scott GR (2020) Chronic cold exposure induces mitochondrial plasticity in deer mice native to high altitudes. J Physiol [Epub ahead of print].LEAK
OXPHOS
F
N
S
CIV
NS
Isolated mitochondriaMouseSkeletal muscle
Mezeiova 2020 Eur J Med Chem2020Mezeiova E, Janockova J, Andrys R, Soukup O, Kobrlova T, Muckova L, Pejchal J, Simunkova M, Handl J, Micankova P, Capek J, Rousar T, Hrabinova M, Nepovimova E, Marco-Contelles JL, Valko M, Korabecny J (2020) 2-Propargylamino-naphthoquinone derivatives as multipotent agents for the treatment of Alzheimer's disease. Eur J Med Chem [Epub ahead of print].LEAK
OXPHOS
ET
ROXIntact cellsHumanNeuroblastoma
Liepinsh 2020 Physiol Rep2020Liepinsh E, Makarova E, Plakane L, Konrade I, Liepins K, Videja M, Sevostjanovs E, Grinberga S, Makrecka-Kuka M, Dambrova M (2020) Low-intensity exercise stimulates bioenergetics and increases fat oxidation in mitochondria of blood mononuclear cells from sedentary adults. Physiol Rep 8:e14489.LEAK
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F
N
CIV
Permeabilized cells
Intact cells
HumanBlood cells
Lensu 2020 Preprints2020Lensu S, Pariyani R, Mäkinen E, Yang B, Saleem W, Munukka E, Lehti M, Driuchina A, Linden J, Tiirola M, Lahti L, Pekkala S (2020) Prebiotic xylo-oligosaccharides targeting Faecalibacterium prausnitzii prevent high fat diet-induced hepatic steatosis in rats. Preprints 2020:2020090241.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateRatLiver
Mann 2020 Sci Rep2020Mann J, Yang N, Montpetit R, Kirschenman R, Lemieux H, Goping IS (2020) BAD sensitizes breast cancer cells to docetaxel with increased mitotic arrest and necroptosis. Sci Rep 10:355.LEAK
ROUTINE
ET
Intact cellsHumanOther cell lines
Zhang 2020 Chemosphere2020Zhang Y, Li Y, Feng Q, Shao M, Yuan F, Liu F (2020) Polydatin attenuates cadmium-induced oxidative stress via stimulating SOD activity and regulating mitochondrial function in Musca domestica larvae. Chemosphere 248:126009.LEAK
OXPHOS
N
S
ROX
Isolated mitochondriaHexapods
Peres de Oliveira 2020 Proteome Sci2020Peres de Oliveira A, Basei FL, Slepicka PF, de Castro Ferezin C, Melo-Hanchuk TD, de Souza EE, Lima TI, Dos Santos VT, Mendes D, Silveira LR, Menck CFM, Kobarg J (2020) NEK10 interactome and depletion reveal new roles in mitochondria. Proteome Sci 18:4.LEAK
ROUTINE
ET
Intact cellsHumanHeLa
Macasoi 2020 Oncol Rep2020Macașoi I, Pavel IZ, Moacă AE, Avram S, David LV, Coricovac D, Mioc A, Spandidos DA, Tsatsakis A, Șoica C, Dumitrașcu V, Dehelean C (2020) Mechanistic investigations of antitumor activity of a Rhodamine B‑oleanolic acid derivative bioconjugate. Oncol Rep 44:1169-83.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
HumanEndothelial;epithelial;mesothelial cell
Simard 2020b Metabolites2020Simard CJ, Touaibia M, Allain EP, Hebert-Chatelain E, Pichaud N (2020) Role of the mitochondrial pyruvate carrier in the occurrence of metabolic inflexibility in Drosophila melanogaster exposed to dietary sucrose. Metabolites 10:E411.LEAK
OXPHOS
ET
N
Gp
NS
Other combinations
ROX
Permeabilized tissueDrosophila
Ledur 2020 Sci Rep2020Ledur PF, Karmirian K, Pedrosa CDSG, Souza LRQ, Assis-de-Lemos G, Martins TM, Ferreira JCCG, de Azevedo Reis GF, Silva ES, Silva D, Salerno JA, Ornelas IM, Devalle S, Madeiro da Costa RF, Goto-Silva L, Higa LM, Melo A, Tanuri A, Chimelli L, Murata MM, Garcez PP, Filippi-Chiela EC, Galina A, Borges HL, Rehen SK (2020) Zika virus infection leads to mitochondrial failure, oxidative stress and DNA damage in human iPSC-derived astrocytes. Sci Rep 10:1218.LEAK
ROUTINE
ET
ROXIntact cellsHumanNervous system
Owiredu 2020 Am J Physiol Cell Physiol2020Owiredu S, Ranganathan A, Eckmann DM, Shofer FS, Hardy K, Lambert DS, Kelly M, Jang DH (2020) Ex vivo use of cell-permeable succinate prodrug attenuates mitochondrial dysfunction in blood cells obtained from carbon monoxide poisoned individuals. Am J Physiol Cell Physiol 319:C129-35.LEAK
ROUTINE
ET
S
CIV
ROX
Permeabilized cells
Intact cells
HumanBlood cells
Pajuelo 2020 Cells2020Pajuelo Reguera D, Čunátová K, Vrbacký M, Pecinová A, Houštěk J, Mráček T, Pecina P (2020) Cytochrome c oxidase subunit 4 isoform exchange results in modulation of oxygen affinity. Cells 9:443.LEAK
OXPHOS
ET
N
S
Gp
CIV
NS
ROX
Permeabilized cellsHumanHEK
Kunz 2020 J Biol Chem2020Kunz HE, Dorschner JM, Berent TE, Meyer T, Wang X, Jatoi A, Kumar R, Lanza IR (2020) Methylarginine metabolites are associated with attenuated muscle protein synthesis in cancer-associated muscle wasting. J Biol Chem [Epub ahead of print].LEAK
ROUTINE
OXPHOS
ET
N
NS
ROX
S
Permeabilized tissue
Intact cells
MouseSkeletal muscle
Szibor 2020 J Cell Mol Med2020Szibor Marten, Schreckenberg Rolf, Gizatullina Zemfira, Dufour Eric, Wiesnet Marion, Dhandapani Praveen Kumar, Debska-Vielhaber Grazyna, Heidler Juliana, Wittig Ilka, Nyman Tuula A, Gaertner Ulrich, Hall Andrew R, Pell Victoria, Viscomi Carlo, Krieg Thomas, Murphy Michael P, Braun Thomas, Gellerich Frank Norbert, Schlueter Klaus-Dieter, Jacobs Howard T(2020) Respiratory chain signalling is essential for adaptive remodelling following cardiac ischaemia. J Cell Mol Med 24:3534-48.LEAK
OXPHOS
N
S
CIV
Permeabilized tissue
Isolated mitochondria
MouseHeart
Keller 2020 Oxid Med Cell Longev2020Keller Amy, Hull Sara E, Elajaili Hanan, Johnston Aspen, Knaub Leslie A, Chun Ji hye, Walker Lori, Nozik-Grayck Eva, Reusch Jane EB (2020) (–)-Epicatechin modulates mitochondrial redox in vascular cell models of oxidative stress. Oxid Med Cell Longev 2020:6392629.LEAK
OXPHOS
ET
N
NS
Permeabilized cellsHumanEndothelial;epithelial;mesothelial cell
Dirks 2020 J Physiol2020Dirks ML, Miotto PM, Goossens GH, Senden JM, Petrick HL, van Kranenburg J, van Loon LJC, Holloway GP (2020) Short-term bed rest-induced insulin resistance cannot be explained by increased mitochondrial H2O2 emission. J Physiol 598:123-37.LEAK
OXPHOS
N
NS
Permeabilized tissueHumanSkeletal muscle
Bertero 2020 Circ Res2020Bertero E, O'Rourke B, Maack C (2020) Mitochondria do not survive calcium overload during transplantation. Circ Res 126:784-86.LEAK
OXPHOS
NIsolated mitochondriaMouseSkeletal muscle
Ulgherait 2020 Nat Commun2020Ulgherait Matt, Chen Anna, McAllister Sophie F, Kim Han X, Delventhal Rebecca, Wayne Charlotte R, Garcia Christian J, Recinos Yocelyn, Oliva Miles, Canman Julie C, Picard Martin, Owusu-Ansah Edward, Shirasu-Hiza Mimi (2020) Circadian regulation of mitochondrial uncoupling and lifespan. Nat Commun 11:1927.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Isolated mitochondriaDrosophila
Robledo-Cadena 2020 Pharmaceuticals (Basel)2020Robledo-Cadena DX, Gallardo-Pérez JC, Dávila-Borja V, Pacheco-Velázquez SC, Belmont-Díaz JA, Ralph SJ, Blanco-Carpintero BA, Moreno-Sánchez R, Rodríguez-Enríquez S (2020) Non-steroidal anti-inflammatory drugs increase cisplatin, paclitaxel, and doxorubicin efficacy against human cervix cancer cells. Pharmaceuticals (Basel) 13:463.LEAKIntact cellsHumanEndothelial;epithelial;mesothelial cell
HeLa
Fibroblast
Skemiene 2020 J Bioenerg Biomembr2020Skemiene K, Pampuscenko K, Rekuviene E, Borutaite V (2020) Protective effects of anthocyanins against brain ischemic damage. J Bioenerg Biomembr 52:71-82.LEAK
OXPHOS
NIsolated mitochondriaRatNervous system
Edmunds 2020 Mol Metab2020Edmunds LR, Xie B, Mills AM, Huckestein BR, Undamatla R, Murali A, Pangburn MM, Martin J, Sipula I, Kaufman BA, Scott I, Jurczak MJ (2020) Liver-specific Prkn knockout mice are more susceptible to diet-induced hepatic steatosis and insulin resistance. Mol Metab 41:101051.LEAK
OXPHOS
ET
F
N
ROX
HomogenateMouseLiver
Wei 2020 Cell Rep2020Wei X, Lu Z, Li L, Zhang H, Sun F, Ma H, Wang L, Hu Y, Yan Z, Zheng H, Yang G, Liu D, Tepel M, Gao P, Zhu Z (2020) Reducing NADPH synthesis counteracts diabetic nephropathy through restoration of AMPK activity in type 1 diabetic rats. Cell Rep 32:108207.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Isolated mitochondriaRatKidney
Al-Azab 2020 FEBS J2020Al-Azab M, Qaed E, Ouyang X, Elkhider A, Walana W, Li H, Li W, Tang Y, Adlat S, Wei J, Wang B, Li X (2020) TL1A/TNFR2-mediated mitochondrial dysfunction of fibroblast-like synoviocytes increases inflammatory response in patients with rheumatoid arthritis via reactive oxygen species generation. FEBS J 287:3088-104.LEAK
ROUTINE
OXPHOS
ET
N
ROX
Permeabilized cells
Intact cells
HumanOther cell lines
Chen 2020 Mol Genet Genomic Med2020Chen D, Zhao Q, Xiong J, Lou X, Han Q, Wei X, Xie J, Li X, Zhou H, Shen L, Yang Y, Fang H, Lyu J (2020) Systematic analysis of a mitochondrial disease-causing ND6 mutation in mitochondrial deficiency. Mol Genet Genomic Med 8:e1199.LEAK
ROUTINE
Intact cellsHumanLymphocyte
Belosludtsev 2020 Biochimie2020Belosludtsev KN, Belosludtseva NV, Kosareva EA, Talanov EY, Gudkov SV, Dubinin MV (2020) Itaconic acid impairs the mitochondrial function by the inhibition of complexes II and IV and induction of the permeability transition pore opening in rat liver mitochondria. Biochimie 176:150-57.LEAK
OXPHOS
N
S
CIV
Isolated mitochondriaRatLiver
P-L control efficiency2020Gnaiger E (2020) Cell ergometry: OXPHOS-control and ET-coupling efficiency. Mitochondr Physiol Network (2015-01-18) last update 2020-11-12.LEAK
OXPHOS
Pena 2020 Int J Chronic Dis2020Pena GS, Paez HG, Johnson TK, Halle JL, Carzoli JP, Visavadiya NP, Zourdos MC, Whitehurst MA, Khamoui AV (2020) Hippocampal growth factor and myokine cathepsin B expression following aerobic and resistance training in 3xTg-AD mice. Int J Chronic Dis 2020:Article ID 5919501.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateMouseNervous system
Woessner 2020 J Appl Physiol (1985)2020Woessner MN, Neil C, Saner NJ, Goodman CA, McIlvenna LC, Ortiz de Zevallos J, Garnham AP, Levinger I, Allen JD (2020) Effect of inorganic nitrate on exercise capacity, mitochondria respiration and vascular function in heart failure reduced ejection fraction. J Appl Physiol (1985) 128:1355-64.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Schleier 2020 J Cardiovasc Transl Res2020Schleier Y, Moreno-Loaiza O, López Alarcón MM, Lopes Martins EG, Braga BC, Ramos IP, Galina A, Medei EH (2020) NOD mice recapitulate the cardiac disturbances observed in type 1 diabetes. J Cardiovasc Transl Res [Epub ahead of print].LEAK
OXPHOS
N
NS
ROX
Isolated mitochondriaMouseHeart
Hoffmann 2020 J Clin Endocrinol Metab2020Hoffmann C, Schneeweiss P, Randrianarisoa E, Schnauder G, Kappler L, Machann J, Schick F, Fritsche A, Heni M, Birkenfeld A, Niess AM, Häring HU, Weigert C, Moller A (2020) Response of mitochondrial respiration in adipose tissue and muscle to 8 weeks of endurance exercise in obese subjects. J Clin Endocrinol Metab 105:dgaa571.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Frambach 2020 Biochim Biophys Acta Mol Basis Dis2020Frambach SJCM, van de Wal MAE, van den Broek PHH, Smeitink JAM, Russel FGM, de Haas R, Schirris TJJ (2020) Effects of clofibrate and KH176 on life span and motor function in mitochondrial complex I-deficient mice. Biochim Biophys Acta Mol Basis Dis 1866:165727.LEAK
OXPHOS
F
N
S
Gp
CIV
Other combinations
ROX
Permeabilized tissueMouseSkeletal muscle
Carvalho 2020 BMC Nutr2020Carvalho E, Adams SH, Borsheim E, Blackburn ML, Ono-Moore KD, Cotter M, Bowlin AK, Yeruva L (2020) Neonatal diet impacts liver mitochondrial bioenergetics in piglets fed formula or human milk. BMC Nutr 6:13.LEAK
OXPHOS
N
NS
ROX
Permeabilized tissuePigLiver
Vega 2020 Physiol Rep2020Vega RB, Brouwers B, Parsons SA, Stephens NA, Pino MF, Hodges A, Yi F, Yu G, Pratley RE, Smith SR, Sparks LM (2020) An improvement in skeletal muscle mitochondrial capacity with short-term aerobic training is associated with changes in Tribbles 1 expression. Physiol Rep 8:e14416.LEAK
OXPHOS
ET
F
N
NS
Permeabilized tissueHumanSkeletal muscle
Silva-Rodrigues 2020 Free Radic Biol Med2020Silva-Rodrigues T, De-Souza-Ferreira E, Machado CM, Cabral-Braga B, Rodrigues-Ferreira C, Galina A (2020) Hyperglycemia in a Type 1 Diabetes Mellitus model causes a shift in mitochondria coupled-glucose phosphorylation and redox metabolism in rat brain. Free Radic Biol Med [Epub ahead of print].LEAK
OXPHOS
ET
N
NS
Isolated mitochondriaRatNervous system
Groennebaek 2020 Cells2020Groennebaek T, Billeskov TB, Schytz CT, Jespersen NR, Bøtker HE, Olsen RKJ, Eldrup N, Nielsen J, Farup J, De Paoli FV, Vissing K (2020) Mitochondrial structure and function in the metabolic myopathy accompanying patients with critical limb ischemia. Cells 9:E570.LEAK
OXPHOS
N
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Feng 2020 Int J Biol Macromol2020Feng Q, Shao M, Han J, Tang T, Zhang Y, Liu F (2020) TFAM, a potential oxidative stress biomarker used for monitoring environment pollutants in Musca domestica. Int J Biol Macromol 155:524-34.LEAK
OXPHOS
N
S
ROX
Isolated mitochondriaHexapods
Gnad 2020 Cell Metab2020Gnad T, Navarro G, Lahesmaa M, Reverte-Salisa L, Copperi F, Cordomi A, Naumann J, Hochhäuser A, Haufs-Brusberg S, Wenzel D, Suhr F, Jespersen NZ, Scheele C, Tsvilovskyy V, Brinkmann C, Rittweger J, Dani C, Kranz M, Deuther-Conrad W, Eltzschig HK, Niemi T, Taittonen M, Brust P, Nuutila P, Pardo L, Fleischmann BK, Blüher M, Franco R, Bloch W, Virtanen KA, Pfeifer A (2020) Adenosine/A2B receptor signaling ameliorates the effects of aging and counteracts obesity. Cell Metab 32:56-70.e7.LEAK
OXPHOS
ET
N
S
Permeabilized tissueMouseSkeletal muscle
Alahmad 2020 EMBO Mol Med2020Alahmad A, Nasca A, Heidler J, Thompson K, Oláhová M, Legati A, Lamantea E, Meisterknecht J, Spagnolo M, He L, Alameer S, Hakami F, Almehdar A, Ardissone A, Alston CL, McFarland R, Wittig I, Ghezzi D, Taylor RW (2020) Bi-allelic pathogenic variants in NDUFC2 cause early-onset Leigh syndrome and stalled biogenesis of complex I. EMBO Mol Med [Epub ahead of print].LEAK
ROUTINE
ET
ROXIntact cellsHumanFibroblast
Hardee 2020 Mol Metab2020Hardee JP, Martins KJB, Miotto PM, Ryall JG, Gehrig SM, Reljic B, Naim T, Chung JD, Trieu J, Swiderski K, Philp AM, Philp A, Watt MJ, Stroud DA, Koopman R, Steinberg GR, Lynch GS (2020) Metabolic remodeling of dystrophic skeletal muscle reveals biological roles for dystrophin and utrophin in adaptation and plasticity. Mol Metab [Epub ahead of print].OXPHOS
LEAK
N
NS
Permeabilized tissueMouseSkeletal muscle
Ajime 2020 Nicotine Tob Res2020Ajime TT, Serré J, Wüst RCI, Messa GAM, Poffé C, Swaminathan A, Maes K, Janssens W, Troosters T, Degens H, Gayan-Ramirez G (2020) Two weeks smoking cessation reverses cigarette smoke-induced skeletal muscle atrophy and mitochondrial dysfunction in mice. Nicotine Tob Res [Epub ahead of print].LEAK
ET
SPermeabilized tissueMouseSkeletal muscle
Roy Chowdhury 2020 Cancers (Basel)2020Roy Chowdhury S, Bouchard EDJ, Saleh R, Nugent Z, Peltier C, Mejia E, Hou S, McFall C, Squires M, Hewitt D, Davidson L, Shen GX, Johnston JB, Doucette C, Hatch GM, Fernyhough P, Marshall A, Gibson SB, Dawe DE, Banerji V (2020) Mitochondrial respiration correlates with prognostic markers in chronic lymphocytic leukemia and Is normalized by ibrutinib treatment. Cancers (Basel) 12:E650.LEAK
ET
ROXIntact cellsHumanLymphocyte
Weber 2020 FASEB J2020Weber M, Mera P, Casas J, Salvador J, Rodríguez A, Alonso S, Sebastián D, Soler-Vázquez MC, Montironi C, Recalde S, Fucho R, Calderón-Domínguez M, Mir JF, Bartrons R, Escola-Gil JC, Sánchez-Infantes D, Zorzano A, Llorente-Cortes V, Casals N, Valentí V, Frühbeck G, Herrero L, Serra D (2020) Liver CPT1A gene therapy reduces diet-induced hepatic steatosis in mice and highlights potential lipid biomarkers for human NAFLD. FASEB J [Epub ahead of print].LEAK
OXPHOS
N
NS
Isolated mitochondriaMouseLiver
Vanweert 2020 J Clin Endocrinol Metab2020Vanweert F, de Ligt M, Hoeks J, Hesselink MKC, Schrauwen P, Phielix E (2020) Elevated plasma branched-chain amino acid levels correlate with type 2 diabetes-related metabolic disturbances. J Clin Endocrinol Metab [Epub ahead of print].LEAK
OXPHOS
ET
F
N
Permeabilized tissueHumanSkeletal muscle
Shi 2020 Diabetes2020Shi JH, Lu JY, Chen HY, Wei CC, Xu X, Li H, Bai Q, Xia FZ, Lam SM, Zhang H, Shi YN, Cao D, Chen L, Shui G, Yang X, Lu Y, Chen YX, Zhang WJ (2020) Liver ChREBP protects against fructose-induced glycogenic hepatotoxicity by regulating L-type pyruvate kinase. Diabetes 120:29.LEAK
ROUTINE
ET
Intact cellsMouseLiver
Gvozdjakova 2020 Diagnostics (Basel)2020Gvozdjakova Anna, Sumbalova Zuzana, Kucharska Jarmila, Komlosi Maria, Rausova Zuzana, Vancova Olga, Szamosova Monika, Mojto Viliam(2020) Platelet mitochondrial respiration, endogenous coenzyme Q10 and oxidative stress in patients with chronic kidney disease. Diagnostics (Basel) 10:E176.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
HumanPlatelet
Brunetta 2020 J Physiol2020Brunetta HS, Politis-Barber V, Petrick HL, Dennis KMJH, Kirsh AJ, Barbeau PA, Nunes EA, Holloway GP (2020) Nitrate attenuates HFD-induced glucose intolerance in association with reduced epididymal adipose tissue inflammation and mitochondrial ROS emission. J Physiol 598:3357-71.LEAK
OXPHOS
N
NS
Permeabilized tissueMouseFat
Boardman 2020 Am J Physiol Heart Circ Physiol2020Boardman NT, Pedersen TM, Rossvoll L, Hafstad AD, Aasum E (2020) Diet-induced obese mouse hearts tolerate an acute high fatty acid exposure that also increases ischemic tolerance. Am J Physiol Heart Circ Physiol 319:H682-93.LEAK
OXPHOS
F
N
Isolated mitochondriaMouseHeart
Rodriguez 2020 J Gerontol A Biol Sci Med Sci2020Rodríguez E, Hakkou M, Hagen TM, Lemieux H, Blier PU (2020) Divergences in the control of mitochondrial respiration are associated with lifespan variation in marine bivalves. J Gerontol A Biol Sci Med Sci [Epub ahead of print].LEAK
OXPHOS
ET
F
N
S
Gp
CIV
ROX
Isolated mitochondriaMolluscs
Grewal 2020 Exp Neurol2020Grewal R, Reutzel M, Dilberger B, Hein H, Zotzel J, Marx S, Tretzel J, Sarafeddinov A, Fuchs C, Eckert GP (2020) Purified oleocanthal and ligstroside protect against mitochondrial dysfunction in models of early Alzheimer's disease and brain ageing. Exp Neurol 328:113248.LEAK
ROUTINE
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cells
Intact cells
HumanNeuroblastoma
Almoiliqy 2020 Acta Pharmacol Sin2020Almoiliqy M, Wen J, Xu B, Sun YC, Lian MQ, Li YL, Qaed E, Al-Azab M, Chen DP, Shopit A, Wang L, Sun PY, Lin Y (2020) Cinnamaldehyde protects against rat intestinal ischemia/reperfusion injuries by synergistic inhibition of NF-κB and p53. Acta Pharmacol Sin 41:1208-22.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
RatEndothelial;epithelial;mesothelial cell
Kapser-Fischer 2020 Thesis2020Kapser-Fischer IP (2020) Dietary interventions in C57BL/6 mice and their interplay with selected metabolic and genetic parameters. PhD Thesis 120.LEAK
OXPHOS
HomogenateMouseFat
Bhaskaran 2020 Aging Cell2020Bhaskaran S, Pollock N, C Macpherson P, Ahn B, Piekarz KM, Staunton CA, Brown JL, Qaisar R, Vasilaki A, Richardson A, McArdle A, Jackson MJ, Brooks SV, Van Remmen H (2020) Neuron-specific deletion of CuZnSOD leads to an advanced sarcopenic phenotype in older mice. Aging Cell 19:e13225.LEAK
OXPHOS
N
S
CIV
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Dubinin 2020 Biochim Biophys Acta Bioenerg2020Dubinin MV, Talanov EY, Tenkov KS, Starinets VS, Mikheeva IB, Belosludtsev KN (2020) Transport of Ca2+ and Ca2+-dependent permeability transition in heart mitochondria in the early stages of duchenne muscular dystrophy. Biochim Biophys Acta Bioenerg 1861:148250.LEAK
OXPHOS
NIsolated mitochondriaMouseHeart
Soliman 2020 Toxicology2020Soliman E, Elhassanny AEM, Malur A, McPeek M, Bell A, Leffler N, Van Dross R, Jones JL, Malur AG, Thomassen MJ (2020) Impaired mitochondrial function of alveolar macrophages in carbon nanotube-induced chronic pulmonary granulomatous disease. Toxicology 445:152598.LEAKF
N
Permeabilized cellsMouseLung;gill
Cassereau 2020 Exp Neurol2020Cassereau J, Chevrollier A, Codron P, Goizet C, Gueguen N, Verny C, Reynier P, Bonneau D, Lenaers G, Procaccio V (2020) Oxidative stress contributes differentially to the pathophysiology of Charcot-Marie-Tooth disease type 2K. Exp Neurol 323:113069.LEAK
OXPHOS
ET
N
S
NS
Permeabilized cellsHumanFibroblast
Le 2020 J Biol Chem2020Le CH, Benage LG, Specht KS, Li Puma LC, Mulligan CM, Heuberger AL, Prenni JE, Claypool SM, Chatfield KC, Sparagna GC, Chicco AJ (2020) Tafazzin deficiency impairs CoA-dependent oxidative metabolism in cardiac mitochondria . J Biol Chem 295:12485-97.LEAK
OXPHOS
F
N
S
NS
Intact organismHumanHeart
He 2020 Clin Transl Med2020He C, Gao P, Cui Y, Li Q, Li Y, Lu Z, Ma H, Zhao Y, Li L, Sun F, Chen, X, Jia H, Liu D, Yang G, Zheng H, Zhu Z (2020) Low‐glucose‐sensitive TRPC6 dysfunction drives hypoglycemia‐induced cognitive impairment in diabetes. Clin Transl Med 10:e205.LEAK
OXPHOS
ET
N
S
NS
ROX
Isolated mitochondriaMouseNervous system
Lara-Marqueza 2020 J Funct Foods2020Lara-Márquez M, Báez-Magaña M, Raymundo-Ramos C, Spagnuolo PA, Macías-Rodríguez L, Salgado-Garciglia R, Ochoa-Zarzosa A, López-Meza JE (2020) Lipid-rich extract from Mexican avocado (Persea americana var. drymifolia) induces apoptosis and modulates the inflammatory response in Caco-2 human colon cancer cells. J Funct Foods 64:103658.LEAK
ROUTINE
ET
Intact cellsHumanEndothelial;epithelial;mesothelial cell
Xiong 2020 Biomed Pharmacother2020Xiong Xiaowei, Lu Weihang, Qin Xuan, Luo Qingyu, Zhou Weimin (2020) Downregulation of the GLP-1/CREB/adiponectin pathway is partially responsible for diabetes-induced dysregulated vascular tone and VSMC dysfunction. Biomed Pharmacother 127:110218.LEAK
OXPHOS
ET
N
S
NS
Permeabilized cellsHuman
Rat
Endothelial;epithelial;mesothelial cell
Smith 2020 J Biol Chem2020Smith CD, Schmidt CA, Lin CT, Fisher-Wellman KH, Neufer PD (2020) Flux through mitochondrial redox circuits linked to nicotinamide nucleotide transhydrogenase generates counterbalance changes in energy expenditure. J Biol Chem [Epub ahead of print].LEAK
OXPHOS
ET
F
N
Isolated mitochondriaMouseSkeletal muscle
Contreras Mostazo 2020 Cancers (Basel)2020Mostazo MGC, Kurrle N, Casado M, Fuhrmann D, Alshamleh I, Häupl B, Martín-Sanz P, Brüne B, Serve H, Schwalbe H, Schnütgen F, Marin S, Cascante M (2020) Metabolic plasticity is an essential requirement of acquired tyrosine kinase inhibitor resistance in chronic myeloid leukemia. Cancers (Basel) 12:E3443.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
ROX
Permeabilized cells
Intact cells
HumanBlood cells
Ehrlicher 2020 FASEB J2020Ehrlicher SE, Stierwalt HD, Miller BF, Newsom SA, Robinson MM (2020) Mitochondrial adaptations to exercise do not require Bcl2-mediated autophagy but occur with BNIP3/Parkin activation. FASEB J 34:4602-18.LEAK
OXPHOS
ET
F
N
S
NS
Isolated mitochondriaMouseSkeletal muscle
Vaccari 2020 Eur J Appl Physiol2020Vaccari F, Passaro A, D'Amuri A, Sanz JM, Di Vece F, Capatti E, Magnesa B, Comelli M, Mavelli I, Grassi B, Fiori F, Bravo G, Avancini A, Parpinel M, Lazzer S (2020) Effects of 3-month high-intensity interval training vs. moderate endurance training and 4-month follow-up on fat metabolism, cardiorespiratory function and mitochondrial respiration in obese adults. Eur J Appl Physiol 120:1787-803.LEAK
OXPHOS
ET
N
S
NS
Permeabilized tissueHumanSkeletal muscle
D'Souza 2020 Nutrients2020D'Souza K, Mercer A, Mawhinney H, Pulinilkunnil T, Udenigwe CC, Kienesberger PC (2020) Whey peptides stimulate differentiation and lipid metabolism in adipocytes and ameliorate lipotoxicity-induced insulin resistance in muscle cells. Nutrients 12:E425.LEAK
ET
F
N
Permeabilized cellsMouseSkeletal muscle
Fat
Matsuo 2020 Am J Physiol Endocrinol Metab2020Matsuo FS, Araújo PHC, Mota RF, Carvalho AJR, Queiroz MS, Almeida BB, Ferreira KCOS, Metzner RJM, Ferrari GD, Alberici LC, Osako MK (2020) RANKL induces beige adipocyte differentiation in preadipocytes. Am J Physiol Endocrinol Metab 318:E866-77.LEAK
OXPHOS
NPermeabilized cellsMouseFat
Oellermann 2020 Sci Rep2020Oellermann M, Hickey AJR, Fitzgibbon QP, Smith G (2020) Thermal sensitivity links to cellular cardiac decline in three spiny lobsters. Sci Rep 10:202.LEAK
OXPHOS
ET
N
S
NS
HomogenateCrustaceansHeart
Vulczak 2020 Cells2020Vulczak A, Souza AO, Ferrari GD, Azzolini AECS, Pereira-da-Silva G, Alberici LC (2020) Moderate exercise modulates tumor metabolism of triple-negative breast cancer. Cells 9:E628.LEAK
OXPHOS
ET
N
ROX
Permeabilized cellsMouseEndothelial;epithelial;mesothelial cell
Sowton 2020 Mol Genet Metab Rep2020Sowton AP, Padmanabhan N, Tunster SJ, McNally BD, Murgia A, Yusuf A, Griffin JL, Murray AJ, Watson ED (2020) Mtrr hypomorphic mutation alters liver morphology, metabolism and fuel storage in mice. Mol Genet Metab Rep 23:100580.LEAK
OXPHOS
N
NS
HomogenateMouseLiver
Karabatsiakis 2020 Transl Psychiatry2020Karabatsiakis DA, Schönfeldt-Lecuona PDC (2020) Depression, mitochondrial bioenergetics, and electroconvulsive therapy: a new approach towards personalized medicine in psychiatric treatment - a short review and current perspective. Transl Psychiatry 10:226.LEAK
ROUTINE
ET
ROXIntact cellsHumanBlood cells
Deleye 2020 J Biol Chem2020Deleye Y, Cotte AK, Hannou SA, Hennuyer N, Bernard L, Derudas B, Caron S, Legry V, Vallez E, Dorchies E, Martin N, Lancel S, Annicotte JS, Bantubungi K, Pourtier A, Raverdy V, Pattou F, Lefebvre P, Abbadie C, Staels B, Haas JT, Paumelle R (2020) CDKN2A/p16INK4a suppresses hepatic fatty acid oxidation through the AMPKα2-SIRT1-PPARα signaling pathway. J Biol Chem [Epub ahead of print].LEAK
OXPHOS
F
N
HomogenateMouseLiver
Nascimento-Dos-Santos 2020 Biochim Biophys Acta Mol Basis Dis2020Nascimento-Dos-Santos G, de-Souza-Ferreira E, Lani R, de Faria CC, Araujo VG, Teixeira-Pinheiro LC, de Souza Vasconcelos T, Leandro TG, Santiago MF, Linden R, Galina A, Petrs-Silva H (2020) Neuroprotection from optic nerve injury and modulation of oxidative metabolism by transplantation of active mitochondria to the retina. Biochim Biophys Acta Mol Basis Dis 1866:165686.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Isolated mitochondria
Intact cells
RatLiver
Nervous system
Bloise 2020 Thyroid2020Bloise FF, Santos AT, Brito JT, Andrade CBV, Oliveira TS, Souza AF, Fontes KN, Silva JD, Blanco NG, Silva PL, Rocco PRM, Fliers E, Boelen A, da-Silva WS, Ortiga-Carvalho TM (2020) Sepsis impairs thyroid hormone signaling and mitochondrial function in the mouse diaphragm. Thyroid 30:1079-90.LEAK
OXPHOS
ET
N
CIV
NS
Permeabilized tissueMouseSkeletal muscle
Catalan-Garcia 2020 J Clin Med2020Catalán-García M, García-García FJ, Moreno-Lozano PJ, Alcarraz-Vizán G, Tort-Merino A, Milisenda JC, Cantó-Santos J, Barcos-Rodríguez T, Cardellach F, Lladó A, Novials A, Garrabou G, Grau-Junyent JM (2020) Mitochondrial dysfunction: A common hallmark underlying comorbidity between sIBM and other degenerative and age-related diseases. J Clin Med 9:E1446.LEAK
ET
Permeabilized cellsHumanFibroblast
Pelster 2020 PLoS One2020Pelster B, Wood CM, Campos DF, Val AL (2020) Cellular oxygen consumption, ROS production and ROS defense in two different size-classes of an Amazonian obligate air-breathing fish (Arapaima gigas). PLoS One 15:e0236507.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized tissueFishesKidney
Lung;gill
E-L coupling efficiency2020Gnaiger E (2020) Biochemical coupling efficiency: from 0 to <1. Mitochondr Physiol Network (2015-01-18) last update 2020-11-12.LEAK
ET
McCann 2020 Metabolites2020McCann MR, McHugh CE, Kirby M, Jennaro TS, Jones AE, Stringer KA, Puskarich MA (2020) A multivariate metabolomics method for estimating platelet mitochondrial oxygen consumption rates in patients with sepsis. Metabolites 10:E139.LEAK
ROUTINE
ET
ROXIntact cellsHumanPlatelet
Truong 2020 Cytokine2020Truong NTT, Lydic TA, Bazil JN, Suryadevara A, Olson LK (2020) Regulation of lipid metabolism in pancreatic beta cells by interferon gamma: a link to anti-viral function. Cytokine 133:155147.LEAK
ROUTINE
ET
Intact cellsRatIslet cell;pancreas;thymus
Chang 2020 J Biol Chem2020Chang L, Liu X, Diggle CP, Boyle JP, Hopkins PM, Shaw MA, Allen PD (2020) Bioenergetic defects in muscle fibers of RYR1 mutant knock-in mice associated with malignant hyperthermia. J Biol Chem [Epub ahead of print].LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Thome 2020 JCI Insight2020Thome T, Kumar RA, Burke SK, Khattri RB, Salyers ZR, Kelley RC, Coleman MD, Christou DD, Hepple RT, Scali ST, Ferreira LF, Ryan TE (2020) Impaired muscle mitochondrial energetics is associated with uremic metabolite accumulation in chronic kidney disease. JCI Insight [Epub ahead of print].LEAK
OXPHOS
F
N
S
Isolated mitochondriaMouseSkeletal muscle
Locatelli 2020 FASEB J2020Locatelli L, Cazzaniga A, De Palma C, Castiglioni S, Maier JAM (2020) Mitophagy contributes to endothelial adaptation to simulated microgravity. FASEB J 34:1833-45.LEAK
OXPHOS
ET
N
S
NS
ROX
Isolated mitochondria
Intact cells
HumanEndothelial;epithelial;mesothelial cell
Hafstad 2020 Antioxidants (Basel)2020Hafstad AD, Hansen SS, Lund J, Santos CXC, Boardman NT, Shah AM, Aasum E (2020) NADPH oxidase 2 mediates myocardial oxygen wasting in obesity. Antioxidants (Basel) 9:E171.LEAK
OXPHOS
F
N
Isolated mitochondriaMouseHeart
Silaidos 2020 Mitochondrion2020Silaidos C, Grube J, Muley C, Eckert GP (2020) Time-dependent melatonin secretion is associated with mitochondrial function in peripheral blood mononuclear cells (PBMC) of male volunteers. Mitochondrion 53:21-29.LEAK
ROUTINE
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cells
Intact cells
HumanBlood cells
Severo 2020 Life Sci2020Severo L, Godinho D, Machado F, Hartmann D, Fighera MR, Soares FA, Furian AF, Oliveira MS, Royes LF (2020) The role of mitochondrial bioenergetics and oxidative stress in depressive behavior in recurrent concussion model in mice. Life Sci 257:117991.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateMouseNervous system
Weaver 2020 Biol Lett2020Weaver RJ, Carrion G, Nix R, Maeda GP, Rabinowitz S, Iverson ENK, Thueson K, Havird JC (2020) High mitochondrial mutation rates in Silene are associated with nuclear-mediated changes in mitochondrial physiology. Biol Lett 16:20200450.LEAK
OXPHOS
N
S
CIV
NS
Isolated mitochondriaPlants
Woessner 2020 Thesis2020Woessner MN (2020) BEET-HF: The effects of dietary inorganic nitrate supplementation on aerobic exercise performance, vascular function, cardiac performance and mitochondrial respiration in patients with heart failure with reduced ejection fraction. PhD Thesis 198.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Cruz 2020 Drug Alcohol Depend2020Cruz JV, Maba IK, Correia D, Kaziuk FD, Cadena SMSC, Zampronio AR (2020) Intermittent binge-like ethanol exposure during adolescence attenuates the febrile response by reducing brown adipose tissue thermogenesis in rats. Drug Alcohol Depend 209:107904.LEAK
OXPHOS
NIsolated mitochondriaRatFat
Gutierrez 2020 Sci Signal2020Gutiérrez T, Qi H, Yap MC, Tahbaz N, Milburn LA, Lucchinetti E, Lou PH, Zaugg M, LaPointe PG, Mercier P, Overduin M, Bischof H, Burgstaller S, Malli R, Ballanyi K, Shuai J, Simmen T (2020) The ER chaperone calnexin controls mitochondrial positioning and respiration . Sci Signal 13:eaax6660.LEAK
ROUTINE
ET
Intact cellsMouseFibroblast
Gumpp 2020 Proc Natl Acad Sci U S A2020Gumpp AM, Boeck C, Behnke A, Bach AM, Ramo-Fernández L, Welz T, Gündel H, Kolassa IT, Karabatsiakis A (2020) Childhood maltreatment is associated with changes in mitochondrial bioenergetics in maternal, but not in neonatal immune cells. Proc Natl Acad Sci U S A 117:24778-84.LEAK
ROUTINE
ET
ROXIntact cellsHumanBlood cells
Gruenig 2020 Biochem Pharmacol2020Grünig D, Szabo L, Marbet M, Krähenbühl S (2020) Valproic acid affects fatty acid and triglyceride metabolism in HepaRG cells exposed to fatty acids by different mechanisms. Biochem Pharmacol 177:113860.LEAK
OXPHOS
ET
N
S
DQ
CIV
ROX
Isolated mitochondriaMouseLiver
Allen 2020 Commun Biol2020Allen ME, Pennington ER, Perry JB, Dadoo S, Makrecka-Kuka M, Dambrova M, Moukdar F, Patel HD, Han X, Kidd GK, Benson EK, Raisch TB, Poelzing S, Brown DA, Shaikh SR (2020) The cardiolipin-binding peptide elamipretide mitigates fragmentation of cristae networks following cardiac ischemia reperfusion in rats. Commun Biol 3:389.LEAK
OXPHOS
ET
N
S
CIV
Permeabilized tissueRatHeart
Garcia 2020 Mol Hum Reprod2020Garcia BM, Machado TS, Carvalho KF, Nolasco P, Nociti RP, Del Collado M, Capo Bianco MJD, Grejo MP, Neto JDA, Sugiyama FHC, Tostes K, Pandey AK, Gonçalves LM, Perecin F, Meirelles FV, Ferraz JBS, Vanzela EC, Boschero AC, Guimarães FEG, Abdulkader F, Laurindo FRM, Kowaltowski AJ, Chiaratti MR (2020) Mice born to females with oocyte-specific deletion of mitofusin 2 have increased weight gain and impaired glucose homeostasis. Mol Hum Reprod [Epub ahead of print].LEAK
OXPHOS
ET
SIsolated mitochondriaMouseLiver
Dawson 2020 J Exp Biol2020Dawson NJ, Millet C, Selman C, Metcalfe NB (2020) Measurement of mitochondrial respiration in permeabilized fish gills. J Exp Biol 223:jeb216762.LEAK
OXPHOS
N
CIV
NS
ROX
Permeabilized tissueFishesLung;gill
Burgin 2020 Int J Mol Sci2020Burgin HJ, Lopez Sanchez MIG, Smith CM, Trounce IA, McKenzie M (2020) Pioglitazone and deoxyribonucleoside combination treatment increases mitochondrial respiratory capacity in m.3243A>G MELAS cybrid cells. Int J Mol Sci 21:E2139.LEAK
ROUTINE
ET
ROXIntact cellsHumanOther cell lines
Fecker 2020 Biomolecules2020Fecker R, Buda V, Alexa E, Avram S, Pavel IZ, Muntean D, Cocan I, Watz C, Minda D, Dehelean CA, Soica C, Danciu C (2020) Phytochemical and biological screening of Oenothera biennis L. hydroalcoholic extract. Biomolecules 10:E818.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
HumanEndothelial;epithelial;mesothelial cell
Guo 2020 Hum Gene Ther2020Guo Y, Zhang K, Gao X, Zhou Z, Liu Z, Yang K, Huang K, Yang Q, Long Q (2020) Sustained oligomycin sensitivity conferring protein expression in cardiomyocytes protects against cardiac hypertrophy induced by pressure-overload via improving mitochondrial function. Hum Gene Ther [Epub ahead of print].LEAK
OXPHOS
ET
N
NS
ROX
Isolated mitochondriaMouseHeart
Herpich 2020 Exp Gerontol2020Herpich C, Franz K, Klaus S, Müller-Werdan U, Ost M, Norman K (2020) Age-related fatigue is associated with reduced mitochondrial function in peripheral blood mononuclear cells. Exp Gerontol [Epub ahead of print].LEAK
ROUTINE
ET
ROXIntact cellsHumanBlood cells
Cornelissen 2020 Hum Mol Genet2020Cornelissen T, Spinazzi M, Martin S, Imberechts D, Vangheluwe P, Bird M, De Strooper B, Vandenberghe W (2020) CHCHD2 harboring the Parkinson's disease-linked T61I mutation precipitates inside mitochondria and induces precipitation of wild-type CHCHD2. Hum Mol Genet 29:1096-106.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cellsHumanFibroblast
Politis-Barber 2020 Am J Physiol Endocrinol Metab2020Politis-Barber V, Brunetta HS, Paglialunga S, Petrick HL, Holloway GP (2020) Long-term high-fat feeding exacerbates short-term increases in adipose mitochondrial reactive oxygen species, without impairing mitochondrial respiration. Am J Physiol Endocrinol Metab 319:E376-87.LEAK
OXPHOS
F
N
Gp
NS
Permeabilized cellsMouseFat
Bundgaard 2020 J Exp Biol2020Bundgaard A, Qvortrup K, Rasmussen LJ, Fago A (2020) Turtles maintain mitochondrial integrity but reduce mitochondrial respiratory capacity in the heart after cold acclimation and anoxia. J Exp Biol 222:jeb200410.LEAK
OXPHOS
ET
N
NS
Permeabilized tissueAmphibiansHeart
Esselun 2020 Neuromolecular Med2020Esselun C, Dilberger B, Silaidos CV, Koch E, Schebb NH, Eckert GP (2020) A walnut diet in combination with enriched environment improves cognitive function and affects lipid metabolites in brain and liver of aged NMRI mice. Neuromolecular Med [Epub ahead of print].LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Isolated mitochondriaMouseNervous system
Remie 2020 Am J Clin Nutr2020Remie CME, Roumans KHM, Moonen MPB, Connell NJ, Havekes B, Mevenkamp J, Lindeboom L, de Wit VHW, van de Weijer T, Aarts SABM, Lutgens E, Schomakers BV, Elfrink HL, Zapata-Pérez R, Houtkooper RH, Auwerx J, Hoeks J, Schrauwen-Hinderling VB, Phielix E, Schrauwen P (2020) Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans. Am J Clin Nutr 112:413-26.LEAK
OXPHOS
ET
F
N
S
NS
Permeabilized tissueHumanSkeletal muscle
Irion 2020 Stem Cells Int2020Irion CI, Martins EL, Christie MLA, de Andrade CBV, de Moraes ACN, Ferreira RP, Pimentel CF, Suhett GD, Campos de Carvalho AC, Lindoso RS, Vieyra A, Galina A, Goldenberg RCS (2020) Acute myocardial infarction reduces respiration in rat cardiac fibers, despite adipose tissue mesenchymal stromal cell transplant. Stem Cells Int 2020:4327965 .LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueRatHeart
Song 2020 Obes Facts2020Song K, Zhang Y, Ga Q, Bai Z, Ge RL (2020) Increased insulin sensitivity by high-altitude hypoxia in mice with high-fat diet-induced obesity is associated with activated AMPK signaling and subsequently enhanced mitochondrial biogenesis in skeletal muscles. Obes Facts 13:455-72.LEAK
OXPHOS
F
N
Permeabilized tissueSkeletal muscle
Jian 2020 Cell Metab2020Jian C, Fu J, Cheng X, Shen LJ, Ji YX, Wang X, Pan S, Tian H, Tian S, Liao R, Song K, Wang HP, Zhang X, Wang Y, Huang Z, She ZG, Zhang XJ, Zhu L, Li H (2020) Low-dose sorafenib acts as a mitochondrial uncoupler and ameliorates nonalcoholic steatohepatitis. Cell Metab 31:892-908.LEAK
OXPHOS
ET
N
S
CIV
ROX
Permeabilized cellsMouseLiver
Cruz 2020 Cancers (Basel)2020Cruz B, Oliveira A, Viana LR, Lopes-Aguiar L, Canevarolo R, Colombera MC, Valentim RR, Garcia-Fóssa F, de Sousa LM, Castelucci BG, Consonni SR, Martins-de-Souza D, de Jesus MB, Russell ST, Gomes-Mardondes MCC (2020) Leucine-tich diet modulates the metabolomic and proteomic profile of skeletal muscle during cancer cachexia. Cancers (Basel) 12:E1880.LEAK
ROUTINE
ET
Intact cellsMouseSkeletal muscle
Lensu 2020 Nutrients2020Lensu S, Pariyani R, Mäkinen E, Yang B, Saleem W, Munukka E, Lehti M, Driuchina A, Lindén J, Tiirola M, Lahti L, Pekkala S (2020) Prebiotic xylo-oligosaccharides ameliorate high-fat-diet-induced hepatic steatosis in rats . Nutrients 12:E3225.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateRatLiver
Kahancova 2020 Sci Rep2020Kahancová A, Sklenář F, Ježek P, Dlasková A (2020) Overexpression of native IF1 downregulates glucose-stimulated insulin secretion by pancreatic INS-1E cells. Sci Rep 10:1551.LEAK
ROUTINE
ET
Intact cellsRatIslet cell;pancreas;thymus
Tichanek 2020 Sci Rep2020Tichanek F, Salomova M, Jedlicka J, Kuncova J, Pitule P, Macanova T, Petrankova Z, Tuma Z, Cendelin J (2020) Hippocampal mitochondrial dysfunction and psychiatric-relevant behavioral deficits in spinocerebellar ataxia 1 mouse model. Sci Rep 10:5418.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
HomogenateMouseNervous system
Heinonen 2020 Sci Rep2020Heinonen I, Sorop O, van Dalen BM, Wüst RCI, van de Wouw J, de Beer VJ, Octavia Y, van Duin RWB, Hoogstrate Y, Blonden L, Alkio M, Anttila K, Stubbs A, van der Velden J, Merkus D, Duncker DJ (2020) Cellular, mitochondrial and molecular alterations associate with early left ventricular diastolic dysfunction in a porcine model of diabetic metabolic derangement. Sci Rep 10:13173.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissuePigHeart
Piel 2020 FEBS J2020Piel MS, Masscheleyn S, Bouillaud F, Moncoq K, Miroux B (2020) Structural models of mitochondrial uncoupling proteins obtained in DPC micelles are not functionally relevant. FEBS J [Epub ahead of print].LEAK
OXPHOS
ET
Permeabilized cellsSaccharomyces cerevisiae
Ost 2020 EMBO Rep2020Ost M, Igual Gil C, Coleman V, Keipert S, Efstathiou S, Vidic V, Weyers M, Klaus S (2020) Muscle-derived GDF15 drives diurnal anorexia and systemic metabolic remodeling during mitochondrial stress. EMBO Rep 21:e48804.LEAK
OXPHOS
ET
N
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Piel 2020 PLoS One2020Piel S, Chamkha I, Dehlin AK, Ehinger JK, Sjövall F, Elmér E, Hansson MJ (2020) Cell-permeable succinate prodrugs rescue mitochondrial respiration in cellular models of acute acetaminophen overdose. PLoS One 15:e0231173.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
HumanLiver
Platelet
Dolezelova 2020 PLoS Biol2020Doleželová E, Kunzová M, Dejung M, Levin M, Panicucci B, Regnault C, Janzen CJ, Barrett MP, Butter F, Zíková A (2020) Cell-based and multi-omics profiling reveals dynamic metabolic repurposing of mitochondria to drive developmental progression of Trypanosoma brucei. PLoS Biol 18:e3000741.LEAK
ROUTINE
S
Gp
CIV
Permeabilized cells
Intact cells
Protists
D'Urso 2020 Surg Endosc2020D'Urso A, Agnus V, Barberio M, Seeliger B, Marchegiani F, Charles AL, Geny B, Marescaux J, Mutter D, Diana M (2020) Computer-assisted quantification and visualization of bowel perfusion using fluorescence-based enhanced reality in left-sided colonic resections. Surg Endosc [Epub ahead of print].LEAK
OXPHOS
N
NS
HumanEndothelial;epithelial;mesothelial cell
Hingst 2020 Mol Metab2020Hingst JR, Kjøbsted R, Birk JB, Jørgensen NO, Larsen MR, Kido K, Larsen JK, Kjeldsen SAS, Fentz J, Frøsig C, Holm S, Fritzen AM, Dohlmann TL, Larsen S, Foretz M, Viollet B, Schjerling P, Overby P, Halling JF, Pilegaard H, Hellsten Y, Wojtaszewski JFP (2020) Inducible deletion of skeletal muscle AMPKα reveals that AMPK is required for nucleotide balance but dispensable for muscle glucose uptake and fat oxidation during exercise. Mol Metab 40:101028.LEAK
OXPHOS
ET
N
S
NS
Permeabilized tissueMouseSkeletal muscle
Protasoni 2020 EMBO J2020Protasoni M, Pérez-Pérez R, Lobo-Jarne T, Harbour ME, Ding S, Peñas A, Diaz F, Moraes CT, Fearnley IM, Zeviani M, Ugalde C, Fernández-Vizarra E (2020) Respiratory supercomplexes act as a platform for complex III-mediated maturation of human mitochondrial complexes I and IV. EMBO J 39:e102817.LEAK
ROUTINE
ET
ROXIntact cellsHumanOther cell lines
Ferreira 2020 PLoS Genet2020Ferreira N, Andoniou CE, Perks KL, Ermer JA, Rudler DL, Rossetti G, Periyakaruppiah A, Wong JKY, Rackham O, Noakes PG, Degli-Esposti MA, Filipovska A (2020) Murine cytomegalovirus infection exacerbates complex IV deficiency in a model of mitochondrial disease. PLoS Genet 16:e1008604.LEAK
OXPHOS
ET
N
ROX
Isolated mitochondriaMouseLiver
Reutzel 2020 Oxid Med Cell Longev2020Reutzel M, Grewal R, Dilberger B, Silaidos C, Joppe A, Eckert GP (2020) Cerebral mitochondrial function and cognitive performance during aging: A longitudinal study in NMRI mice. Oxid Med Cell Longev 2020:4060769.LEAK
ET
OXPHOS
N
S
CIV
ROX
Isolated mitochondriaMouseNervous system
Wefers 2020 Mol Metab2020Wefers J, Connell NJ, Fealy CE, Andriessen C, de Wit V, van Moorsel D, Moonen-Kornips E, Jörgensen JA, Hesselink MKC, Havekes B, Hoeks J, Schrauwen P (2020) Day-night rhythm of skeletal muscle metabolism is disturbed in older, metabolically compromised individuals. Mol Metab 41:101050.LEAK
OXPHOS
ET
F
N
NS
Permeabilized tissueHumanSkeletal muscle
Kamarauskaite 2020 Biomed Res Int2020Kamarauskaite J, Baniene R, Trumbeckas D, Strazdauskas A, Trumbeckaite S (2020) Increased succinate accumulation induces ROS generation in in vivo ischemia/reperfusion-affected rat kidney mitochondria. Biomed Res Int 2020:8855585.LEAK
OXPHOS
N
S
RatKidney
Tepp 2020 Biochim Biophys Acta Gen Subj2020Tepp K, Puurand M, Timohhina N, Aid-Vanakova J, Reile I, Shevchuk I, Chekulayev V, Eimre M, Peet N, Kadaja L, Paju K, Kaambre T (2020) Adaptation of striated muscles to Wolframin deficiency in mice: Alterations in cellular bioenergetics. Biochim Biophys Acta Gen Subj 1864:129523.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized tissueMouseHeart
Skeletal muscle
Ayari 2020 Commun Biol2020Ayari Asma, Rosa-Calatrava Manuel, Lancel Steve, Barthelemy Johanna, Pizzorno Andres, Mayeuf-Louchart Alicia, Baron Morgane, Hot David, Deruyter Lucie, Soulard Daphnee, Julien Thomas, Faveeuw Christelle, Molendi-Coste Olivier, Dombrowicz David, Sedano Laura, Sencio Valentin, Le Goffic Ronan, Trottein Francois, Wolowczuk Isabelle (2020) Influenza infection rewires energy metabolism and induces browning features in adipose cells and tissues. Commun Biol 3:237.LEAK
ROUTINE
ET
ROXIntact cellsMouseFat
Marrocco 2020 Thesis2020Marrocco A (2020) Alterations of CCSP expression and macrophages metabolism in the development of silica-induced pulmonary inflammation and fibrosis. PhD Thesis 108.LEAK
OXPHOS
ET
S
ROX
Intact cellsMouseMacrophage-derived
Anand 2020 Toxicol In Vitro2020Anand CR, Bhavya B, Jayakumar K, Harikrishnan VS, Gopala S (2020) Inorganic nitrite alters mitochondrial dynamics without overt changes in cell death and mitochondrial respiration in cardiomyoblasts under hyperglycemia. Toxicol In Vitro [Epub ahead of print].LEAK
ROUTINE
ET
ROXIntact cellsRatHeart
No 2020 Pflugers Arch2020No MH, Heo JW, Yoo SZ, Kim CJ, Park DH, Kang JH, Seo DY, Han J, Kwak HB (2020) Effects of aging and exercise training on mitochondrial function and apoptosis in the rat heart. Pflugers Arch 472:179-93.LEAK
OXPHOS
N
NS
Permeabilized tissueRatHeart
Luevano-Martinez 2020 FEBS Lett2020Luévano-Martínez LA, Girard RMBM, Alencar MB, Silber AM (2020) ATP regulates the activity of an alternative oxidase in Trypanosoma brucei. FEBS Lett [Epub ahead of print].LEAK
ROUTINE
ET
Intact cellsEubacteria
Magnesa 2020 Thesis2020Magnesa B (2020) Skeletal muscle mitochondrial oxidative phosphorylation plasticity in two studies on humans: exercise training effect in obese subjects and bed rest effect in healthy subjects. PhD Thesis 81.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Cipullo 2020 Nucleic Acids Res2020Cipullo M, Pearce SF, Lopez Sanchez IG, Gopalakrishna S, Krüger A, Schober F, Busch JD, Li X, Wredenberg A, Atanassov I, Rorbach J (2020) Human GTPBP5 is involved in the late stage of mitoribosome large subunit assembly. Nucleic Acids Res [Epub ahead of print].LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
HumanHEK
Wang 2020 J Mol Med (Berl)2020Wang SY, Zhu Siyu, Wu Jian, Zhang Maomao, Xu Yousheng, Xu Wei, Cui Jinjin, Yu Bo, Cao Wei, Liu Jingjin (2020) Exercise enhances cardiac function by improving mitochondrial dysfunction and maintaining energy homoeostasis in the development of diabetic cardiomyopathy. J Mol Med (Berl) 98:245-61.LEAK
OXPHOS
N
ROX
Isolated mitochondriaMouseHeart
Mohsin 2020 Arch Biochem Biophys2020Mohsin AA, Thompson J, Hu Y, Hollander J, Lesnefsky EJ, Chen Q (2020) Endoplasmic reticulum stress-induced complex I defect: Central role of calcium overload. Arch Biochem Biophys 683:108299.LEAK
OXPHOS
N
S
Permeabilized cellsRatSkeletal muscle
Fuller 2020 J Appl Physiol (1985)2020Fuller KNZ, McCoin CS, Allen J, Bell-Glenn S, Koestler DC, Dorn Ii GW, Thyfault JP (2020) Sex and BNIP3 genotype, rather than acute lipid injection, modulate hepatic mitochondrial function and steatosis risk in mice. J Appl Physiol (1985) 128:1251-61.LEAK
OXPHOS
ET
F
N
NS
Isolated mitochondriaMouseLiver
Kuzniewska 2020 EMBO Rep2020Kuzniewska B, Cysewski D, Wasilewski M, Sakowska P, Milek J, Kulinski TM, Winiarski M, Kozielewicz P, Knapska E, Dadlez M, Chacinska A, Dziembowski A, Dziembowska M (2020) Mitochondrial protein biogenesis in the synapse is supported by local translation. EMBO Rep [Epub ahead of print].LEAK
ET
N
S
Permeabilized cellsHuman
Mouse
Nervous system
HEK
Krajcova 2020 PLOS ONE2020Krajčová A, Urban T, Megvinet D, Waldauf P, Balík M, Hlavička J, Budera P, Janoušek L, Pokorná E, Duška F (2020) High resolution respirometry to assess function of mitochondria in native homogenates of human heart muscle. PLOS ONE 15:e0226142.LEAK
OXPHOS
ET
N
S
NS
ROX
Homogenate
Isolated mitochondria
HumanHeart
Madeo 2020 US Patent2020Madeo F, Eisenberg T, Stekovic S (2020) Use of spermidine for the enhancement of mitochondrial respiration. US Patent US20200054579 A1.LEAK
OXPHOS
ET
N
ROX
Isolated mitochondriaMouseHeart
Anderson 2020 Cells2020Anderson Vulczak, de Oliveira Souza Anderson, Ferrari Gustavo Duarte, Caleiro Seixas Azzolini Ana Elisa, Pereira-da-Silva Gabriela, Alberici Luciane Carla (2020) Moderate exercise modulates tumor metabolism of triple-negative breast cancer. Cells 9:628.LEAK
OXPHOS
ET
N
ROX
Permeabilized tissueMouse
Macedo 2020 FASEB J2020Macedo F, Romanatto T, Gomes de Assis C, Buis A, Kowaltowski AJ, Aguilaniu H, Marques da Cunha F (2020) Lifespan-extending interventions enhance lipid-supported mitochondrial respiration in Caenorhabditis elegans. FASEB J [Epub ahead of print].LEAK
OXPHOS
F
N
CIV
ROX
Intact organism
Isolated mitochondria
Caenorhabditis elegans
Avila-Rojas 2020 Food Chem Toxicol2020Avila-Rojas SH, Aparicio-Trejo OE, Briones-Herrera A, Medina-Campos ON, Reyes-Fermín LM, Martínez-Klimova E, León-Contreras JC, Hernández-Pando R, Tapia E, Pedraza-Chaverri J (2020) Alterations in mitochondrial homeostasis in a potassium dichromate model of acute kidney injury and their mitigation by curcumin. Food Chem Toxicol 145:111774.LEAK
OXPHOS
ET
N
S
NS
ROX
Isolated mitochondriaRatKidney
Purhonen 2020 Nat Commun2020Purhonen J, Grigorjev V, Ekiert R, Aho N, Rajendran J, Pietras R, Truvé K, Wikström M, Sharma V, Osyczka A, Fellman V, Kallijärvi J (2020) A spontaneous mitonuclear epistasis converging on Rieske Fe-S protein exacerbates complex III deficiency in mice. Nat Commun 11:322.LEAK
OXPHOS
ET
N
NS
ROX
Isolated mitochondriaMouseLiver
Kidney
Yadav 2020 Cell Death Dis2020Yadav SK, Kambis TN, Kar S, Park SY, Mishra PK (2020) MMP9 mediates acute hyperglycemia-induced human cardiac stem cell death by upregulating apoptosis and pyroptosis in vitro. Cell Death Dis 11:186.LEAK
OXPHOS
ET
N
CIV
NS
ROX
Permeabilized cellsHumanHeart
Stem cells
Allen 2020 Thesis2020Allen FM (2020) Mitochondrial metabolism elucidated by rapid fractionation from tissue. PhD Thesis 298.LEAK
ET
SIsolated mitochondriaMouse
Rat
Heart
Liver
Seo 2020 J Clin Med2020Seo DY, Heo JW, No MH, Yoo SZ, Ko JR, Park DH, Kang JH, Kim CJ, Jung SJ, Han J, Kwak HB (2020) Exercise training protects against atorvastatin-induced skeletal muscle dysfunction and mitochondrial dysfunction in the skeletal muscle of rats. J Clin Med 9:E2292.LEAK
OXPHOS
NPermeabilized tissueRatSkeletal muscle
Risiglione 2020 Int J Mol Sci2020Risiglione P, Leggio L, Cubisino SAM, Reina S, Paternò G, Marchetti B, Magrì A, Iraci N, Messina A (2020) High-resolution respirometry reveals MPP+ mitochondrial toxicity mechanism in a cellular model of parkinson's disease. Int J Mol Sci 21:E7809.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
HumanNeuroblastoma
MitoEAGLE blood cells 12020Åsander Frostner Eleonor*, Aburel Oana M*, Avram Vlad F*, Calabria Elisa, Castelo Rueda Maria Paulina*, Chamkha Imen*, Čižmárová Beata, Danila Maria-Daniela*, Doerrier Carolina*, Eckert Gunter P*, Ehinger Johannes K, Elmer Eskil*, Garcia-Souza Luiz F*, Gnaiger Erich*, Hoppel Florian*, Karabatsiakis Alexander*, Keppner Gloria, Kidere Dita*, Krako Jakovljević Nina, Labieniec-Watala Magdalena*, Lelcu Theia*, Micankova Petra, Michalak Slawomir*, Molina Anthony JA*, Pavlovic Kasja, Pichler Irene*, Piel Sarah, Rousar Tomas, Rybacka-Mossakowska Joanna, Schartner Melanie, Siewiera Karolina*, Silaidos Carmina*, Sjövall Fredrik*, Sobotka Ondrej*, Sumbalova Zuzana*, Swiniuch Daria, Vernerova Andrea*, Volani Chiara*, Vujacic-Mirski Ksenija*, Watala Cezary* (2020) Interlaboratory guide to mitochondrial respiratory studies with peripheral blood mononuclear cells and platelets. - Updated: 2020-03-06 - *ConfirmedLEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
Other combinations
ROX
Intact cells
Permeabilized cells
HumanBlood cells
Platelet
Ugarteburu 2020 J Clin Med2020Ugarteburu O, Sánchez-Vilés M, Ramos J, Barcos-Rodríguez T, Garrabou G, García-Villoria J, Ribes A, Tort F (2020) Physiopathological bases of the disease caused by HACE1 mutations: alterations in autophagy, mitophagy and oxidative stress response. J Clin Med 9:E913.LEAK
ROUTINE
ET
ROXIntact cellsHumanFibroblast
Pham 2020 Eur J Appl Physiol2020Pham T, MacRae CL, Broome SC, D'souza RF, Narang R, Wang HW, Mori TA, Hickey AJR, Mitchell CJ, Merry TL (2020) MitoQ and CoQ10 supplementation mildly suppresses skeletal muscle mitochondrial hydrogen peroxide levels without impacting mitochondrial function in middle-aged men. Eur J Appl Physiol 120:1657-69.LEAK
OXPHOS
ET
N
CIV
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Visavadiya 2020 Mol Cell Biochem2020Visavadiya NP, Pena GS, Khamoui AV (2020) Mitochondrial dynamics and quality control are altered in a hepatic cell culture model of cancer cachexia. Mol Cell Biochem [Epub ahead of print].LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized cellsMouseLiver
Wen 2020 Biomedicines2020Wen JJ, Cummins CB, Williams TP, Radhakrishnan RS (2020) The genetic evidence of burn-induced cardiac mitochondrial metabolism dysfunction . Biomedicines 8:E566.LEAK
OXPHOS
ET
N
S
NS
Permeabilized tissueRatHeart
Doig 2020 Skelet Muscle2020Doig CL, Zielinska AE, Fletcher RS, Oakey LA, Elhassan YS, Garten A, Cartwright D, Heising S, Alsheri A, Watson DG, Prehn C, Adamski J, Tennant DA, Lavery GG (2020) Induction of the nicotinamide riboside kinase NAD+ salvage pathway in a model of sarcoplasmic reticulum dysfunction. Skelet Muscle 10:5.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Boel 2020 J Exp Biol2020Boël M, Romestaing C, Duchamp C, Veyrunes F, Renaud S, Roussel D, Voituron Y (2020) Improved mitochondrial coupling as a response to high mass-specific metabolic rate in extremely small mammals. J Exp Biol 223:jeb215558.LEAK
ET
N
NS
Permeabilized tissueMouseSkeletal muscle
Falcao-Tebas 2020 J Physiol2020Falcão-Tebas F, Marin EC, Kuang J, Bishop DJ, McConell GK (2020) Maternal exercise attenuates the lower skeletal muscle glucose uptake and insulin secretion caused by paternal obesity in female adult rat offspring. J Physiol [Epub ahead of print].LEAK
OXPHOS
ET
N
NS
ROX
Permeabilized tissueRatSkeletal muscle
Russell 2020 Nutrients2020Russell JS, Griffith TA, Naghipour S, Vider J, Du Toit EF, Patel HH, Peart JN, Headrick JP (2020) Dietary α-linolenic acid counters cardioprotective dysfunction in diabetic mice: unconventional PUFA protection. Nutrients 12:E2679.LEAK
OXPHOS
ET
N
S
NS
HomogenateMouseHeart
Zavadskis 2020 Pharmaceutics2020Zavadskis S, Weidinger A, Hanetseder D, Banerjee A, Schneider C, Wolbank S, Marolt Presen D, Kozlov AV (2020) Effect of diphenyleneiodonium chloride on intracellular reactive oxygen species metabolism with emphasis on NADPH oxidase and mitochondria in two therapeutically relevant human cell types. Pharmaceutics 13:E10.LEAK
OXPHOS
ET
N
S
Permeabilized cellsHumanOther cell lines
Krabbendam 2020 Cell Death Dis2020Krabbendam IE, Honrath B, Dilberger B, Iannetti EF, Branicky RS, Meyer T, Evers B, Dekker FJ, Koopman WJH, Beyrath J, Bano D, Schmidt M, Bakker BM, Hekimi S, Culmsee C, Eckert GP, Dolga AM (2020) SK channel-mediated metabolic escape to glycolysis inhibits ferroptosis and supports stress resistance in C. elegans. Cell Death Dis 11:263.LEAK
OXPHOS
N
S
Isolated mitochondriaMouseNervous system
Dawid 2020 Biochim Biophys Acta Bioenerg2020Dawid C, Weber D, Musiol E, Janas V, Baur S, Lang R, Fromme T (2020) Comparative assessment of purified saponins as permeabilization agents during respirometry. Biochim Biophys Acta Bioenerg 1861:148251.LEAK
ROUTINE
OXPHOS
ET
N
S
Gp
NS
ROX
Permeabilized cells
Isolated mitochondria
Intact cells
Human
Mouse
Nervous system
HEK
Lopez 2020 Function (Oxf)2020Lopez R, Marzban B, Gao X, Lauinger E, Van den Bergh F, Whitesall SE, Converso-Baran K, Burant CF, Michele DE, Beard DA (2020) Impaired myocardial energetics causes mechanical dysfunction in decompensated failing hearts. Function (Oxf) 1:zqaa018.LEAK
OXPHOS
F
N
Isolated mitochondriaRatHeart
Baxter 2020 Elife2020Baxter M, Voronkov M, Poolman T, Galli G, Pinali C, Goosey L, Knight A, Krakowiak K, Maidstone R, Iqbal M, Zi M, Prehar S, Cartwright EJ, Gibbs J, Matthews LC, Adamson AD, Humphreys NE, Rebelo-Guiomar P, Minczuk M, Bechtold DA, Loudon A, Ray D (2020) Cardiac mitochondrial function depends on BUD23 mediated ribosome programming. Elife 9:e50705.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
HomogenateMouseHeart
Stepanova 2020 Methods Cell Biol2020Stepanova A, Galkin A (2020) Measurement of mitochondrial H2O2 production under varying O2 tensions. Methods Cell Biol 155:273-93.LEAK
OXPHOS
S
N
Gp
Isolated mitochondriaMouseNervous system
De Souza 2020 Heliyon2020De Souza CEA, Andrade Pires AR, Cardoso CR, Carlos RM, Cadena SMSC, Acco A (2020) Antineoplastic activity of a novel ruthenium complex against human hepatocellular carcinoma (HepG2) and human cervical adenocarcinoma (HeLa) cells. Heliyon 6:e03862.LEAK
ROUTINE
ET
ROXIntact cellsHumanLiver
HeLa
Davidson 2020 Circ Res2020Davidson MT, Grimsrud P, Lai L, Draper J, Fisher-Wellman KH, Narowski TM, Koves TR, Kelly DP, Muoio DM (2020) Extreme acetylation of the cardiac mitochondrial proteome does not promote heart failure. Circ Res 127:1094-108.LEAKF
N
Isolated mitochondriaMouseHeart
Dymkowska 2020 J Appl Toxicol2020Dymkowska D, Wrzosek A, Zabłocki K (2020) Atorvastatin and pravastatin stimulate nitric oxide and reactive oxygen species generation, affect mitochondrial network architecture and elevate nicotinamide N-methyltransferase level in endothelial cells. J Appl Toxicol [Epub ahead of print].LEAK
ET
ROUTINE
Intact cellsHumanEndothelial;epithelial;mesothelial cell
Hayes 2020 Nutrients2020Hayes P, Fergus C, Ghanim M, Cirzi C, Burtnyak L, McGrenaghan CJ, Tuorto F, Nolan DP, Kelly VP (2020) Queuine micronutrient deficiency promotes Warburg metabolism and reversal of the mitochondrial ATP synthase in HeLa cells. Nutrients 12:E871.LEAK
ROUTINE
OXPHOS
ET
N
S
Gp
CIV
ROX
Permeabilized cells
Intact cells
HumanHeLa
Beninca 2020 J Med Genet2020Beninca C, Zanette V, Brischigliaro M, Johnson M, Reyes A, Valle DAD, Robinson AJ, Degiorgi A, Yeates A, Telles BA, Prudent J, Baruffini E, Santos ML, de Souza RL, Fernandez-Vizarra E, Whitworth A, Zeviani M (2020) Mutation in the MICOS subunit gene APOO (MIC26) associated with an X-linked recessive mitochondrial myopathy, lactic acidosis, cognitive impairment and autistic features. J Med Genet [Epub ahead of print].LEAK
ROUTINE
ET
Intact cellsHumanFibroblast
Larsen 2020 Cardiovasc Drugs Ther2020Larsen AH, Wiggers H, Dollerup OL, Jespersen NR, Hansson NH, Frøkiær J, Brøsen K, Nørrelund H, Bøtker HE, Møller N, Jessen N (2020) Metformin lowers body weight but fails to increase insulin sensitivity in chronic heart failure patients without diabetes: a randomized, double-blind, placebo-controlled study. Cardiovasc Drugs Ther [Epub ahead of print].LEAK
OXPHOS
ET
N
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Kupats 2020 Oxid Med Cell Longev2020Kupats E, Stelfa G, Zvejniece B, Grinberga S, Vavers E, Makrecka-Kuka M, Svalbe B, Zvejniece L, Dambrova M (2020) Mitochondrial-protective effects of R-phenibut after experimental traumatic brain injury. Oxid Med Cell Longev 2020:9364598.LEAK
OXPHOS
ET
N
S
NS
Homogenate
Isolated mitochondria
MouseNervous system
Stankova 2020 Int J Mol Sci2020Staňková P, Kučera O, Peterová E, Lotková H, Maseko TE, Nožičková K, Červinková Z (2020) Adaptation of mitochondrial substrate flux in a mouse model of nonalcoholic fatty liver disease. Int J Mol Sci 21:E1101.LEAK
OXPHOS
F
N
S
Gp
NS
ROX
HomogenateMouseLiver
Sharma 2020 Integr Cancer Ther2020Sharma P, Singh S (2020) Combinatorial effect of DCA and let-7a on triple-negative MDA-MB-231 cells: A metabolic approach of treatment. Integr Cancer Ther 19:1534735420911437.LEAK
OXPHOS
N
S
Permeabilized cellsHumanEndothelial;epithelial;mesothelial cell
Rondot 2020 Thesis2020Rondot A (2020) Fuels for winter: the role of proline in overwintering bumblebee queens (Bombus impatiens). Master's Thesis 41.LEAK
OXPHOS
N
S
NS
ROX
Permeabilized tissueHexapodsSkeletal muscle
Assis-de-Lemos 2020 Curr Protoc Toxicol2020Assis-de-Lemos G, Ledur PF, Karmirian K, Rehen SK, Galina A (2020) A protocol to study mitochondrial function in human neural progenitors and iPSC-derived astrocytes. Curr Protoc Toxicol 85:e97.LEAK
ROUTINE
ET
ROXIntact cellsHumanNervous system
McCommis 2020 bioRxiv2020McCommis KS, Kovacs A, Weinheimer CJ, Shew TM, Koves TR, Ilkayeva OR, Kamm DR, Pyles KD, Todd King M, Veech RL, DeBosch BJ, Muoio DM, Gross RW, Finck BN (2020) Ketogenic diet prevents heart failure from defective mitochondrial pyruvate metabolism. bioRxiv doi: https://doi.org/10.1101/2020.02.21.959635 .LEAK
OXPHOS
F
N
Isolated mitochondriaMouseHeart
Agil 2020 J Clin Med2020Agil A, Chayah M, Visiedo L, Navarro-Alarcon M, Rodríguez Ferrer JM, Tassi M, Reiter RJ, Fernández-Vázquez G (2020) Melatonin improves mitochondrial dynamics and function in the kidney of Zücker diabetic fatty rats. J Clin Med 9:E2916.LEAK
OXPHOS
N
S
Isolated mitochondriaRatKidney
Wei 2020 Hum Mutat2020Wei X, Du M, Li D, Wen S, Xie J, Li Y, Chen A, Zhang K, Xu P, Jia M, Wen C, Zhou H, Lyu J, Yang Y, Fang H (2020) Mutations in FASTKD2 are associated with mitochondrial disease with multi-OXPHOS deficiency. Hum Mutat 41:961-72.LEAK
ROUTINE
Intact cellsHumanLymphocyte
Jayakumari 2020 J Diabetes2020Jayakumari NR, Rajendran RS, Sivasailam A, Vimala SS, Nanda S, Manjunatha S, Pillai VV, Karunakaran J, Gopala S (2020) Impaired substrate-mediated cardiac mitochondrial complex I respiration with unaltered regulation of fatty acid metabolism and oxidative stress status in type 2 diabetic Asian Indians. J Diabetes 12:542-55.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Isolated mitochondriaHumanHeart
Franco 2020 bioRxiv2020Franco JLM, Genoula M, Corral D, Duette G, Ferreyra M, Maio M, Dolotowicz MB, Aparicio-Trejo OE, Patiño-Martínez E, Fuentes F, Soldan V, Moraña EJ, Palmero D, Ostrowski M, Schierloh P, Sánchez-Torres C, Hernández-Pando R, Pedraza-Chaverri J, Rombouts Y, Layre E, Hudrisier D, Vérollet C, Neyrolles O, Sasiain MC, Lugo-Villarino G, Balboa L (2020) Host-derived lipids from tuberculous pleurisy impair macrophage microbicidal-associated metabolic activity. bioRxiv doi: https://doi.org/10.1101/2020.03.23.001818 .LEAK
ROUTINE
N
S
CIV
ROX
Intact cellsHumanMacrophage-derived
Leguina-Ruzzi 2020 Biomolecules2020Leguina-Ruzzi A, Vodičková A, Holendová B, Pavluch V, Tauber J, Engstová H, Dlasková A, Ježek P (2020) Glucose-induced expression of DAPIT in pancreatic β-cells. Biomolecules 10:E1026.LEAK
ROUTINE
ET
Intact cellsRatIslet cell;pancreas;thymus
Bose 2020 Aging Cell2020Bose C, Alves I, Singh P, Palade PT, Carvalho E, Børsheim E, Jun SR, Cheema A, Boerma M, Awasthi S, Singh SP (2020) Sulforaphane prevents age-associated cardiac and muscular dysfunction through Nrf2 signaling. Aging Cell [Epub ahead of print].LEAK
OXPHOS
F
N
CIV
NS
ROX
Permeabilized tissueMouseHeart
Friederich-Persson 2020 Am J Physiol Renal Physiol2020Friederich-Persson M, Persson P (2020) Mitochondrial angiotensin II receptors regulate oxygen consumption in kidney mitochondria from healthy and type 1 diabetic rats. Am J Physiol Renal Physiol 318:F683-88.LEAK
OXPHOS
N
Gp
Isolated mitochondriaRatKidney
Alexopoulos 2020 Nat Commun2020Alexopoulos SJ, Chen SY, Brandon AE, Salamoun JM, Byrne FL, Garcia CJ, Beretta M, Olzomer EM, Shah DP, Philp AM, Hargett SR, Lawrence RT, Lee B, Sligar J, Carrive P, Tucker SP, Philp A, Lackner C, Turner N, Cooney GJ, Santos WL, Hoehn KL (2020) Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice. Nat Commun 11:2397.LEAKNPermeabilized tissue
Homogenate
MouseSkeletal muscle
Liver
Fat
Lin 2020 Preprints2020Lin M, Fu T, Hsu C, Huang S, Lin Y, Wang J (2020) Cycling exercise training enhances mitochondrial bioenergetics of platelets in patients with peripheral arterial disease: a randomized controlled trial. Preprints 2020070567.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
NS
ROX
Permeabilized cells
Intact cells
HumanPlatelet
Palavicini 2020 JCI Insight2020Palavicini JP, Chen J, Wang C, Wang J, Qin C, Baeuerle E, Wang X, Woo JA, Kang DE, Musi N, Dupree JL, Han X (2020) Early disruption of nerve mitochondrial and myelin lipid homeostasis in obesity-induced diabetes. JCI Insight 5:137286.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueMouseNervous system
Padilla-Flores 2020 Biochem Biophys Res Commun2020Padilla-Flores T, Lopez-Gonzalez Z, Vaca L, Aparicio-Trejo OE, Briones-Herrera A, Riveros-Rosas H, Pedraza-Chaverri J, Leon-Aparicio D, Salvador C, Sampieri A, Escobar LI (2020) "Funny" channels in cardiac mitochondria modulate membrane potential and oxygen consumption. Biochem Biophys Res Commun 524:1030-36.LEAK
ROUTINE
ROXIntact cellsRatHeart
Keppner 2020 Thesis2020Keppner G (2020) Impact of gut microbiota composition, liver metabolism and respiratory capacity of peripheral blood mononuclear cells on resting metabolic rate. PhD Thesis 100.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
HumanBlood cells
Messner 2020 Thesis2020Messner M (2020) Sorafenib resistance of hepatocellular carcinoma. PhD Thesis 130.LEAK
ROUTINE
ET
ROXIntact cellsHumanLiver
Gnaiger 2020 BEC MitoPathways2020Gnaiger E (2020) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 5th ed. Bioenerg Commun 2020.2: 112 pp. doi:10.26124/bec:2020-0002LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
ROX
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
Intact cells
Human
Mouse
Heart
Skeletal muscle
Fibroblast
Hraoui 2020 J Exp Biol2020Hraoui G, Bettinazzi S, Gendron AD, Boisclair D, Breton S (2020) Mitochondrial thermo-sensitivity in invasive and native freshwater mussels. J Exp Biol 223:jeb215921.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized tissueMolluscsLung;gill
Andrade 2020 Nutr Metab Cardiovasc Dis2020Andrade D, Oliveira G, Menezes L, Nascimento AL, Carvalho S, Stumbo AC, Thole A, Garcia-Souza É, Moura A, Carvalho L, Cortez E (2020) Insulin-like growth factor-1 short-period therapy improves cardiomyopathy stimulating cardiac progenitor cells survival in obese mice. Nutr Metab Cardiovasc Dis 30:151-61.LEAK
OXPHOS
F
N
NS
Permeabilized tissueMouseHeart
Silva Ferraz 2020 Biochem Pharmacol2020Silva Ferraz L, Torres da Costa R, Alves da Costa C, Augusto João Ribeiro C, Costa Arruda D, Stuchi Maria-Engler S, Rodrigues T (2020) Targeting mitochondria in melanoma: interplay between MAPK signaling pathway and mitochondrial dynamics . Biochem Pharmacol 178:114104.LEAK
ROUTINE
ET
Intact cellsHumanEndothelial;epithelial;mesothelial cell
Close 2020 Cells2020Close AF, Dadheech N, Lemieux H, Wang Q, Buteau J (2020) Disruption of beta-cell mitochondrial networks by the orphan nuclear receptor Nor1/Nr4a3. Cells 9:E168.LEAK
ROUTINE
N
S
CIV
NS
ROX
Permeabilized cells
Intact cells
RatIslet cell;pancreas;thymus
MitoEAGLE muscle 12020Doerrier C, Gama-Perez P, Distefano G, Pesta D, Soendergaard SD, Chroeis KM, Gonzalez-Franquesa A, Goodpaster BH, Coen P, Larsen S, Gnaiger E, Garcia-Roves PM (2020) Inter-laboratory harmonization of respiratory protocols in permeabilized human muscle fibers. - Updated: 2020-03-08LEAK
OXPHOS
ET
N
NS
S
ROX
Permeabilized tissueHumanSkeletal muscle
Oliveira 2020 Anim Reprod2020Oliveira VS, Castro AJG, Domingues JT, Souza AZP, Scheffer DL, Latini A, Soares CHL, Van Der Kraak G, Silva FRMB (2020) A brazilian pulp and paper mill effluent disrupts energy metabolism in immature rat testis and alters sertoli cell secretion and mitochondrial activity. Anim Reprod 17:e20190116.LEAK
ROUTINE
ET
ROXIntact cellsRatGenital
Nicolaisen 2020 FASEB J2020Nicolaisen TS, Klein AB, Dmytriyeva O, Lund J, Ingerslev LR, Fritzen AM, Carl CS, Lundsgaard AM, Frost M, Ma T, Schjerling P, Gerhart-Hines Z, Flamant F, Gauthier K, Larsen S, Richter EA, Kiens B, Clemmensen C (2020) Thyroid hormone receptor α in skeletal muscle is essential for T3-mediated increase in energy expenditure. FASEB J 34:15480-91.LEAK
OXPHOS
N
NS
Permeabilized tissueMouseSkeletal muscle
Liu 2020 Cell Death Dis2020Liu YF, Zhu Juan-Juan, Yu Tian X, Liu Han, Zhang Tao, Zhang Yun-Peng, Xie Si-An, Zheng Ming, Kong Wei, Yao Wei-Juan, Pang Wei, Zhao Chuan-Rong, Tang Yuan-Jun, Zhou Jing (2020) Hypermethylation of mitochondrial DNA in vascular smooth muscle cells impairs cell contractility. Cell Death Dis 11:35.LEAK
OXPHOS
N
S
CIV
ROX
Permeabilized tissueMouseEndothelial;epithelial;mesothelial cell
Yurre 2020 Arq Bras Cardiol2020Yurre AR, Silva JDFD, Torres MKDS, Martins EL, Ramos IP, Silva WSFLD, Sarpa JDS, Guedes CCDS, Napoleão TH, Coelho LCBB, Paiva PMG, Medei E (2020) Evaluation of the cardiac effects of a water-soluble lectin (Wsmol) from Moringa oleifera seeds. Arq Bras Cardiol 114:1029-37.LEAK
OXPHOS
N
NS
ROX
Isolated mitochondriaMouseHeart
Coppin 2020 Cell Death Dis2020Coppin L, Jannin A, Ait Yahya E, Thuillier C, Villenet C, Tardivel M, Bongiovanni A, Gaston C, de Beco S, Barois N, van Seuningen I, Durand E, Bonnefond A, Vienne JC, Vamecq J, Figeac M, Vincent A, Delacour D, Porchet N, Pigny P (2020) Galectin-3 modulates epithelial cell adaptation to stress at the ER-mitochondria interface. Cell Death Dis 11:360.LEAK
ROUTINE
OXPHOS
ET
N
S
Gp
CIV
NS
ROX
Permeabilized cells
Intact cells
HumanIslet cell;pancreas;thymus
Endothelial;epithelial;mesothelial cell
Brum 2020 Mol Neurobiol2020Brum EDS, Fialho MFP, Fischer SPM, Hartmann DD, Gonçalves DF, Scussel R, Machado-de-Ávila RA, Dalla Corte CL, Soares FAA, Oliveira SM (2020) Relevance of mitochondrial dysfunction in the reserpine-induced experimental fibromyalgia model. Mol Neurobiol 57:4202-17.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissue
Homogenate
MouseSkeletal muscle
Nervous system
Rebane-Klemm 2020 Cancers (Basel)2020Rebane-Klemm E, Truu L, Reinsalu L, Puurand M, Shevchuk I, Chekulayev V, Timohhina N, Tepp K, Bogovskaja J, Afanasjev V, Suurmaa K, Valvere V, Kaambre T (2020) Mitochondrial respiration in KRAS and BRAF mutated colorectal tumors and polyps. Cancers (Basel) 12:E815.LEAK
OXPHOS
N
NS
Permeabilized tissueHumanEndothelial;epithelial;mesothelial cell
Fisher 2020 Placenta2020Fisher J, McKeating D, Pennell E, Cuffe J, Holland O, Perkins A (2020) Mitochondrial isolation, cryopreservation and preliminary biochemical characterisation from placental cytotrophoblast and syncytiotrophoblast. Placenta 82:1-4.LEAK
OXPHOS
ET
N
NS
ROX
Isolated mitochondriaHumanGenital
Souza da Silva 2020 Mol Neurobiol2020Souza da Silva J, Nonose Y, Rohden F, Lukasewicz Ferreira PC, Fontella FU, Rocha A, Wigner Brochier A, Vieira Apel R, de Lima TM, Seminotti B, Amaral AU, Galina A, Souza DO (2020) Guanosine neuroprotection of presynaptic mitochondrial calcium homeostasis in a mouse study with amyloid-β oligomers. Mol Neurobiol 57:4790-809.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateMouseNervous system
Rocha 2020 Sci Adv2020Rocha AL, de Lima TI, de Souza GP, Corrêa RO, Ferrucci DL, Rodrigues B, Lopes-Ramos C, Nilsson D, Knittel TL, Castro PR, Fernandes MF, Dos Santos Martins F, Parmigiani RB, Silveira LR, Carvalho HF, Auwerx J, Vinolo MAR, Boucher J, Mori MA (2020) Enoxacin induces oxidative metabolism and mitigates obesity by regulating adipose tissue miRNA expression. Sci Adv 6:eabc6250.LEAK
ROUTINE
ET
ROXIntact cellsMouseFat
Dawson 2020 Exp Gerontol2020Dawson NJ, Salmón P (2020) Age-related increase in mitochondrial quantity may mitigate a decline in mitochondrial quality in red blood cells from zebra finches (Taeniopygia guttata). Exp Gerontol 133:110883.LEAK
ROUTINE
ET
ROXIntact cellsBirdsBlood cells
Dulac 2020 J Physiol2020Dulac M, Leduc-Gaudet JP, Reynaud O, Ayoub MB, Guérin A, Finkelchtein M, Hussain SN, Gouspillou G (2020) Drp1 knockdown induces severe muscle atrophy and remodelling, mitochondrial dysfunction, autophagy impairment and denervation . J Physiol 598:3691-710.LEAK
OXPHOS
N
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Simard 2020 Metabolites2020Simard C, Lebel A, Allain EP, Touaibia M, Hebert-Chatelain E, Pichaud N (2020) Metabolic characterization and consequences of mitochondrial pyruvate carrier deficiency in Drosophila melanogaster. Metabolites 109:E363.LEAK
OXPHOS
ET
N
S
Gp
NS
ROX
Permeabilized tissueDrosophila
Boehmert 2020 Transfusion2020Böhmert S, Kübel S, Müller MM, Weber CF, Adam EH, Dröse S, Zacharowski K, Fischer D (2020) The effect of the interruption of agitation, temporary cooling, and pneumatic tube transportation on platelet quality during storage for transfusion. Transfusion [Epub ahead of print].LEAK
ROUTINE
ET
CIVIntact cellsHumanPlatelet
Chen 2020 Biochim Biophys Acta Mol Basis Dis2020Chen T, Hill JT, Moore TM, Cheung ECK, Olsen ZE, Piorczynski TB, Marriott TD, Tessem JS, Walton CM, Bikman BT, Hansen JM, Thomson DM (2020) Lack of skeletal muscle liver kinase B1 alters gene expression, mitochondrial content, inflammation and oxidative stress without affecting high-fat diet-induced obesity or insulin resistance. Biochim Biophys Acta Mol Basis Dis 1866:165805.LEAK
OXPHOS
ET
N
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Pereira 2020 PLoS One2020Pereira GC, Lee L, Rawlings N, Ouwendijk J, Parker JE, Andrienko TN, Henley JM, Halestrap AP (2020) Hexokinase II dissociation alone cannot account for changes in heart mitochondrial function, morphology and sensitivity to permeability transition pore opening following ischemia. PLoS One 15:e0234653.LEAK
OXPHOS
NIsolated mitochondriaRatHeart
Seitaj 2020 Cells2020Seitaj B, Maull F, Zhang L, Wüllner V, Wolf C, Schippers P, La Rovere R, Distler U, Tenzer S, Parys JB, Bultynck G, Methner A (2020) Transmembrane BAX inhibitor-1 motif containing protein 5 (TMBIM5) sustains mitochondrial structure, shape, and function by impacting the mitochondrial protein synthesis machinery. Cells 9:E2147.LEAK
ROUTINE
ET
ROXIntact cellsHumanKidney
Kline 2020 Nitric Oxide2020Kline JA, Puskarich MA, Pike JW, Zagorski J, Alves NJ (2020) Inhaled nitric oxide to control platelet hyper-reactivity in patients with acute submassive pulmonary embolism. Nitric Oxide 96:20-8.LEAK
ET
ROXIntact cellsHumanPlatelet
Blood cells
Schoepf 2020 Nat Commun2020Schöpf Bernd, Weissensteiner Hansi, Schäfer Georg, Fazzini Federica, Charoentong Pornpimol, Naschberger Andreas, Rupp Bernhard, Fendt Liane, Bukur Valesca, Giese Irina, Sorn Patrick, Sant’Anna-Silva Ana Carolina, Iglesias-Gonzalez Javier, Sahin Ugur, Kronenberg Florian, Gnaiger Erich, Klocker Helmut (2020) OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and increased succinate oxidation. Nat Commun 11:1487.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
Permeabilized cells
Permeabilized tissue
HumanGenital
Other cell lines
Buch 2020 FASEB J2020Buch BT, Halling JF, Ringholm S, Gudiksen A, Kjøbsted R, Olsen MA, Wojtaszewski JFP, Pilegaard H (2020) Colchicine treatment impairs skeletal muscle mitochondrial function and insulin sensitivity in an age-specific manner. FASEB J 34:8653-70.LEAK
OXPHOS
N
NS
Permeabilized tissueMouseSkeletal muscle
Courtes 2020 Brain Res Bull2020Courtes AA, Gonçalves DF, Hartmann DD, da Rosa PC, Cassol G, Royes LFF, de Carvalho NR, Soares FAA (2020) Guanosine protects against behavioural and mitochondrial bioenergetic alterations after mild traumatic brain injury. Brain Res Bull 163:31-39.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateRatNervous system
McLaughlin 2020b Sci Rep2020McLaughlin KL, Hagen JT, Coalson HS, Nelson MAM, Kew KA, Wooten AR, Fisher-Wellman KH (2020) Novel approach to quantify mitochondrial content and intrinsic bioenergetic efficiency across organs. Sci Rep 10:17599.LEAK
OXPHOS
ET
F
N
S
Gp
CIV
ROX
Isolated mitochondriaMouseHeart
Liver
Kidney
Fat
Kawamura 2021 Mol Ther Nucleic Acids2020Kawamura E, Maruyama M, Abe J, Sudo A, Takeda A, Takada S, Yokota T, Kinugawa S, Harashima H, Yamada Y (2021) Validation of gene therapy for mutant mitochondria by delivering mitochondrial RNA using a MITO-porter. Mol Ther Nucleic Acids 20:687-98.LEAK
OXPHOS
Permeabilized cellsHumanFibroblast
De-Souza 2020 J Biol Chem2020De-Souza EA, Pimentel FSA, De-Queiroz ALFV, Camara H, Felix-Formiga ML, Machado CM, Pinto S, Galina A, Mori MA, Montero-Lomelí M, Masuda CA (2020) The yeast protein Ubx4p contributes to mitochondrial respiration and lithium-galactose-mediated activation of the unfolded protein response. J Biol Chem 295:3773-82.LEAK
OXPHOS
N
Gp
NS
ROX
Isolated mitochondria
Intact cells
Caenorhabditis elegans
Saccharomyces cerevisiae
Maeda 2020 J Cell Mol Med2020Maeda H, Kami D, Maeda R, Murata Y, Jo JI, Kitani T, Tabata Y, Matoba S, Gojo S (2020) TAT-dextran-mediated mitochondrial transfer enhances recovery from models of reperfusion injury in cultured cardiomyocytes. J Cell Mol Med 24:5007-20.LEAK
ROUTINE
OXPHOS
ET
N
ROX
Isolated mitochondria
Intact cells
RatHeart
Chausse 2020 Brain Behav Immun2020Chausse B, Lewen A, Poschet G, Kann O (2020) Selective inhibition of mitochondrial respiratory complexes controls the transition of microglia into a neurotoxic phenotype in situ. Brain Behav Immun 88:802-14.LEAK
OXPHOS
SPermeabilized cellsMouseNervous system
Charles 2020 Nanomedicine (Lond)2020Charles C, Cohen-Erez I, Kazaoka B, Melnikov O, Stein DE, Sensenig R, Rapaport H, Orynbayeva Z (2020) Mitochondrial responses to organelle-specific drug delivering nanoparticles composed of polypeptide and peptide complexes. Nanomedicine (Lond) [Epub ahead of print].LEAK
OXPHOS
N
S
CIV
ROX
Isolated mitochondriaHumanEndothelial;epithelial;mesothelial cell
Kuffner 2020 Cells2020Kuffner K, Triebelhorn J, Meindl K, Benner C, Manook A, Sudria-Lopez D, Siebert R, Nothdurfter C, Baghai TC, Drexler K, Berneburg M, Rupprecht R, Milenkovic VM, Wetzel CH (2020) Major depressive disorder is associated with impaired mitochondrial function in skin fibroblasts. Cells 9:884. doi: 10.3390/cells9040884.LEAK
ROUTINE
ET
ROXIntact cellsHumanFibroblast
Janowska 2020 Toxicol In Vitro2020Janowska JI, Piel S, Saliba N, Kim CD, Jang DH, Karlsson M, Kilbaugh TJ, Ehinger JK (2020) Mitochondrial respiratory chain Complex I dysfunction induced by N-methyl carbamate ex vivo can be alleviated with a cell-permeable succinate prodrug carbamate toxicity and treatment. Toxicol In Vitro 65:104794.LEAK
ROUTINE
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
HumanPlatelet
Blood cells
Venediktova 2020 Mitochondrion2020Venediktova NI, Mashchenko OV, Talanov EY, Belosludtseva NV, Mironova GD (2020) Energy metabolism and oxidative status of rat liver mitochondria in conditions of experimentally induced hyperthyroidism. Mitochondrion [Epub ahead of print].LEAK
OXPHOS
N
NS
Isolated mitochondriaRatLiver
Liu 2020 J Clin Invest2020Liu L, Ding C, Fu T, Feng Z, Lee JE, Xiao L, Xu Z, Yin Y, Guo Q, Sun Z, Sun W, Mao Y, Yang L, Zhou Z, Zhou D, Xu L, Zhu Z, Qiu Y, Ge K, Gan Z (2020) Histone methyltransferase MLL4 controls myofiber identity and muscle performance through MEF2 interaction. J Clin Invest 130:4710-25.LEAK
OXPHOS
NPermeabilized tissueMouseSkeletal muscle
Abid 2020 FASEB J2020Abid H, Ryan ZC, Delmotte P, Sieck GC, Lanza IR (2020) Extramyocellular interleukin-6 influences skeletal muscle mitochondrial physiology through canonical JAK/STAT signaling pathways. FASEB J 34:14458-72.LEAK
OXPHOS
N
S
NS
Intact cellsMouseSkeletal muscle
Rodriguez de Yurre 2020 An Acad Bras Cienc2020Rodriguez de Yurre A, Martins EGL, Lopez-Alarcon M, Cabral B, Vera N, Lopes JA, Galina A, Takiya CM, Lindoso RS, Vieyra A, SÁenz OC, Medei E (2020) Type 2 diabetes mellitus alters cardiac mitochondrial content and function in a non-obese mice model. An Acad Bras Cienc 92:e20191340.LEAK
OXPHOS
N
NS
ROX
Isolated mitochondriaMouseHeart
Peruzzotti-Jametti 2020 bioRxiv2020Peruzzotti-Jametti L, Bernstock JD, Manferrari G, Rogall R, Fernandez-Vizarra E, Williamson JC, Braga A, van den Bosch A, Leonardi T, Kittel A, Benincá C, Vicario N, Tan S, Bastos C, Bicci I, Iraci N, Smith JA, Lehner PJ, Buzas EI, Faria N, Zeviani M, Frezza C, Brisson A, Matheson NJ, Viscomi C, Pluchino S (2020) Neural stem cells traffic functional mitochondria via extracellular vesicles to correct mitochondrial dysfunction in target cells. bioRxiv doi: https://doi.org/10.1101/2020.01.29.923441 .LEAKN
S
Gp
CIV
ROX
Permeabilized cellsMouseStem cells
Rodrigues 2020 J Appl Physiol (1985)2020Rodrigues GC, Rocha NN, Maia LA, Melo I, Simões AC, Antunes MA, Bloise FF, Woyames J, da-Silva WS, Capelozzi VL, Abela G, Ball L, Pelosi P, Rocco PRM, Silva PL (2020) Impact of experimental obesity on diaphragm structure, function and bioenergetics. J Appl Physiol (1985) [Epub ahead of print].LEAK
OXPHOS
ET
N
CIV
NS
Permeabilized tissueRatSkeletal muscle
Xia 2020 Biomed Res Int2020Xia W, Wang Q, Lu Y, Hu Y, Zhang X, Zhang J, Liu D, Song J, Zhu Z, Liu D, Zhang H (2020) Transient receptor potential channel canonical type 3 deficiency antagonizes myofibroblast transdifferentiation in vivo. Biomed Res Int 2020:1202189.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
HumanFibroblast
Aparicio-Trejo 2020 Free Radic Biol Med2020Aparicio-Trejo OE, Avila-Rojas SH, Tapia E, Rojas-Morales P, León-Contreras JC, Martínez-Klimova E, Hernández-Pando R, Sánchez-Lozada LG, Pedraza-Chaverri J (2020) Chronic impairment of mitochondrial bioenergetics and β-oxidation promotes experimental AKI-to-CKD transition induced by folic acid. Free Radic Biol Med 154:18-32.LEAK
OXPHOS
F
N
S
ROX
Isolated mitochondriaRatKidney
Cheng 2020 Am J Physiol Heart Circ Physiol2020Cheng TC, Philip JL, Tabima DM, Kumari S, Yakubov B, Frump AL, Hacker TA, Bellofiore A, Li R, Sun X, Goss KN, Lahm T, Chesler N (2020) Estrogen receptor alpha prevents right ventricular diastolic dysfunction and fibrosis in female rats . Am J Physiol Heart Circ Physiol [Epub ahead of print].LEAK
OXPHOS
N
S
CIV
ROX
Permeabilized tissueRatHeart
BEC 2020.1 doi10.26124bec2020-0001.v12020Gnaiger Erich et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenerg Commun 2020.1:44 pp. doi:10.26124/bec:2020-0001.v1LEAK
OXPHOS
ET
F
N
S
Gp
DQ
CIV
NS
Other combinations
ROX
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
Zhang 2020 Acta Pharmacol Sin2020Zhang L, Wang YN, Ju JM, Shabanova A, Li Y, Fang RN, Sun JB, Guo YY, Jin TZ, Liu YY, Li TY, Shan HL, Liang HH, Yang BF (2020) Mzb1 protects against myocardial infarction injury in mice via modulating mitochondrial function and alleviating inflammation. Acta Pharmacol Sin [Epub ahead of print].LEAK
ROUTINE
ET
ROXIntact cellsMouseHeart
McCommis 2020 Nat Metab2020McCommis KS, Kovacs A, Weinheimer CJ, Shew TM, Koves TR, Ilkayeva OR, Kamm DR, Pyles KD, King MT, Veech RL, DeBosch BJ, Muoio DM, Gross RW, Finck BN (2020) Nutritional modulation of heart failure in mitochondrial pyruvate carrier-deficient mice. Nat Metab 2:1232-47.LEAK
OXPHOS
F
N
S
NS
Permeabilized tissue
Isolated mitochondria
MouseHeart
Hartmann 2020 Free Radic Res2020Hartmann DD, Gonçalves DF, Da Rosa PC, Martins RP, Courtes AA, Franco JL, A Soares FA, Puntel GO (2020) A single muscle contusion promotes an immediate alteration in mitochondrial bioenergetics response in skeletal muscle fibres with different metabolism. Free Radic Res 54:137-49.LEAK
OXPHOS
ET
N
S
NS
Permeabilized tissueRatSkeletal muscle
Liu 2020 Am J Physiol Heart Circ Physiol2020Liu R, Jagannathan R, Sun L, Li F, Yang P, Lee J, Negi V, Perez-Garcia EM, Shiva S, Yechoor VK, Moulik M (2020) Tead1 is essential for mitochondrial function in cardiomyocytes. Am J Physiol Heart Circ Physiol 319:H89-99.LEAK
OXPHOS
F
N
NS
Isolated mitochondriaMouseHeart
Pola 2020 Invest New Drugs2020Pola M, Kolarova H, Ruzicka J, Zholobenko A, Modriansky M, Mosinger J, Bajgar R (2020) Effects of zinc porphyrin and zinc phthalocyanine derivatives in photodynamic anticancer therapy under different partial pressures of oxygen in vitro. Invest New Drugs [Epub ahead of print].LEAK
ROUTINE
ET
ROXIntact cellsHumanHeLa
Scrima 2020 bioRxiv2020Scrima R, Fugetto S, Capitanio N, Gatti DL (2020) Hemoglobin non-equilibrium oxygen dissociation curve. bioRxiv https://doi.org/10.1101/2020.01.09.900001.LEAKS
ROX
Isolated mitochondriaRatLiver
Szibor 2020 J Biol Chem2020Szibor Marten, Gizatullina Zemfira, Gainutdinov Timur, Endres Thomas, Debska-Vielhaber Grazyna, Kunz Matthias, Karavasili Niki, Hallmann Kerstin, Schreiber Frank, Bamberger Alexandra, Schwarzer Michael, Doenst Torsten, Heinze Hans-Jochen, Leßmann Volkmar, Vielhaber Stefan, Kunz Wolfram S, Gellerich Frank Norbert (2020) Cytosolic, but not matrix, calcium is essential for adjustment of mitochondrial pyruvate supply. J Biol Chem 295:4383-97.LEAK
OXPHOS
N
S
Gp
CIV
NS
ROX
Isolated mitochondria
Intact cells
MouseNervous system
Briones-Herrera 2020 Free Radic Biol Med2020Briones-Herrera A, Ramírez-Camacho I, Zazueta C, Tapia E, Pedraza-Chaverri J (2020) Altered proximal tubule fatty acid utilization, mitophagy, fission and supercomplexes arrangement in experimental Fanconi syndrome are ameliorated by sulforaphane-induced mitochondrial biogenesis. Free Radic Biol Med 153:54-70.LEAK
OXPHOS
F
N
S
NS
ROX
Isolated mitochondriaRatKidney
Eshima 2020 J Appl Physiol (1985)2020Eshima H, Siripoksup P, Mahmassani ZS, Johnson JM, Ferrara PJ, Verkerke ARP, Salcedo A, Drummond MJ, Funai K (2020) Neutralizing mitochondrial ROS does not rescue muscle atrophy induced by hindlimb unloading in female mice. J Appl Physiol (1985) 129:124-32.LEAK
OXPHOS
ET
N
NS
Isolated mitochondriaMouseSkeletal muscle
Roginski 2020 Biochim Biophys Acta Mol Basis Dis2020Roginski AC, Wajner A, Cecatto C, Wajner SM, Castilho RF, Wajner M, Amaral AU (2020) Disturbance of bioenergetics and calcium homeostasis provoked by metabolites accumulating in propionic acidemia in heart mitochondria of developing rats. Biochim Biophys Acta Mol Basis Dis 1866:165682.LEAK
OXPHOS
ET
N
S
NS
Permeabilized cells
Isolated mitochondria
Homogenate
RatHeart
Other cell lines
Brand 2020 J Clin Med2020Brand S, Ebner K, Mikoteit T, Lejri I, Gerber M, Beck J, Holsboer-Trachsler E, Eckert A (2020) Influence of regular physical activity on mitochondrial activity and symptoms of burnout-an interventional pilot study. J Clin Med 9:E667.LEAK
OXPHOS
ET
N
CIV
ROX
Permeabilized cellsHumanLymphocyte
Mouithys-Mickalad 2020 Chem Biol Interact2020Mouithys-Mickalad A, Ceusters J, Charif M, El Moualij B, Schoumacher M, Plyte S, Franck T, Bettendorff L, Pirotte B, Serteyn D, de Tullio P (2020) Modulation of mitochondrial respiration rate and calcium-induced swelling by new cromakalim analogues. Chem Biol Interact 331:109272.LEAK
ROUTINE
ET
ROXIntact cellsRatHeart
Evinova 2020 J Membr Biol2020Evinova A, Cizmarova B, Hatokova Z, Racay P (2020) High‑resolution respirometry in assessment of mitochondrial function in neuroblastoma SH‑SY5Y intact cells. J Membr Biol 253:129-36.LEAK
ROUTINE
ET
N
S
ROX
Permeabilized cells
Intact cells
HumanNeuroblastoma
Marquez 2020 J Am Heart Assoc2020Marquez AM, Morgan RW, Ko T, Landis WP, Hefti MM, Mavroudis CD, McManus MJ, Karlsson M, Starr J, Roberts AL, Lin Y, Nadkarni V, Licht DJ, Berg RA, Sutton RM, Kilbaugh TJ (2020) Oxygen exposure during cardiopulmonary resuscitation is associated with cerebral oxidative injury in a randomized, blinded, controlled, preclinical trial. J Am Heart Assoc 9:015032.LEAK
OXPHOS
ET
N
S
CIV
NS
HomogenatePigNervous system
Baggio 2020 Neurotoxicology2020Baggio S, Zenki K, Martins Silva A, Dos Santos TG, Rech G, Lazzarotto G, Dias RD, Mussulini BH, Rico EP, de Oliveira DL (2020) Fetal alcohol spectrum disorders model alters the functionality of glutamatergic neurotransmission in adult zebrafish. Neurotoxicology 78:152-160.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateZebrafishNervous system
Fuchs 2020 J Funct Foods2020Fuchs C, Bakuradze T, Steinke R, Grewal R, Eckert GP, Richling E (2020) Polyphenolic composition of extracts from winery by-products and effects on cellular cytotoxicity and mitochondrial functions in HepG2 cells. J Funct Foods 70:103988.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cellsHumanLiver
Parker 2020 Thesis2020Parker EP (2020) The effect of isoleucine supplementation of peripheral blood mononuclear cell metabolism in subjects with type 2 diabetes. URS Thesis 31.LEAK
ROUTINE
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cells
Intact cells
HumanBlood cells
Kanellopoulos 2020 Cell2020Kanellopoulos AK, Mariano V, Spinazzi M, Woo YJ, McLean C, Pech U, Li KW, Armstrong JD, Giangrande A, Callaerts P, Smit AB, Abrahams BS, Fiala A, Achsel T, Bagni C (2020) Aralar sequesters GABA into hyperactive mitochondria, causing social behavior deficits. Cell 180:1178-97.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
HomogenateDrosophilaNervous system
Other cell lines
Serna 2020 J Bioenerg Biomembr2020Serna JDC, Caldeira da Silva CC, Kowaltowski AJ (2020) Functional changes induced by caloric restriction in cardiac and skeletal muscle mitochondria. J Bioenerg Biomembr 52:269-77.LEAK
OXPHOS
SIsolated mitochondriaRatHeart
Skeletal muscle
Wu 2020 Chemosphere2020Wu F, Sokolov EP, Dellwig O, Sokolova IM (2020) Season-dependent effects of ZnO nanoparticles and elevated temperature on bioenergetics of the blue mussel Mytilus edulis. Chemosphere 263:127780.LEAK
OXPHOS
ET
N
NS
Isolated mitochondriaMolluscsOther cell lines
Makrecka-Kuka 2020 Sci Rep2020Makrecka-Kuka M, Dimitrijevs P, Domracheva I, Jaudzems K, Dambrova M, Arsenyan P (2020) Fused isoselenazolium salts suppress breast cancer cell growth by dramatic increase in pyruvate-dependent mitochondrial ROS production. Sci Rep 10:21595.LEAK
OXPHOS
N
S
NS
ROX
Permeabilized cellsMouseEndothelial;epithelial;mesothelial cell
Schneider 2020 PLoS One2020Schneider J, Han WH, Matthew R, Sauve Y, Lemieux H (2020) Age and sex as confounding factors in the relationship between cardiac mitochondrial function and type 2 diabetes in the Nile Grass rat. PLoS One 15:e0228710.LEAK
OXPHOS
F
N
S
CIV
NS
ROX
Permeabilized tissueRatHeart
Li Puma 2020 Am J Physiol Regul Integr Comp Physiol2020Li Puma LC, Hedges M, Heckman JM, Mathias AB, Engstrom MR, Brown AB, Chicco AJ (2020) Experimental oxygen concentration influences rates of mitochondrial hydrogen peroxide release from cardiac and skeletal muscle preparations. Am J Physiol Regul Integr Comp Physiol 318:972-80.LEAK
OXPHOS
N
NS
Permeabilized tissue
Homogenate
Isolated mitochondria
MouseHeart
Skeletal muscle
Miotto 2020 Am J Physiol Endocrinol Metab2020Miotto PM, Petrick HL, Holloway GP (2020) Acute insulin deprivation results in altered mitochondrial substrate sensitivity conducive to greater fatty acid transport. Am J Physiol Endocrinol Metab 319:E345-53.OXPHOS
LEAK
N
NS
F
Permeabilized tissueRatSkeletal muscle
Musi 2020 Aging Cell2020Musi N, Valentine JM, Sickora KR, Baeuerle E, Thompson CS, Shen Q, Orr ME (2020) Tau protein aggregation is associated with cellular senescence in the brain. Aging Cell 17:e12840.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateMouseNervous system
Chabi 2019 MitoFit Preprint Arch EA2019-10-10Chabi Béatrice, Ost M, Gama-Perez P, Dahdah N, Lemieux H, Holody CD, Carpenter RG, Tepp K, Puurand M, Kaambre T, Dubouchaud H, Cortade F, Pesta D, Calabria E, Casado M, Fernandez-Ortiz M, Acuña-Castroviejo D, Villena JA, Grefte S, Keijer J, O'Brien K, Sowton A, Murray AJ, Campbell MD, Marcinek DJ, Nollet E, Wüst R, Dayanidhi S, Gnaiger E, Doerrier C, Garcia-Roves PM (2019) Generating reference values on mitochondrial respiration in permeabilized muscle fibers. MitoFit Preprint Arch doi:10.26124/mitofit:ea19.MitoEAGLE.0001.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Gnaiger 2019 MitoFit Preprints2019-08-30Gnaiger E, Aasander Frostner E, Abdul Karim N, Abdel-Rahman EA, Abumrad NA, Acuna-Castroviejo D, Adiele RC, et al (2019) Mitochondrial respiratory states and rates. MitoFit Preprint Arch doi:10.26124/mitofit:190001.v6. — Published in BEC: 2020-05-20 Mitochondrial physiology. Bioenerg Commun 2020.1. doi:10.26124/bec:2020-0001.v1LEAK
OXPHOS
ET
F
N
S
Gp
DQ
CIV
NS
Other combinations
ROX
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
Doerrier 2019 MitoFit Preprint Arch EA2019-07-04Doerrier C, Gama-Perez P, Distefano G, Pesta D, Soendergaard SD, Chroeis KM, Gonzalez-Franquesa A, Goodpaster BH, Coen P, Larsen S, Gnaiger E, Garcia-Roves PM (2019) Inter-laboratory harmonization of respiratory protocols in permeabilized human muscle fibers. MitoFit Preprint Arch doi:10.26124/mitofit:ea19.MiPSchool.0009.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
MiPNet20.13 Safranin mt-membranepotential2019-06-24
O2k-Protocols
O2k-FluoRespirometry: HRR and simultaneous determination of mt-membrane potential with safranin or TMRM.
LEAK
ET
S
ROX
HomogenateMouseNervous system
MiPNet20.14 AmplexRed H2O2-production2019-06-24
O2k-Protocols
O2k-FluoRespirometry: HRR and simultaneous determination of H2O2 production with Amplex UltraRed.
LEAK
OXPHOS
ET
SIsolated mitochondriaMouseHeart
MiPNet18.05 Amplex-Mouse-heart2019-06-24
O2k-Protocols
O2k-Fluorometry: HRR and H2O2 production in mouse cardiac tissue homogenate.
LEAK
OXPHOS
ET
N
S
NS
HomogenateMouseHeart
Schoepf 2019 MitoFit Preprint Arch2019-06-11Schöpf B, Weissensteiner H, Schäfer G, Fazzini F, Charoentong P, Naschberger A, Rupp B, Fendt L, Bukur V, Eichelbrönner I, Sorn P, Sahin U, Kronenberg F, Gnaiger E, Klocker H (2019) OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and a prognostic gene expression signature. MitoFit Preprint Arch doi:10.26124/mitofit:190003. - 2020-03-20 Published in »Nature Communications 11:1487«LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueHumanGenital
Rodriguez-Enriquez 2019 Toxicol Appl Pharmacol2019Rodríguez-Enríquez S, Pacheco-Velázquez SC, Marín-Hernández Á, Gallardo-Pérez JC, Robledo-Cadena DX, Hernández-Reséndiz I, García-García JD, Belmont-Díaz J, López-Marure R, Hernández-Esquivel L, Sánchez-Thomas R, Moreno-Sánchez R (2019) Resveratrol inhibits cancer cell proliferation by impairing oxidative phosphorylation and inducing oxidative stress. Toxicol Appl Pharmacol 370:65-77.LEAK
OXPHOS
N
S
Isolated mitochondriaRatHeart
Liver
Christian 2019 Respir Physiol Neurobiol2019Christian AR, Losantos-Ramos K, Marcelino G, Daniela F, Jorge S (2019) NADH-linked mitochondrial respiration in the developing mouse brain is sex-, age- and tissue-dependent. Respir Physiol Neurobiol 266:156-62.LEAK
OXPHOS
NPermeabilized tissueMouseNervous system
Cooper 2019 Exp Physiol2019Cooper MA, McCoin C, Pei D, Thyfault JP, Koestler D, Wright DE (2019) Reduced mitochondrial reactive oxygen species production in peripheral nerves of mice fed a ketogenic diet. Exp Physiol 103:1206-12.LEAK
OXPHOS
ET
F
N
Permeabilized tissueMouseNervous system
Wang 2019 Metabolism2019Wang D, Liu CD, Li HF, Tian ML, Pan JQ, Shu G, Jiang QY, Yin YL, Zhang L (2019) LSD1 mediates microbial metabolite butyrate-induced thermogenesis in brown and white adipose tissue. Metabolism 102:154011.LEAKF
N
Isolated mitochondriaMouseFat
Inigo 2019 Mol Metab2019Inigo MR, Amorese AJ, Tarpey MD, Balestrieri NP, Jones KG, Patteson DJ, Jackson KC, Torres MJ, Lin CT, Smith CD, Heden TD, McMillin SL, Weyrauch LA, Stanley EC, Schmidt CA, Kilburg-Basnyat BB, Reece SW, Psaltis CE, Leinwand LA, Funai K, McClung JM, Gowdy KM, Witczak CA, Lowe DA, Neufer PD, Spangenburg EE (2019) Estrogen receptor-α in female skeletal muscle is not required for regulation of muscle insulin sensitivity and mitochondrial regulation. Mol Metab 34:1-15.LEAK
OXPHOS
F
N
S
CIV
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Cardinale 2019 Front Physiol2019Cardinale DA, Larsen FJ, Lännerström J, Manselin T, Södergård O, Mijwel S, Lindholm P, Ekblom B, Boushel R (2019) Influence of hyperoxic-supplemented high-intensity interval training on hemotological and muscle mitochondrial adaptations in trained cyclists. Front Physiol 10:730.LEAK
OXPHOS
ET
F
N
CIV
NS
ROX
Permeabilized tissue
Isolated mitochondria
HumanSkeletal muscle
Brunetta 2019 J Funct Foods2019Brunetta HS, de Paula GC, Fritzen M, Cecchini MS, dos Santos GJ, Nazari EM, Rafacho A, de Bem AF, Nunes EA (2019) Leucine increases muscle mitochondrial respiration and attenuates glucose intolerance in diet-induced obesity in Swiss mice. J Funct Foods 62:103544.LEAK
OXPHOS
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Gaglianone 2019 Sci Rep2019Gaglianone RB, Santos AT, Bloise FF, Ortiga-Carvalho TM, Costa ML, Quirico-Santos T, da Silva WS, Mermelstein C (2019) Reduced mitochondrial respiration and increased calcium deposits in the EDL muscle, but not in soleus, from 12-week-old dystrophic mdx mice. Sci Rep 9:1986.LEAK
OXPHOS
ET
N
CIV
NS
Permeabilized tissueMouseSkeletal muscle
Trefts 2019 Thesis2019Trefts E (2019) Integrin linked kinase is critical for hepatic cellular organization, metabolism, and glucoregulation. PhD Thesis 164.LEAK
ROUTINE
ET
Intact cellsMouseLiver
Electron-transfer-pathway state2019Gnaiger E (2019) ET-pathway states. Mitochondr Physiol Network 2019-06-11 (last edit since 2016-11-08).LEAK
OXPHOS
ET
F
N
S
Gp
CIV
NS
Other combinations
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
SMP
Pignanelli 2019 Thesis2019Pignanelli CJ (2019) Muscular adaptations to low-load resistance training to repetition failure with and without blood flow restriction. Master's Thesis 80.LEAK
OXPHOS
N
NS
Permeabilized tissueHumanSkeletal muscle
Cannon 2019 J Appl Physiol (1985)2019Cannon DT, Rodewohl L, Adams V, Breen EC, Bowen TS (2019) Skeletal myofiber VEGF deficiency leads to mitochondrial, structural and contractile alterations in mouse diaphragm. J Appl Physiol (1985) 127:1360-69.LEAK
OXPHOS
ET
N
S
NS
Permeabilized tissueMouseSkeletal muscle
Vaka 2019 Am J Physiol Regul Integr Comp Physiol2019Vaka VR, Mcmasters KM, Cornelius DC, Ibrahim T, Jayaram A, Usry N, Cunningham MW Jr, Amaral LM, LaMarca BD (2019) Natural killer cells contribute to mitochondrial dysfunction in response to placental ischemia in Reduced Uterine Perfusion Pressure (RUPP) rats. Am J Physiol Regul Integr Comp Physiol 316:R441-R447.LEAK
OXPHOS
ET
N
CIV
ROX
Intact cells
Isolated mitochondria
Human
Rat
Endothelial;epithelial;mesothelial cell
Genital
Crescenzo 2019 Mol Neurobiol2019Crescenzo R, Spagnuolo MS, Cancelliere R, Iannotta L, Mazzoli A, Gatto C, Iossa S, Cigliano L (2019) Effect of initial aging and high-fat/high-fructose diet on mitochondrial bioenergetics and oxidative status in rat brain. Mol Neurobiol 56:7651-63.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateRatNervous system
Dilberger 2019 Nutrients2019Dilberger B, Passon M, Asseburg H, Silaidos CV, Schmitt F, Schmiedl T, Schieber A, Eckert GP (2019) Polyphenols and metabolites enhance survival in rodents and nematodes-impact of mitochondria. Nutrients 11:E1886.LEAK
OXPHOS
ET
N
S
CIV
NS
Isolated mitochondriaCaenorhabditis elegans
Kumari 2019 Am J Physiol Heart Circ Physiol2019Kumari S, Braun RK, Tetri L, Barton GP, Hacker TA, Goss KN (2019) Bimodal right ventricular dysfunction after postnatal hyperoxia exposure: implications for the preterm heart. Am J Physiol Heart Circ Physiol 317:H1272-81.LEAK
OXPHOS
ET
N
S
CIV
ROX
Permeabilized tissueRatHeart
Adeyemi 2019 Ecotoxicol Environ Saf2019Adeyemi JA, Machado ART, Ogunjimi AT, Alberici LC, Antunes LMG, Barbosa F Jr (2019) Cytotoxicity, mutagenicity, oxidative stress and mitochondrial impairment in human hepatoma (HepG2) cells exposed to copper oxide, copper-iron oxide and carbon nanoparticles. Ecotoxicol Environ Saf 189:109982.LEAK
ROUTINE
ET
Intact cellsHumanLiver
Castellano-Gonzalez 2019 Neurotox Res2019Castellano-Gonzalez G, Jacobs KR, Don E, Cole NJ, Adams S, Lim CK, Lovejoy DB, Guillemin GJ (2019) Kynurenine 3-monooxygenase activity in human primary neurons and effect on cellular bioenergetics identifies new neurotoxic mechanisms. Neurotox Res 35:530-41.LEAK
ET
ROUTINE
ROXIntact cellsHumanHEK
Axton 2019 J Nutr2019Axton ER, Beaver LM, St Mary L, Truong L, Logan CR, Spagnoli S, Prater MC, Keller RM, Garcia-Jaramillo M, Ehrlicher SE, Stierwalt HD, Newsom SA, Robinson MM, Tanguay RL, Stevens JF, Hord NG (2019) Treatment with nitrate, but not nitrite, lowers the oxygen cost of exercise and decreases glycolytic intermediates while increasing fatty acid metabolites in exercised zebrafish. J Nutr 00:1–13.LEAK
OXPHOS
ET
N
S
NS
ROX
Isolated mitochondriaZebrafishSkeletal muscle
Chang 2019 Br J Anaesth2019Chang L, Daly C, Miller DM, Allen PD, Boyle JP, Hopkins PM, Shaw MA (2019) Permeabilised skeletal muscle reveals mitochondrial deficiency in malignant hyperthermia-susceptible individuals. Br J Anaesth 122:613-21.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
HumanSkeletal muscle
Park 2019 Behav Brain Res2019Park SS, Park HS, Kim CJ, Baek SS, Kim TW (2019) Exercise attenuates maternal separation-induced mood disorder-like behaviors by enhancing mitochondrial functions and neuroplasticity in the dorsal raphe. Behav Brain Res 372:112049.LEAK
OXPHOS
N
NS
RatNervous system
Pino 2019 Physiol Genomics2019Pino MF, Stephens NA, Eroshkin AM, Yi F, Hodges A, Cornnell HH, Pratley RE, Smith SR, Wang M, Han X, Coen PM, Goodpaster BH, Sparks LM (2019) Endurance training remodels skeletal muscle phospholipid composition and increases intrinsic mitochondrial respiration in men with type 2 diabetes. Physiol Genomics 51:586-95.LEAK
OXPHOS
ET
N
NS
Permeabilized cells
Permeabilized tissue
HumanSkeletal muscle
Qaed 2019 Oxid Med Cell Longev2019Qaed E, Wang J, Almoiliqy M, Song Y, Liu W, Chu P, Alademi S, Alademi M, Li H, Alshwmi M, Al-Azab M, Ahsan A, Mahdi S, Han G, Niu M, Ali A, Shopit A, Wang H, Li X, Qaid A, Ma X, Li T, Peng J, Ma J, Zhang J, Tang Z (2019) Phosphocreatine improves cardiac dysfunction by normalizing mitochondrial respiratory function through JAK2/STAT3 signaling pathway in vivo and in vitro. Oxid Med Cell Longev 2019:6521218.LEAK
OXPHOS
ET
ROUTINE
N
S
NS
ROX
Homogenate
Isolated mitochondria
Permeabilized cells
Intact cells
RatHeart
Magga 2019 Mol Ther2019Magga J, Vainio L, Kilpiö T, Hulmi JJ, Taponen S, Lin R, Räsänen M, Szabó Z, Gao E, Rahtu-Korpela L, Alakoski T, Ulvila J, Laitinen M, Pasternack A, Koch WJ, Alitalo K, Kivelä R, Ritvos O, Kerkelä R (2019) Systemic blockade of ACVR2B ligands protects myocardium from acute ischemia-reperfusion injury. Mol Ther 27:600-10.LEAK
OXPHOS
ET
N
S
NS
HomogenateMouseHeart
Miotto 2019 FASEB J2019Miotto PM, McGlory C, Bahniwal R, Kamal M, Phillips SM, Holloway GP (2019) Supplementation with dietary ω-3 mitigates immobilization-induced reductions in skeletal muscle mitochondrial respiration in young women. FASEB J 33:8232-40.LEAK
OXPHOS
N
NS
F
Permeabilized tissueHumanSkeletal muscle
Sukovas 2019 J Bioenerg Biomembr2019Sukovas A, Silkuniene G, Trumbeckaite S, Jasukaitiene A, Degutyte-Fomins L, Mildaziene V, Gulbinas A, Baniene R, Dambrauskas Z, Paskauskas S (2019) Hyperthermia potentiates cisplatin cytotoxicity and negative effects on mitochondrial functions in OVCAR-3 cells. J Bioenerg Biomembr 51:301-10.LEAK
OXPHOS
NPermeabilized cellsHumanGenital
Kim 2019 Biochim Biophys Acta Mol Basis Dis2019Kim HK, Jeon J, Song IS, Heo HJ, Jeong SH, Long LT, Thu VT, Ko TH, Kim M, Kim N, Lee SR, Yang JS, Kang MS, Ahn JM, Cho JY, Ko KS, Rhee BD, Nilius B, Ha NC, Shimizu I, Minamino T, Cho KI, Park YS, Kim S, Han J (2019) Tetrahydrobiopterin enhances mitochondrial biogenesis and cardiac contractility via stimulation of PGC1α signaling. Biochim Biophys Acta Mol Basis Dis 1865:165524.LEAK
OXPHOS
NIsolated mitochondria
Permeabilized tissue
MouseHeart
Bodis 2019 J Clin Endocrinol Metab2019Bodis K, Jelenik T, Lundbom J, Markgraf DF, Strom A, Zaharia OP, Karusheva Y, Burkart V, Muessig K, Kupriyanova Y, Ouni M, Wolkersdorfer M, Hwang JH, Ziegler D, Schuermann A, Roden M, Szendroedi J (2019) Expansion and impaired mitochondrial efficiency of deep subcutaneous adipose tissue in recent-onset type 2 diabetes. J Clin Endocrinol Metab 105:dgz267.LEAK
OXPHOS
ET
F
N
NS
Permeabilized cellsHumanFat
Pichaud 2019 Front Genet2019Pichaud N, Bérubé R, Côté G, Belzile C, Dufresne F, Morrow G, Tanguay RM, Rand DM, Blier PU (2019) Age dependent dysfunction of mitochondrial and ROS metabolism induced by mitonuclear mismatch. Front Genet 10:130.LEAK
OXPHOS
ET
N
Gp
CIV
ROX
Permeabilized tissueDrosophilaSkeletal muscle
Seo 2019 Exp Neurol2019Seo JH, Park HS, Park SS, Kim CJ, Kim DH, Kim TW (2019) Physical exercise ameliorates psychiatric disorders and cognitive dysfunctions by hippocampal mitochondrial function and neuroplasticity in post-traumatic stress disorder. Exp Neurol 322:113043.LEAK
OXPHOS
N
NS
Isolated mitochondriaRatNervous system
Chatfield 2019 JACC Basic Transl Sci2019Chatfield KC, Sparagna GC, Chau S, Phillips EK, Ambardekar AV, Aftab M, Mitchell MB, Sucharov CC, Miyamoto SD, Stauffer BL (2019) Elamipretide improves mitochondrial function in the failing human heart. JACC Basic Transl Sci 4:147-57.LEAK
OXPHOS
ET
N
S
NS
Permeabilized tissueHumanHeart
Gururaja Rao 2019 Cells2019Gururaja Rao S, Bednarczyk P, Towheed A, Shah K, Karekar P, Ponnalagu D, Jensen HN, Addya S, Reyes BAS, Van Bockstaele EJ, Szewczyk A, Wallace DC, Singh H (2019) BKCa (Slo) channel regulates mitochondrial function and lifespan in Drosophila melanogaster. Cells 8:E945.LEAK
OXPHOS
ET
N
S
NS
ROX
Isolated mitochondriaDrosophila
Macedo 2019 Biochim Biophys Acta Mol Cell Biol Lipids2019Macedo F, Martins GL, Luévano-Martínez LA, Viana GM, Riske KA, Inague A, Yoshinaga MY, Aguilaniu H, Miyamoto S, Glezer I, da Cunha FM (2019) Lipase-like 5 enzyme controls mitochondrial activity in response to starvation in Caenorhabditis elegans. Biochim Biophys Acta Mol Cell Biol Lipids 1865:158539.LEAK
OXPHOS
N
CIV
NS
Isolated mitochondriaCaenorhabditis elegans
Hall 2019 Methods Mol Biol2019Hall A, Moghimi SM (2019) Determination of polycation-mediated perturbation of mitochondrial respiration in intact cells by high-resolution respirometry (Oxygraph-2k, OROBOROS). Methods Mol Biol 1943:313-22.LEAK
ROUTINE
ET
ROXIntact cellsHumanEndothelial;epithelial;mesothelial cell
Halbach 2019 Am J Physiol Regul Integr Comp Physiol2019Halbach JL, Prieto JM, Wang AW, Hawisher D, Cauvi DM, Reyes T, Okerblom J, Ramirez-Sanchez I, Villarreal F, Patel HH, Bickler SW, Perdrizet GA, De Maio A (2019) Early hyperbaric oxygen therapy improves survival in a model of severe sepsis. Am J Physiol Regul Integr Comp Physiol 317:R160-R168.LEAK
OXPHOS
N
NS
Intact cellsMouseLiver
Pharaoh 2019 Mol Neurobiol2019Pharaoh G, Owen D, Yeganeh A, Premkumar P, Farley J, Bhaskaran S, Ashpole N, Kinter M, Van Remmen H, Logan S (2019) Disparate central and peripheral effects of circulating IGF-1 deficiency on tissue mitochondrial function. Mol Neurobiol 57:1317-31.LEAK
OXPHOS
N
S
CIV
NS
ROX
Permeabilized tissue
Isolated mitochondria
Intact cells
MouseSkeletal muscle
Nervous system
Fat
Szibor 2019 Biochim Biophys Acta Bioenerg2019Szibor Marten, Gainutdinov Timur, Fernandez-Vizarra Erika, Dufour Eric, Gizatullina Zemfira, Debska-Vielhaber Grazyna, Heidler Juliana, Wittig Ilka, Viscomi Carlo, Gellerich Frank Norbert, Moore Anthony L (2019) Bioenergetic consequences from xenotopic expression of a tunicate AOX in mouse mitochondria: switch from RET and ROS to FET. Biochim Biophys Acta Bioenerg 1861:148137.LEAK
OXPHOS
ET
N
S
NS
ROX
Isolated mitochondriaMouseHeart
Ferey 2019 Am J Physiol Heart Circ Physiol2019Ferey J, Boudoures AL, Reid M, Drury A, Scheaffer S, Modi Z, Kovacs A, Pietka T, DeBosch BJ, Thompson MD, Diwan A, Moley KH (2019) Maternal high-fat, high-sucrose diet induces transgenerational cardiac mitochondrial dysfunction independent of maternal mitochondrial inheritance. Am J Physiol Heart Circ Physiol 316:H1202-H1210.LEAK
OXPHOS
N
S
NS
Permeabilized tissueMouseHeart
Berg 2019 Front Physiol2019Berg J, Undebakke V, Rasch-Halvorsen Ø, Aakerøy L, Sandbakk Ø, Tjønna AE (2019) Comparison of mitochondrial respiration in M. triceps brachii and M. vastus lateralis between elite cross-country skiers and physically active controls. Front Physiol 10:365.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Zhao 2019 Pharmacol Res2019Zhao X, Jin Y, Li L, Xu L, Tang Z, Qi Y, Yin L, Peng J (2019) MicroRNA-128-3p aggravates doxorubicin-induced liver injury by promoting oxidative stress via targeting Sirtuin-1. Pharmacol Res 146:104276.LEAK
ROUTINE
ET
ROXIntact cellsMouseLiver
Other cell lines
Gustafson 2019 PLoS One2019Gustafson MA, McCormick EM, Perera L, Longley MJ, Bai R, Kong J, Dulik M, Shen L, Goldstein AC, McCormack SE, Laskin BL, Leroy BP, Ortiz-Gonzalez XR, Ellington MG, Copeland WC, Falk MJ (2019) Mitochondrial single-stranded DNA binding protein novel de novo SSBP1 mutation in a child with single large-scale mtDNA deletion (SLSMD) clinically manifesting as Pearson, Kearns-Sayre, and Leigh syndromes. PLoS One 14:e0221829.LEAK
ROUTINE
ET
ROXIntact cellsHumanFibroblast
Lymphocyte
Shao 2019 Cardiovasc Diabetol2019Shao Q, Meng L, Lee S, Tse G, Gong M, Zhang Z, Zhao J, Zhao Y, Li G, Liu T (2019) Empagliflozin, a sodium glucose co-transporter-2 inhibitor, alleviates atrial remodeling and improves mitochondrial function in high-fat diet/streptozotocin-induce diabetic rats. Cardiovasc Diabetol 18:165.LEAK
OXPHOS
NIsolated mitochondriaRatHeart
Fisar 2019 Clin Biochem2019Fišar Z, Jirák R, Zvěřová M, Setnička V, Habartová L, Hroudová J, Vaníčková Z, Raboch J (2019) Plasma amyloid beta levels and platelet mitochondrial respiration in patients with Alzheimer's disease. Clin Biochem 72:71-80.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
HumanPlatelet
Blood cells
Mueller 2019 Thesis2019Müller T (2019) Role of MICOS for mitochondrial morphology and function. PhD Thesis 77.LEAK
ROUTINE
ET
Intact cellsHumanHEK
Bianco 2019 PLoS One2019Bianco M, Lopes JA, Beiral HJV, Filho JDD, Frankenfeld SP, Fortunato RS, Gattass CR, Vieyra A, Takiya CM (2019) The contralateral kidney presents with impaired mitochondrial functions and disrupted redox homeostasis after 14 days of unilateral ureteral obstruction in mice. PLoS One 14:e0218986.LEAK
OXPHOS
ET
N
S
Isolated mitochondriaMouseKidney
Grandoch 2019 Nat Metab2019Grandoch M, Flögel U, Virtue S, Maier JK, Jelenik T, Kohlmorgen C, Feldmann K, Ostendorf Y, Castañeda TR, Zhou Z, Yamaguchi Y, Nascimento EBM, Sunkari VG, Goy C, Kinzig M, Sörgel F, Bollyky PL, Schrauwen P, Al-Hasani H, Roden M, Keipert S, Vidal-Puig A, Jastroch M5, Haendeler J, Fischer JW (2019) 4-Methylumbelliferone improves the thermogenic capacity of brown adipose tissue. Nat Metab 1:546-59.LEAK
OXPHOS
ET
N
NS
ROX
Permeabilized tissue
Isolated mitochondria
MouseFat
Shrum 2019 Biomolecules2019Shrum S, Rusch NJ, MacMillan-Crow LA (2019) Specific BK channel activator NS11021 protects rat renal proximal tubular cells from cold storage-induced mitochondrial injury in vitro. Biomolecules 9:E825.LEAK
OXPHOS
N
S
CIV
ROX
Permeabilized cellsRatKidney
Douros 2019 JCI Insight2019Douros JD, Niu J, Sdao SM, Gregg T, Fisher-Wellman KH, Bharadwaj MS, Molina A, Arumugam R, Martin MD, Petretto E, Merrins MJ, Herman MA, Tong J, Campbell JE, D'Alessio D (2019) Sleeve gastrectomy rapidly enhances islet function independently of body weight. JCI Insight 4:126688.LEAK
OXPHOS
ET
N
Gp
NS
Permeabilized tissueMouseIslet cell;pancreas;thymus
Halle 2019 Am J Physiol Regul Integr Comp Physiol2019Halle JL, Pena GS, Paez HG, Castro AJ, Rossiter HB, Visavadiya NP, Whitehurst MA, Khamoui AV (2019) Tissue-specific dysregulation of mitochondrial respiratory capacity and coupling control in colon-26 tumor-induced cachexia. Am J Physiol Regul Integr Comp Physiol 317:R68-R82.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissue
Intact cells
MouseSkeletal muscle
Liver
Fat
Rodinova 2019 Dis Model Mech2019Rodinova M, Krizova J, Stufkova H, Bohuslavova B, Askeland G, Dosoudilova Z, Juhas S, Juhasova J, Ellederova Z, Zeman J, Eide L, Motlik J, Hansikova H (2019) Deterioration of mitochondrial bioenergetics and ultrastructure impairment in skeletal muscle of a transgenic minipig model in the early stages of Huntington's disease. Dis Model Mech 12:dmm038737.LEAK
OXPHOS
ET
N
S
CIV
ROX
Isolated mitochondriaPigSkeletal muscle
Mazzoli 2019 Nutrients2019Mazzoli A, Crescenzo R, Cigliano L, Spagnuolo MS, Cancelliere R, Gatto C, Iossa S (2019) Early hepatic oxidative stress and mitochondrial changes following western diet in middle aged rats. Nutrients 11:E2670.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateRatLiver
Chen 2019 Ecotoxicol Environ Saf2019Chen H, Liu G, Qiao N, Kang Z, Hu L, Liao J, Yang F, Pang C, Liu B, Zeng Q, Li Y, Li Y (2019) Toxic effects of arsenic trioxide on spermatogonia are associated with oxidative stress, mitochondrial dysfunction, autophagy and metabolomic alterations. Ecotoxicol Environ Saf 190:110063.LEAK
ROUTINE
ET
ROXIntact cellsMouseGenital
Mann 2019 Oncogene2019Mann J, Githaka JM, Buckland TW, Yang N, Montpetit R, Patel N, Li L, Baksh S, Godbout R, Lemieux H, Goping IS (2019) Non-canonical BAD activity regulates breast cancer cell and tumor growth via 14-3-3 binding and mitochondrial metabolism. Oncogene 38:3325-39.LEAK
ROUTINE
OXPHOS
ET
N
S
CIV
NS
ROX
F
Permeabilized cells
Intact cells
HumanEndothelial;epithelial;mesothelial cell
Doig 2019 bioRxiv2019Doig CD, Zelinska AE, Oakey LA, Fletcher RS, El Hassan Y, Garten A, Cartwright D, Heising S, Tennant DA, Watson D, Adamski J, Lavery GG (2019) Induction of the nicotinamide riboside kinase NAD+ salvage pathway in skeletal muscle of H6PDH KO mice. bioRxiv doi: https://doi.org/10.1101/567297 .LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Robinson 2019 Am J Physiol Cell Physiol2019Robinson MM, Sather BK, Burney ER, Ehrlicher SE, Stierwalt HD, Franco MC, Newsom SA (2019) Robust intrinsic differences in mitochondrial respiration and H2O2 emission between L6 and C2C12 cells. Am J Physiol Cell Physiol 317:C339-C347.LEAK
OXPHOS
ET
F
N
S
Gp
NS
Other combinations
ROX
Permeabilized cellsMouse
Rat
Skeletal muscle
Reda 2019 Sci Rep2019Reda A, Refaat A, Abd-Rabou AA, Mahmoud AM, Adel M, Sabet S, Ali SS (2019) Role of mitochondria in rescuing glycolytically inhibited subpopulation of triple negative but not hormone-responsive breast cancer cells. Sci Rep 9:13748.LEAK
OXPHOS
N
S
CIV
ROX
Permeabilized cellsHumanEndothelial;epithelial;mesothelial cell
Ruegsegger 2019 FASEB J2019Ruegsegger GN, Manjunatha S, Summer P, Gopala S, Zabeilski P, Dasari S, Vanderboom PM, Lanza IR, Klaus KA, Nair KS (2019) Insulin deficiency and intranasal insulin alter brain mitochondrial function: a potential factor for dementia in diabetes. FASEB J 33:4458-72.LEAK
OXPHOS
N
NS
ROX
Isolated mitochondriaMouseNervous system
Cormier 2019 Sci Rep2019Cormier RPJ, Champigny CM, Simard CJ, St-Coeur PD, Pichaud N (2019) Dynamic mitochondrial responses to a high-fat diet in Drosophila melanogaster. Sci Rep 9:4531.LEAK
OXPHOS
ET
N
Gp
NS
ROX
CIV
Permeabilized tissueDrosophilaSkeletal muscle
Long 2019 Methods Mol Biol2019Long Q, Huang L, Huang K, Yang Q (2019) Assessing mitochondrial bioenergetics in isolated mitochondria from mouse heart tissues using Oroboros Oxygraph-2k. Methods Mol Biol 1966:237-46.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Isolated mitochondriaMouseHeart
Gancheva 2019 Nat Commun2019Gancheva S, Ouni M, Jelenik T, Koliaki C, Szendroedi J, Toledo FGS, Markgraf DF, Pesta DH, Mastrototaro L, De Filippo E, Herder C, Jähnert M, Weiss J, Strassburger K, Schlensak M, Schürmann A, Roden M (2019) Dynamic changes of muscle insulin sensitivity after metabolic surgery. Nat Commun 10:4179.LEAK
OXPHOS
ET
Permeabilized tissueHumanSkeletal muscle
Ferreira 2019 EMBO J2019Ferreira N, Perks KL, Rossetti G, Rudler DL, Hughes LA, Ermer JA, Scott LH, Kuznetsova I, Richman TR, Narayana VK, Abudulai LN, Shearwood AJ, Cserne Szappanos H, Tull D, Yeoh GC, Hool LC, Filipovska A, Rackham O (2019) Stress signaling and cellular proliferation reverse the effects of mitochondrial mistranslation. EMBO J 38:e102155.LEAK
OXPHOS
ET
N
S
Isolated mitochondriaMouseHeart
Liver
Fisher-Wellman 2019 Cell Rep2019Fisher-Wellman KH, Draper JA, Davidson MT, Williams AS, Narowski TM, Slentz DH, Ilkayeva OR, Stevens RD, Wagner GR, Najjar R, Hirschey MD, Thompson JW, Olson DP, Kelly DP, Koves TR, Grimsrud PA, Muoio DM (2019) Respiratory phenomics across multiple models of protein hyperacylation in cardiac mitochondria reveals a marginal impact on bioenergetics. Cell Rep 26:1557-72.LEAK
OXPHOS
ET
F
N
S
Gp
Isolated mitochondriaMouseHeart
Skeletal muscle
Manfredini 2019 Clin Sci (Lond)2019Manfredini A, Constantino L, Pinto MC, Michels M, Burger H, Kist LW, Silva MC, Gomes LM, Dominguini D, Steckert A, Simioni C, Bogo M, Streck E, Barichello T, de Quevedo J, Singer M, Ritter C, Dal-Pizzol F (2019) Mitochondrial dysfunction is associated with long-term cognitive impairment in an animal sepsis model. Clin Sci (Lond) 133:1993-2004.LEAK
OXPHOS
N
NS
Permeabilized tissueRatNervous system
Halling 2019 Am J Physiol Endocrinol Metab2019Halling JF, Jessen H, Nøhr-Meldgaard J, Thiellesen Buch B, Masselkhi Christensen N, Gudiksen A, Ringholm S, Neufer PD, Prats C, Pilegaard H (2019) PGC-1α regulates mitochondrial properties beyond biogenesis with aging and exercise training. Am J Physiol Endocrinol Metab 317:E513-E525.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Miranda-Silva 2019 Acta Physiologica2019Miranda-Silva D, Wüst RCI, Conceição G, Gonçalves-Rodrigues P, Gonçalves N, Gonçalves A, Kuster DWD, Leite-Moreira AF, van der Velden J, de Sousa Beleza JM, Magalhães J, Stienen GJM, Falcão-Pires I (2019) Disturbed cardiac mitochondrial and cytosolic calcium handling in a metabolic risk-related rat model of heart failure with preserved ejection fraction. Acta Physiol e13378.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Intact organ
Permeabilized tissue
Isolated mitochondria
RatHeart
Svensson 2019 Am J Physiol Endocrinol Metab2019Svensson K, Tahvilian S, Martins VF, Dent JR, Lemanek A, Barooni N, Greyslak K, McCurdy CE, Schenk S (2019) Combined overexpression of SIRT1 and knockout of GCN5 in adult skeletal muscle does not affect glucose homeostasis or exercise performance in mice. Am J Physiol Endocrinol Metab 318:E145-51.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Zhao 2019 Basic Res Cardiol2019Zhao J, Gao JL, Zhu JX, Zhu HB, Peng X, Jiang M, Fu Y, Xu J, Mao XH, Hu N, Ma MH, Dong DL (2019) The different response of cardiomyocytes and cardiac fibroblasts to mitochondria inhibition and the underlying role of STAT3. Basic Res Cardiol 114:12.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Intact cells
Permeabilized cells
RatHeart
Fibroblast
De-Souza-Ferreira 2019 J Neurochem2019de-Souza-Ferreira E, Rios-Neto IM, Martins EL, Galina A (2019) Mitochondria-coupled glucose phosphorylation develops after birth to modulate H2O2 release and calcium handling in rat brain. J Neurochem 149:624-40.LEAK
OXPHOS
ET
N
Gp
CIV
NS
Isolated mitochondriaRatNervous system
Scavuzzo 2019 J Neurophysiol2019Scavuzzo CJ, Leblancq MJ, Nargang F, Lemieux H, Hamilton TJ, Dickson CT (2019) The amnestic agent anisomycin disrupts intrinsic membrane properties of hippocampal neurons via a loss of cellular energetics. J Neurophysiol 122:1123-35.LEAK
OXPHOS
N
S
CIV
NS
ROX
HomogenateRatNervous system
Mejia 2019 Reprod Biol Endocrinol2019Mejia JF, Hirschi KM, Tsai KYF, Long MG, Tullis BC, Bitter EEK, Bikman BT, Reynolds PR, Arroyo JA (2019) Differential placental ceramide levels during gestational diabetes mellitus (GDM). Reprod Biol Endocrinol 17:81.LEAK
OXPHOS
ET
N
NS
Permeabilized cellsHumanGenital
Zhang 2019 Nephron2019Zhang R, Wang X, Gao Q, Jiang H, Zhang S, Lu M, Liu F, Xue X (2019) Taurine supplementation reverses diabetes-induced podocytes injury via modulation of the CSE/TRPC6 axis and improvement of mitochondrial function. Nephron 144:84-95.LEAK
ROUTINE
OXPHOS
ET
N
S
CIV
NS
ROX
Intact cells
Permeabilized cells
MouseKidney
Rajendran 2019 EMBO Mol Med2019Rajendran J, Purhonen J, Tegelberg S, Smolander OP, Mörgelin M, Rozman J, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Auvinen P, Mervaala E, Jacobs HT, Szibor M, Fellman V, Kallijärvi J (2019) Alternative oxidase-mediated respiration prevents lethal mitochondrial cardiomyopathy. EMBO Mol Med 11:e9456.LEAK
OXPHOS
ET
N
S
CIV
NS
Isolated mitochondriaMouseLiver
Kidney
Heart
Callegari 2019 J Mol Biol2019Callegari S, Müller T, Schulz C, Lenz C, Jans DC, Wissel M, Opazo F, Rizzoli SO, Jakobs S, Urlaub H, Rehling P, Deckers M (2019) A MICOS-TIM22 association promotes carrier import into human mitochondria. J Mol Biol 431:2835-51.LEAK
ET
ROUTINE
Intact cellsHumanHEK
Bouitbir 2019 Toxicology2019Bouitbir J, Alshaikhali A, Panajatovic MV, Abegg VF, Paech F, Krähenbühl S (2019) Mitochondrial oxidative stress plays a critical role in the cardiotoxicity of sunitinib. Toxicology 426:152281.LEAK
OXPHOS
N
S
CIV
NS
ROX
Permeabilized cells
Permeabilized tissue
Rat
Mouse
Heart
Dollerup 2019 J Physiol2019Dollerup OL, Chubanava S, Agerholm M, Søndergård SD, Altıntaş A, Møller AB, Høyer KF, Ringgaard S, Stødkilde-Jørgensen H, Lavery GG, Barres R, Larsen S, Prats C, Jessen N, Treebak JT (2019) Nicotinamide riboside does not alter mitochondrial respiration, content or morphology in skeletal muscle from obese and insulin resistant men. J Physiol 598:731-54.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Skrivergaard 2019 Viruses2019Skrivergaard S, Jensen MS, Rolander TB, Nguyen TBN, Bundgaard A, Nejsum LN, Martensen PM (2019) The cellular localization of the p42 and p46 oligoadenylate synthetase 1 isoforms and their impact on mitochondrial respiration. Viruses 11:E1122.LEAK
ROUTINE
OXPHOS
ET
N
S
ROX
Permeabilized cells
Intact cells
HumanOther cell lines
HeLa
Fiorenza 2019 FASEB J2019Fiorenza M, Lemminger AK, Marker M, Eibye K, Iaia FM, Bangsbo J, Hostrup M (2019) High-intensity exercise training enhances mitochondrial oxidative phosphorylation efficiency in a temperature-dependent manner in human skeletal muscle: implications for exercise performance. FASEB J 33:8976-89.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Kumar 2019 Free Radic Biol Med2019Kumar A, Davuluri G, Welch N, Kim A, Gangadhariah M, Allawy A, Priyadarshini A, McMullen MR, Sandlers Y, Willard B, Hoppel CL, Nagy LE, Dasarathy S (2019) Oxidative stress mediates ethanol-induced skeletal muscle mitochondrial dysfunction and dysregulated protein synthesis and autophagy. Free Radic Biol Med 145:284-99.LEAK
ROUTINE
OXPHOS
ET
F
N
S
DQ
CIV
NS
ROX
Permeabilized cells
Permeabilized tissue
Intact cells
MouseSkeletal muscle
Courtes 2019 Biomed Pharmacother2019Courtes AA, de Carvalho NR, Gonçalves DF, Hartmann DD, da Rosa PC, Dobrachinski F, Franco JL, de Souza DOG, Soares FAA (2019) Guanosine protects against Ca2+-induced mitochondrial dysfunction in rats. Biomed Pharmacother 111:1438-46.OXPHOS
LEAK
N
S
NS
ROX
Isolated mitochondriaRatLiver
Krylova 2019 Mitochondrion2019Krylova TD, Sheremet NL, Tabakov VY, Lyamzaev KG, Itkis YS, Tsygankova PG, Andreeva NA, Shmelkova MS, Nevinitsyna TA, Kadyshev VV, Zakharova EY (2019) Three rare pathogenic mtDNA substitutions in LHON patients with low heteroplasmy. Mitochondrion 50:139-144.LEAK
ROUTINE
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cells
Intact cells
HumanFibroblast
Wessels 2019 Obesity (Silver Spring)2019Wessels B, Honecker J, Schöttl T, Stecher L, Klingenspor M, Hauner H, Skurk T (2019) Adipose mitochondrial respiratory capacity in obesity is impaired independently of glycemic status of tissue donors. Obesity (Silver Spring) 27:756-66.LEAK
OXPHOS
ET
N
NS
ROX
Permeabilized cellsHumanFat
Havird 2019 Mitochondrion2019Havird JC, Noe GR, Link L, Torres A, Logan DC, Sloan DB, Chicco AJ (2019) Do angiosperms with highly divergent mitochondrial genomes have altered mitochondrial function? Mitochondrion 49:1-11.LEAK
OXPHOS
N
S
CIV
NS
ROX
Isolated mitochondriaPlants
Ederle 2019 J Clin Med2019Ederle C, Charles AL, Khayath N, Poirot A, Meyer A, Clere-Jehl R, Andres E, De Blay F, Geny B (2019) Mitochondrial function in peripheral blood mononuclear cells (PBMC) is enhanced, together with increased reactive oxygen species, in severe asthmatic patients in exacerbation. J Clin Med 8:E1613.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cellsHumanBlood cells
Kharechkina 2019 Biochim Biophys Acta Gen Subj2019Kharechkina ES, Nikiforova AB, Teplova VV, Odinokova IV, Krestinina OV, Baburina YL, Kruglova SA, Kruglov AG (2019) Regulation of permeability transition pore opening in mitochondria by external NAD(H). Biochim Biophys Acta Gen Subj 1863:771-83.LEAK
OXPHOS
ET
SIsolated mitochondriaRatLiver
Sundstroem 2019 Acta Neuropathol Commun2019Sundstrøm T, Prestegarden L, Azuaje F, Aasen SN, Røsland GV, Varughese JK, Bahador M, Bernatz S, Braun Y, Harter PN, Skaftnesmo KO, Ingham ES, Mahakian LM, Tam S, Tepper CG, Petersen K, Ferrara KW, Tronstad KJ, Lund-Johansen M, Beschorner R, Bjerkvig R, Thorsen F (2019) Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis. Acta Neuropathol Commun 7:55.ET
LEAK
N
S
NS
ROX
Permeabilized cellsHumanEndothelial;epithelial;mesothelial cell
Dall 2019 J Biol Chem2019Dall M, Trammell SAJ, Asping M, Hassing AS, Agerholm M, Vienberg SG, Gillum MP, Larsen S, Treebak JT (2019) Mitochondrial function in liver cells is resistant to perturbations in NAD+ salvage capacity. J Biol Chem 294:13304-26.LEAK
OXPHOS
ET
F
N
S
Intact cellsMouseLiver
Viana 2019 Sci Rep2019Viana LR, Tobar N, Busanello ENB, Marques AC, de Oliveira AG, Lima TI, Machado G, Castelucci BG, Ramos CD, Brunetto SQ, Silveira LR, Vercesi AE, Consonni SR, Gomes-Marcondes MCC (2019) Leucine-rich diet induces a shift in tumour metabolism from glycolytic towards oxidative phosphorylation, reducing glucose consumption and metastasis in Walker-256 tumour-bearing rats. Sci Rep 9:15529.LEAK
OXPHOS
NPermeabilized tissueRatEndothelial;epithelial;mesothelial cell
Rudler 2019 Sci Adv2019Rudler DL, Hughes LA, Perks KL, Richman TR, Kuznetsova I, Ermer JA, Abudulai LN, Shearwood AJ, Viola HM, Hool LC, Siira SJ, Rackham O, Filipovska A (2019) Fidelity of translation initiation is required for coordinated respiratory complex assembly. Sci Adv 5:eaay2118.LEAK
OXPHOS
ET
N
S
Isolated mitochondriaMouseHeart
Flis 2019 Int J Mol Sci2019Flis DJ, Dzik K, Kaczor JJ, Cieminski K, Halon-Golabek M, Antosiewicz J, Wieckowski MR, Ziolkowski W (2019) Swim training modulates mouse skeletal muscle energy metabolism and ameliorates reduction in grip strength in a mouse model of amyotrophic lateral sclerosis. Int J Mol Sci 20:E233.LEAK
OXPHOS
NIsolated mitochondriaMouseSkeletal muscle
Lewis 2019 Am J Physiol Regul Integr Comp Physiol2019Lewis MT, Kasper JD, Bazil JN, Frisbee JC, Wiseman RW (2019) Skeletal muscle energetics are compromised only during high-intensity contractions in the Goto-Kakizaki rat model of type 2 diabetes. Am J Physiol Regul Integr Comp Physiol 317:R356-68.LEAK
OXPHOS
F
N
Isolated mitochondriaRatSkeletal muscle
Lauridsen 2019 Mitochondrion2019Lauridsen PE, Rasmussen LJ, Desler C (2019) Mitochondrial oxidative phosphorylation capacity of cryopreserved cells. Mitochondrion 47:47-53.LEAK
ROUTINE
ET
ROXIntact cellsHumanOther cell lines
Zhang 2019 Biochem Biophys Res Commun2019Zhang WY, Hu XF, Wan N, Zhang JF, Yang P, Wen Q, Chen WJ, Zhu F, Liang ML, Cheng LX, Shu YW (2019) Protective effect of the glucagon-like peptide-1 analogue liraglutide on carbon tetrachloride-induced acute liver injury in mice. Biochem Biophys Res Commun 514:386-92.LEAK
OXPHOS
ET
N
NS
ROX
Isolated mitochondriaMouseLiver
Wolf 2019 Cells2019Wolf C, Zimmermann R, Thaher O, Bueno D, Wüllner V, Schäfer MKE, Albrecht P, Methner A (2019) The Charcot-Marie tooth disease mutation R94Q in MFN2 decreases ATP production but increases mitochondrial respiration under conditions of mild oxidative stress. Cells 8:E1289.LEAK
ROUTINE
ET
OXPHOS
ROX
N
NS
Intact cells
Permeabilized cells
MouseFibroblast
Rawat 2019 J Mol Biol2019Rawat S, Anusha V, Jha M, Sreedurgalakshmi K, Raychaudhuri S (2019) Aggregation of respiratory complex subunits marks the onset of proteotoxicity in proteasome inhibited cells. J Mol Biol 431:996-1015.OXPHOS
LEAK
N
S
CIV
ROX
Permeabilized cellsMouseNervous system
Other cell lines
Nambu 2019 Eur J Pharmacol2019Nambu H, Takada S, Fukushima A, Matsumoto J, Kakutani N, Maekawa S, Shirakawa R, Nakano I, Furihata T, Katayama T, Yamanashi K, Obata Y, Saito A, Yokota T, Kinugawa S (2019) Empagliflozin restores lowered exercise endurance capacity via the activation of skeletal muscle fatty acid oxidation in a murine model of heart failure. Eur J Pharmacol 866:172810.LEAK
OXPHOS
F
N
NS
Permeabilized tissueMouseSkeletal muscle
Fernando 2019 Exp Gerontol2019Fernando R, Drescher C, Deubel S, Jung T, Ost M, Klaus S, Grune T, Castro JP (2019) Low proteasomal activity in fast skeletal muscle fibers is not associated with increased age-related oxidative damage. Exp Gerontol 117:45-52.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Shirakawa 2019 Sci Rep2019Shirakawa R, Yokota T, Nakajima T, Takada S, Yamane M, Furihata T, Maekawa S, Nambu H, Katayama T, Fukushima A, Saito A, Ishimori N, Dela F, Kinugawa S, Anzai T (2019) Mitochondrial reactive oxygen species generation in blood cells is associated with disease severity and exercise intolerance in heart failure patients. Sci Rep 9:14709.LEAK
OXPHOS
ET
N
S
NS
Permeabilized cellsHumanBlood cells
Esselun 2019 Oxid Med Cell Longev2019Esselun C, Bruns B, Hagl S, Grewal R, Eckert GP (2019) Differential effects of silibinin A on mitochondrial function in neuronal PC12 and HepG2 liver cells. Oxid Med Cell Longev 2019:1652609.LEAK
OXPHOS
ET
N
S
CIV
NS
Permeabilized cellsHuman
Rat
Nervous system
Liver
Gonzalez-Mariscal 2019 FASEB J2019González-Mariscal I, Montoro RA, O'Connell JF, Kim Y, Gonzalez-Freire M, Liu QR, Alfaras I, Carlson OD, Lehrmann E, Zhang Y, Becker KG, Hardivillé S, Ghosh P, Egan JM (2019) Muscle cannabinoid 1 receptor regulates Il-6 and myostatin expression, governing physical performance and whole-body metabolism. FASEB J 33:5850-63.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Monteiro 2019 Thesis2019Monteiro ARB (2019) Effects of resistance training on mitochondrial function and gene expression of UCP-3 in muscles of ovariectomized rats. Dissertation 82.LEAK
OXPHOS
ET
NPermeabilized tissueRatSkeletal muscle
Kopinski 2019 Proc Natl Acad Sci U S A2019Kopinski PK, Janssen KA, Schaefer PM, Trefely S, Perry CE, Potluri P, Tintos-Hernandez JA, Singh LN, Karch KR, Campbell SL, Doan MT, Jiang H, Nissim I, Nakamaru-Ogiso E, Wellen KE, Snyder NW, Garcia BA, Wallace DC (2019) Regulation of nuclear epigenome by mitochondrial DNA heteroplasmy. Proc Natl Acad Sci U S A 116:16028-35.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized cellsHumanOther cell lines
Ejarque 2019 Int J Obes (Lond)2019Ejarque M, Ceperuelo-Mallafré V, Serena C, Maymo-Masip E, Duran X, Díaz-Ramos A, Millan-Scheiding M, Núñez-Álvarez Y, Núñez-Roa C, Gama P, Garcia-Roves PM, Peinado MA, Gimble JM, Zorzano A, Vendrell J, Fernández-Veledo S (2019) Adipose tissue mitochondrial dysfunction in human obesity is linked to a specific DNA methylation signature in adipose-derived stem cells. Int J Obes (Lond) 43:1256-68.LEAK
ROUTINE
ET
Intact cellsHumanFat
Havird 2019 Philos Trans R Soc Lond B Biol Sci2019Havird JC, Shah AA, Chicco AJ (2019) Powerhouses in the cold: mitochondrial function during thermal acclimation in montane mayflies. Philos Trans R Soc Lond B Biol Sci 375:20190181.LEAK
OXPHOS
N
NS
Isolated mitochondriaHexapods
Altinok 2019 J Cell Physiol2019Altinok O, Poggio JL, Stein DE, Bowne WB, Shieh AC, Snyder NW, Orynbayeva Z (2019) Malate-aspartate shuttle promotes l-lactate oxidation in mitochondria. J Cell Physiol 235:2569-81.LEAK
OXPHOS
N
S
Isolated mitochondriaHumanOther cell lines
Bertolini 2019 MBio2019Bertolini MS, Chiurillo MA, Lander N, Vercesi AE, Docampo R (2019) MICU1 and MICU2 play an essential role in mitochondrial Ca2+ uptake, growth, and infectivity of the human pathogen Trypanosoma cruzi. MBio 10:e00348-19.LEAK
OXPHOS
ET
Permeabilized cellsProtists
Ling 2019 Am J Clin Nutr2019Ling Y, Carayol J, Galusca B, Canto C, Montaurier C, Matone A, Vassallo I, Minehira K, Alexandre V, Cominetti O, Núñez Galindo A, Corthésy J, Dayon L, Charpagne A, Métairon S, Raymond F, Descombes P, Casteillo F, Peoc'h M, Palaghiu R, Féasson L, Boirie Y, Estour B, Hager J, Germain N, Gheldof N (2019) Persistent low body weight in humans is associated with higher mitochondrial activity in white adipose tissue. Am J Clin Nutr 110:605-16.LEAK
OXPHOS
ET
N
S
NS
Permeabilized tissueHumanSkeletal muscle
Fat
Tarpey 2019 J Biol Chem2019Tarpey MD, Amorese AJ, Balestrieri NP, Fisher-Wellman KH, Spangenburg EE (2019) Doxorubicin causes lesions in the electron transport system of skeletal muscle mitochondria that are associated with a loss of contractile function. J Biol Chem 294:19709-22.LEAK
ET
F
N
S
CIV
Permeabilized tissue
Isolated mitochondria
MouseSkeletal muscle
McBride 2019 Arch Biochem Biophys2019McBride S, Wei-LaPierre L, McMurray F, MacFarlane M, Qiu X, Patten DA, Dirksen RT, Harper ME (2019) Skeletal muscle mitoflashes, pH, and the role of uncoupling protein-3. Arch Biochem Biophys 663:239-48.LEAK
OXPHOS
F
N
CIV
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Carteri 2019 Toxicol Lett2019Carteri RB, Kopzynski A, Menegassi LN, Rodolphi MS, Strogulski NR, Portela LV (2019) Anabolic-androgen steroids effects on bioenergetics responsiveness of synaptic and extrasynaptic mitochondria. Toxicol Lett 307:72-80.LEAK
OXPHOS
ET
N
NS
ROX
Isolated mitochondriaMouseNervous system
Reyes-Fermin 2019 Antioxidants (Basel)2019Reyes-Fermín LM, Avila-Rojas SH, Aparicio-Trejo OE, Tapia E, Rivero I, Pedraza-Chaverri J (2019) The protective effect of alpha-mangostin against cisplatin-induced cell death in LLC-PK1 cells is associated to mitochondrial function preservation. Antioxidants (Basel) 8:E133.LEAK
ROUTINE
ET
CIV
ROX
Intact cellsPigKidney
Svab 2019 Neurochem Res2019Svab G, Doczi J, Gerencser AA, Ambrus A, Gallyas F, Sümegi B, Tretter L (2019) The mitochondrial targets of neuroprotective drug vinpocetine on primary neuron cultures, brain capillary endothelial cells, synaptosomes, and brain mitochondria. Neurochem Res 44:2435-47.LEAK
OXPHOS
ET
N
S
Isolated mitochondria
Intact cells
Guinea pigNervous system
Zverova 2019 Neuropsychiatr Dis Treat2019Zvěřová M, Hroudová J, Fišar Z, Hansíková H, Kališová L, Kitzlerová E, Lambertová A, Raboch J (2019) Disturbances of mitochondrial parameters to distinguish patients with depressive episode of bipolar disorder and major depressive disorder. Neuropsychiatr Dis Treat 15:233-40.LEAK
ROUTINE
ET
ROXIntact cellsHumanPlatelet
Blood cells
Garcia-Roche 2019 PLoS One2019García-Roche M, Casal A, Mattiauda DA, Ceriani M, Jasinsky A, Mastrogiovanni M, Trostchansky A, Carriquiry M, Cassina A, Quijano C (2019) Impaired hepatic mitochondrial function during early lactation in dairy cows: Association with protein lysine acetylation. PLoS One 14:e0213780.LEAK
OXPHOS
ET
N
S
NS
ROX
Intact cellsBovinesLiver
Paradis 2019 Antioxidants (Basel)2019Paradis S, Charles AL, Georg I, Goupilleau F, Meyer A, Kindo M, Laverny G, Metzger D, Geny B (2019) Aging exacerbates ischemia-reperfusion-induced mitochondrial respiration impairment in skeletal muscle. Antioxidants (Basel) 8:E168.LEAK
OXPHOS
N
S
CIV
Permeabilized tissueMouseSkeletal muscle
Bahhir 2019 PLoS Genet2019Bahhir D, Yalgin C, Ots L, Jaervinen S, George J, Naudi A, Krama T, Krams I, Tamm M, Andjelkovic A, Dufour E, Gonzalez de Cozar JM, Gerards M, Parhiala M, Pamplona R, Jacobs HT, Joers P (2019) Manipulating mtDNA in vivo reprograms metabolism via novel response mechanisms. PLoS Genet 15:e1008410.LEAK
OXPHOS
N
Gp
CIV
ROX
HomogenateDrosophila
Penniman 2019 Mol Metab2019Penniman CM, Suarez Beltran PA, Bhardwaj G, Junck TL, Jena J, Poro K, Hirshman MF, Goodyear LJ, O'Neill BT (2019) Loss of FoxOs in muscle reveals sex-based differences in insulin sensitivity but mitigates diet-induced obesity. Mol Metab 30:203-220.LEAK
OXPHOS
ET
F
N
S
NS
Permeabilized tissue
Isolated mitochondria
MouseSkeletal muscle
Kladnicka 2019 Physiol Res2019Kladnická I, Čedíková M, Kripnerová M, Dvořáková J, Kohoutová M, Tůma Z, Müllerová D, Kuncová J (2019) Mitochondrial respiration of adipocytes differentiating from human mesenchymal stem cells derived from adipose tissue. Physiol Res 68:287-96.LEAK
ROUTINE
ET
ROXIntact cellsHumanFat
Stem cells
Kakimoto 2019 PLoS One2019Kakimoto PA, Chausse B, Caldeira da Silva CC, Donato Júnior J, Kowaltowski AJ (2019) Resilient hepatic mitochondrial function and lack of iNOS dependence in diet-induced insulin resistance. PLoS One 14:e0211733.LEAK
OXPHOS
F
NS
Isolated mitochondriaMouseLiver
Holsgrove 2019 Thesis2019Holsgrove A (2019) The effect of temperature on cardiac energetics in the rainbow trout, Onchorhynchus mykiss. Phd Thesis 166.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
HomogenateFishesHeart
Dlaskova 2019 Biochim Biophys Acta Bioenerg2019Dlasková A, Špaček T, Engstová H, Špačková J, Schröfel A, Holendová B, Smolková K, Plecitá-Hlavatá L, Ježek P (2019) Mitochondrial cristae narrowing upon higher 2-oxoglutarate load. Biochim Biophys Acta Bioenerg 1860:659-78.LEAK
ET
N
ROX
Intact cellsHumanLiver
Martines 2019 Sci Rep2019Martines AMF, Gerding A, Stolle S, Vieira-Lara MA, Wolters JC, Jurdzinski A, Bongiovanni L, de Bruin A, van der Vlies P, van der Vries G, Bloks VW, Derks TGJ, Reijngoud DJ, Bakker BM (2019) Transcriptome analysis suggests a compensatory role of the cofactors coenzyme A and NAD+ in medium-chain acyl-CoA dehydrogenase knockout mice. Sci Rep 9:14539.LEAK
OXPHOS
F
N
Isolated mitochondriaMouseLiver
Gratl 2019 Eur J Vasc Endovasc Surg2019Gratl A, Frese J, Speichinger F, Pesta D, Frech A, Omran S, Greiner A (2019) Regeneration of mitochondrial function in gastrocnemius muscle in peripheral arterial disease after successful revascularisation. Eur J Vasc Endovasc Surg 59:109-15.LEAK
OXPHOS
ET
F
N
NS
Permeabilized tissueHumanSkeletal muscle
Scheiber 2019 Exp Mol Med2019Scheiber D, Jelenik T, Zweck E, Horn P, Schultheiss HP, Lassner D, Boeken U, Saeed D, Kelm M, Roden M, Westenfeld R, Szendroedi J (2019) High-resolution respirometry in human endomyocardial biopsies shows reduced ventricular oxidative capacity related to heart failure. Exp Mol Med 51:16.LEAK
OXPHOS
ET
F
N
NS
Permeabilized tissue
Isolated mitochondria
HumanHeart
Pedrotti 2019 Sci Adv2019Pedrotti S, Caccia R, Neguembor MV, Garcia-Manteiga JM, Ferri G, de Palma C, Canu T, Giovarelli M, Marra P, Fiocchi A, Molineris I, Raso M, Sanvito F, Doglioni C, Esposito A, Clementi E, Gabellini D (2019) The Suv420h histone methyltransferases regulate PPAR-γ and energy expenditure in response to environmental stimuli. Sci Adv 5:eaav1472.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Intact cellsMouseFat
Germain 2019 Int J Med Sci2019Germain N, Dessein AF, Vienne JC, Dobbelaere D, Mention K, Joncquel M, Dekiouk S, Laine W, Kluza J, Marchetti P (2019) First-line screening of OXPHOS deficiencies using microscale oxygraphy in human skin fibroblasts: A preliminary study. Int J Med Sci 16:931-38.LEAK
ET
ROX
N
Intact cellsHumanFibroblast
Kirby 2019 Comp Biochem Physiol C Toxicol Pharmacol2019Kirby AR, Cox GK, Nelson D, Heuer RM, Stieglitz JD, Benetti DD, Grosell M, Crossley DA 2nd (2019) Acute crude oil exposure alters mitochondrial function and ADP affinity in cardiac muscle fibers of young adult Mahi-mahi (Coryphaena hippurus). Comp Biochem Physiol C Toxicol Pharmacol 218:88-95.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized tissueFishesHeart
Datzmann 2019 J Neurosurg2019Datzmann T, Kapapa T, Scheuerle A, McCook O, Merz T, Unmuth S, Hoffmann A, Mathieu R, Mayer S, Mauer UM, Roehrer S, Yilmazer-Hanke D, Moeller P, Nussbaum BL, Calzia E, Groeger M, Hartmann C, Radermacher P, Wepler M (2019) In-depth characterization of a long-term, resuscitated model of acute subdural hematoma-induced brain injury. J Neurosurg [Epub ahead of print].LEAK
OXPHOS
ET
N
NS
HomogenatePigNervous system
Trefts 2019 Am J Physiol Endocrinol Metab2019Trefts E, Hughey CC, Lantier L, Lark DS, Boyd KL, Pozzi A, Zent R, Wasserman DH (2019) Energy metabolism couples hepatocyte integrin-linked kinase to liver glucoregulation and the postabsorptive response of mice in an age-dependent manner. Am J Physiol Endocrinol Metab 316:1118-35.LEAK
ROUTINE
ET
Intact cellsMouseLiver
Rocco-Machado 2019 Free Radic Biol Med2019Rocco-Machado N, Cosentino-Gomes D, Nascimento MT, Paes-Vieira L, Khan YA, Mittra B, Andrews NW, Meyer-Fernandes JR (2019) Leishmania amazonensis ferric iron reductase (LFR1) is a bifunctional enzyme: Unveiling a NADPH oxidase activity. Free Radic Biol Med 143:341-53.LEAK
ROUTINE
ET
ROXIntact organism
Intact cells
Eubacteria
Garnham 2019 J Cachexia Sarcopenia Muscle2019Garnham JO, Roberts LD, Caspi T, Al-Owais MM, Bullock M, Swoboda PP, Koshy A, Gierula J, Paton MF, Cubbon RM, Kearney MT, Bowen TS, Witte KK (2019) Divergent skeletal muscle mitochondrial phenotype between male and female patients with chronic heart failure. J Cachexia Sarcopenia Muscle 11:79-88.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Maekawa 2019 Cell Commun Signal2019Maekawa S, Takada S, Nambu H, Furihata T, Kakutani N, Setoyama D, Ueyanagi Y, Kang D, Sabe H, Kinugawa S (2019) Linoleic acid improves assembly of the CII subunit and CIII2/CIV complex of the mitochondrial oxidative phosphorylation system in heart failure. Cell Commun Signal 17:128.LEAK
OXPHOS
N
NS
Isolated mitochondriaMouseHeart
Johnson 2019 Mol Metab2019Johnson JM, Verkerke ARP, Maschek JA, Ferrara PJ, Lin CT, Kew KA, Neufer PD, Lodhi IJ, Cox JE, Funai K (2019) Alternative splicing of UCP1 by non-cell-autonomous action of PEMT. Mol Metab 31:55-66.LEAK
OXPHOS
NIsolated mitochondriaMouseFat
Chroeis 2019 Eur J Sport Sci2019Chrøis KM, Dohlmann TL, Søgaard D, Hansen CV, Dela F, Helge JW, Larsen S (2019) Mitochondrial adaptations to high intensity interval training in older females and males. Eur J Sport Sci 20:135-45.LEAK
OXPHOS
ET
N
NS
Permeabilized tissueHumanSkeletal muscle
De Moura Escobar 2019 Toxicol In Vitro2019de Moura Escobar SJ, Simone M, de Oliveira Ribeiro CA, Martinez GR, Winnischofer SMB, Witting PK, Rocha MEM (2019) Cytotoxic effects of 4'-hydroxychalcone on human neuroblastoma cells (SH-SY5Y). Toxicol In Vitro 61:104640.LEAK
OXPHOS
N
S
ROX
Permeabilized cellsHumanNeuroblastoma
Deutschman 2019 J Cell Sci2019Deutschman E, Ward JR, Kumar A, Ray G, Welch N, Lemieux ME, Dasarathy S, Longworth MS (2019) Condensin II protein dysfunction impacts mitochondrial respiration and mitochondrial oxidative stress responses. J Cell Sci 132:jcs233783.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cellsHumanEndothelial;epithelial;mesothelial cell
Djeungoue-Petga 2019 Cell Death Dis2019Djeungoue-Petga MA, Lurette O, Jean S, Hamel-Côté G, Martín-Jiménez R, Bou M, Cannich A, Roy P, Hebert-Chatelain E (2019) Intramitochondrial Src kinase links mitochondrial dysfunctions and aggressiveness of breast cancer cells. Cell Death Dis 10:940.LEAK
ROUTINE
ET
Intact cellsHumanEndothelial;epithelial;mesothelial cell
Woodman 2019 Cardiovasc Res2019Woodman AG, Mah R, Keddie DL, Noble RMN, Holody CD, Panahi S, Gragasin FS, Lemieux H, Bourque SL (2019) Perinatal iron deficiency and a high salt diet cause long-term kidney mitochondrial dysfunction and oxidative stress. Cardiovasc Res 116:183-92.LEAK
OXPHOS
ET
N
S
CIV
NS
HomogenateRatKidney
Ahmed 2019 Mol Nutr Food Res2019Ahmed N, Tcheng M, Roma A, Buraczynski M, Jayanth P, Rea K, Akhtar TA, Spagnuolo PA (2019) Avocatin B protects against lipotoxicity and improves insulin sensitivity in diet-induced obesity. Mol Nutr Food Res 63:e1900688.LEAK
ROUTINE
ET
N
ROX
Intact cellsMouse
Rat
Skeletal muscle
Islet cell;pancreas;thymus
Chao 2019 J Appl Physiol (1985)2019Chao T, Burmeister DM, Corona BT, Greising SM (2019) Oxidative pathophysiology following volumetric muscle loss injury in a porcine model. J Appl Physiol (1985) 126:1541-49.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissuePigSkeletal muscle
Powers 2019 Neurourol Urodyn2019Powers SA, Ryan TE, Pak ES, Fraser MO, McClung JM, Hannan JL (2019) Chronic high-fat diet decreased detrusor mitochondrial respiration and increased nerve-mediated contractions. Neurourol Urodyn 38:1524-32.LEAK
OXPHOS
N
S
CIV
NS
HomogenateMouseOther cell lines
Gvozdjakova 2019 Bratisl Lek Listy2019Gvozdjakova A, Sumbalova Z, Kucharska J, Chladekova A, Rausova Z, Vancova O, Komlosi M, Ulicna O, Mojto V (2019) Platelet mitochondrial bioenergetic analysis in patients with nephropathies and non-communicable diseases: a new method. Bratisl Lek Listy 120:630-35.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
HumanPlatelet
Blood cells
Spinazzi 2019 Proc Natl Acad Sci U S A2019Spinazzi M, Radaelli E, Horré K, Arranz AM, Gounko NV, Agostinis P, Maia TM, Impens F, Morais VA, Lopez-Lluch G, Serneels L, Navas P, De Strooper B (2019) PARL deficiency in mouse causes Complex III defects, coenzyme Q depletion, and Leigh-like syndrome. Proc Natl Acad Sci U S A 116:277-86.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Intact cells
Permeabilized cells
Isolated mitochondria
MouseNervous system
Itkis 2019 Mitochondrion2019Itkis Y, Krylova T, Pechatnikova NL, De Grassi A, Tabakov VY, Pierri CL, Aleshin V, Boyko A, Bunik VI, Zakharova EY (2019) A novel variant m.641A>T in the mitochondrial MT-TF gene is associated with epileptic encephalopathy in adolescent. Mitochondrion 47:10-17.LEAK
ROUTINE
OXPHOS
ET
N
CIV
NS
ROX
Intact cells
Permeabilized cells
HumanFibroblast
Cedrone 2019 Thesis2019Cedrone M (2019) Low birth weight and post-natal diet induced alterations in skeletal muscle oxygen consumption and fiber type composition. Master's Thesis 83.LEAK
OXPHOS
N
S
Permeabilized tissue
Intact cells
Guinea pig
Mouse
Skeletal muscle
Hirschi 2019 Biol Reprod2019Hirschi KM, Tsai KYF, Davis T, Clark JC, Knowlton MN, Bikman BT, Reynolds PR, Arroyo JA (2019) Growth arrest specific protein (Gas)-6/AXL signaling induces preeclampsia (PE) in rats. Biol Reprod 102:199-210.LEAK
OXPHOS
ET
N
S
NS
Permeabilized cells
Permeabilized tissue
RatGenital
Sabogal-Guaqueta 2019 Biomed Pharmacother2019Sabogal-Guáqueta AM, Hobbie F, Keerthi A, Oun A, Kortholt A, Boddeke E, Dolga A (2019) Linalool attenuates oxidative stress and mitochondrial dysfunction mediated by glutamate and NMDA toxicity. Biomed Pharmacother 118:109295.LEAK
OXPHOS
ET
NIsolated mitochondriaMouseNervous system
Naszai 2019 Sci Rep2019Nászai A, Terhes E, Kaszaki J, Boros M, Juhász L (2019) Ca(2+)N it be measured? Detection of extramitochondrial calcium movement with high-resolution FluoRespirometry. Sci Rep 9:19229.LEAK
OXPHOS
N
S
NS
ROX
Isolated mitochondriaRatLiver
Jaskiewicz 2019 J Clin Med2019Jaśkiewicz A, Pająk B, Łabieniec-Watała M, De Palma C, Orzechowski A (2019) Diverse action of selected statins on skeletal muscle cells - An attempt to explain the protective effect of geranylgeraniol (GGOH) in statin-associated myopathy (SAM). J Clin Med 8:694.ROUTINE
OXPHOS
ET
LEAK
N
S
NS
ROX
Permeabilized cells
Intact cells
MouseSkeletal muscle
Other cell lines
Dannheisig 2019 Cells2019Dannheisig DP, Beck E, Calzia E, Walther P, Behrends C, Pfister AS (2019) Loss of Peter Pan (PPAN) affects mitochondrial homeostasis and autophagic flux. Cells 8:E894.LEAK
ROUTINE
ET
N
S
CIV
NS
ROX
Intact cells
Permeabilized cells
HumanHeLa
Moscheni 2019 Cancers (Basel)2019Moscheni C, Malucelli E, Castiglioni S, Procopio A, De Palma C, Sorrentino A, Sartori P, Locatelli L, Pereiro E, Maier JA, Iotti S (2019) 3D quantitative and ultrastructural analysis of mitochondria in a model of doxorubicin sensitive and resistant human colon carcinoma cells. Cancers (Basel) 11:E1254.LEAK
ROUTINE
ET
ROXIntact cellsHumanEndothelial;epithelial;mesothelial cell
Hamraz 2019 FASEB J2019Hamraz M, Abolhassani R, Andriamihaja M, Ransy C, Lenoir V, Schwartz L, Bouillaud F (2019) Hypertonic external medium represses cellular respiration and promotes Warburg/Crabtree effect. FASEB J 34:222-36.LEAK
ET
OXPHOS
ROX
N
CIV
Isolated mitochondria
Intact cells
Other mammals
Human
Rat
Endothelial;epithelial;mesothelial cell
Liver
HEK
Neuroblastoma
Paumelle 2019 J Hepatol2019Paumelle R, Haas J, Hennuyer N, Bauge E, Deleye Y, Mesotten D, Langouche L, Vanhoutte J, Cudejko C, Wouters K, Hannou SA, Legry V, Lancel S, Lalloyer F, Polizzi A, Smati S, Gourdy P, Vallez E, Bouchaert E, Derudas B, Dehondt H, Gheeraert C, Fleury S, Tailleux A, Montagner A, Wahli W, Van Den Berghe G, Guillou H, Dombrowicz D, Staels B (2019) Hepatic PPARα is critical in the metabolic adaptation to sepsis. J Hepatol 70:963-73.OXPHOS
LEAK
F
N
HomogenateHumanLiver
Gaiser 2019 Adv Ther (Weinh)2019Gaiser A, Hafner S, Schmiech M, Büchele B, Schäfer P, Arnim CA, Calzia, E, Feuring‐Buske M, Buske C, Vick B, Jeremias I, Syrovets T, Simmet T (2019) Gold nanoparticles with selective antileukemic activity in vitro and in vivo target mitochondrial respiration. Adv Ther (Weinh) doi:10.1002/adtp.201800149.LEAK
ROUTINE
ET
ROXIntact cellsHumanBlood cells
Chroeis 2019 Basic Clin Pharmacol Toxicol2019Chroeis KM, Larsen S, Pedersen JS, Rygg MO, Boilsen AEB, Bendtsen F, Dela F (2019) Acetaminophen toxicity induces mitochondrial complex I inhibition in human liver tissue. Basic Clin Pharmacol Toxicol [Epub ahead of print].LEAK
OXPHOS
N
S
ROX
Intact cellsHumanLiver
Johansen 2019 Comp Biochem Physiol C Toxicol Pharmacol2019Johansen JL, Esbaugh AJ (2019) Oil-induced responses of cardiac and red muscle mitochondria in red drum (Sciaenops ocellatus). Comp Biochem Physiol C Toxicol Pharmacol 219:35-41.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueFishesHeart
Skeletal muscle
Petrick 2019 J Physiol2019Petrick HL, Pignanelli C, Barbeau PA, Churchward-Venne TA, Dennis KMJH, van Loon LJC, Burr JF, Goossens GH, Holloway GP (2019) Blood flow restricted resistance exercise and reductions in oxygen tension attenuate mitochondrial H2O2 emission rates in human skeletal muscle. J Physiol 597:3985-97.LEAK
OXPHOS
N
NS
Permeabilized tissueHumanSkeletal muscle
Hunter 2019 J Appl Physiol (1985)2019Hunter GR, Moellering DR, Windham ST, Mathis SL, Bamman MM, Fisher G (2019) Relationship between VO2max, cycle economy & mitochondrial respiration in untrained/trained. J Appl Physiol (1985) 127:1562-68.LEAK
OXPHOS
F
N
NS
Permeabilized tissueHumanSkeletal muscle
Mitroshina 2019 Oxid Med Cell Longev2019Mitroshina EV, Mishchenko TA, Shirokova OM, Astrakhanova TA, Loginova MM, Epifanova EA, Babaev AA, Tarabykin VS, Vedunova MV (2019) Intracellular neuroprotective mechanisms in neuron-glial networks mediated by glial cell line-derived neurotrophic factor. Oxid Med Cell Longev 2019:1036907.LEAK
OXPHOS
N
NS
Isolated mitochondriaMouseNervous system
Alvarez 2019 Chem Biol Interact2019Álvarez Santos MR, Duarte YB, Güiza FM, Romero Bohórquez AR, Mendez-Sanchez SC (2019) Effects of new tetrahydroquinoline-isoxazole hybrides on bioenergetics of hepatocarcinoma Hep-G2 cells and rat liver mitochondria. Chem Biol Interact 302:164-71.LEAK
ROUTINE
ET
ROXIntact cellsHumanLiver
... further results



Publications in the MiPMap


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» Abstracts: LEAK
Sort in ascending/descending order by a click on one of the small symbols in squares below.
 YearReferenceCouplingPathwayPreparationOrganismTissue;cell
Doerrier 2020 PaduaMuscleDays Poster2020Doerrier C, Gama-Perez P, Chabi B, Ost M, Distefano G, Pesta D, Dahdah N, Lemieux H, Holody C, Carpenter RG, Tepp K, Puurand M, Kaambre T, Dubouchaud H, Cortade F, Calabria E, Casado M, Fernandez-Ortiz M, Acuna-Castroviejo D, Villena JA, Grefte S, Keijer J, O'Brien K, Sowton A, Murray AJ, Campbell MD, Marcinek DJ, Nollet E, Wuest R, Dayanidhi S, Soendergaard SD, Chroeis KM, Gonzalez-Franquesa A, Goodpaster BH, Coen PM, Larsen S, Gnaiger E, Garcia-Roves PM (2020) Commitment to reproducibility in mitochondrial respiration studies with permeabilized muscle fibers. PaduaMuscleDays.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueHuman
Mouse
Skeletal muscle
Betiu 2019 MiP20192019
MiPsociety
Cell-permeable succinate improves amiodarone-induced mitochondrial Complex I and II inhibition in human platelets.
LEAK
ET
ROXPermeabilized cells
Intact cells
HumanPlatelet
Timohhina 2019 MiP20192019
Natalja Timohhina
Metabolic effects of mitochondria-targeted antioxidant peptides in colorectal cancer cells.
LEAK
OXPHOS
ET
ROXHumanEndothelial;epithelial;mesothelial cell
Garcia 2019 MiPschool Coimbra2019
Geovana Garcia
Functional interactions between the Drosophila melanogaster mitochondrial glycerol-3-phosphate dehydrogenase and a xenotopically expressed alternative oxidase.
LEAK
OXPHOS
N
Gp
Drosophila
Sumbalova 2019a MiP20192019
Zuzana Sumbalova
Platelet mitochondrial function, coenzyme Q10, and oxidative stress in patients with chronic kidney diseases.
LEAK
OXPHOS
F
N
S
Gp
CIV
NS
ROX
Intact cellsHumanPlatelet
Kandel 2019 Biophys J2019Kandel SM, Tomar N, Zheleznova N, Audi SH, Cowley Jr AW, Dash RK (2019) Calcium stimulation of mitochondrial respiration is substrate dependent and tissue specific. Biophys J.LEAK
OXPHOS
F
N
S
Isolated mitochondriaRatHeart
Kidney
Chabi 2019 MiP20192019
Béatrice Chabi
Generating reference values on mitochondrial respiration in permeabilized muscle fibers.
LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Aid-Vanakova 2019 MiP20192019
MiPsociety
Adaptation of muscle OXPHOS in developing glucose intolerance - Wfs1 mice model.
LEAK
OXPHOS
N
S
MouseSkeletal muscle
Heart
Beleza 2019 MiPschool Coimbra2019
Jorge Beleza
Gestational exercise counteracts the deleterious consequences imposed by diabetes mellitus developed during pregnancy on 16 weeks old male offspring liver mitochondrial function.
LEAK
OXPHOS
N
S
RatLiver
Sumbalova 2019b MiP20192019
Zuzana Sumbalova
The decline of mitochondrial respiration in isolated platelets after short-term storage.
LEAK
OXPHOS
F
N
S
Gp
CIV
NS
ROX
Intact cellsHumanPlatelet
Doerrier 2019 MiP20192019
Carolina Doerrier
Inter-laboratory harmonization of respiratory protocols in permeabilized human muscle fibers.
LEAK
ET
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Lelcu 2019 MiP20192019
Theia Lelcu
Assessment of platelet respiration in blood malignancies: a pilot study in children and adults.
LEAK
OXPHOS
ET
N
NS
ROX
Permeabilized cellsHumanPlatelet
Evinova 2019 MiPschool Coimbra2019
MiPsociety
High resolution respirometry of neuroblastoma SK-N-SH and SH-SY 5Y cell lines.
LEAK
ROUTINE
ET
NIntact cellsHumanNeuroblastoma
Hatokova 2019 MiPschool Coimbra2019
MiPsociety
Influence the passage number on a respiration of SH-SY 5Y cells.
LEAK
ROUTINE
ET
Intact cellsHumanNeuroblastoma
Lemieux 2019a MiP20192019
Hélène Lemieux
Partial prevention of oxidative stress damage to mitochondria with photobiomodulation.
LEAK
OXPHOS
ET
N
S
CIV
NS
Other invertebrates
Dominguez-Amorocho 2019 MiP20192019
MiPsociety
Role of Sirtuin 1/3 in CD4+ T cells activation and differentiation in obese and transplanted animals.
LEAK
ET
OXPHOS
ROXMouseLymphocyte
Goncalves Debora 2019 MiPschool Coimbra2019
MiPsociety
Aging effects on mitochondrial control factors in Pink1 knockout Drosophila melanogaster.
LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateDrosophila
Van der Ende 2019 MiPschool Coimbra2019
Miranda van der Ende
Mitochondrial respiration in muscle tissue of colon cancer patients.
LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Cardoso 2019 MiP20192019
Luiza Cardoso
Effects of glucose concentration in cell culture media on hepatocellular carcinoma HuH7 cells evaluated by high-resolution respirometry.
LEAK
ROUTINE
ET
ROXIntact cellsHumanLiver
Kramer 2019 Abstract IOC1412019Kramer P, Distefano G, Monte J, Mills A, Edmunds L, Jurczak M, Cummings SR, Kritchevsky S, Newman AB, Hepple RT, Goodpaster B, Coen PM, Molina A (2019) The Study of Muscle, Mobility, and Aging (SOMMA): A multi-institutional respirometry study. Mitochondr Physiol Network 24.02.LEAK
OXPHOS
ET
N
CIV
NS
ROX
HumanSkeletal muscle
Garcia-Roves 2019 MiPschool Coimbra2019
Pablo Garcia-Roves
Generating reference values on mitochondrial respiration in permeabilized muscle fibers.
LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Minuzzi 2019 MiPschool Coimbra2019
MiPsociety
A pilot study on mitochondrial function of mouse skin using high-resolution respirometry.
LEAK
OXPHOS
ET
F
N
S
Permeabilized tissueMouseEndothelial;epithelial;mesothelial cell
Li 2018 IBEC2018Li C, Li N, Zhang Y (2018) UPRmt and mitophagy are selectively activated depending on muscle fiber types in insulin resistant rats. IBEC.LEAK
OXPHOS
RatSkeletal muscle
Chang 2018 Life Sciences Meeting 2018 Innsbruck AT2018pH dependence of mitochondrial respiration and H2O2 production in oral cancer cells – a pilot study.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
Other combinations
ROX
Permeabilized cellsHumanHEK
Kidney
Evinova 2018 MiP20182018
MiPsociety
High-resolution respirometry of neuroblastoma SH-SY 5Y cell line.
LEAK
ROUTINE
ET
Intact cellsHumanOther cell lines
Neuroblastoma
Harper 2018 MiPschool Tromso D12018
Mary-Ellen Harper
OXPHOS efficiency in skeletal and cardiac muscles: Proton leaks, ROS and glutathione redox.
LEAKHeart
Skeletal muscle
Meszaros 2018 EBEC20182018Tissue- and substrate-specific patterns in the oxygen kinetics of mitochondrial respiration.LEAK
OXPHOS
ET
NIsolated mitochondriaMouseHeart
Nervous system
Liver
Doerrier 2018 MiP2018a2018
Carolina Anneliese Doerrier
Inter-laboratory harmonization of protocols for mitochondrial function evaluation in permeabilized muscle fibers.
LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Doerrier 2018 ESCI20182018
Carolina Anneliese Doerrier
High-resolution respirometry, two techniques combined in one to explore mitochondrial function in health and disease
LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
ROX
CIV
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
Human
Mouse
Heart
Skeletal muscle
Nervous system
Blood cells
HEK
Kuka 2018 MiP20182018
MiPsociety
The discovery of methyl-GBB - acylcarnitine lowering as an effective strategy to treat cardiometabolic diseases.
LEAK
OXPHOS
RatHeart
Bastos Sant'Anna Silva 2018 MiPschool Tromso C42018
Ana Bastos Sant'Anna
Role of succinate in prostate cancer cells: uptake and mitochondrial respiratory function.
LEAK
ROUTINE
OXPHOS
ET
S
ROX
Intact cellsHumanGenital
Avram 2018 MiP20182018
MiPsociety
Cell-permeable succinate bypasses statin-induced mitochondrial complex I inhibition in human platelets. Avram_Presentation
LEAK
ET
SPermeabilized cells
Intact cells
HumanPlatelet
Ravasz 2018 Abstract The evolving concept of mitochondria2018Vast pools of endogenous quinones sustain NADH oxidation by Complex I during anoxia, supporting substrate-level phosphorylation in mouse liver mitochondria.LEAK
OXPHOS
NIsolated mitochondriaMouseLiver
Doerrier 2018 MiP2018c2018
Carolina Doerrier
Inter-laboratory study on human permeabilized myofibers: effects of fiber preparation, respiration buffer, and blebbistatin on mitochondrial respiratory capacity and oxygen limitation.
LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Meszaros 2018 Mt Med Hinxton2018High-resolution mitochondrial oxygen kinetics as diagnostic tool in Complex IV impairments.LEAK
OXPHOS
ET
N
CIV
NS
Isolated mitochondriaMouseHeart
Nervous system
Liver
Pchelin 2018 IOC1302018Activation of heterodimeric receptor to erythropoietin with its agonist CdEPO regulates brain mitochondrial bioenergetics after local acute ischemia/reperfusion in C57BL/6 mice.LEAKNIsolated mitochondriaMouseNervous system
Bastos Sant'Anna Silva 2018 TRANSMIT Bertinoro di Romagna IT2018Cellular succinate transport and mitochondrial respiratory function in prostate cancer.ROUTINE
LEAK
OXPHOS
ET
S
ROX
Permeabilized cells
Intact cells
HumanHEK
Genital
Garipi 2018 MiPschool Tromso E22018Phenotyping mitochondrial metabolism in Barrett’s metaplasia-dysplasia-adenocarcinoma sequence: respiratory capacity, extracelular proton flux and ROS productionLEAK
ROUTINE
OXPHOS
ET
CIV
NS
ROX
Permeabilized cells
Permeabilized tissue
HumanEndothelial;epithelial;mesothelial cell
Other cell lines
McMaster 2018 Am J Obstet Gynecol2018Preeclampsia is associated with placental mitochondrial dysfunction.LEAK
ROUTINE
OXPHOS
ET
NIsolated mitochondriaHuman
Gnaiger 2018 EBEC20182018The protonmotive force under pressure: an isomorphic analysis.LEAK
Komlodi 2018 AussieMit2018Komlodi T, Hunger M, Moore AL, Gnaiger E (2018) Electron transfer at the Q-junction: new perspectives from combined measurement of mitochondrial O2 flux, H2O2 flux, and coenzyme Q redox state. AussieMit 2018 Melbourne AU.LEAK
OXPHOS
S
Gp
Isolated mitochondriaMouseNervous system
Porter 2018 MiP2018b2018
MiPsociety
Skeletal muscle mitochondrial thermogenesis in hypermetabolic humans.
LEAK
OXPHOS
Komlodi 2018 EBEC20182018Electron supply to the Q-junction: assessment of mitochondrial respiration, H2O2 flux and the redox state of the Q-pool.LEAK
OXPHOS
S
Gp
Isolated mitochondriaMouseNervous system
Sobotka 2018 MiP20182018
Ondrej Sobotka
Measurement of ROS production under hypoxia and unexpected methodological pitfalls of Amplex UltraRed assay.
LEAK
OXPHOS
Isolated mitochondriaMouse
Saccharomyces cerevisiae
Heart
Nervous system
Krajcova 2018 MiPschool Tromso E22018
Adela Krajcova
High-resolution respirometry to assess function of mitochondria in native homogenates of human heart muscle.
LEAK
OXPHOS
ET
N
NS
ROX
HomogenateHumanHeart
Schoepf 2018 33rd Annual EAU Congress Copenhagen2018Shift of mitochondrial oxidative phosphorylation is associated with mtDNA mutational load in primary prostate cancer tissue.LEAK
OXPHOS
ET
F
N
NS
Other combinations
ROX
Permeabilized cells
Permeabilized tissue
HumanGenital
Acuna-Castroviejo 2018 MiP20182018
Dario Acuna-Castroviejo
Mitochondria, melatonin, and neuroinflammation in Parkinson's disease. Acuna-Castroviejo_Presentation
LEAK
OXPHOS
NMouseNervous system
Gnaiger 2018 AussieMit2018Komlodi Timea, Sobotka Ondrej, Doerrier Carolina, Gnaiger Erich (2018) Mitochondrial H2O2 production is low under tissue normoxia but high at in-vitro air-level oxygen pressure - comparison of LEAK and OXPHOS states. AussieMit 2018 Melbourne AU.LEAK
ROUTINE
OXPHOS
NSIsolated mitochondria
Intact cells
Mouse
Saccharomyces cerevisiae
Heart
Nervous system
Doerrier 2018 EBEC20182018
Carolina Anneliese Doerrier
Respiratory mapping of mitochondrial pathways for establishing a database of mitochondrial physiology.
LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
Other combinations
ROX
Permeabilized cells
Homogenate
Isolated mitochondria
Human
Mouse
Heart
Nervous system
Blood cells
HEK
Platelet
Bovard 2018 IOC1342018Integrative determinants of oxygen uptake and biomolecular markers of exercise training.LEAKHumanSkeletal muscle
Kovalev 2018 EMBS2018Kovalev A, Sokolova I, Sukhotin A (2018) Allometry of mitochondrial respiration in mussels. EMBS.LEAK
OXPHOS
ET
CIVIsolated mitochondriaMolluscsLiver
Islet cell;pancreas;thymus
Garcia-Souza 2018 Life Sciences Meeting 2018 Innsbruck AT2018A respirometric cell viability test for peripheral-blood mononuclear cells and platelets.LEAK
ROUTINE
ET
SIntact cellsHumanBlood cells
Platelet
Nemec 2018 MiP20182018
Michal Nemec
Aerobic/strength exercise intervention modulates skeletal muscle mitochondrial function in seniors.
LEAKF
N
NS
Other combinations
Permeabilized tissueHumanSkeletal muscle
Gnaiger 2018 MiPschool Tromso A12018
Erich Gnaiger
Mitochondrial states and rates: 1. Electron transfer pathways and respiratory control. 2. Coupling control.
LEAK
ET
OXPHOS
F
N
S
Gp
DQ
CIV
NS
Other combinations
Han 2018 MiP20182018
MiPsociety
Mitochondrial functional changes elicited by a single near-infrared (670nm) exposure. Han_Presentation
LEAK
ROUTINE
ET
HumanKidney
HEK
Krajcova 2018 ICO1342018Skeletal muscle bioenergetics in critically ill patients: effect of early rehabilitation on mitochondrial functions and insulin resistance during and 6 months after critical illness.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateHumanSkeletal muscle
Michalak 2017 Abstract MITOEAGLE Barcelona2017
COST Action MITOEAGLE
Mitochonrial respiration in intact peripheral blood mononuclear cells in patients with extrapyramidal syndromes.
LEAK
ROUTINE
OXPHOS
ET
ROXIntact cellsHumanBlood cells
Doerrier 2017 Abstract MitoEAGLE Barcelona2017
COST Action MitoEAGLE
SUIT reference protocol for comparative mitochondrial physiology.
LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
Permeabilized cells
Homogenate
Isolated mitochondria
Human
Mouse
Heart
Nervous system
HEK
Giampieri 2017 MiPschool Obergurgl2017
COST Action MitoEAGLE
Strawberry extract protects human dermal fibroblasts against oxidative stress and improves mitochondrial functionality.
LEAKROXFibroblast
Michalak 2017 MiP20172017
MiPsociety
The effect of anticoagulants on mitochondrial respiration in intact peripheral blood mononuclear cells.
LEAK
ROUTINE
ET
ROXIntact cellsHumanBlood cells
Karavyraki 2017 MiPschool Obergurgl2017
KaravyrakiMarilena.jpg
Mitochondrial function and morphology linked to metabolic differences in normal, dysplastic and cancerous oral cells.
LEAKROXIntact cellsHuman
Lin 2017 FASEB J2017Mitochondrial respiration is fiber-type specific in skeletal muscles.LEAK
ROUTINE
N
NS
Permeabilized tissueRatSkeletal muscle
Hellgren 2017 MiPschool Obergurgl2017
Kim Hellgren IMG 4885.JPG
Effect of prenatal hypoxia on adult mitochondrial respiration and ROS production.
LEAK
ROUTINE
ET
NHomogenateMouseHeart
Cizmarova 2017 MiP20172017
Beate Cizmarova
PBMC cryopreservation and evaluation for functional mitochondrial diagnosis.
LEAK
ROUTINE
ET
Intact cellsHumanBlood cells
Krajcova 2017 MITOEAGLE Obergurgl2017
Krajcova A
Developing a method of assessing mitochondrial functions in homogenates of human heart muscle.
LEAK
OXPHOS
ET
N
NS
HomogenateHuman
Irving 2017 MiP20172017
Brian Irving
Impact of acute exercise on PBMC respiratory function and methodological considerations.
LEAK
ROUTINE
OXPHOS
ET
N
NS
ROX
Blood cells
Amick 2017 MiPschool Obergurgl2017
Amick picture.jpg
Bioenergetic profiling of mitochondria isolated from three distinct brain regions relevant to AD pathology in non-human primates.
LEAK
OXPHOS
F
N
Isolated mitochondriaOther mammalsNervous system
Afrin 2017 MiPschool Obergurgl2017
AfrinS.jpg
Induction of mitochondrial dysfunction by Manuka honey as a strategy for prevention of colon cancer in vitro model: a rising role on reactive oxygen species, apoptosis, and cell metabolism.
LEAKROX
Rybacka-Mossakowska 2017 MiP20172017
MiPsociety
Mitochondrial respiration in intact peripheral blood mononuclear cells in multiple sclerosis patients.
LEAK
ROUTINE
ET
ROXIntact cellsHumanBlood cells
Komlodi 2017 MiPschool Obergurgl2017
Timea Komlodi
Electron pressure exerted by convergent succinate- and glycerophosphate-pathways to the Q-junction regulate reversed electron transfer to Complex I and H2O2 production.
LEAK
OXPHOS
N
S
Gp
Other combinations
ROX
Isolated mitochondriaMouseNervous system
Nemec 2017 MiP20172017
Michal Nemec
Three-month exercise modulates skeletal muscle mitochondria function in patients with mild cognitive impairment.
LEAKN
NS
Permeabilized tissueHumanSkeletal muscle
Chowdhury 2017 Blood2017Importance of mitochondrial metabolism as a selective therapeutic approach in chronic lymphocytic leukemia patients.LEAKROXIntact cellsHumanLymphocyte
Distefano 2017 MiPschool Obergurgl2017
Giovanna Distefano
Effects of calorie restriction-induced weight loss and exercise on skeletal muscle mitochondrial energetics of older obese subjects.
LEAK
OXPHOS
ET
F
NS
Permeabilized tissueHumanSkeletal muscle
Bento 2017 MITOEAGLE Obergurgl2017
Guida Bento Foto.JPG
Isolation of human urine-derived stem cells for mitochondrial function profile assessment.
LEAK
ET
ROXIntact cellsHumanStem cells
Iyer 2017 MiP20172017
Iyer Shilpa
Bioenergetic profiling of patient derived human fibroblasts for mitochondrial diseases. Iyer_Presentation
LEAK
ROUTINE
HumanFibroblast
Markova 2017 MiPschool Obergurgl2017
Michaela Markova
Mitochondrial respiration in the rat left heart ventricle after inhibition of pyruvate dehydrogenase kinase.
LEAK
OXPHOS
N
S
CIV
NS
ROX
HomogenateRatHeart
MitoFit Open Seminar 2017-07-142017
MitoFit
Innsbruck AT, 2017 Jul 14. MitoFit Open Seminar on immune cell bioenergetics.
Investigating the role of mitochondria in healthy and psychopathological aging.
LEAK
ROUTINE
ET
Intact cellsHumanBlood cells
Han 2017 MiP20172017
MiPsociety
Metabolic syndrome differentially impacts the retina and underlying retinal pigment epithelium cells.
LEAK
OXPHOS
S
CIV
NS
RatNervous system
Reboredo-Rodriguez 2017 MiPschool Obergurgl2017
Reboredo-Rodriguez Patricia
Protective effect of a polyphenol-rich strawberry extract on oxidative and endoplasmic reticulum stresses in HepG2 cell line.
LEAK
ET
ROXHumanLiver
Siewiera 2017 MiP20172017
Karolina Siewiera
Changes in blood platelet and brain mitochondrial respiration during short and long-lasting STZ-induced diabetes.
LEAK
ET
NHomogenate
Intact cells
RatNervous system
Blood cells
Platelet
O'Brien 2017 Abstract IOC1222017PPARα independent effects of nitrate supplementation on skeletal muscle mitochondrial function in hypoxia.LEAK
OXPHOS
FMouseSkeletal muscle
Waldauf 2017 MITOEAGLE Obergurgl2017
COST Action MitoEAGLE
Effect of propofol on energy metabolism in an in vitro model of human skeletal muscle homogenates.
LEAK
OXPHOS
ET
F
N
S
CIV
NS
HomogenateHumanSkeletal muscle
Komlodi 2017 MiP20172017
Timea Komlodi
H2O2 production under hypoxia in brain and heart mitochondria: does O2 concentration matter?
LEAK
OXPHOS
N
NS
Isolated mitochondriaMouseHeart
Nervous system
Meszaros 2017 MiPschool Obergurgl2017
Andras Meszaros
(Very) High-resolution respirometry – a deep dive into oxygen dependence of mitochondrial respiration.
LEAK
OXPHOS
N
S
Isolated mitochondriaMouseLiver
Nervous system
Kidney
Krylova 2017 MiPschool Obergurgl2017
KrylovaT.jpg
High-resolution respirometry in diagnostic of mitochondrial complex I deficiency.
LEAK
ROUTINE
ET
N
S
Intact cells
Permeabilized cells
Endothelial;epithelial;mesothelial cell
Fibroblast
Doerrier 2017 MiP2017 WG22017
Carolina Anneliese Doerrier
Upper limit of OXPHOS capacity in permeabilized myofibers: effect of oxygen, ADP and blebbistatin in MiR05Cr and Buffer Z.
LEAK
OXPHOS
ET
N
NS
Permeabilized tissueMouseSkeletal muscle
Komlodi 2017 Abstract MITOEAGLE Barcelona2017
COST Action MitoEAGLE
Succinate dehydrogenase regulation via oxaloacetate in brain mitochondria.
OXPHOS
LEAK
ET
N
S
Isolated mitochondria
Homogenate
Guinea pig
Mouse
Nervous system
Kidney
Heart
Liver
Hoel 2017 MiPschool Obergurgl2017
Hoel Fredrik
A study on mitochondrial stress responses due to OXPHOS inhibition.
LEAKROXHumanNervous system
Kovalcikova 2017 MiP20172017
Kovalcikova Jana
Mitochondrial protein TMEM70: key role in the biogenesis of ATP synthase verified in a mouse knockout model.
LEAK
OXPHOS
MouseHeart
Liver
Keppner 2017 MiPschool Obergurgl2017
COST Action MitoEAGLE
Different respiratory states to determine LEAK and uncoupled respiration in the SUIT protocol: effect and consequences.
LEAK
OXPHOS
ET
N
NS
Permeabilized cellsBlood cells
Gnaiger 2017 MiPschool A12017
Gnaiger Erich.jpg
Elemental steps towards understanding mitochondrial core energy metabolism: coupling control.
LEAK
ROUTINE
OXPHOS
ET
ROXIntact cells
Permeabilized cells
Permeabilized tissue
Isolated mitochondria
Meszaros 2017 MiP20172017
Andras Meszaros
Mitochondrial oxygen kinetics as a sensitive diagnostic tool to determine apparent cytochrome c oxidase excess capacity.
LEAK
OXPHOS
ET
N
NS
Isolated mitochondriaMouseNervous system
Liver
Kidney
Nogueras 2017 MiPschool Obergurgl2017
Lara Nogueras.jpg
Mitochondrial dysfunction in peripheral blood mononuclear cells from multiple sclerosis patients.
LEAK
ROUTINE
ET
ROXIntact cellsBlood cells
Ukropec 2017 MITOEAGLE Obergurgl2017
COST Action MitoEAGLE
Could functional state of muscle mitochondria reflect exercise-induced changes in insulin sensitivity, glucose tolerance and cognitive performance in individuals with mild cognitive impairment?
LEAK
OXPHOS
ET
F
N
S
Gp
NS
Permeabilized cellsSkeletal muscle
Doerrier 2017 MiP2017 C12017
Carolina Anneliese Doerrier
Effects of warm ischemia on cardiac mitochondria to detect specific targets by high-resolution respirometry (HRR)
LEAK
ET
F
N
S
CIV
NS
Isolated mitochondriaMouseHeart
Hartmann 2017 Abstract MITOEAGLE Barcelona2017
COST Action MITOEAGLE
Mitochondrial respiration of isolated peripheral blood mononuclear cells in an experimental porcine brain injury model.
LEAK
ROUTINE
ET
Intact cellsHuman
Pig
Blood cells
Gnaiger 2017 Abstract MitoEAGLE Barcelona2017
COST Action MitoEAGLE
Quality first: a paradigm shift in mt-respiratory control towards global connection.
LEAK
OXPHOS
ET
N
S
NS
Permeabilized tissueHuman
Mouse
Heart
Genital
Gasparrini 2017 MiPschool Obergurgl2017
COST Action MitoEAGLE
Anti-inflammatory effects of strawberry and honey extracts in RAW 264.7 macrophages stressed with LPS.
LEAKROXMouseMacrophage-derived
Markova 2017 MiP20172017
Michaela Markova
Porcine sepsis and associated myocardial depression.
LEAK
OXPHOS
N
S
CIV
NS
ROX
PigHeart
Siewiera 2017 MiPschool Obergurgl2017
Karolina Siewiera
Blood platelets as bioenergetic markers of brain damage in STZ-diabetes.
LEAK
ROUTINE
ET
Intact cellsRatBlood cells
Platelet
Doerrier 2017 MiPschool C22017
DoerrierC.JPG
Substrate-uncoupler-inhibitor titration (SUIT) protocols – fundamental principles.
LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
Permeabilized cells
Homogenate
Isolated mitochondria
Human
Mouse
Heart
Nervous system
HEK
Calabria 2017 MiP20172017
Elisa Calabria
Age and frailty related changes in PBMCs mitochondrial function and whole body physiology.
LEAK
ET
SPermeabilized cellsHumanBlood cells
Juhasz 2017 MiPschool Obergurgl2017
Juhasz L.jpg
Blockade of N-methyl-D-aspartate receptors improves polymicrobial sepsis-evoked mitochondrial dysfunction in rats.
LEAK
OXPHOS
N
S
HomogenateRatLiver
Chabi 2017 MITOEAGLE Obergurgl2017
ChabiB.JPG
Optimization of permeabilized fibers preparation for mitochondrial respiration measurements using Design of Experiments methodology.
LEAKNSPermeabilized tissueMouseSkeletal muscle
Gnaiger 2017 MiP20172017Gnaiger E (2017) Protonmotive force and chemiosmotic pressure: a generalization of non-ohmic flux control of the proton leak. MiP2017.LEAK
Krajcova 2016 Abstract MitoFit Science Camp 20162016Mitochondrial pathogenesis of propofol infusion syndrome in an in vitro model of human skeletal muscle.LEAK
ET
FHomogenateHumanSkeletal muscle
Sparagna 2016 Abstract IOC1092016Sparagna GC (2016) Measuring cardiac mitochondrial function in pediatric patients before and after implantation of a left ventricular assist device. Mitochondr Physiol Network 21.01.LEAK
OXPHOS
N
S
NS
HumanHeart
Cecatto 2016 Abstract IOC1162016Cecatto C, Silva JC, Wajner A, Godoy KS, Ribeiro, RT, Amaral AU, Wajner M (2016) cis-4-Decenoic and decanoic acids impair mitochondrial energy, redox and Ca2+ homeostasis and induce mitochondrial permeability transition pore opening in rat brain and liver. Mitochondr Physiol Network 21.11LEAK
OXPHOS
ET
F
N
CIV
Other combinations
Permeabilized tissue
Isolated mitochondria
RatNervous system
Liver
Krumschnabel 2016a Abstract MitoFit Science Camp 20162016O2k-Protocols: Mitochondrial preparations for HRR.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissue
Homogenate
Isolated mitochondria
MouseHeart
Schoepf 2016 Abstract Mito Xmas Meeting Innsbruck2016Mitochondrial function in primary prostate cancer.LEAK
OXPHOS
ET
N
S
Other combinations
Permeabilized tissueHuman
Calzia 2016 Abstract MitoFit Science Camp 20162016Mitochondrial respiration shows tissue- and strain-specific aging in short- and long-lived N. furzeri strains.LEAK
OXPHOS
ET
NSFishesHeart
Skeletal muscle
Nervous system
Liver
Gnaiger 2016 Abstract UMDF20162016Schöpf B, Schäfer G, Weber A, Talasz H, Eder IE, Klocker H, Gnaiger E (2016) Oxidative phosphorylation and mitochondrial function differ between human prostate tissue and cultured cells.LEAK
OXPHOS
ET
F
N
NS
Permeabilized cells
Permeabilized tissue
HumanEndothelial;epithelial;mesothelial cell
Genital
Other cell lines
Fibroblast
Volani 2016 Abstract Mito Xmas Meeting Innsbruck2016Effects of systemic iron perturbations on mitochondrial activity and on cellular metabolism in vivo.LEAK
ROUTINE
OXPHOS
ET
N
S
HomogenateMouseLiver
Doerrier 2016 Abstract MitoFit Science Camp 20162016Development of a SUIT reference protocol for OXPHOS analysis by high-resolution respirometry.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
ROX
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
Human
Mouse
Heart
Blood cells
HEK
Platelet
Volani 2016 Abstract MitoFit Science Camp 20162016Effects of iron imbalances on mitochondrial activity in mouse liver homogenate and permabilized rat PBMCs.LEAK
OXPHOS
ET
N
S
HomogenateMouse
Rat
Liver
Blood cells
Lymphocyte
Davies 2016 Abstract Proceedings of The Physiological Society2016Development of mitochondrial function in the cortex and cerebellum of the ovine fetus.LEAK
OXPHOS
N
S
NS
HomogenateBovinesNervous system
Chicco 2016b Abstract MitoFit Science Camp 20162016OXPHOS coupling efficiency of permeabilized muscle fibers predicts metabolic efficiency of subjects exercising at 5260 m.LEAK
OXPHOS
ET
F
N
Permeabilized tissueHumanSkeletal muscle
Laner 2016 Abstract MitoFit Science Camp 20162016OXPHOS and ET-capacity in permeabilized fibers of canine superathletes. Analysis of HRR data presenting unexpected challenges.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueDogSkeletal muscle
Krumschnabel 2016b Abstract MitoFit Science Camp 20162016O2k-MultiSensor: Mitochondrial respiration media for HRR and simultaneous O2k-Fluorometry.LEAK
OXPHOS
ET
N
S
NS
ROX
HumanKidney
HEK
Sumbalova 2016 Abstract Mito Xmas Meeting Innsbruck2016Methods for evaluation of mitochondrial membrane potential with multi-sensor high-resolution respirometry: potentiometry vs fluorometry.LEAK
OXPHOS
ET
F
N
S
NS
ROX
MouseNervous system
Herminghaus 2016 Abstract MitoFit Science Camp 20162016Sterile laparotomy time-dependently modulates hepatic but not colonic mitochondrial function similar to moderate abdominal sepsis.LEAK
OXPHOS
N
NS
RatLiver
Endothelial;epithelial;mesothelial cell
Sumbalova 2016b Abstract MitoFit Science Camp 20162016Human blood cells: isolation and HRR.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
Other combinations
ROX
Permeabilized cells
Intact cells
HumanBlood cells
Lymphocyte
Platelet
Bezuidenhout 2016b Abstract MitoFit Science Camp 20162016Analysis and comparison of mitochondrial function using cooling plate or ice during mechanical separation of mouse skeletal muscle fibers.LEAK
OXPHOS
ET
N
S
ROX
Permeabilized tissueMouseSkeletal muscle
Laner 2016 Abstract Mito Xmas Meeting Innsbruck2016OXPHOS and ET capacity in permeabilized fibers of canine superathletes.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueDogSkeletal muscle
Madlala 2016 Abstract MitoFit Science Camp 20162016Fructose-induced defects in selected mitochondrial enzymes is detected by respirometry using glutamate&malate but not pyruvate&malate substrates.LEAK
OXPHOS
ET
NPermeabilized cellsHumanLiver
Sobotka 2016 Abstract IOC1162016Sobotka O, Kucera Otto, Stankova P, Endlicher R, Nozickova K, Banni A, Cervinkova Z (2016) Mitochondrial respiration in fatty liver. Mitochondr Physiol Network 21.11LEAK
OXPHOS
ET
F
N
S
Gp
CIV
NS
Other combinations
ROX
Isolated mitochondriaRatLiver
Lamberti 2016 Abstract MitoFit Science Camp 20162016Development of a reference sample for HRR.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
Other combinations
ROX
HumanKidney
HEK
Doerrier 2016b Abstract Mito Xmas Meeting Innsbruck2016Searching for specific targets of ischemic damage of cardiac mitochondria using O2k-Fluorometry.LEAK
OXPHOS
ET
F
N
S
Gp
CIV
ROX
Isolated mitochondriaMouseHeart
Gnaiger 2015 Abstract MiPschool Cape Town 2015 II2015On coupling control of mitochondrial respiration. What is wrong with the RCR?LEAK
ROUTINE
OXPHOS
ET
N
S
ROX
Devaux 2015 Abstract MiP20152015Mitochondrial complexes I and II behave differently in two anoxia-tolerant species: adaptive mitochondrial plasticity may be related to the ability to undergo metabolic depression.LEAK
OXPHOS
ET
N
S
HomogenateFishesNervous system
Van Dyk 2015 Abstract MiPschool Cape Town 20152015Optimization of selected cell lines for use on the Seahorse extracellular flux analyzer.LEAK
ROUTINE
ET
N
ROX
Isolated mitochondriaHumanOther cell lines
Fibroblast
Gnaiger 2015 Abstract MiP20152015Mitochondrial function of cyropreserved HEK 293T cells: development of a reference sample for high-resolution respirometry.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
Permeabilized cells
Intact cells
HumanHEK
Galina 2015 Abstract MiP20152015High intensity interval training (HIIT) induces specific changes in respiration and electron leakage in the mitochondria of different rat skeletal muscles.LEAKN
S
ROX
Permeabilized tissueRatSkeletal muscle
Doerrier 2015 Abstract MiPschool Greenville 20152015"Succinate paradox" study by high resolution respirometry combined with fluorometry and spectrofluorometry: NextGen-O2k.LEAK
OXPHOS
SIsolated mitochondriaMouseHeart
Maarman 2015 Abstract MiPschool Cape Town 20152015Characterisation of mitochondrial function in a model of pulmonary hypertension-induced right ventricular failure.LEAK
OXPHOS
N
S
NS
Isolated mitochondriaRatHeart
Doerrier 2015 Abstract MiP20152015Simultaneous measurement of mitochondrial respiration, hydrogen peroxide production, and NADH autofluorescence to assess mitochondrial function.LEAK
OXPHOS
SIsolated mitochondriaMouseHeart
Smenes 2015 Abstract IOC1002015Smenes BT, Baekkerud FH, Hassel E, Wohlwend M, Slagsvold KH, Rognmo O, Wahba A (2015) Mitochondrial function in patients exercising prior to coronary surgery – A single blinded randomized controlled trial. Mitochondr Physiol Network 20.01.LEAK
ROUTINE
ET
N
S
HumanSkeletal muscle
Karabatsiakis 2015 Abstract MiP20152015Mitochondrial respiration of peripheral blood mononuclear cells in patients with borderline personality disorder.LEAK
ROUTINE
OXPHOS
ET
ROXHumanBlood cells
Funk 2015 Abstract MiPschool Greenville 20152015Isolated mitochondria from liver and brain of long-lived growth hormone receptor gene disrupted mice demonstrate reduced respiration rates.LEAK
OXPHOS
Isolated mitochondriaMouseNervous system
Liver
Ojuka 2015 Abstract MiPschool Cape Town 20152015Use of malate or carnitine as co-substrates for assessment of fatty acid oxidation.LEAK
OXPHOS
ET
Permeabilized cells
Permeabilized tissue
Isolated mitochondria
Renshaw 2015 Abstract MiP20152015Mitochondrial responses to thermal stress: is the ability to withstand anoxia-induced stress associated with cross-tolerance to thermal stress?LEAK
OXPHOS
ET
N
S
HomogenateFishesNervous system
Gnaiger 2015 Abstract MiPschool Cape Town 20152015The functional design of the electron transfer system (ETS) and mitochondrial respiratory control.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
Ali 2015 Abstract MiP20152015Mitochondrial function and ROS homeostasis in young mouse heart and brain: the sex factor!LEAK
OXPHOS
ET
HomogenateMouseHeart
Nervous system
Cannon 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Cannon 2015 Fatty Acid Oxidation O2k-Network Discussion ForumLEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueHuman
Mouse
Skeletal muscle
Rutkai 2015 Abstract MiPschool Greenville 20152015Sex-differences in mitochondrial respiration is mediated by nitric oxide in rat cerebral arteries.LEAK
ROUTINE
ET
RatEndothelial;epithelial;mesothelial cell
Ali 2015 Abstract MiPschool Cape Town 20152015Early gender-related dimorphism in heart and brain mitochondria function and ROS dynamics.LEAK
OXPHOS
ET
MouseHeart
Nervous system
Sumbalova 2015 Abstract MiP20152015High-resolution measurement of mitochondrial membrane potential and respiration – comparison of potentiometric and fluorometric methods.LEAK
OXPHOS
ET
N
S
NS
Isolated mitochondriaMouseNervous system
Laner 2015 Abstract MiPschool Cape Town 20152015The Oroboros Oxygraph-2k for high-resolution respirometry and O2k-Fluorometry: a new quality in OXPHOS analysis.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
Isolated mitochondria
Intact cells
Mouse
Saccharomyces cerevisiae
Heart
Sleiman 2015 Abstract MiP20152015Mitochondrial respiration in sequential biospies from skeletal muscles during hemorrhagic shock and over the course of 48h of reperfusion in pigs.LEAK
OXPHOS
ET
N
S
HomogenatePigSkeletal muscle
Chavanelle 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Chavanelle 2015 Fatty Acid Oxidation O2k-Network Discussion ForumLEAK
OXPHOS
F
N
Permeabilized tissueMouseSkeletal muscle
Blecha 2015 Abstract MiP20152015Modulation of mitochondrial electron transport chain activity differentially regulates cell death in proliferating and quiescent cells.LEAK
ET
ROX
Dyrstad 2015 Abstract MiPschool London 20152015Activation of epithelial to mesenchymal transition (EMT) regulates stemness and metabolic reprogramming in mammary epithelial cells.LEAK
ROUTINE
ET
N
ROX
HumanEndothelial;epithelial;mesothelial cell
Other cell lines
Laner 2015 Abstract MiP20152015Comparative mitochondrial physiology: OXPHOS and ET capacity in permeabilized fibers of canine superathletes.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueDogSkeletal muscle
Ost 2015 Abstract IOC1002015Ost M (2015) “Mitokines” and the organismal role of mitochondrial function in energy homeostasis & metabolism. Mitochondr Physiol Network 20.01.LEAK
OXPHOS
Permeabilized tissueMouseSkeletal muscle
Fibroblast
Weidgang 2015 Abstract MiP20152015Mitochondrial respiration in homogenized biopsies from kidney, liver, heart and diaphragm from mice after blunt thoracic trauma and hemorrhagic shock. Effects of a novel hydrogen sulfide donor AP39.LEAK
OXPHOS
ET
N
S
HomogenateMouseHeart
Skeletal muscle
Liver
Kidney
Ciapaite 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Ciapaite 2015 Fatty Acid Oxidation O2k-Network Discussion ForumLEAK
OXPHOS
ET
FPermeabilized tissueHuman
Rat
Skeletal muscle
Calzia 2015 Abstract MiP20152015Mitochondrial respiration in homogenized small tissue biopsies from the M. Vastus lateralis of patients with Huntington's Disease before and after cycling exercise.LEAK
OXPHOS
ET
N
S
ROX
HumanSkeletal muscle
Sheldon 2015 Abstract MiPschool Greenville 20152015eNOS is required to preserve hepatic mitochondrial function in western diet-induced nonalcoholic fatty liver disease.LEAK
OXPHOS
ET
N
NS
MouseLiver
Salin 2015 Abstract MiP20152015Individual variation in whole-organism performance is related to mitochondrial properties at high temperatures.LEAKFishesSkeletal muscle
Liver
Mendonca 2014 Abstract IOC 2014-04 Schroecken2014Mendonca AP, Rodrigues MF, Amoedo ND, Oliveira MF (2014) Effects of iron on mitochondrial physiology of central nervous system cell lines. Mitochondr Physiol Network 19.02.LEAK
OXPHOS
ET
Nervous system
Other cell lines
Neuroblastoma
Krumschnabel 2014 Abstract MiP20142014Simultaneous high-resolution measurement of mitochondrial respiration and hydrogen peroxide production.LEAK
OXPHOS
ET
N
S
NS
Homogenate
Isolated mitochondria
MouseNervous system
Volodina 2014 Abstract MiP20142014Multipotent stromal cells injection improves rat liver regeneration through activation of mitochondrial functions after subtotal hepatectomy.LEAK
OXPHOS
ET
N
NS
Isolated mitochondriaRatLiver
Alberici 2014 Abstract MiP20142014Effects of long-chain acyl-CoA synthetase 6 knockdown in primary skeletal muscle cells metabolism.LEAK
ROUTINE
ET
Intact cellsRatSkeletal muscle
Lai 2014 Abstract1 MiP20142014Improved isolation of high quality subsarcolemmal and interfibrillar mitochondria from skeletal muscle.LEAK
OXPHOS
NIsolated mitochondriaRat
Dog
Heart
Skeletal muscle
Fibroblast
Doerrier 2014 Abstract SECF2014Evaluation of melatonin treatment in mitochondria of permeabilized myocardial fibers from septic mice.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissue
Isolated mitochondria
MouseHeart
Zorzano 2014 Abstract MiP20142014Metabolic implications of mitofusin 2 dysfunction.LEAK
OXPHOS
MouseSkeletal muscle
Bristot 2014 Abstract MiP20142014High-resolution respirometry and bioenergetics evaluation in fibroblasts derived from patients with TP53 germline mutations.LEAK
OXPHOS
Intact cellsHumanFibroblast
El-Bacha 2014 Abstract MiP20142014Cytotoxicity of grape pomace extract (Vitis vinifera L.) from Brazilian wine industry in human hepatocarcinoma HepG2 cells.LEAK
ROUTINE
ET
Intact cellsHumanLiver
Porter 2014 Abstract IOC952014Porter C (2014) The impact of resistance exercise training on skeletal muscle mitochondrial respiration in healthy young adults. Mitochondr Physiol Network 19.10LEAK
OXPHOS
ET
Permeabilized tissueHumanSkeletal muscle
Power 2014 Abstract MiP20142014The hot heart: cardiac mitochondrial energetics during hyperthermia.LEAK
OXPHOS
Isolated mitochondriaRatHeart
Herminghaus 2014 Abstract MiP20142014Severity of polymicrobial sepsis modulates mitochondrial function in rat liver.LEAK
OXPHOS
N
S
Isolated mitochondriaRatLiver
Laner 2014 Abstract MiP20142014Cytochrome c flux control factor as a quality criterion in respiratory OXPHOS analysis in canine permeabilized fibers.LEAK
ROUTINE
OXPHOS
ET
N
NS
Permeabilized tissueDogSkeletal muscle
Schoepf 2014 Abstract MiP20142014OXPHOS analysis in small prostate biopsies.LEAK
OXPHOS
ET
N
S
CIV
NS
Permeabilized tissueHumanGenital
Paes 2014 Abstract IOC 2014-04 Schroecken2014Paes MC, Saraiva FMS, Nogueira NP, Laranja GAT, Coelho MGP, Oliveira MF (2014) Heme increases mitochondrial membrane potential and ROS production in Trypanosoma cruzi epimastigotes. Mitochondr Physiol Network 19.02.LEAK
OXPHOS
ET
S
Other combinations
Permeabilized cells
Oxidase;biochemical oxidation
Protists
Jezek 2014 Abstract MiP20142014Mitochondrial cristae morphology changes: from Hackenbrock to hypoxia.LEAK
OXPHOS
Isolated mitochondriaOther cell lines
Karabatsiakis 2014 Abstract IOC962014Karabatsiakis A (2014) Consequences of depression on respiratory activity in peripheral blood mononuclear cells. Mitochondr Physiol Network 19.11.LEAK
ROUTINE
ET
Intact cellsHumanBlood cells
Lymphocyte
Sparks 2014 Abstract MiP20142014NAMPT remodels substrate metabolism in skeletal muscle.LEAK
OXPHOS
N
S
Permeabilized tissueMouseSkeletal muscle
Salin 2013 Abstract MiP20132013Salin K, Luquet E, Rey B, Roussel D, Voituron Y (2013) Mitochondrial functioning, a proximate mechanism underlying the pace-of- life? Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ET
S
CIV
Isolated mitochondria
Enzyme
Oxidase;biochemical oxidation
Other mammals
Amphibians
Liver
Calzia 2013 Abstract MiP20132013Calzia E, Wagner K, Wagner F, Groeger M, Matallo J, McCook O, Wachter U, Vogt J, Radermacher P (2013) Studying mitochondrial effects of sulfide. Does the species matter? Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ET
Pig
Mouse
Liver
Oliveira MF 2013 Abstract MiP20132013Oliveira MF (2013) Comparative mitochondrial physiology in blood feeding insect vectors and parasites. Mitochondr Physiol Network 18.08.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
ROX
Intact organism
Intact organ
Permeabilized cells
Permeabilized tissue
Homogenate
Intact cells
Human
Drosophila
Hexapods
Other invertebrates
Skeletal muscle
Neuroblastoma
Garcia-Souza 2013 Abstract IOC802013Garcia-Souza LF (2013) Thrombin trigger mitochondrial functional remodeling in human platelets. Mitochondr Physiol Network 18.09.LEAK
ROUTINE
ET
Intact cellsHumanBlood cells
DeLany 2013 TOS2013Skeletal muscle mitochondrial respiration is lower in African American compared to Caucasian women and is associated with resting metabolic rate and cardiorespiratory fitness.LEAK
OXPHOS
Permeabilized tissueHumanSkeletal muscle
Gomez Rodriguez 2013 Abstract IOC752013Gomez Rodriguez A (2013) ß-adrenergic receptor signaling interruption with two β-blockers (atenolol or nebivolol) can modify different oxidative stress related parameters linked to longevity in mouse liver. Mitochondr Physiol Network 18.03.LEAKIsolated mitochondriaMouseLiver
Kressig 2013 Abstract IOC792013Kressig F (2013) et al. Mechanism of increased pulmonary vascular remodeling in UCP2 k/o mice. Mitochondr Physiol Network 18.07LEAKPermeabilized cells
Isolated mitochondria
MouseLung;gill
Other cell lines
Jezek 2013 Abstract MiP20132013Ježek P, Ježek J, Zelenka J, Dlasková A, Jabůrek M (2013) Antioxidant synergy of mitochondrial uncoupling protein UCP2 and phospholipase iPLA2γ. Mitochondr Physiol Network 18.08.LEAK
ROUTINE
OXPHOS
ET
N
S
ROX
Isolated mitochondria
Intact cells
MouseLung;gill
Islet cell;pancreas;thymus
Slinde 2013 Abstract MiP20132013Slinde E, Egelandsdal B, Olsen RE (2013) Respiration of tissue and mitochondria from Atlantic salmon (Salmo salar, L) liver, muscle, heart, brain and blood. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ET
N
ROX
Permeabilized tissue
Isolated mitochondria
Other mammals
Fishes
Heart
Liver
Blood cells
Chicco 2013 Abstract MiP20132013Chicco AJ, Le CH, Schlater A, Kanatous S (2013) Comparative muscle mitochondrial physiology of the northern elephant seal. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ET
F
N
Other combinations
Permeabilized tissueHuman
Other mammals
Skeletal muscle
Palm 2013 Abstract MiP20132013Palm F, Hansell P, Friederich-Persson M (2013) Role of mitochondrial function for the onset and progression of kidney disease. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
Intact organ
Intact cells
Isolated mitochondria
Mouse
Rat
Kidney
Laner 2013 ASMRM2013Laner V, Gradl P, Eigentler A, Fontana-Ayoub M, Fasching M, Gnaiger E (2013) The Oroboros O2k for high-resolution respirometry and O2k-Fluorometry: a new quality in OXPHOS analysis. ASMRM2013.LEAK
OXPHOS
ET
N
S
NS
HomogenateMouseHeart
Skulachev 2013 Abstract MiP20132013Skulachev VP (2013) SkQ1, the first mitochondria-targeted medicine available in drugstores. Mitochondr Physiol Network 18.08.LEAK
ET
Intact organism
Isolated mitochondria
SMP
Intact cells
Human
Mouse
Horse
Dog
Rabbit
Fishes
Other invertebrates
Fungi
Plants
Heart
Skeletal muscle
Nervous system
Kidney
Islet cell;pancreas;thymus
Other cell lines
HeLa
Fibroblast
Stem cells
Camacho-Pereira 2013 Abstract IOC752013Camacho-Pereira J (2013) CD38 as a regulator of mitochondrial function. Mitochondr Physiol Network 18.03.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
Intact cells
Permeabilized cells
Isolated mitochondria
MouseLiver
HEK
Macrophage-derived
Hand 2013 Abstract MiP20132013Hand SC, Patil Y (2013) Defense against ATP depletion during the energy-limited state of diapause. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ET
N
S
Intact organism
Homogenate
Isolated mitochondria
Enzyme
Artemia
Crustaceans
Szibor 2013 Abstract MiP20132013Szibor M, Heidler J, Gizatullina Z, Salwig I, Dhandapani PK, Wittig I, Rustin P (2013) Expression of Ciona intestinalis alternative oxidase in mouse. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ROXIsolated mitochondria
Oxidase;biochemical oxidation
MouseHeart
Skeletal muscle
Nervous system
Liver
Lung;gill
Dzialowski 2013 Abstract MiP20132013Dzialowski EM, Ream S, Duquaine A, Sirsat TS, Goy Sirsat SK (2013) Mitochondrial function and the development of endothermy in the precocial Pekin duck (Anas pekin). Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ET
F
N
S
NS
Intact organism
Permeabilized tissue
BirdsSkeletal muscle
Pichaud 2013 Abstract MiP20132013Pichaud N, Blier PU(2013) Importance of mitochondrial haplotypes in the expression of metabolic phenotypes under different conditions. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ET
N
S
Gp
CIV
NS
ROX
Permeabilized tissueDrosophila
Hexapods
Skeletal muscle
Gnaiger 2013 Abstract ASMRM2013Gnaiger E(2013) Loss of mitochondrial competence and degenerative disease: cause and effect. Abstract ASMRM-Seoul.LEAK
OXPHOS
Human
Shabalina 2013 Abstract IOC792013Shabalina IG (2013) Enhanced Complex I but low Complex II substrate-derived ROS production rates in mice, prematurely aging due to enhanced mitochondrial DNA mutation rate. Mitochondr Physiol Network 18.07LEAK
OXPHOS
ET
N
S
NS
Isolated mitochondriaMouseHeart
Skeletal muscle
Liver
Scott 2013 Abstract MiP20132013Scott GR, Mahalingam S, McClelland GB(2013) Mitochondrial adaptations to hypoxia in high-altitude birds and mammals. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
Isolated mitochondria
Enzyme
Other mammals
Birds
Skeletal muscle
Menze 2013 Abstract MiP20132013Menze MA, Marunde MA, Samarajeewa DA, Anderson J, Li S, Hand SC (2013) Group1 LEA protein ameliorates inhibition of mitochondrial respiration in Drosophila melanogaster Kc167 cells and isolated mitochondria. Mitochondr Physiol Network 18.08.LEAK
ROUTINE
OXPHOS
NIntact organism
Intact cells
Permeabilized cells
Isolated mitochondria
Enzyme
Drosophila
Artemia
Crustaceans
Hexapods
Other cell lines
CHO
HEK
Macrophage-derived
Schulte 2013 Abstract MiP20132013Chung DJ, Schulte PM, Richards JG (2013) The effect of low-temperature acclimation on mitochondrial function in the common killifish (Fundulus heteroclitus), a top-down elasticity analysis. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
Isolated mitochondriaFishesLiver
Volska 2013 Abstract MiP20132013Volska K, Makrecka-Kuka M, Svalbe B, Dambrova M (2013) The inhibitor of L-carnitine biosynthesis protects brain mitochondria against anoxia-reoxygenation injury. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
NIsolated mitochondriaRatNervous system
Hickey 2013 Abstract MiP20132013Hickey AJ, Iftikar FI, MacDonald J, Baker D (2013) Mitochondria in a changing climate? The role of mitochondrial in hyperthermic heart failure in different fish species. Mitochondr Physiol Network 18.08.LEAK
ROUTINE
OXPHOS
ET
N
S
CIV
NS
Permeabilized tissueOther mammals
Fishes
Heart
Quistorff 2013 Abstract MiP20132013Quistorff B (2013) With type 2 diabetes mitochondrial dysfunction develops earlier in liver than in skeletal muscle. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
F
S
Other combinations
RatSkeletal muscle
Liver
Gnaiger 2013 Abstract Mito20132013Gnaiger E, Søndergaard H, Munch-Andersen T, Damsgaard R, Hagen C, Díez-Sánchez C, Ara I, Wright-Paradis C, Schrauwen P, Hesselink M, Calbet J, Christiansen M, Helge JW, Saltin B, Boushel R (2013) Conserved mitochondrial coupling efficiency and adaptive substrate control in Inuit and Caucasians: adaptation and acclimatization to the Arctic winter.LEAK
OXPHOS
ET
F
N
S
NS
Permeabilized tissueHumanSkeletal muscle
Amoedo 2013 Abstract MiP20132013Amoêdo ND, Rodrigues MF, Pereira S, Melo F, Jasiulionis M, Galina A, Rumjanek FD(2013) Comparative biochemistry of tumorigenesis: role of mitochondria in the metastatic process. Mitochondr Physiol Network 18.08.LEAK
ROUTINE
OXPHOS
ET
N
S
ROX
Permeabilized cells
Enzyme
Intact cells
MouseEndothelial;epithelial;mesothelial cell
Other cell lines
Korzeniewski 2013 Abstract MiP20132013Korzeniewski B (2013) Regulation of oxidative phosphorylation during work transitions in different tissues results from its kinetic properties. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
Heart
Skeletal muscle
Krumschnabel 2013 Abstract MiP20132013Krumschnabel G, Eigentler A, Fontana-Ayoub M, Draxl A, Fasching M, Gnaiger E (2013) Tissue homogenates for respiratory OXPHOS analysis in comparative mitochondrial physiology: mouse and trout – heart and liver. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateMouse
Fishes
Heart
Nervous system
Liver
Gnaiger 2013 Abstract MiP20132013Gnaiger E, Søndergaard H, Munch-Andersen T, Damsgaard R, Hagen C, Díez-Sánchez C, Ara I, Wright-Paradis C, Schrauwen P, Hesselink M, Calbet J, Christiansen M, Helge JW, Saltin B, Boushel R (2013) Biochemical coupling efficiency in permeabilized fibers from arm and leg muscle in Inuit versus Caucasians: A functional test of the uncoupling hypothesis in Greenland. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ET
F
N
S
NS
Permeabilized tissueHumanSkeletal muscle
Cavalcanti de Albuquerque 2013 Abstract MiP20132013Cavalcanti de Albuquerque JP, Salvador IC, Martins EG, Jardim-Messeder D; Werneck de Castro JPS; Carvalho DP; Galina A (2013) Skeletal muscle mitochondrial function in ovariectomized rats: A time course study and the role of estrogen replacement. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ET
F
N
S
Gp
NS
ROX
Intact organism
Permeabilized tissue
RatSkeletal muscle
Irving 2013 Abstract MiP20132013Irving BA, Stahl R, Kane CJ, Chernousov M, Argyropoulos G, Carey D (2013) Sex differences in murine mitochondrial oxidative capacity following a 24 week high-fat diet. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ET
N
NS
Permeabilized tissue
Homogenate
MouseSkeletal muscle
Liver
Fat
Rodrigues 2013 Abstract MiP20132013Rodrigues MF, Amoedo ND, Rumjanek FD (2013) Studies of bioenergetics alterations in breast cancer lines induced by histone desacetylase inhibitors. Mitochondr Physiol Network 18.08.LEAK
ROUTINE
ET
ROXIntact cellsGenital
Borutaite 2013 Abstract MiP20132013Borutaite V, Jablonskiene G, Arandarcikaite O (2013) Mitochondrial response to heart and brain ischemia. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
N
S
Isolated mitochondriaPig
Rat
Heart
Nervous system
Kotwica 2013 Abstract MiP20132013Kotwica AO, Horscroft JA, Murray AJ(2013) Mitochondrial respiration in heart and soleus of ob/ob mice. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
F
N
S
Permeabilized tissueMouseHeart
Skeletal muscle
Pecina 2013 Abstract MiP20132013Pecina P, Houšťková H, Mráček T, Pecinová A, Nůsková H, Tesařová M, Hansíková H, Janota J, Zeman J, Houštěk J (2013) The use of lymphocytes for diagnostics of mitochondrial oxidative phosphorylation disorders. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ET
N
S
Gp
NS
Other combinations
ROX
Permeabilized cells
Homogenate
HumanBlood cells
Lymphocyte
Hendricks 2013 Abstract MiP20132013Hendricks E, Nathan BP, Menze MA (2013) Bioenergetics of permeabilized and intact nerve cell terminals from ApoE deficient and wild type mice. Mitochondr Physiol Network 18.08.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
Intact cells
Permeabilized cells
Isolated mitochondria
MouseNervous system
Galina 2013 Abstract MiP20132013Galina A, Messeder DJM, Camacho-Pereira J, Pereira da Silva AP, Rodrigues-Ferreira C (2013) Effects of antitumor alkylating agent 3-bromopyruvate on energy transducing pathways in hepatoma HepG2, liver mitochondria and SERCA: Is there any role for mitochondrial hexokinase activity? Mitochondr Physiol Network 18.08.LEAK
ROUTINE
OXPHOS
ET
N
S
Permeabilized cells
Isolated mitochondria
Enzyme
Intact cells
RatSkeletal muscle
Nervous system
Liver
Other cell lines
Garcia-Roves 2013 Abstract MiP20132013Garcia-Roves PM, Gonzalez-Franquesa A, Martinez-Navarro L, Fernandez-Ruiz R (2013) Metabolic flexibility before and after lifestyle intervention in a diet-induced type 2 diabetes animal model. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ET
N
S
CIV
NS
Permeabilized cells
Permeabilized tissue
Homogenate
MouseSkeletal muscle
Nervous system
Liver
Islet cell;pancreas;thymus
Fat
Amoedo 2012 Abstract Bioblast2012Amoedo ND, Rodrigues MF, Pereira SAS, Melo FH, Jasiulionis MG, Galina A, Rumjanek FD (2012) Mitochondrial function and bioenergetics during malignant transformation and metastasis. Mitochondr Physiol Network 17.12.LEAK
ROUTINE
OXPHOS
ET
SIntact cellsMouseOther cell lines
Harper 2012 Abstract Bioblast2012Harper ME, Yin H, Pasut A, Soleimani VD, Bentzinger CF, Antoun G, Thorn S, Seale P, Fernando P, Van IJcken W Frank Grosveld F, Dekemp RA, Boushel RC, Rudnicki MA (2012) Metabolic effects of microRNA-133 and its antagomir in mice. Mitochondr Physiol Network 17.12.LEAKIntact organism
Permeabilized cells
MouseSkeletal muscle
Fat
Horvath 2012 Abstract Bioblast2012Horvath G, Eigentler A, Gnaiger E, Tretter L (2012) Respiratory substrate effects on mitochondrial membrane potential - experiments with mouse cardiac muscle homogenate. Mitochondr Physiol Network 17.12.LEAK
OXPHOS
ET
N
S
NS
HomogenateMouseHeart
Albertini 2012 Abstract Bioblast2012Albertini E, Koziel R, Duerr A, Neuhaus M, Jansen-Duerr P (2012) Cystathionine beta synthase modulates senescence of human endothelial cells. Mitochondr Physiol Network 17.12.LEAK
ROUTINE
ET
Intact cellsEndothelial;epithelial;mesothelial cell
HUVEC
Labieniec-Watala 2012 Abstract Bioblast2012Labieniec-Watala M, Siewiera K, Watala C (2012) Seasonal fluctuations affect the physiology of laboratory animals – facts and artifacts from the perspective of heart mitochondrial respiratory response to tested compounds. Mitochondr Physiol Network 17.12.LEAK
OXPHOS
ET
N
S
NS
Homogenate
Isolated mitochondria
Mouse
Rat
Heart
Liver
Fibroblast
Dzialowski 2012 Abstract IOC722012Dzialowski EM, Sirsat T, Goy S (2012) T3: Does it really make the alligator go “Tick, Tock”? Mitochondr Physiol Network 17.13.LEAK
OXPHOS
N
S
NS
Isolated mitochondriaReptilesHeart
Skeletal muscle
Jacobs 2012 Abstract Bioblast2012Jacobs R, Lundby C (2012) Mitochondria express enhanced quality as well as quantity in parallel with aerobic fitness across recreationally active individuals up to elite athletes. Mitochondr Physiol Network 17.12.LEAK
OXPHOS
ET
F
N
S
NS
Permeabilized cellsHumanSkeletal muscle
Towheed 2012 Abstract IOC722012Towheed A (2012) Elucidating pathogenesis of ATP synthase dysfunction in a Drosophila model of mitochondrial encephalomyopathy. Mitochondr Physiol Network 17.13.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
Intact organism
Permeabilized tissue
Drosophila
Hexapods
Mark 2012 Abstract Bioblast2012Mark FC, Strobel A, Poertner HO (2012) Ocean warming and acidification – when fish mitochondria turn sour. Mitochondr Physiol Network 17.12.LEAK
ROUTINE
OXPHOS
N
S
CIV
NS
Permeabilized tissue
Isolated mitochondria
FishesHeart
Liver
Horscroft 2012 Abstract IOC722012Horscroft JA, Kotwica AO, Ashmore T, Colleoni F, Morash AJ, Gilbert E, Gnaiger E, Martin DS, Murray AJ (2012) Mitochondrial function at altitude in lowland Europeans and highland Sherpas. Mitochondr Physiol Network 17.13.LEAK
OXPHOS
ET
N
NS
HumanSkeletal muscle
Rodrigues 2012 Abstract IOC722012Rodrigues MF, Amoedo ND, Rumjanek FD (2012) Studies of bioenergetics alterations in breast cancer lines induced by sodium butyrate. Mitochondr Physiol Network 17.13.LEAK
ROUTINE
ET
Kamath 2012 Abstract IOC722012Kamath VG, Lizenby ZJ, Adusumilli VRKR, Hsiung CH, McKee EE (2012) Measuring mitochondrial OXPHOS as a nucleoside reverse transcriptase inhibitor induced cardiac toxicity endpoint. Mitochondr Physiol Network 17.13.LEAK
OXPHOS
ET
Isolated mitochondriaRat
Doerrier 2012 Abstract Bioblast2012Doerrier C, Garcia JA, Escames G, Acuna-Castroviejo D (2012) Treatment with melatonin prevents myocardial mitochondrial dysfunction in experimental sepsis in mice. Mitochondr Physiol Network 17.12.LEAK
OXPHOS
ET
N
S
NS
Permeabilized tissueMouseHeart
Hepple 2012 Abstract Bioblast2012Hepple RT, Picard M, Taivassalo T (2012) Is latent mitochondrial dysfunction in aging muscle exposed through mitochondrial isolation? Mitochondr Physiol Network 17.12.LEAK
OXPHOS
Permeabilized tissue
Isolated mitochondria
Skeletal muscle
Pesta 2011Abstract Mitochondrial Medicine-Training2011Pesta D, Hoppel F, Macek C, Messner H, Faulhaber M, Kobel C, Parson W, Burtscher M, Schocke M, Gnaiger E (2011) Mitochondrial improvements after strength, endurance, and intermittend hypoxic training in sedentary humans. A respiratory study on permeabilized muscle fibers. Abstract Mitochondrial Medicine Chicago.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Gnaiger 2011 Abstract SMRM-Hyderabad2011Gnaiger E, Wright-Paradis C, Sondergaard H, Calbet J, Damsgaard R, Munck-Andersen T, Saltin B, Boushel RC (2011) Conserved mitochondrial coupling and adaptive substrate control in Inuit and Caucasians: Acclimatization to active life styles in the Arctic winter. Abstract SMRM-Hyderabad.LEAK
OXPHOS
Human
Sumbalova 2011 Abstract Mitochondrial Medicine2011Sumbalova Z, Fasching M, Gnaiger E (2011) Substrate control in mitochondrial respiration and regulation of mitochondrial membrane potential. Abstract Mitochondrial Medicine Chicago.LEAK
OXPHOS
ET
N
S
NS
Homogenate
Isolated mitochondria
MouseNervous system
Borutaite MiP20102010Borutaite V, Cizas P, Morkuniene R, Budvytyte R (2010) Effect of beta amyloid oligomers on neuronal viability and mitochondrial functions.LEAKIsolated mitochondriaRatNervous system
Pesta 2010 MiP Abstract2010Pesta D, Faulhaber M, Burtscher M, Gnaiger E, Schocke M (2010) Investigation of muscle metabolism of the M. quadriceps via 31P MRS and high-resolution respirometry in connection with 10 weeks of strength and endurance training in normoxia and hypoxia. MiP2010.LEAK
OXPHOS
ET
F
N
S
NS
Human



MitoPedia concepts: Respiratory state, SUIT state, Recommended 


MitoPedia methods: Respirometry 


MitoPedia topics: EAGLE 


Labels:




Regulation: Coupling efficiency;uncoupling  Coupling state: LEAK, ET 

HRR: Theory