Difference between revisions of "Malate-aspartate shuttle"
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|description=The malate-aspartate shuttle involves the glutamate-aspartate carrier and the 2-oxoglutarate carrier exchanging malate<sup>2-</sup> for 2-oxoglutarate<sup>2-</sup>. Cytosolic and mitochondrial malate dehydrogenase and transaminase complete the shuttle for the transport of cytosolic NADH into the mitochondrial matrix. It is most important in heart, liver and kidney. | |description=The malate-aspartate shuttle involves the glutamate-aspartate carrier and the 2-oxoglutarate carrier exchanging malate<sup>2-</sup> for 2-oxoglutarate<sup>2-</sup>. Cytosolic and mitochondrial malate dehydrogenase and transaminase complete the shuttle for the transport of cytosolic NADH into the mitochondrial matrix. It is most important in heart, liver and kidney. | ||
|info=[ | |info=[[Gnaiger 2020 BEC MitoPathways]] | ||
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{{MitoPedia methods| | |||
::::* Scaduto RC Jr (1994) Calcium and 2-oxoglutarate-mediated control of aspartate formation by rat heart mitochondria. Eur J Biochem 223:751-8. - [[Scaduto 1994 Eur J Biochem |»Bioblast link«]] | |||
{{MitoPedia methods | |||
|mitopedia method=Respirometry | |||
}} | }} | ||
{{MitoPedia topics| | {{MitoPedia topics | ||
|mitopedia topic=Enzyme | |||
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Latest revision as of 19:30, 1 January 2021
Description
The malate-aspartate shuttle involves the glutamate-aspartate carrier and the 2-oxoglutarate carrier exchanging malate2- for 2-oxoglutarate2-. Cytosolic and mitochondrial malate dehydrogenase and transaminase complete the shuttle for the transport of cytosolic NADH into the mitochondrial matrix. It is most important in heart, liver and kidney.
Reference: Gnaiger 2020 BEC MitoPathways
- Scaduto RC Jr (1994) Calcium and 2-oxoglutarate-mediated control of aspartate formation by rat heart mitochondria. Eur J Biochem 223:751-8. - »Bioblast link«
MitoPedia methods:
Respirometry
MitoPedia topics:
Enzyme