Difference between revisions of "MitoCom O2k-Fluorometer"

Revision as of 15:10, 18 December 2014

K-Regio Project MitoCom O2k-Fluorometer

The O2k-Fluorometer and Mitochondrial Physiology - Das O2k-Fluorometer und mitochondriale Physiologie (deutsch)

The aim of the project is the development, evaluation and application of a new high-resolution instrument, the O2k-Fluorometer, which builds upon the OROBOROS Oxygraph-2k developed and extended since 2001 by OROBOROS INSTRUMENTS and WGT-Elektronik. The Oxygraph-2k (O2k) provides the instrumental basis for high-resolution respirometry (HRR) and represents world-wide the technologically leading instrument for diagnostic evaluation of mitochondrial respiratory function. The integration of optical devices (fluorometry, spectrophotometry) into the O2k opens up the potential for the analysis of various diagnostically significant cellular functions, simultaneously with the measurement of mitochondrial respiration. In particular, HRR will be combined with the fluorometric detection of reactive oxygen species (ROS; oxidative stress) and mitochondrial membrane potential using established fluorescent dyes. This innovation will further establish our technological leadership, and will extend a growing market (presently the O2k is represented in 42 countries). The technological ‘sole source’ status will be systematically secured, as a decisive feature for the successful world-wide export of a high-end diagnostic instrument.

Applicant: Medical University of Innsbruck, A.Univ.-Prof. Dr. Erich Gnaiger

Application: 2011-04-15; Granted: 2011-07-13 (total budget € 1.05 Mill)

Project duration: 2011-05-01 to 2014-07-31

Project Partners: OROBOROS INSTRUMENTS; WGT Elekronik; Leopold-Franzens University of Innsbruck; Medical University of Innsbruck (lead partner)

Diagnostic_Concept

Regional impact

Progress report

Financial support

The project MitoCom is partially supported by K-Regio:

Förderung von Wissenschaft, Forschung und Entwicklung (Programm K-Regio); EU-Regionalförderungsprogramm "Stärkung der regionalen Wettbewerbsfähigkeit Tirols 2007-2013; Landes- und EU-Förderung

EU funding: € 283,295.97 State funding at the expense of the economic funding by the state Tyrol: € 283,295.97 Funding in total: € 566,591.95 Basis of assessment of the fundable costs: € 1,049,010.70

Landesrätin Patrizia Zoller-Frischauf

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 {{MitoCom}}
+== '''K-Regio Project ''MitoCom O2k-Fluorometer''''' ==
+'''The O2k-Fluorometer and Mitochondrial Physiology  -  [[K-Regio_MitoCom Tyrol_(de)|Das O2k-Fluorometer und mitochondriale Physiologie (deutsch)]]'''
+The aim of the project is the development, evaluation and application of a new high-resolution instrument, the '''O2k-Fluorometer''', which builds upon the [http://www.oroboros.at/index.php?oxygraph OROBOROS Oxygraph-2k] developed and extended since 2001 by [[OROBOROS INSTRUMENTS]] and [http://www.wgt.at WGT-Elektronik].  The Oxygraph-2k (O2k) provides the instrumental basis for [http://www.oroboros.at/index.php?high-resolution-respirometry high-resolution respirometry] (HRR) and represents world-wide the technologically leading instrument for diagnostic evaluation of mitochondrial respiratory function.  The integration of optical devices (fluorometry, spectrophotometry) into the O2k opens up the potential for the analysis of various diagnostically significant cellular functions, simultaneously with the measurement of mitochondrial respiration. In particular, HRR will be combined with the fluorometric detection of reactive oxygen species (ROS; oxidative stress) and mitochondrial membrane potential using established fluorescent dyes.  This innovation will further establish our technological leadership, and will extend a growing market (presently the O2k is represented in [http://www.oroboros.at/index.php?mipnet-labs 42 countries]). The technological ‘sole source’ status will be systematically secured, as a decisive feature for the successful world-wide export of a high-end diagnostic instrument.
+: '''Applicant:''' Medical University of Innsbruck, A.Univ.-Prof. Dr. Erich Gnaiger
+: '''Application:''' 2011-04-15; '''Granted:''' 2011-07-13 (total budget € 1.05 Mill)
-== Impact on life style: Tyrol – a heart for sport ==
+: '''Project duration:''' 2011-05-01 to 2014-07-31
-Mitochondrial knowledge will, with its innovative approach, arouse a new awareness of preventive medicine, to which a physically active and calorie-balanced lifestyle can contribute significantly. Of particular importance is “healthy aging”, a generally improved quality of life and a reduced risk of a multiplicity of degenerative diseases influenced by the mitochondria: e.g. obesity, diabetes 2, various forms of cancer and dementias. Mitochondrial competence will be made a reality to a larger proportion of the population and the regional identity strengthened both amongst our own population and amongst tourists through the offer of exercise-orientated leisure packages in the Alpine landscape of Tyrol.
-[[File:MitoCom Regional Impact.jpg|700px|right|Instrumental innovation and interdisciplinary cooperation in mitochondrial physiology lead to new perspectives of functional mitochondrial diagnosis. Check your mitochondrial health is conveyed to the public as a keyword for taking care of a physically active life style as an invaluable component of preventive and therapeutic medicine.]]
+*'''[[MitoCom Partners|Project Partners]]''': [[OROBOROS INSTRUMENTS]]; WGT Elekronik; Leopold-Franzens University of Innsbruck; Medical University of Innsbruck (lead partner)
+*'''[[MitoCom_Diagnostic_Concept|Diagnostic_Concept]]'''
+*'''[[MitoCom_Tyrol_-_a_heart_for_sport|Regional impact]]'''
+*'''[[MitoCom Tyrol - Report|Progress report]]
+== Financial support ==
+[[File:K-Regio Icon Englisch 01.jpg|thumb|290px|left]]
+[[File:K-Regio Icon.jpg|thumb|290px|right]]The project ''MitoCom'' is partially supported by K-Regio:
+'''Förderung von Wissenschaft, Forschung und Entwicklung (Programm K-Regio); EU-Regionalförderungsprogramm "Stärkung der regionalen Wettbewerbsfähigkeit Tirols 2007-2013; Landes- und EU-Förderung'''
+EU funding: '''€ 283,295.97'''
+State funding at the expense of the economic funding by the state Tyrol: '''€ 283,295.97'''
+Funding in total:''' € 566,591.95'''
+Basis of assessment of the fundable costs:''' € 1,049,010.70'''
+Landesrätin Patrizia Zoller-Frischauf
-Linkages will be created by ''MitoCom'' between research and clinical/practical needs with regard to the very recently established Olympic centre at the Institute of Sport Science of the LFU in Innsbruck and the Altitude Training Centre in Kühtai near Innsbruck leading to optimization of diagnostic exercise testing and training strategies. Importantly, this project seeks to promote research on exercise effects at moderate altitude. Tyrol represents a unique location which is visited by several millions of skiers and mountaineers, annually. On the one hand, regular physical activity and probably also exposures to moderate altitudes up to about 2500 m may contribute to well-being and longevity. On the other hand, however, unaccustomed exercise and acute altitude exposure may trigger serious cardiovascular adverse events in subjects at risk. This project should contribute to a better understanding of mechanisms responsible for beneficial and adverse effects supporting the development of appropriate preventive measures.
-Appreciation by politicians and communication with an aspirational general public are essential to benefit from world-class research, for comprehensive mitochondrial and exercise testing and implementation of exercise as a medicine, and the development of a scientific foundation that may allow us to translate the complex diagnostic results into a patient-related mitochondrial score. The regional ''MitoCom'' network will emphasize the connections to international mitochondrial networks, for exchange of expertise and standardization of diagnostic approaches, in a joint effort to helping mitochondrial patients and making a difference to society.
-* Perspectives of cooperation: http://www.hoehentraining-kuehtai.at/
+[[Category:MitoCom]]
-* Health tourism: http://www.tt.com/wirtschaft/7750785-91/mehr-gesundheit-f%C3%BCr-tirol-urlauber.csp
-* [http://www.uibk.ac.at/ipoint/dossiers/forschung_im_fokus/983677.html More information]