Difference between revisions of "NADH"
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|description='''Nicotinadeninedinucleotide (NADH)''' is not permeable through the inner mt-membrane.ย The NADH pool integrates the activity of the [[TCA cycle]] and various matrix dehydrogenases upstream of [[CI]], and thus forms a junction or funnel of electron transfer to CI.ย Cytosolic NADH is effectively made available for mitochondrial respiration through the [[malate-aspartate shuttle]] or [[Glycerophosphate_dehydrogenase_complex|glycerophosphate dehydrogenase]]. | |description='''Nicotinadeninedinucleotide (NADH)''' is not permeable through the inner mt-membrane.ย The NADH pool integrates the activity of the [[TCA cycle]] and various matrix dehydrogenases upstream of [[CI]], and thus forms a junction or funnel of electron transfer to CI.ย Cytosolic NADH is effectively made available for mitochondrial respiration through the [[malate-aspartate shuttle]] or [[Glycerophosphate_dehydrogenase_complex|glycerophosphate dehydrogenase]]. | ||
|type=Substrate ETS | |type=Substrate ETS |
Revision as of 08:47, 24 January 2016
Description
Nicotinadeninedinucleotide (NADH) is not permeable through the inner mt-membrane. The NADH pool integrates the activity of the TCA cycle and various matrix dehydrogenases upstream of CI, and thus forms a junction or funnel of electron transfer to CI. Cytosolic NADH is effectively made available for mitochondrial respiration through the malate-aspartate shuttle or glycerophosphate dehydrogenase.
Abbreviation: NADH
MitoPedia topics: Substrate and metabolite
Labels:
Enzyme: Complex I
Application in HRR
n: Nicotinadeninedinucleotide, NADH (ฮฒ-Nicotinamide adenine dinucleotide, reduced potassium salt, C21H27N7O14P2K2); Sigma A 4505, 100 mg, store at -20 ยฐC (old Sigma recommendation : 4-8ยฐ); FW = 742.61, for important considerations concerning storage of NADH (powder and solutions) and preparation of solutions see the product information from Sigma: [1]. The same precautions are recommended by Sigma for the sodium salt.