Difference between revisions of "NS e-input"
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Electron input though Complexes [[CI]] plus [[CII]] simultaneously into the [[Q-junction]] corresponds to [[TCA cycle]] function in vivo, with [[convergent electron flow]] through the [[ETS]]. In [[mt-preparations]], CI+II e-input requires addition not only of CI substrate (pyruvate+malate or glutamate+malate), but of succinate simultaneously, since [[metabolite depletion]] in the absence of succinate prevents a significant activity of CII. | {{MitoPedia | ||
= | |description=Electron input though Complexes [[CI]] plus [[CII]] simultaneously into the [[Q-junction]] corresponds to [[TCA cycle]] function in vivo, with [[convergent electron flow]] through the [[ETS]]. In [[mt-preparations]], CI+II e-input requires addition not only of CI substrate (pyruvate+malate or glutamate+malate), but of succinate simultaneously, since [[metabolite depletion]] in the absence of succinate prevents a significant activity of CII. | ||
|info=[[MiPNet12.12]]; [[Gnaiger_2009_IJCBC]] | |||
|type=Transport | |||
}} | |||
{{ | {{Labeling | ||
|discipline=Mitochondrial Physiology | |||
|enzymes=Complex I, Complex II; Succinate Dehydrogenase | |||
}} | |||
Revision as of 08:42, 14 September 2010
- high-resolution terminology - matching measurements at high-resolution
NS e-input
Description
Electron input though Complexes CI plus CII simultaneously into the Q-junction corresponds to TCA cycle function in vivo, with convergent electron flow through the ETS. In mt-preparations, CI+II e-input requires addition not only of CI substrate (pyruvate+malate or glutamate+malate), but of succinate simultaneously, since metabolite depletion in the absence of succinate prevents a significant activity of CII.
Reference: MiPNet12.12; Gnaiger_2009_IJCBC
Labels:
Enzyme: Complex I, Complex II; Succinate Dehydrogenase"Complex II; Succinate Dehydrogenase" is not in the list (Adenine nucleotide translocase, Complex I, Complex II;succinate dehydrogenase, Complex III, Complex IV;cytochrome c oxidase, Complex V;ATP synthase, Inner mt-membrane transporter, Marker enzyme, Supercomplex, TCA cycle and matrix dehydrogenases, ...) of allowed values for the "Enzyme" property.
