Difference between revisions of "NS e-input"
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{{MitoPedia | {{MitoPedia | ||
|description= | |description='''CI+II e-input''' is electron input though Complexes [[CI]] plus [[CII]] simultaneously into the [[Q-junction]] corresponding to [[TCA cycle]] function ''in vivo'', with [[convergent electron flow]] through the [[ETS]]. In [[mt-preparations]], CI+II e-input requires addition not only of CI substrate (pyruvate+malate or glutamate+malate), but of succinate simultaneously, since [[metabolite depletion]] in the absence of succinate prevents a significant stimulation of CII. | ||
|info=[[MiPNet12.12]]; [[ | |info=[[MiPNet12.12]]; [[Gnaiger_2009_IJBCB]] | ||
|type=Transport | |type=Transport | ||
}} | }} | ||
{{Labeling | {{Labeling | ||
|discipline=Mitochondrial Physiology | |discipline=Mitochondrial Physiology | ||
|topics=Respiration; OXPHOS; ETS Capacity, Flux Control; Additivity; Threshold; Excess Capacity | |||
|enzymes=Complex I, Complex II; Succinate Dehydrogenase | |enzymes=Complex I, Complex II; Succinate Dehydrogenase | ||
}} | }} | ||
Revision as of 22:36, 18 September 2010
- high-resolution terminology - matching measurements at high-resolution
NS e-input
Description
CI+II e-input is electron input though Complexes CI plus CII simultaneously into the Q-junction corresponding to TCA cycle function in vivo, with convergent electron flow through the ETS. In mt-preparations, CI+II e-input requires addition not only of CI substrate (pyruvate+malate or glutamate+malate), but of succinate simultaneously, since metabolite depletion in the absence of succinate prevents a significant stimulation of CII.
Reference: MiPNet12.12; Gnaiger_2009_IJBCB
Labels:
Enzyme: Complex I, Complex II; Succinate Dehydrogenase"Complex II; Succinate Dehydrogenase" is not in the list (Adenine nucleotide translocase, Complex I, Complex II;succinate dehydrogenase, Complex III, Complex IV;cytochrome c oxidase, Complex V;ATP synthase, Inner mt-membrane transporter, Marker enzyme, Supercomplex, TCA cycle and matrix dehydrogenases, ...) of allowed values for the "Enzyme" property. Regulation: Respiration; OXPHOS; ETS Capacity"Respiration; OXPHOS; ETS Capacity" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property., Flux Control; Additivity; Threshold; Excess Capacity"Flux Control; Additivity; Threshold; Excess Capacity" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property.
