Difference between revisions of "OctPM pathway control state"

Revision as of 10:30, 8 November 2016

high-resolution terminology - matching measurements at high-resolution

OctPM pathway control state

Description

OctPM: Octanoylcarnitine & Pyruvate & Malate.

MitoPathway control state: FN

SUIT protocol: SUIT_FNSGp(PGM)01 - SUIT RP1, SUIT_FNSGp(PGM)02 - SUIT RP1

This substrate combination supports CI-linked flux which is typically higher than FAO capacity. In SUIT-RP1, PMOct is induced after PM(E), to evaluate any additive effect of adding Oct. In SUIT-RP2, FAO OXPHOS capacity is measured first, testing for the effect of increasing malate concentration (compare malate control state, M alone), and pyruvate is added to compare FAO as the background state with CI&FAO as the reference state.

Abbreviation: PMOct

Reference: MiPNet21.06 SUIT reference protocol

MitoPedia concepts: Respiratory state, SUIT state

OctPM(L)

OctPM(P)

SUIT_FNSGp(PGM)02_4P: 1D 2Oct 3Mtit&Mc (&McNADH) 4P 5G 6S 7U 8Gp 9Rot 10Ama 11Tm 12Azd

OctPM(E)

SUIT_FNSGp(PGM)01_4Oct: 1PM 2D&Dc (&DcNADH) 3U 4Oct 5G 6S 7Rot 8Gp 9Ama 10Tm 11Azd

@@ Line 3: / Line 3: @@
 |description='''OctPM''': [[Octanoylcarnitine]] & [[Pyruvate]] & [[Malate]].
-'''MitoPathway control:''' FAO<small>&</small>CI
+'''MitoPathway control state:''' FN
 '''SUIT protocol:''' [[SUIT_FNSGp(PGM)01]] - SUIT RP1, [[SUIT_FNSGp(PGM)02]] - SUIT RP1
@@ Line 16: / Line 16: @@
 == OctPM(P) ==
-# [[SUIT_FNSGp(PGM)02]]_'''4P''': 1D 2Oct 3Mtit&Mc (&McNADH) '''<u>4P</u>''' 5G 6S 7U 8Gp 9Rot 10Ama 11Tm 12Azd'''
+:::# [[SUIT_FNSGp(PGM)02]]_'''4P''': 1D 2Oct 3Mtit&Mc (&McNADH) '''<u>4P</u>''' 5G 6S 7U 8Gp 9Rot 10Ama 11Tm 12Azd'''
 == OctPM(E) ==
-# [[SUIT_FNSGp(PGM)01]]_'''4Oct''': 1PM 2D&Dc (&DcNADH) 3U '''<u>4Oct</u>''' 5G 6S 7Rot 8Gp 9Ama 10Tm 11Azd
+:::# [[SUIT_FNSGp(PGM)01]]_'''4Oct''': 1PM 2D&Dc (&DcNADH) 3U '''<u>4Oct</u>''' 5G 6S 7Rot 8Gp 9Ama 10Tm 11Azd
 ----