Difference between revisions of "Q-junction"
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{{MitoPedia | {{MitoPedia | ||
|abbr=Q | |abbr=Q | ||
|description=[[File: | |description=[[File:SUIT-Catg NFSGp.jpg|right|300px|Q-junction]] | ||
The '''Q-junction''' is a junction for [[convergent electron flow]] in the [[electron transfer system]] (ETS) from type N substrates through [[Complex I]] (CI),ย from succinate (S) through [[Complex II]] (CII), from type F substrates and FA oxidation through [[electron-transferring flavoprotein complex]] (CETF), from glycoreophosphate (Gp) thorugh[[glycerophosphate dehydrogenase complex]] (CGpDH), from choline through [[choline dehydrogenase]], from dihydro-orotate through [[dihydro-orotate dehydrogenase]], and other enzyme complexes into the Q-cycle (ubiquinol/ubiquinone), and further downstream to [[Complex III]] (CIII) and CIV. The concept of the Q-junction, with the [[N-junction]] and [[F-junction]] upstream, provides the rationale for defining [[categories of SUIT protocols]]. | The '''Q-junction''' is a junction for [[convergent electron flow]] in the [[electron transfer system]] (ETS) from type N substrates through [[Complex I]] (CI),ย from succinate (S) through [[Complex II]] (CII), from type F substrates and FA oxidation through [[electron-transferring flavoprotein complex]] (CETF), from glycoreophosphate (Gp) thorugh[[glycerophosphate dehydrogenase complex]] (CGpDH), from choline through [[choline dehydrogenase]], from dihydro-orotate through [[dihydro-orotate dehydrogenase]], and other enzyme complexes into the Q-cycle (ubiquinol/ubiquinone), and further downstream to [[Complex III]] (CIII) and CIV. The concept of the Q-junction, with the [[N-junction]] and [[F-junction]] upstream, provides the rationale for defining [[categories of SUIT protocols]]. | ||
|info=[[Gnaiger 2009 Int J Biochem Cell Biol]], [[Gnaiger 2014 MitoPathways]] | |info=[[Gnaiger 2009 Int J Biochem Cell Biol]], [[Gnaiger 2014 MitoPathways]] | ||
}} | }} | ||
{{MitoPedia methods | {{MitoPedia methods | ||
|mitopedia method=Respirometry | |mitopedia method=Respirometry | ||
}} | }} | ||
{{MitoPedia O2k and high-resolution respirometry | {{MitoPedia O2k and high-resolution respirometry | ||
|mitopedia O2k and high-resolution respirometry=SUIT protocol | |mitopedia O2k and high-resolution respirometry=SUIT protocol | ||
}} | }} | ||
{{MitoPedia topics | {{MitoPedia topics | ||
|mitopedia topic=Enzyme | |mitopedia topic=Enzyme | ||
}} | }} | ||
ย Contributed by [[Gnaiger E]] 2010-08-15, edited 2016-02-12. | ย Contributed by [[Gnaiger E]] 2010-08-15, edited 2016-02-12. |
Revision as of 11:01, 20 March 2016
Description
The Q-junction is a junction for convergent electron flow in the electron transfer system (ETS) from type N substrates through Complex I (CI), from succinate (S) through Complex II (CII), from type F substrates and FA oxidation through electron-transferring flavoprotein complex (CETF), from glycoreophosphate (Gp) thorughglycerophosphate dehydrogenase complex (CGpDH), from choline through choline dehydrogenase, from dihydro-orotate through dihydro-orotate dehydrogenase, and other enzyme complexes into the Q-cycle (ubiquinol/ubiquinone), and further downstream to Complex III (CIII) and CIV. The concept of the Q-junction, with the N-junction and F-junction upstream, provides the rationale for defining categories of SUIT protocols.
Abbreviation: Q
Reference: Gnaiger 2009 Int J Biochem Cell Biol, Gnaiger 2014 MitoPathways
MitoPedia methods:
Respirometry
MitoPedia O2k and high-resolution respirometry: "SUIT protocol" is not in the list (O2k hardware, DatLab, Oroboros QM, O2k-Open Support, O2k-Respirometry, O2k-FluoRespirometry) of allowed values for the "MitoPedia O2k and high-resolution respirometry" property.
SUIT protocol"SUIT protocol" is not in the list (O2k hardware, DatLab, Oroboros QM, O2k-Open Support, O2k-Respirometry, O2k-FluoRespirometry) of allowed values for the "MitoPedia O2k and high-resolution respirometry" property.
MitoPedia topics:
Enzyme
Contributed by Gnaiger E 2010-08-15, edited 2016-02-12.
- Convergent NS-linked electron flow at the Q-junction, exerting an additive effect on flux, versus electron gaiting for separation of single N- and S-input pathways (upper panel: Gnaiger 2009; lower panel: Hatefi 1962 J Biol Chem-XLII). Modified Fig. 1.5 in Gnaiger 2014 MitoPathways.