Difference between revisions of "Rojas-Morales 2019 Free Radic Biol Med"

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Latest revision as of 10:28, 16 August 2019

Publications in the MiPMap
Rojas-Morales P, León-Contreras JC, Aparicio-Trejo OE, Reyes- Ocampo JG, Medina-Campos ON, Jiménez-Osorio AS, González-Reyes S, Marquina- Castillo B, Hernández-Pando R, Barrera-Oviedo D, Sánchez-Lozada LG, Pedraza-Chaverri J, Tapia E (2019) Fasting reduces oxidative stress, mitochondrial dysfunction and fibrosis induced by renal ischemia-reperfusion injury. Free Radic Biol Med 135:60-67.

» PMID: 30818054

Rojas-Morales P, Leon-Contreras JC, Aparicio-Trejo OE, Reyes- Ocampo JG, Medina-Campos ON, Jimenez-Osorio AS, Gonzalez-Reyes S, Marquina-Castillo B, Hernandez-Pando R, Barrera-Oviedo D, Sanchez-Lozada LG, Pedraza-Chaverri J, Tapia E (2019) Free Radic Biol Med

Abstract: Food deprivation protects against ischemia-reperfusion (IR) injury through unknown mechanisms. In an experimental rat model of acute IR injury, we found that preoperative fasting for 3 days protects rats from tubular damage and renal functional decline by increasing antioxidant protection independently of the NF-E2-related factor 2 (Nrf2), and by maintaining mitochondrial morphology and function. In addition, further analysis revealed that fasting protects against tubulointerstitial fibrosis. In summary, our results point out to fasting as a robust nutritional intervention to limit oxidative stress and mitochondrial dysfunction in early acute kidney injury and also to promote long-term protection against fibrosis.

Keywords: Fasting, Oxidative stress, Mitochondrial dysfunction, Fibrosis, Ischemia-reperfusion injury, Acute kidney injury, Chronic kidney disease Bioblast editor: Plangger M O2k-Network Lab: MX Mexico City Pedraza Chaverri J


Labels: MiParea: Respiration, Exercise physiology;nutrition;life style 

Stress:Ischemia-reperfusion, Oxidative stress;RONS  Organism: Rat  Tissue;cell: Kidney  Preparation: Isolated mitochondria 

Regulation: mt-Membrane potential  Coupling state: LEAK, OXPHOS  Pathway:HRR: Oxygraph-2k, O2k-Fluorometer 

2019-02, Safranin