SRot

high-resolution terminology - matching measurements at high-resolution

SRot

Description

SRot: Succinate (S) supports electron flux through Complex II via flavin adenine dinucleotide (FADH2) into the membrane-bound electron transfer system. Inhibition of Complex I by rotenone (Rot; or amytal, piericidine) prevents accumulation of oxaloacetate which is a potent inhibitor of succinate dehydrogenase. After inhibition of CI by rotenone, the NADH-linked dehydrogenases become inhibited by the redox shift from NAD⁺ to NADH. Succinate dehydrogenase is activated by succinate and ATP, which explains in part the time-dependent increase of respiration in isolated mitochondria after addition of rotenone (first), succinate and ADP.

Abbreviation: SRot, CII

Reference: Gnaiger 2014 MitoPathways - Chapter 4.1

MitoPedia topics: "Respiratory substrate-coupling state" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property. Respiratory substrate-coupling state"Respiratory substrate-coupling state" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property. 

Succinate+rotenone, S(Rot). From Gnaiger 2014 MitoPathways.

SRot(L)

1. MiPNet12.11 MitoRespiration
2. Makrecka-Kuka 2015 Biomolecules

SRot(P)

1. MiPNet12.11 MitoRespiration
2. Makrecka-Kuka 2015 Biomolecules

SRot(E)

1. MiPNet12.11 MitoRespiration