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From Bioblast
- ...s JA, Sazanov LA (2015) Gaining mass: the structure of respiratory complex I-from bacterial towards mitochondrial versions. Curr Opin Struct Biol 33:135 ...a ∼3.8 Å resolution X-ray crystallographic study of mitochondrial complex I from yeast Yarrowia lipotytica. In this review we will discuss what we have1 KB (161 words) - 20:07, 6 November 2023
- ...anov LA (2005) Organization of iron-sulfur clusters in respiratory complex I. Science 309:771-4. https://doi.org/10.1126/science.1113988 ...for the interpretation of the large amounts of data accumulated on complex I.1 KB (165 words) - 20:08, 6 November 2023
- ...nner workings: The X-ray crystal structure of the entire bacterial complex I at 3.3 Å resolution offers fascinating insights into a giant 536 kDa molec |enzymes=Complex I848 bytes (121 words) - 10:27, 4 November 2023
- ...alemou Yoga E, Angerer H, Parey K, Zickermann V (2020) Respiratory complex I - Mechanistic insights and advances in structure determination. https://doi ...ress in structure determination and functional characterization of complex I and discuss current mechanistic models.2 KB (207 words) - 16:55, 22 March 2023
- ...chiller J, Zickermann V (2021) Ubiquinone binding and reduction by complex I-open questions and mechanistic implications. https://doi.org/10.3389/fchem. ...tively. We here review the current knowledge on the interaction of complex I with Q and discuss recent hypothetical models for the coupling mechanism.2 KB (216 words) - 16:15, 22 March 2023
- ...s and structural basis of conformational coupling in mitochondrial complex I. https://doi.org/10.1126/science.1191046 ...ere, we report an x-ray crystallographic analysis of mitochondrial complex I. The positions of all iron-sulfur clusters relative to the membrane arm wer1 KB (176 words) - 14:10, 29 March 2023
- ...mechanism: what have we learned from the structures of respiratory complex I. Biochem J 480:319-33. https://doi.org/10.1042/BCJ20210285 ...s of complex I. In this review I discuss the state of knowledge on complex I, including the current most controversial issues.2 KB (274 words) - 20:04, 6 November 2023
- ...5) Mechanistic insight from the crystal structure of mitochondrial complex I. https://doi.org/10.1126/science.1259859 ...nerative disorders. We report the x-ray structure of mitochondrial complex I at a resolution of 3.6 to 3.9 angstroms, describing in detail the central s2 KB (219 words) - 14:06, 28 March 2023
- ...a Zn-binding site and is essential for biogenesis of mitochondrial complex I. https://doi.org/10.1073/pnas.1424353112 ...UMM gene or mutation of Zn-binding residues blocked a late step of complex I assembly. An accumulating assembly intermediate lacked accessory subunit N72 KB (250 words) - 16:30, 27 March 2023
- ...Puentes Fabiola, Kip Maarten, Hilditch Laura, Walker Paul, Simone Michela I, Chan AW Edith, Towers Greg J, Coker Alun R, Duchen Michael R, Szabadkai Gy ...ibitor, JW47, using a quinolinium cation tethered to cyclosporine (CsA). X-ray analysis was used to validate the design concept and biological evaluation3 KB (349 words) - 20:10, 7 March 2020
- ...zed the active/deactive conformational transition of mitochondrial Complex I, which became a dynamic area of research in the studies of tissue ischemia/3 KB (345 words) - 09:25, 11 May 2024
- ...sup> ([Ca<sup>2+</sup>]<sub>i</sub>) and Zn<sup>2+</sup> [Zn<sup>2+</sup>]i in cells from 24-month-old rats were about 5-fold higher than those of cell ...increases in both [Ca<sup>2+</sup>]<sub>i</sub> and [Zn<sup>2+</sup>]<sub>i</sub>, which can in turn contribute to mechanical dysfunction of the heart.3 KB (492 words) - 09:57, 3 October 2017
- ...a decline in cardiac function and an increase in plasma levels of troponin-I, while no such changes were observed in ''Gsta4''-null mice. Radiation-indu2 KB (303 words) - 15:35, 7 November 2016
- ...miot A, Kenny H, Chery I, Zahariev A, Normand S, Crampes F, de Glisezinski I, Rochfort KD, Laurens C, Bareille MP, Simon C, Bergouignan A, Blanc S, O'Go ...up> ; 33.50 ± 8.541 years; n = 10). Indirect calorimetry and dual-energy x-ray absorptiometry were used for measures of energy expenditure, exercise capac3 KB (412 words) - 17:42, 13 December 2023
- |abstract=Over a decade has passed since the elucidation of the first X-ray crystal structure of any complex II homolog. In the intervening time, the s ::::* .. electrons enter the electron transport chain through either complex I or complex II. Complex II bridges the processes of oxidative phosphorylatio3 KB (362 words) - 15:41, 1 April 2023
- ...Cherian A, Goyal JP, Khadilkar A, Kumaravel V, Mohan V, Narayanappa D, Ray I, Yewale V (2015) Revised IAP growth charts for height, weight and body mass ...Cherian A, Goyal JP, Khadilkar A, Kumaravel V, Mohan V, Narayanappa D, Ray I, Yewale V5 KB (831 words) - 22:51, 8 March 2020
- ...er a 17-day period. 2) Body composition was determined using dual-energy X-ray absorptiometry and by measuring organ and skeletal muscle masses. 3) Mitoch ...rubinemic rats demonstrated increased flux control ratio (FCR) via complex I and II (CI+II) (Gunn: 0.78 ± 0.16 vs. Control: 0.62 ± 0.09, ''p'' < 0.05)4 KB (474 words) - 11:23, 8 July 2021
- ...ifically, RCR was lowest among children with HBP and low aerobic capacity (i.e., mean peak ˙''V''O2 -1SD). HOMA2-IR did not associate with measures of3 KB (384 words) - 15:17, 5 October 2023
- ...rials and methods. Male Wistar rats were subjected to irradiation with a X-ray YXLON Y.Tu 320-D03 irradiator, and the animals received a dose of 7.5 Gy/da ...pical gel melatonin. Melatonin decreases the expression of NF-kB, iNOS/i-mtNOS, NLRP3, ASC, caspase-1, and proinflammatory cytokines. Melaton3 KB (409 words) - 00:58, 10 February 2020
- ...nt mitochondrial flavoprotein dehydrogenases to the ubiquinone pool. The X-ray structure of the pig liver enzyme has been solved in the presence and absen ...rom carbohydrate and ketone body (β-hydroxybutyrate) oxidation via complex I of the main respiratory chain [10]. This potential for cross-talk may provi3 KB (483 words) - 08:17, 13 September 2023
- ...ne insulin sensitivity, and body composition was assessed by dual-energy x-ray absorptiometry (DEXA). |enzymes=Complex I, Complex II;succinate dehydrogenase, Complex III, Complex V;ATP synthase3 KB (472 words) - 10:31, 16 August 2018
- ...ed towards this study. Body composition was determined using dual energy X-ray absorptiometry (DXA). Muscle samples from the ''vastus lateralis'' were ana ...Gallagher PR, Lipman TH, Brooks LJ, Koren(2014) Insulin-like growth factor-I and insulin-like growth factor binding protein-1 are related to cardiovascu3 KB (468 words) - 13:29, 28 March 2018
- :::# Bunnett JF, Jones RAY (1988) Names for hydrogen atoms, ions, and groups, and for reactions involv :::# Cohen ER, Cvitas T, Frey JG, Holmström B, Kuchitsu K, Marquardt R, Mills I, Pavese F, Quack M, Stohner J, Strauss HL, Takami M, Thor HL (2008) Quantit6 KB (902 words) - 08:22, 17 July 2023
- ...E) strength (Nm), grip strength (kg), leg lean mass (kg, via dual energy X-ray absorptiometry [DXA]), muscle quality (Nm/kg), and plasma IL-6 (pg/mL) were ...Grip strength (kg) plotted against (G) SRC, (H) Maximal Respiration, and (I) Basal Respiration in peripheral blood mononuclear cells.5 KB (714 words) - 08:08, 25 October 2016
- ...dering the fact that numerous studies have pointed at mitochondria complex I as a target in the metformin-induced inhibitory effects on cancer progressi ...) or both at 24 hours prior to the irradiation (2 Gy/min, 1 min) with an X-ray generator. After irradiation the cells were incubated for further 24 hours.9 KB (1,293 words) - 04:19, 12 February 2020
- :::# '''[[#Chapter 4. NADH-linked pathways through Complex I: respiratory pathway control with pruvate, glutamate, malate |NADH-linked p :::: I thank all collaborators of the NextGen-O2k project and the authors and coau89 KB (12,074 words) - 17:54, 6 May 2024