Talk:Granata 2022 Abstract Bioblast
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Comment by the Reviewers
Donnelly Chris 2022-05-30
- A reservation about the abstract in this format would be that the third paragraph is rather dense with information. It could benefit from breaking up/condensing some of this to align with the main point. In particular the first sentence of this paragraph is four lines long and mentions that increases in mitochondrial content drive increases in mitochondrial content. I'm not sure this makes sense, but I may be wrong.
Moreno-Sanchez Rafael 2022-06-01
- This study analyzes the exercise-induced mitochondrial adaptations in human skeletal muscle by applying a multi-omics experimental approach. The results concisely summarized seem interesting and deserve to be published. However, a couple of issues appear to require clarification. One is the apparent non-linear or non-proportional relationship found between the OXPHOS enzyme contents and the respective mRNA levels. This is not surprising, and it has been documented (doi: 10,1111/febs.13535). If this is what it was observed, then it should be clearly stated in the abstract. Other relationships might be established, and described in the abstract, such as that between enzyme content and activity, or enzyme activity and pathway flux.
- The second minor issue is regarding the approach used. It is mentioned that a multi-omics approach was used, together with “classical biological techniques”, in which metabolic pathway fluxes (fluxomics) and enzyme activities (kinetomics) were assessed. These last two experimental approaches may also be classified as omics approaches.
