Difference between revisions of "Uncoupler"
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Revision as of 11:01, 9 August 2011
- high-resolution terminology - matching measurements at high-resolution
Uncoupler
Description
An uncoupler is a protonophore (FCCP, CCCP, DNP) which cycles across the inner mt-membrane with transport of protons and dissipation of the electrochemical proton gradient. Mild uncoupling may be induced at low uncoupler concentrations, the non-coupled state of ETS capacity is obtained at optimum uncoupler concentration for maximum flux, whereas at higher concentrations an uncoupler-induced inhibition is observed.
See also:
Abbreviation: u
MitoPedia topics:
Uncoupler
