Difference between revisions of "Uncoupler"
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{{MitoPedia | {{MitoPedia | ||
|abbr=u | |abbr=''u'' | ||
|description=An '''uncoupler''' is a protonophore ([[FCCP]], [[CCCP]], [[DNP]]) which cycles across the inner mt-membrane with transport of protons and dissipation of the electrochemical proton gradient. Mild uncoupling may be induced at low uncoupler concentrations, the non-coupled state of ETS capacity is obtained at optimum uncoupler concentration for maximum flux, whereas at higher concentrations an uncoupler-induced inhibition is observed. | |description=An '''uncoupler''' is a protonophore ([[FCCP]], [[CCCP]], [[DNP]]) which cycles across the inner mt-membrane with transport of protons and dissipation of the electrochemical proton gradient. Mild uncoupling may be induced at low uncoupler concentrations, the non-coupled state of ETS capacity is obtained at optimum uncoupler concentration for maximum flux, whereas at higher concentrations an uncoupler-induced inhibition is observed. See also: [[Uncoupled respiration]]. | ||
|info=http://www.bmb.leeds.ac.uk/illingworth/oxphos/poisons.htm | |info=http://www.bmb.leeds.ac.uk/illingworth/oxphos/poisons.htm | ||
|type=Chemicals | |type=Chemicals | ||
}} | }} | ||
{{Labeling | {{Labeling | ||
|instruments=Chemicals; Media | |||
|discipline=Mitochondrial Physiology | |||
|kinetics=Inhibitor; Uncoupler | |kinetics=Inhibitor; Uncoupler | ||
}} | }} | ||
Revision as of 12:40, 16 September 2010
- high-resolution terminology - matching measurements at high-resolution
Uncoupler
Description
An uncoupler is a protonophore (FCCP, CCCP, DNP) which cycles across the inner mt-membrane with transport of protons and dissipation of the electrochemical proton gradient. Mild uncoupling may be induced at low uncoupler concentrations, the non-coupled state of ETS capacity is obtained at optimum uncoupler concentration for maximum flux, whereas at higher concentrations an uncoupler-induced inhibition is observed. See also: Uncoupled respiration.
Abbreviation: u
Reference: http://www.bmb.leeds.ac.uk/illingworth/oxphos/poisons.htm
Labels:
HRR: Chemicals; Media"Chemicals; Media" is not in the list (Oxygraph-2k, TIP2k, O2k-Fluorometer, pH, NO, TPP, Ca, O2k-Spectrophotometer, O2k-Manual, O2k-Protocol, ...) of allowed values for the "Instrument and method" property.
