Difference between revisions of "Uncoupler"
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{{MitoPedia | {{MitoPedia | ||
|abbr=''u'' | |abbr=''u'' | ||
|description=An '''uncoupler''' is a protonophore ([[FCCP]], [[CCCP]], [[DNP]]) which cycles across the inner mt-membrane with transport of protons and dissipation of the electrochemical proton gradient. Mild uncoupling may be induced at low uncoupler concentrations, the non-coupled state of ETS capacity is obtained at optimum uncoupler concentration for maximum flux, whereas at higher concentrations an uncoupler-induced inhibition is observed. See also: [[Uncoupled respiration]] | |description=An '''uncoupler''' is a protonophore ([[FCCP]], [[CCCP]], [[DNP]]) which cycles across the inner mt-membrane with transport of protons and dissipation of the electrochemical proton gradient. Mild uncoupling may be induced at low uncoupler concentrations, the non-coupled state of ETS capacity is obtained at optimum uncoupler concentration for maximum flux, whereas at higher concentrations an uncoupler-induced inhibition is observed. | ||
See also: | |||
*[[Uncoupled respiration]] | |||
*[[Uncoupler titration]] | |||
|type=Chemicals | |type=Chemicals | ||
}} | }} | ||
Revision as of 12:42, 16 September 2010
- high-resolution terminology - matching measurements at high-resolution
Uncoupler
Description
An uncoupler is a protonophore (FCCP, CCCP, DNP) which cycles across the inner mt-membrane with transport of protons and dissipation of the electrochemical proton gradient. Mild uncoupling may be induced at low uncoupler concentrations, the non-coupled state of ETS capacity is obtained at optimum uncoupler concentration for maximum flux, whereas at higher concentrations an uncoupler-induced inhibition is observed.
See also:
Abbreviation: u
Labels:
HRR: Chemicals; Media"Chemicals; Media" is not in the list (Oxygraph-2k, TIP2k, O2k-Fluorometer, pH, NO, TPP, Ca, O2k-Spectrophotometer, O2k-Manual, O2k-Protocol, ...) of allowed values for the "Instrument and method" property.
