Difference between revisions of "Weissig 2015 Methods Mol Biol I"
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{{Publication | {{Publication | ||
|title=Weissig V, Edeas M (eds) (2015) Mitochondrial medicine. Methods Mol Biol 1264:1-480. | |title=Weissig V, Edeas M (eds) (2015) Mitochondrial medicine. Methods Mol Biol 1264:1-480. | ||
|info=[http://link.springer.com/book/10.1007/978-1-4939-2257-4#page=334] | |info=[http://link.springer.com/book/10.1007/978-1-4939-2257-4#page=334 Springer] | ||
|authors=Weissig V, Edeas M (eds) | |authors=Weissig V, Edeas M (eds) | ||
|year=2015 | |year=2015 | ||
|journal=Methods Mol Biol | |journal=Methods Mol Biol | ||
| | |prefacet=Mitochondrial Medicine is an interdisciplinary and rapidly growing new area of biomedical | ||
research comprising genetic, biochemical, pathological, and clinical studies aimed at the | research comprising genetic, biochemical, pathological, and clinical studies aimed at the | ||
diagnosis and therapy of human diseases which are either caused by or associated with mito- | diagnosis and therapy of human diseases which are either caused by or associated with mito- | ||
| Line 29: | Line 29: | ||
diagnosis and therapy of human diseases which are either caused by or associated with mito- | diagnosis and therapy of human diseases which are either caused by or associated with mito- | ||
chondrial dysfunction. The term “Mitochondrial Medicine” was probably used for the fi | chondrial dysfunction. The term “Mitochondrial Medicine” was probably used for the fi | ||
rst | rst time by Rolf Luft [1] who is widely accepted as the father of Mitochondrial Medicine. Over | ||
time by Rolf Luft [1] who is widely accepted as the father of Mitochondrial Medicine. Over | 50 years ago, it was he who described for the very first time a patient with clinical symptoms | ||
50 years ago, it was he who described for the very | caused by malfunctioning mitochondria [2]. The beginning of mitochondria-related research dates back to the end of the nine- | ||
caused by malfunctioning mitochondria [2]. | |||
The beginning of mitochondria-related research dates back to the end of the nine- | |||
teenth century. During the 1890s, early cytological studies revealed the existence of | teenth century. During the 1890s, early cytological studies revealed the existence of | ||
bacteria- | bacteria-resembling subcellular particles in the cytosol of mammalian cells. Robert Altman | ||
resembling subcellular particles in the cytosol of mammalian cells. Robert Altman | |||
termed them bioblasts, and he hypothesized that these particles were the basic unit of cel- | termed them bioblasts, and he hypothesized that these particles were the basic unit of cel- | ||
lular activity. The name mitochondrion, which means thread-like particles, was coined in | lular activity. The name mitochondrion, which means thread-like particles, was coined in | ||
1898 by Carl Benda. During the 1940s, progress was made in the development of cell | 1898 by Carl Benda. During the 1940s, progress was made in the development of cell | ||
fractionation techniques which ultimately allowed the isolation of intact mitochondria from cell homogenates, thereby making them more accessible to biochemical studies. Subsequently, by the end of the 1940s, activities of a variety of enzymes needed for fatty acid oxidation, the Krebs cycle, and other metabolic pathways were found to be associated with mitochondrial fractions. | fractionation techniques which ultimately allowed the isolation of intact mitochondria from cell homogenates, thereby making them more accessible to biochemical studies. Subsequently, by the end of the 1940s, activities of a variety of enzymes needed for fatty acid oxidation, the Krebs cycle, and other metabolic pathways were found to be associated with mitochondrial fractions. | ||
... | |||
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Revision as of 09:34, 4 February 2015
| Weissig V, Edeas M (eds) (2015) Mitochondrial medicine. Methods Mol Biol 1264:1-480. |
» Springer
Weissig V, Edeas M (eds) (2015) Methods Mol Biol
Abstract:
Labels: MiParea: Respiration, mt-Medicine, Patients
HRR: Oxygraph-2k
