Weissig 2015 Methods Mol Biol I

Weissig V, Edeas M (eds) (2015) Mitochondrial medicine. Methods Mol Biol 1264:1-480.

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Weissig V, Edeas M (eds) (2015) Methods Mol Biol

Abstract: Mitochondrial Medicine is an interdisciplinary and rapidly growing new area of biomedical research comprising genetic, biochemical, pathological, and clinical studies aimed at the diagnosis and therapy of human diseases which are either caused by or associated with mito- chondrial dysfunction. The term “Mitochondrial Medicine” was probably used for the fi rst time by Rolf Luft [1] who is widely accepted as the father of Mitochondrial Medicine. Over 50 years ago, it was he who described for the very fi rst time a patient with clinical symptoms caused by malfunctioning mitochondria [2]. The beginning of mitochondria-related research dates back to the end of the nine- teenth century. During the 1890s, early cytological studies revealed the existence of bacteria- resembling subcellular particles in the cytosol of mammalian cells. Robert Altman termed them bioblasts, and he hypothesized that these particles were the basic unit of cel- lular activity. The name mitochondrion, which means thread-like particles, was coined in 1898 by Carl Benda. During the 1940s, progress was made in the development of cell fractionation techniques which ultimately allowed the isolation of intact mitochondria from cell homogenates, thereby making them more accessible to biochemical studies. Subsequently, by the end of the 1940s, activities of a variety of enzymes needed for fatty acid oxidation, the Krebs cycle, and other metabolic pathways were found to be associated with mitochondrial fractions. Mitochondrial Medicine is an interdisciplinary and rapidly growing new area of biomedical research comprising genetic, biochemical, pathological, and clinical studies aimed at the diagnosis and therapy of human diseases which are either caused by or associated with mito- chondrial dysfunction. The term “Mitochondrial Medicine” was probably used for the fi rst time by Rolf Luft [1] who is widely accepted as the father of Mitochondrial Medicine. Over 50 years ago, it was he who described for the very fi rst time a patient with clinical symptoms caused by malfunctioning mitochondria [2]. The beginning of mitochondria-related research dates back to the end of the nine- teenth century. During the 1890s, early cytological studies revealed the existence of bacteria- resembling subcellular particles in the cytosol of mammalian cells. Robert Altman termed them bioblasts, and he hypothesized that these particles were the basic unit of cel- lular activity. The name mitochondrion, which means thread-like particles, was coined in 1898 by Carl Benda. During the 1940s, progress was made in the development of cell fractionation techniques which ultimately allowed the isolation of intact mitochondria from cell homogenates, thereby making them more accessible to biochemical studies. Subsequently, by the end of the 1940s, activities of a variety of enzymes needed for fatty acid oxidation, the Krebs cycle, and other metabolic pathways were found to be associated with mitochondrial fractions.

Labels: MiParea: Respiration, mt-Medicine, Patients 

HRR: Oxygraph-2k