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Scott 2013 Abstract MiP2013
Additional label MiP2013  +
Coupling states LEAK  + , OXPHOS  +
Has abstract The hypoxic and cold environment at high a
The hypoxic and cold environment at high altitudes requires endothermic animals to sustain high rates of O2 consumption for both locomotion and thermogenesis while facing a diminished O2 supply. We are examining the mitochondrial mechanisms of genotypic adaptation and phenotypic plasticity that help maintain ATP supply during hypoxia in high-altitude birds and mammals. Respiratory capacity, cytochrome oxidase activity, phosphorylation efficiency, oxygen kinetics, and several other variables were measured in mitochondria isolated from the flight muscle of bar-headed geese and the hindlimb muscle of highland deer mice, and each were compared to closely-related lowland taxa. Our results suggest that several mitochondrial adaptations, coupled with enhanced mitochondrial O2 supply, contribute to performance in hypoxia.
ply, contribute to performance in hypoxia.  +
Has title Scott GR, Mahalingam S, McClelland GB(2013) Mitochondrial adaptations to hypoxia in high-altitude birds and mammals. Mitochondr Physiol Network 18.08.  +
Instrument and method Oxygraph-2k  +
Mammal and model Other mammals  + , Birds  +
MiP area Respiration  + , Comparative MiP;environmental MiP  + , Exercise physiology;nutrition;life style  +
Preparation Isolated mitochondria  + , Enzyme  +
Respiration and regulation Oxygen kinetics  +
Tissue and cell Skeletal muscle  +
Was published by MiPNetLab CA Hamilton Scott GR +
Was submitted in year 2013  +
Was submitted to event MiPNet18.08 MiP2013 +
Was written by Scott GR + , Mahalingam S + , McClelland GB +
Categories Abstracts
Modification date
"Modification date" is a predefined property that corresponds to the date of the last modification of a subject and is provided by Semantic MediaWiki.
09:23:03, 28 April 2017  +
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