Difference between revisions of "Carnitine"

Revision as of 17:48, 2 October 2014

high-resolution terminology - matching measurements at high-resolution

Carnitine

Description

Carnitine is important factor for the transport of long-chain fatty acids bound to carnitine (carnitine acyltransferase) into the mitochondrial matrix for subsequent β-oxidation. There are two enantiomers: D- and L-carnitine. Only the L-isomer is physiologically active.

MitoPedia topics: Substrate and metabolite

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 {{MitoPedia
-|abbr=
+|description='''Carnitine''' is important factor for the transport of long-chain fatty acids bound to carnitine ([[carnitine acyltransferase]]) into the mitochondrial matrix for subsequent β-oxidation. There are two enantiomers: D- and L-carnitine. Only the L-isomer is physiologically active.
-|description='''Carnitine''' is important factor for long-chain fatty acids transport into the mitochondrial matrix for subsequent β-oxidation. There are two enantiomers: D- and L-carnitine; however, only L-isomer is physiologically active.
 |type=Substrate ETS
 }}
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 |type=Substrate ETS
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-Carnitine acyltransferases mediate the transport of long-chain fatty acids across the membrane by binding them to carnitine.
-First, long-chain fatty acids are activated by an energy-requiring step in which the fatty acid ester of CoA is formed enzymatically at the expense of ATP. The fatty acids then pass through the inner membrane and enter the mitochondria as esters of the compound carnitine. The fatty acyl group is then transferred from carnitine to intramitochondrial CoA and the resulting fatty acyl CoA is then used as a substrate by the fatty acid oxidation cycle, which occurs in the inner matrix compartment.