Difference between revisions of "GM-pathway control state"
From Bioblast
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|description=[[File:GM.jpg|left|200px|GM]] '''GM''': [[Glutamate]] & [[Malate]]. | |description=[[File:GM.jpg|left|200px|GM]] '''GM''': [[Glutamate]] & [[Malate]]. | ||
'''MitoPathway control:''' | '''MitoPathway control state:''' N | ||
When glutamate&malate are added to isolated mitochondria or permeabilized cells, glutamate and transaminase are responsible for the metabolism of [[oxaloacetate]], comparable to the metabolism with acetyl-CoA and citrate synthase | When glutamate&malate are added to isolated mitochondria or permeabilized cells, glutamate and transaminase are responsible for the metabolism of [[oxaloacetate]], comparable to the metabolism with acetyl-CoA and citrate synthase. | ||
|info=[[Gnaiger 2014 MitoPathways |Gnaiger 2014 MitoPathways - Chapter 3.4]] | |info=[[Gnaiger 2014 MitoPathways |Gnaiger 2014 MitoPathways - Chapter 3.4]] | ||
}} | }} | ||
{{MitoPedia concepts}} | {{MitoPedia concepts | ||
|mitopedia concept=Respiratory state, SUIT state | |||
}} | |||
{{MitoPedia methods}} | {{MitoPedia methods}} | ||
{{MitoPedia O2k and high-resolution respirometry | {{MitoPedia O2k and high-resolution respirometry}} | ||
|mitopedia | {{MitoPedia topics | ||
|mitopedia topic=Substrate and metabolite | |||
}} | }} | ||
== GM(L) == | == GM(L) == | ||
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== Discussion == | == Discussion == | ||
In human skeletal muscle mitochondria, respiration with GM in the presence of ADP (GM(P)) is identical or 10% higher than with PM (PM(P)). These results on isolated mitochondria agree with permeabilized fibres, although there are reports on respiratory capacity for PMP being 16% to 25% higher than for GM(P). In fibroblasts, GM(P) supports a higher respiratory flux than PM(P). | :::: In human skeletal muscle mitochondria, respiration with GM in the presence of ADP (GM(P)) is identical or 10% higher than with [[PM]] (PM(P)). These results on isolated mitochondria agree with permeabilized fibres, although there are reports on respiratory capacity for PMP being 16% to 25% higher than for GM(P). In fibroblasts, GM(P) supports a higher respiratory flux than PM(P). | ||
Revision as of 13:29, 8 November 2016
- high-resolution terminology - matching measurements at high-resolution
GM-pathway control state
Description
MitoPathway control state: N
When glutamate&malate are added to isolated mitochondria or permeabilized cells, glutamate and transaminase are responsible for the metabolism of oxaloacetate, comparable to the metabolism with acetyl-CoA and citrate synthase.
Abbreviation: GM
Reference: Gnaiger 2014 MitoPathways - Chapter 3.4
MitoPedia concepts:
Respiratory state,
SUIT state
MitoPedia topics:
Substrate and metabolite
GM(L)
GM(P)
GM(E)
Discussion
- In human skeletal muscle mitochondria, respiration with GM in the presence of ADP (GM(P)) is identical or 10% higher than with PM (PM(P)). These results on isolated mitochondria agree with permeabilized fibres, although there are reports on respiratory capacity for PMP being 16% to 25% higher than for GM(P). In fibroblasts, GM(P) supports a higher respiratory flux than PM(P).
