- high-resolution terminology - matching measurements at high-resolution
GM-pathway control state
Description
MitoPathway control state: N
When glutamate&malate are added to isolated mitochondria or permeabilized cells, glutamate and transaminase are responsible for the metabolism of oxaloacetate, comparable to the metabolism with acetyl-CoA and citrate synthase.
Abbreviation: GM
Reference: Gnaiger 2014 MitoPathways - Chapter 3.4
MitoPedia concepts:
Respiratory state,
SUIT state
MitoPedia topics:
Substrate and metabolite
GM(L)
GM(P)
GM(E)
Discussion
- In human skeletal muscle mitochondria, respiration with GM in the presence of ADP (GM(P)) is identical or 10% higher than with PM (PM(P)). These results on isolated mitochondria agree with permeabilized fibres, although there are reports on respiratory capacity for PMP being 16% to 25% higher than for GM(P). In fibroblasts, GM(P) supports a higher respiratory flux than PM(P).
