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• Loew 1963 Biochim Biophys Acta  + ( # The reduction of added DPN by succinate … </br># The reduction of added DPN by succinate catalyzed by submitochondrial particles from beef heart has been studied.</br># The reduction was endergonic and required specifically the addition of ATP.</br># The reaction had a limited specificity for electron acceptors; six DPN analogues tested were reduced at the same rate or nearly the same rate, as was DPN. TPN was only reduced at a very slow rate.</br># The rate of reduction was influenced by phosphate and ADP and their effects became pronounced if added together.</br># The effect of DPNH was marked only if added in a concentration equal to or exceeding that of DPN.</br># Respiratory inhibitors acting in the flavin region of the respiratory chain blocked the reaction.</br>the respiratory chain blocked the reaction. )
• Slater 1953 Biochem J  + ( # The α-ketoglutaric oxidase system of he … </br># The α-ketoglutaric oxidase system of heartmuscle sarcosomes has a pH optimum at 7.4. The yield of oxidative phosphorylation (P:O ratio) is unchanged between pH 6.2 and 7.7.</br># Hypertonic sucrose (0.88 M) is an inhibitor of the succinic oxidase system in the Keilin & Hartree preparation. Its major effect appears to be on the accessibility of both the endogenous and added cytochrome ''c'' to the other components of the system.</br># Maximum activity of the α-ketoglutaric oxidase system of heart-muscle sarcosomes is obtained under the most highly hypotonic conditions studied, equivalent to about one-third isotonic. Under these conditions, sarcosomes are swollen, but shrink again when placed in isotonic medium. The effect of tonicity on the activity of the α-ketoglutaric oxidase system is also reversible. </br># As the tonicity is increased by saline, sucrose or phosphate, the activity of the α-ketoglutaric oxidase system decreases.</br># The P:O ratio is not affected over a wide range of sucrose concentrations which have a marked effect on the activity of the α-ketoglutaric oxidase system. This and other examples where the oxidase system is more sensitive than the P:O ratio to variations of the conditions indicates that the phosphorylative enzymes are normally in excess of the purely oxidative enzymes and increases the likelihood that measurements of the yield of oxidative phosphorylation on isolated tissue preparations represent the state of affairs in the cell. </br># Phosphate, in high concentration, decreases the P:O ratio; the optimal concentration is 0.03 M. </br># Hypertonic sucrose is unsuitable for the isolation of sarcosomes. There is, however, no significant difference between sarcosomes isolated with isotonic sucrose and isotonic saline, except that the latter are deficient in cytochrome ''c''.</br>t the latter are deficient in cytochrome ''c''. )
• Gear 1970 Biochem J  + ( # [[Mitochondrial marker enzymes|Marker enzymes]] … </br># [[Mitochondrial marker enzymes|Marker enzymes]] for the mitochondrial matrix, inner membrane, inter-membrane space and outer membrane were measured in mitochondria isolated from control and regenerating rat liver. The specific activity of these enzymes was then followed for up to 30 days after operation. </br># The specific activity of marker enzymes for the matrix, inner membrane and inter-membrane space remained constant during liver regeneration.</br># However, the specific activities of monoamine oxidase and kynurenine hydroxylase, both outer-membrane markers, fell by 67% and 49% respectively from their control values at 4 days after operation, and returned to normal by about 3 weeks.</br># The repression of kynurenine hydroxylase activity was shown to be unrelated to any independent variation in tryptophan catabolism, based on tryptophan pyrrolase assays.</br># These results are considered to indicate that enzymes of the inner and outer mitochondrial membranes are synthesized asynchronously during morphogenesis.</br># The enzyme complement of purified outer membrane at 4 days after operation was about 50% of that of the appropriate control. Thus the composition of the outer membrane itself may vary dramatically, and supports the concept that constitutive enzymes may turn over independently of a membrane's existence.</br># The behaviour of the rotenone-insensitive, NADH cytochrome c reductase did not parallel the other outer-membrane enzymes for intact mitochondria, but did so when assayed in highly purified fractions of outer membrane. This suggests a labile binding to the outer membrane during the early stages of morphogenesis.</br># Electrophoresis of inner- and outer-membrane proteins revealed little difference between control and experimental mitochondria at 4 days, except for an increase in several, high-molecular-weight components of the outer membrane. These bands closely correspond to similar bands derived from smooth endoplasmic reticulum.</br># The results are discussed in relation to the biogenesis and turnover of mitochondria, and are considered to provide evidence for turnover as a unit, at least for the matrix, inner membrane, inter-membrane space and possibly some form of primary outer membrane.</br>ssibly some form of primary outer membrane. )
• Burtscher 2022 Antioxid Redox Signal  + ('''''Significance:''''' Oxygen is indispen … '''''Significance:''''' Oxygen is indispensable for aerobic life, but its utilization exposes cells and tissues to oxidative stress; thus, tight regulation of cellular, tissue, and systemic oxygen concentrations is crucial. Here, we review the current understanding of how the human organism (mal-)adapts to low (hypoxia) and high (hyperoxia) oxygen levels and how these adaptations may be harnessed as therapeutic or performance enhancing strategies at the systemic level. </br></br>'''''Recent Advances:''''' Hyperbaric oxygen therapy is already a cornerstone of modern medicine, and the application of mild hypoxia, that is, hypoxia conditioning (HC), to strengthen the resilience of organs or the whole body to severe hypoxic insults is an important preparation for high-altitude sojourns or to protect the cardiovascular system from hypoxic/ischemic damage. Many other applications of adaptations to hypo- and/or hyperoxia are only just emerging. HC-sometimes in combination with hyperoxic interventions-is gaining traction for the treatment of chronic diseases, including numerous neurological disorders, and for performance enhancement. </br></br>'''''Critical Issues:''''' The dose- and intensity-dependent effects of varying oxygen concentrations render hypoxia- and/or hyperoxia-based interventions potentially highly beneficial, yet hazardous, although the risks versus benefits are as yet ill-defined. </br></br>'''''Future Directions:''''' The field of low and high oxygen conditioning is expanding rapidly, and novel applications are increasingly recognized, for example, the modulation of aging processes, mood disorders, or metabolic diseases. To advance hypoxia/hyperoxia conditioning to clinical applications, more research on the effects of the intensity, duration, and frequency of altered oxygen concentrations, as well as on individual vulnerabilities to such interventions, is paramount.ities to such interventions, is paramount.)
• MiP2017/MitoEAGLE Hradec Kralove CZ  + ('''12^th Conference … '''12^th Conference on Mitochondrial Physiology and MitoEAGLE WG and MC Meeting, 2017, Hradec Kralove, Czech Republic.'''</br></br>Co-organized with COST Action MitoEAGLE: [[COST_Action_MitoEAGLE#Grant_periods |Management Committee Meeting and Working Group Meetings]].[[COST_Action_MitoEAGLE#Grant_periods |Management Committee Meeting and Working Group Meetings]].)
• MiP2018/MitoEAGLE Jurmala LV  + ('''13^th Conference on Mitochondrial Physiology and MitoEAGLE WG and MC Meeting, 2018, Jurmala, Latvia.''')
• IOC13  + ('''13th Workshop on High-Resolution Respirometry.''' Innsbruck, Tyrol, Austria; 1997 May 09-16. :>> O2k-Workshop: [[Oroboros Events| Current dates]] :>> Product: [[Oroboros O2k]], [[Oroboros O2k-Catalogue | O2k-Catalogue]])
• ASMRM 2017 Xian CN  + ('''14^thConference of the Asian Society of Mitochondrial Research and Medicine'''. Xi'an, Shaanxi, China; 2017 September.)
• IOC16  + ('''16th International Course on High-Resolution Respirometry.''' Innsbruck, Tyrol, Austria; 1998 December 10. :>> O2k-Workshop: [[Oroboros Events| Current dates]] :>> Product: [[Oroboros O2k]], [[Oroboros O2k-Catalogue | O2k-Catalogue]])
• EBEC2016 Riva del Garda IT  + ('''19^th European Bioenergetics Conference 2016, Riva del Garda, IT''')

• MitoEAGLE MC Meeting 2016 Brussels BE  + ('''1^st MC Meeting, [[COST Action MitoEAGLE]], Brussels, BE''')

• 1st Workshop on Mitochondrial Functional Diagnostics Innsbruck AT  + ('''1st Workshop on Mitochondrial Functional Diagnostics - PBMCs.''' Innsbruck, Austria, 2023)
• MitoFit Science Camp 2016 Kuehtai AT  + ('''2016 Jul 07-13, Kuehtai, AT.''' The pr … '''2016 Jul 07-13, Kuehtai, AT.''' </br>The project [[K-Regio MitoFit |MitoFit]] aims at developing novel laboratory standards and diagnostic monitoring of a mitochondrial fitness score. With an international team of outstanding mitochondrial experts, the '''MitoFit Science Camp''' will provide a unique opportunity to receive first-hand introductions to state-of-the-art diagnostic monitoring of mitochondrial respiratory function combined with hands-on training on HRR (IOC112). Diverse areas are covered such as protective medicine, exercise physiology, mitochondrial pharmacology, aging, and comparative mitochondrial physiology (cell types, tissues, species). The common focus is on methodology, experimental details and quality control. The MitoFit Science Camp is a student- and research-oriented even, and may be considered as a sequence of workshops rather than a conference or school, addressing key topics of the COST Action [[MitoEAGLE]] project. This will provide a key opportunity to prepare the [[COST Action MitoEAGLE |1^st Management Committee Meeting]].[[COST Action MitoEAGLE |1^st Management Committee Meeting]].)
• MiPschool Obergurgl 2017  + ('''2017 Jul 23-30, Obergurgl, AT.''')
• MitoEAGLE Obergurgl 2017  + ('''2017 Jul 27-30, Obergurgl, AT.''')
• Padua-Mit-Innsbruck2017 Padua IT  + ('''2^nd Padua-Mit-Innsbruck “Mitochondrial Conference”. Pauda, Italy; 2017 September.)
• 2nd Workshop on Mitochondrial Functional Diagnostics Innsbruck AT  + ('''2nd Workshop on Mitochondrial Functional Diagnostics - Diagnostic database''' Innsbruck, Austria, 2023)
• Mitochondira in Health and Disease 2017 NY US  + ('''2nd symposium Mitochondria in Health and Disease'''. New York, US; 2017.)
• MiPschool Cambridge UK 2012  + ('''5^th MiP''school'' on Mitochondrial Physiology, 2012 Jul 09-13, Cambridge, UK.''')
• MiP2007 Ambleside UK  + ('''64^th Harden Conference on: Mitochondrial Physiology, 2007, Ambleside , United Kingdom.''')
• Harden Conference 2016 Innsbruck AT  + ('''79^th Harden Conference: Oxygen Evolution and Reduction - Common Principles, [https://www.biochemistry.org/Events/tabid/379/MeetingNo/79HDN/view/Conference/Default.aspx Harden Conference 2016], Innsbruck, AT''')