Talk:MitoEAGLE Verona 2016

News and Events

Working Groups

Short-Term Scientific Missions

Management Committee

Members

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COST Action CA15203 (2016-2021): MitoEAGLE
Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping

Talk:MitoEAGLE Verona 2016

Suggestions and topics of discussion

Next Management Committee Meeting in an Inclusiveness Target Country, Grant Period 2

• Gnaiger E

1. I suggest that we plan one MC Meeting per Grant Period.
2. The MC Meeting should not be too late in the Grant Period, to take early decisions on next MITOEAGLE events and STSM. But it should neither be too close to the Barcelona MC Meeting in March 2017. Therefore, Nov 2017 might be optimum.
3. The Czech Republic as an Inclusiveness Target Country might be considered for the Nov 2017 MC Meeting. This was raised in correspondence with Zuzana Cervinkova.

Dissemination plan

• Makrecka-Kuka M 2016-10-26 Dissemination plan MITOEAGLE.docx (File:Dissemination plan MITOEAGLE.docx)

• All dissemination activities have to follow the specific dissemination rules.

• Gnaiger E 2016-10-26

1. www.mitoeagle.eu – I would strongly prefer www.mitoeagle.org, since the project has a global dimension beyond eu, which is emphasized by the link to the Mitochondrial Physiology Society. However, perhaps you have in mind some specific advantages of ‚eu‘?
2. Password-protected section only accessible to the Action members – I do not consider this as a good option for a COST Action, with full emphasis on Open Accress. Where do you see a need for restricted access?
3. It will be important to break down the dissemination plan into phases coherent with the Grant Periods of our Action, such that the Budget Plans can be prepared according to realistic aims - with volunteers taking responsibility for completing the tasks. The budget for 'Financial and Scientific Administration and Coordination' allocated to the Grant Holder is entirely insufficient to fully administrate the dissemination plan.

Implementation strategy

• COST provides the following examples:

1. Leadership roles
2. Organising and locating MITOEAGLE meetings and events in Inclusiveness Target Countries
3. Benefiting from COST networking tools
4. Promoting STSMs
5. Action Think Tank for Early Career Investigators

• • • • Allocation of funding to promote participation in MITOEAGLE events

• Gnaiger E 2016-10-27

1. Core Group (CG) and Management Committee (MC) meetings: (i) Priority of funding is given to CG and MC members and substitutes. (ii) Experts may be invited and funded by the CG for specifically defined tasks, such as dissemination, organisation, etc. (iii) Early Career Investigators and members from Inclusiveness Target Countries may be invited and funded by the CG for specific management-training purposes.
2. Working Group (WG) meetings: The WG meetings are not teaching or dissemination tools, but focus on deliverables defined in the MITOEAGLE Memorandum of Understanding (joint publications, guidelines, MITOEAGLE database). Priority of funding is given to WG leaders, co-leaders or substitutes preparing and chairing a session, and to members and invited speakers with a presentation (abstract) in the programme or with an active role in a task group. A simple rule should be formulated on the process of invitation and distribution of funding.
3. Training Schools: Collaboration with the Mitochondrial Physiology Society and other organizations will extend the number and scope of training schools offered within various MITOEAGLE Grant Periods. A simple rule should be formulated on the process of invitation of lecturers and distribution of funding to student participants.
4. Short-Term Scientific Missions MITOEAGLE (STSM): Applications for a STSM will be preferentially funded (i) according to specific contributtions to the scientific objectives of MITOEAGLE; (ii) training of new students particularly from Inclusiveness Target Countries, 25% of the STSM budget may thus be allocated even if the primary priority cannot be met; the number and budget of the different, topic-specific STSM could then be advertised, such that a competition between 'more experienced contributors' and 'new learners' can be avoided; (iii) preferential funding will be allocated to those STSM which are extended by matching grants.

Near Neighbour (NNC), International Partner Countries (IPC) and industry participation

• COST provides the following examples for NNC and IPC:

1. Approved NNC and IPC Institutions can host Short-Term Scientific Missions (STSM).
2. Researchers from approved NNC institutions can apply for STSMs and and be supported when attending Training Schools.
3. Researchers from approved IPC and NNC institutions can be supported as trainers in Training Schools.

• COST provides the following examples for SME and industry participation:

1. Sessions and round table discussions dedicated to industrial participation at MITOEAGLE events
2. STSMs with industry acting as home/host institution.

• Suggestion to the Core Group and MC:

• If you collaborate with industrial partners who may have an interest in the MITOEAGLE network, please contact them directly, with Cc to verena.laner@mitophysiology.org.

WG1 and WG4 meeting

• Gnaiger E 2016-10-27

1. I suggest to avoid parallel sessions. WG1 and WG4 topics can be arranged in a sequence to include all participants in the discussions.

Terminology

• Gnaiger E

1. Discussion: MitoPedia: Respiratory control ratios - a basis for discussion, concept for joint publication.
2. Collect and discuss procedures and experimental protocols for the evaluation of mitochondrial capacities and create a library of protocols: reference subsrate-uncoupler-inhibitor titration protocols (SUIT), standard experimental media, and detailed instructions for OXPHOS analysis.
3. Update our internal terminology to facilitate communication.

Programme

Date	Time	Name	Topic	Discussion
Nov 15			Core Group Meeting
			Review the Work and Budget Plan Grant Period 1
		Erich Gnaiger, Chair (AT), Elisa Calabria, Vice chair (IT)	A road map
		Erich Gnaiger, Chair (AT), Elisa Calabria, Vice chair (IT)	Goals for Grant Period 2017-05-01 to 2018-04-30 have been identified according to the Memorandum of Understanding
			Road map and first steps of Working Groups
		Renner-Sattler K (DE)	WG1 Standard operating procedures and user requirement document: Protocols, terminology, documentation
		Garcia-Roves PM (ES)	WG2 MITOEAGLE data repository in muscle tissues
		Cervinkova Z (CZ)	WG3 MITOEAGLE data repository on fat tissues and other tissues
		Calabria E (IT)	WG4 MITOEAGLE data: blood and cultured cells
		Labieniec-Watala M (PL)	Short-Term Scientific Missions MITOEAGLE Grant Period 1
			Dissemination plan
		Makrecka-Kuka M (LV)	Dissemination plan MITOEAGLE.docx	»Discussion
			MITOEAGLE flyer	»Discussion
			Prepare agenda for MC Meeting Barcelona
		Garcia-Roves PM (ES)	General outline
			Programme coordinators will link the specific meeting topics to the global MITOEAGLE targets.
		Labieniec-Watala M (PL)	Short-Term Scientific Missions MITOEAGLE Grant Period 2
		Gnaiger E (AT)	Training School in Obergurgl, Tyrol/Austria in July 2017
			Other networking activities
			Next Management Committee Meeting in an Inclusiveness Target Country, Grant Period 2	»Discussion
		Krako N (RS)	Implementation strategy: plan towards inclusiveness (geographical coverage, early career investigator involvement and gender balance) that is revised and updated at every MC meeting and develop a strategy to attract researchers and stakeholders.	»Discussion
		Laner V (AT)	Aiming to support the involvement of researchers from Near Neighbour (NNC) and International Partner Countries (IPC) in MITOEAGLE - networking with the Mitochondrial Physiology Society - on the basis of mutual benefit. -	»Discussion
			Presentations of independently funded projects according to the Memorandum of Understanding.
Nov 16-17			WG1 and WG4 meeting
		Prof. Andrea Sbarbati, Univ. of Verona	Welcome
		Prof. Federico Schena	Welcome
		Programme coordinator: Erich Gnaiger	WG1 meeting: MITOEAGLE protocols, terminology, documentation
		Calabria E (IT)	Summary of Core Group meeting: relevant topics
			Discussion of concepts and terminology of mitochondrial physiology
			TG1.1 Coupling states and coupling control ratios: consensus statements - TG1.2 SUIT protocols: nomenclature consistent with concept of database.
		Gnaiger E (AT)	Towards a database: why terminology is important. - MitoPedia: Respiratory control ratios	»Discussion
		Doerrier C (AT)	Approaches for finding an universal SUIT reference protocol. - MitoPedia: SUIT
		Wuest RC (NL)	On terminology for mitochondrial respiration using different substrates.
		Ali SS (EG)	Oxygen consumption and ROS production - challenges for evaluation of experimental protocols.
			TG1.5 Knowledge management system
		Drinnan M (AT, UK)	Data management: direction of travel.
		Garcia-Roves PM (ES)	Design and implementation of systems biology approaches to integrate heterogenic data in biomedical research.
		Vendelin M (EE)	A mitochondrial physiology database for the laboratory.
			TG1.6 Interlaboratory proficiency ring test
		Gnaiger E (AT)	The concept of the proficiency test - from coaching to certification. - MitoFit proficiency test
		Programme coordinator: Elisa Calabria	WG4 meeting: MITOEAGLE data: blood and cultured cells - TG4.1 Blood
			Develop a working plan for the establishment of consensus protocols, reporting schemes, and the assignment of specific study tasks for mitochondrial respiratory studies in blood cells.
			PBMCs
		Calabria E (IT)	Blood cells mitochondrial activity in aging and frailty.
		Sumbalova Z (AT, SK)	Isolation of blood cells for high-resolution respirometry: PBMCs and platelets.
		Volani C (AT)	Human and rat PBMCs: what can we do better?
		Keppner G (DE)	Isolation of PBMCs for high-resolution respirometry and association to basal metabolic rate.
			Platelets
		Aasander Frostner E (SE)	Mitochondrial respiration in human viable platelets.
		[Garc[ia e Souza LF]] (AT)	Mitochondrial respiratory control in platelets.
		Westerlund E (SE)	The role of platelet respirometry in diagnosing mitochondrial disease.
			Discussion
			Development of SOPs for blood cell separation and respiration.