Difference between revisions of "Thomas 2011 Mitochondrion"
Bader Helga (talk | contribs) |
|||
| Line 1: | Line 1: | ||
{{Publication | {{Publication | ||
|title=Thomas RR, Khan SM, Portell FR, Smigrodzki RM, Bennett JP Jr (2011) Recombinant human mitochondrial transcription factor A stimulates mitochondrial biogenesis and ATP synthesis, improves motor function after MPTP, reduces oxidative stress and increases survival after endotoxin. Mitochondrion 11: 108-118. | |title=Thomas RR, Khan SM, Portell FR, Smigrodzki RM, Bennett JP Jr (2011) Recombinant human mitochondrial transcription factor A stimulates mitochondrial biogenesis and ATP synthesis, improves motor function after MPTP, reduces oxidative stress and increases survival after endotoxin. Mitochondrion 11:108-118. | ||
|info=[http://www.ncbi.nlm.nih.gov/pubmed/20727424 PMID:20727424 ] | |info=[http://www.ncbi.nlm.nih.gov/pubmed/20727424 PMID:20727424 ] | ||
|authors=Thomas RR, Khan SM, Portell FR, Smigrodzki RM, Bennett JP | |authors=Thomas RR, Khan SM, Portell FR, Smigrodzki RM, Bennett JP | ||
| Line 13: | Line 13: | ||
|tissues=Heart, Skeletal muscle, Nervous system | |tissues=Heart, Skeletal muscle, Nervous system | ||
|model cell lines=Fibroblast | |model cell lines=Fibroblast | ||
|preparations=Homogenate, Isolated | |preparations=Homogenate, Isolated mitochondria | ||
|injuries=RONS | |injuries=Oxidative stress;RONS | ||
|topics=ATP; ADP; AMP; PCr | |topics=ATP; ADP; AMP; PCr | ||
|instruments=Oxygraph-2k | |instruments=Oxygraph-2k | ||
}} | }} | ||
Revision as of 14:39, 13 February 2015
| Thomas RR, Khan SM, Portell FR, Smigrodzki RM, Bennett JP Jr (2011) Recombinant human mitochondrial transcription factor A stimulates mitochondrial biogenesis and ATP synthesis, improves motor function after MPTP, reduces oxidative stress and increases survival after endotoxin. Mitochondrion 11:108-118. |
Thomas RR, Khan SM, Portell FR, Smigrodzki RM, Bennett JP (2011) Mitochondrion
Abstract: Recombinant human mitochondrial transcription factor A protein (rhTFAM) was evaluated for its acute effects on cultured cells and chronic effects in mice. Fibroblasts incubated with rhTFAM acutely increased respiration in a chloramphenicol-sensitive manner. SH-SY5Y cells showed rhTFAM concentration-dependent reduction of methylpyridinium (MPP+)-induced oxidative stress and increases in lowered ATP levels and viability. Mice treated with weekly i.v. rhTFAM showed increased mitochondrial gene copy number, Complex I protein levels and ATP production rates; oxidative damage to proteins was decreased ~50%. rhTFAM treatment improved motor recovery rate after treatment with MPTP and dose-dependently improved survival in the lipopolysaccharide model of endotoxin sepsis. • Keywords: recombinant TFAM, mitochondrial biogenesis, ATP synthesis, MPTP, sepsis
• O2k-Network Lab: US_VA Richmond_Bennett JP, US VA Richmond Iyer S
Labels:
Stress:Oxidative stress;RONS Organism: Human, Mouse Tissue;cell: Heart, Skeletal muscle, Nervous system Preparation: Homogenate, Isolated mitochondria
Regulation: ATP; ADP; AMP; PCr"ATP; ADP; AMP; PCr" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property.
HRR: Oxygraph-2k
