Viruses and mitochondrial medicine

high-resolution terminology - matching measurements at high-resolution

Viruses and mitochondrial medicine

Description

Not enough is known about viruses and mitochondrial medicine, although several studies point towards a link between viral infection and mitochondrial dysfunction using high-resolution respirometry, with potential impact on drug development.

Abbreviation: Virus-mt-Medicine

Communicated by Gnaiger E 2020-02-23, last update 2020-02-29

News: Coronavirus - COVID-19 or 2019-nCoV

2019-nCoV (WHO), SARS-CoV-2 (International Committee on Taxonomy of Viruses)

• COVID-19 — New insights on a rapidly changing epidemic del Rio C, Malani PN (2020) JAMA. Published online February 28, 2020. doi:10.1001/jama.2020.3072

• As of February 27, 2020, more than 82 000 cases of coronavirus disease 2019 (COVID-19) (the disease caused by SARS-CoV-2) and 2800 deaths have been reported, of which approximately 95% of cases and 97% of deaths are in China.1 Cases have now been reported in 49 other countries.
• The reproductive number (R0) (the expected number of secondary cases produced by a single infected person in a susceptible population) for SARS-CoV-2, although still preliminary, is estimated between 2 and 3, suggesting a higher pandemic potential than SARS.
• The data surrounding the biology, epidemiology, and clinical characteristics of the SARS-CoV-2 virus have been growing daily, with more than 400 articles listed in PubMed.
• Named 2019-nCoV by the WHO and SARS-CoV-2 by the International Committee on Taxonomy of Viruses, this virus is a new human-infecting Betacoronavirus that, based on its genetic proximity to 2 bat-derived SARS-like coronaviruses, likely originated in chrysanthemum bats.

• Coronavirus disease 2019 and influenza Livingston E, Bucher K, Rekito A (2020) JAMA. Published online February 26, 2020. doi:10.1001/jama.2020.2633

• Although a great deal of attention has been given to the coronavirus disease 2019 (COVID-19) epidemic, it is most severe in one area of China and appears to have limited clinical ramifications outside of that region. Lost in the discussion about COVID-19 is the fact that the US is experiencing a severe influenza season that has already resulted in more than 16 000 deaths.

COST: European Cooperation in Science and Technology - Statement to the COVID-19

• Following the communication released on Tuesday 25 February 2020, COST follows the advice of public health authorities such as the World Health Organisation (WHO) and national Ministries.

The COST Association is fully dependent and bound to the contractual agreement with the European Commission. As per rules in this agreement, cases of force majeure will be applicable only where participants are forced to cancel their travel due to circumstances out of their control (e.g. national decisions to quarantine specific areas, block borders…). In such cases, “force majeure” will be used to cover otherwise non refundable amounts.

Decisions to cancel travels due to fear of infection, may not be considered as force majeure.

Should the instructions from public health authorities evolve and the European Commission (our funder) make a general decision to cover globally the current situation under force majeure, then force majeure will apply to all cancellations. This is not the case as of now.

National authorities do provide instructions on how to handle suspicious cases. Those instructions must be followed in all cases.

With regards to the conduct of activities in the frame of the COST Action, common sense prevails to decide to continue with an activity, to modify its venue or to postpone it. For the moment, there is no provision to suspend activities or extend period nor to carry forward unspent funding due to potential cases of COVID-19.

»Previous communications«

Publications: Viruses and mt-medicine

	Year	Reference	Organism	Tissue;cell	Stress
Brown 2020 MitoFit Preprint Arch	2020	Brown RA, Sarkar A (2020) Vitamin D deficiency: a factor in COVID-19, progression, severity and mortality? – An urgent call for research. https://doi.org/10.26124/mitofit:200001	Human
Brown 2020 BMJ	2020	Brown Robert A, Rhein Helga M, Alipio Mark M, Annweiler Cedric, Gnaiger Erich, Holick Michael F, Boucher Barbara J, Duque Gustavo, Féron François, Kenny Rose Anne, Montero-Odasso Manuel, Minisola Salvatore, Rhodes Jonathan, Haq Afrozul, Bejerot Susanne, Reiss Lina AJ, Zgaga Lina, Crawford Michael A, Fricker Rosemary A, Cobbold Peter, Lahore Henry W, Humble Mats B, Sarkar Amrita, Karras Spiros, Iglesias-Gonzalez Javier, Gezen-Ak Duygu, Dursun Erdinc, Cooper Isabella, Grimes David, de Voil Cedric WB (2020) COVID-19 ’ICU’ risk – 20-fold greater in the vitamin D deficient. BAME, African Americans, the older, institutionalised and obese, are at greatest risk. Sun and ‘D’-supplementation – game-changers? Research urgently required. https://doi.org/10.1136/bmj.m1548	Human	Lung;gill Fat
Ledur 2020 Sci Rep	2020	Ledur PF, Karmirian K, Pedrosa CDSG, Souza LRQ, Assis-de-Lemos G, Martins TM, Ferreira JCCG, de Azevedo Reis GF, Silva ES, Silva D, Salerno JA, Ornelas IM, Devalle S, Madeiro da Costa RF, Goto-Silva L, Higa LM, Melo A, Tanuri A, Chimelli L, Murata MM, Garcez PP, Filippi-Chiela EC, Galina A, Borges HL, Rehen SK (2020) Zika virus infection leads to mitochondrial failure, oxidative stress and DNA damage in human iPSC-derived astrocytes. Sci Rep 10:1218.	Human	Nervous system
Du 2019 J Virol	2019	Du C, Duan Y, Wang XF, Lin Y, Na L, Wang X, Chen K, Wang X (2019) Attenuation of equine lentivirus alters mitochondrial protein expression profile from inflammation to apoptosis. J Virol 93:e00653-19.	Horse	Blood cells Other cell lines	Cell death
Braz-De-Melo 2019 Sci Rep	2019	Braz-De-Melo HA, Pasquarelli-do-Nascimento G, Corrêa R, das Neves Almeida R, de Oliveira Santos I, Prado PS, Picolo V, de Bem AF, Pizato N, Magalhães KG (2019) Potential neuroprotective and anti-inflammatory effects provided by omega-3 (DHA) against Zika virus infection in human SH-SY5Y cells. Sci Rep 9:20119.	Human	Neuroblastoma
Weinstein 2019 bioRxiv	2019	Weinstein RN, Crawford DL (2019) Effect of EBV-transformation on oxidative phosphorylation physiology in human cell lines. bioRxiv doi: https://doi.org/10.1101/2019.12.16.878025 .	Human	Other cell lines Lymphocyte
Qu 2018 FASEB J	2018	Qu C, Zhang S, Wang W, Li M, Wang Y, van der Heijde-Mulder M, Shokrollahi E, Hakim MS, Raat NJH, Peppelenbosch MP, Pan Q (2018) Mitochondrial electron transport chain complex III sustains hepatitis E virus replication and represents an antiviral target. FASEB J 33:1008-19.	Human	Liver
Fernandes-Siqueira 2018 mSphere	2018	Fernandes-Siqueira LO, Zeidler JD, Sousa BG, Ferreira T, Da Poian AT (2018) Anaplerotic role of glucose in the oxidation of endogenous fatty acids during Dengue virus infection. mSphere 3.pii: e00458-17.	Human	Liver Other cell lines
Wang 2018 Mol Med Rep	2018	Wang B, Li W, Fang H, Zhou H (2018) Hepatitis B virus infection is not associated with fatty liver disease: Evidence from a cohort study and functional analysis. Mol Med Rep 19:320-26. https://doi.org/10.3892/mmr.2018.9619	Human	Liver
Xia 2016 RSC Adv	2016	Xia Z, Yi X, Zhuang Y (2016) Stable over-expression of the human malate–aspartate NADH shuttle member Aralar I in PK15 cells improves energy metabolism and enhances proliferation of porcine circovirus-2. RSC Adv 6:61268-77.	Pig	Kidney
Morse 2012 J Infect Dis	2012	Morse CG, Voss JG, Rakocevic G, McLaughlin M, Vinton CL, Huber C, Hu X, Yang J, Huang da W, Logun C, Danner RL, Rangel ZG, Munson PJ, Orenstein JM, Rushing EJ, Lempicki RA, Dalakas MC, Kovacs JA (2012) HIV infection and antiretroviral therapy have divergent effects on mitochondria in adipose tissue. J Infect Dis 205:1778-1787.	Human	Skeletal muscle Blood cells Fat
Silva 2012 PLOS ONE	2012	Silva da Costa L, Pereira da Silva AP, Da Poian AT, El-Bacha T (2012) Mitochondrial bioenergetic alterations in mouse neuroblastoma cells infected with Sindbis virus: implications to viral replication and neuronal death. PLoS One 7:e33871.	Mouse	Neuroblastoma	Mitochondrial disease
El-Bacha 2012 Int J Biochem Cell Biol	2012	El-Bacha T, Da Poian AT (2012) Virus-induced changes in mitochondrial bioenergetics as potential targets for therapy. Int J Biochem Cell Biol 45:41-6.	Human Mouse	Nervous system Liver Fibroblast	Oxidative stress;RONS
Mutuel 2010 Virology	2010	Mutuel D, Ravallec M, Chabi B, Multeau C, Salmon JM, Fournier P, Ogliastro M (2010) Pathogenesis of Junonia coenia densovirus in Spodoptera frugiperda: a route of infection that leads to hypoxia. Virology 403:137-44.	Hexapods		Ischemia-reperfusion Oxidative stress;RONS
El-Bacha 2007 Biochim Biophys Acta	2007	El-Bacha T, Midlej V, Pereira da Silva AP, Silva da Costa L, Benchimol M, Galina A, Da Poian AT (2007) Mitochondrial and bioenergetic dysfunction in human hepatic cells infected with dengue 2 virus. Biochim Biophys Acta 1772:1158-66.	Human	Liver	Cell death
Yuan 2006 Mol Cells	2006	Yuan X, Shan Y, Yao Z, Li J, Zhao Z, Chen J, Cong Y (2006) Mitochondrial location of severe acute respiratory syndrome coronavirus 3b protein. Mol Cells 21:186–91.	Human		Cell death
Vrbacky 2003 Physiol Res	2003	Vrbacký M, Krijt J, Drahota Z, Mĕlková Z (2003) Inhibitory effects of Bcl-2 on mitochondrial respiration. Physiol Res 52:545-54.	Human Other mammals	Endothelial;epithelial;mesothelial cell Other cell lines HeLa	Cell death

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