Wikstroem 1977 Nature
| Wikstroem MKF (1977) Proton pump coupled to cytochrome c oxidase in mitochondria. Nature 266: 271-273. |
Wikstroem MKF (1977) Nature
Abstract: Cytochrome c oxidase is an important enzyme of aerobic metabolism, catalysing electron transport between cytochrome c and molecular oxygen. Apart from this essential redox reaction the enzyme must be involved in conservation of the released redox energy for utilisation in ATP synthesis at the socalled third site of oxidative phosphorylation. I report here that the redox activity of mitochondrial cytochrome c oxidase is coupled to the translocation of hydrogen ions across the inner mitochondrial membrane. This finding may be a clue to the role of cytochrome oxidase in energy conservation. • Keywords: cytochrome c oxidase, proton pump, inner mitochondrial membrane
Labels:
Enzyme: Complex IV; Cytochrome c Oxidase"Complex IV; Cytochrome c Oxidase" is not in the list (Adenine nucleotide translocase, Complex I, Complex II;succinate dehydrogenase, Complex III, Complex IV;cytochrome c oxidase, Complex V;ATP synthase, Inner mt-membrane transporter, Marker enzyme, Supercomplex, TCA cycle and matrix dehydrogenases, ...) of allowed values for the "Enzyme" property. Regulation: Ion Homeostasis"Ion Homeostasis" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property.
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