Template:MitoPediaAlert2021

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Currently Answered Questions from the »Oroboros Ecosystem Agenda«

Mar 2021

  • Mar-16 Tu
MitoPedia
CI inhibitors like rotenone inhibit fatty acid oxidation (FAO)-linked respiration

Inhibition of CI leads to accumulation of NADH in the mt-matrix. The resultant lack of NAD+ blocks FAO.
- »Fatty acid oxidation pathway control state«, »Mitochondrial Pathways: Chapter 5« 
- communicated by »Cardoso Luiza« and »Cecatto Cristiane«


  • Mar-11 Th
Gnaiger 2020 BEC MitoPathways Internal normalization of rate – what is the difference between flux control ratio and flux control efficiency?

A flux control ratio is the ratio of oxygen flux in a specific respiratory control state, normalized for maximum flux in a common reference state. Flux control efficiency expresses the control of respiration as a fractional change of oxygen flux or flow between protocol steps. Both values vary between theoretical lower and upper limits of 0 and 1.
- »Gnaiger 2020 BEC MitoPathways - Chapter 3« 
- » Posted by: »Komlodi Timea« and »Cecatto Cristiane«


  • Mar-2 Tu
MitoPedia
Measuring fatty acid oxidation (FAO)-linked respiration requires a low concentration of malate

In the absence of malate, accumulation of Acetyl-CoA inhibits FAO.
- »Fatty acid oxidation pathway control state«, »Mitochondrial Pathways: Chapter 5« 
- communicated by »Cecatto Cristiane« and »Cardoso Luiza« 


Jan 2021

  • Jan-21 Th
MitoPedia
Measuring ATP production with Magnesium Green – which sample preparations work?

Magnesium Green (MgG) can be used with mitochondrial preparations: isolated mitochondria, tissue homogenates, and permeabilized cells and tissues.
- »MgG« and »Publications MgG« 
- communicated by »Cardoso Luiza« and »Komlodi Timea«