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	Year	Reference	Coupling	Pathway	Preparation	Organism	Tissue;cell
Thomas 2016 Neurodegeneration Therapeutics	2016	Thomas RR, Keeney PM, Berr SB, Khan SM, Portell FR, Shakenov MZ, Antkowiak PF, Kundu B, Tustison N, Brohawn DG, Bennett JP (2016) Recombinant human TFAM stimulates rat brain, rat cervical spinal cord and human neural stem cell mitochondrial bioenergetics. Neurodegeneration Therapeutics p41.	LEAK OXPHOS	N S CIV	Isolated mitochondria	Rat	Nervous system
Gomez 2016 Thesis	2016	Gomez CR (2016) Mitochondrial responses to anoxia exposure in red eared sliders (Trachemys scripta). Master's Thesis p102.	LEAK OXPHOS ET	S	Permeabilized cells Isolated mitochondria	Reptiles	Heart Nervous system
Lemieux 2016 Mitochondrion	2016	Lemieux H, Boemer F, van Galen G, Serteyn D, Amory H, Baise E, Cassart D, van Loon G, Marcillaud-Pitel C, Votion DM (2016) Mitochondrial function is altered in horse atypical myopathy. Mitochondrion 30:35-41.	OXPHOS ET	N S NS ROX	Permeabilized tissue	Horse	Skeletal muscle
Richman 2016 Nat Commun	2016	Richman TR, Spåhr H, Ermer JA, Davies SM, Viola HM, Bates KA, Papadimitriou J, Hool LC, Rodger J, Larsson NG, Rackham O, Filipovska A (2016) Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice. Nat Commun 7:11884.	LEAK OXPHOS	N S CIV	Isolated mitochondria	Mouse	Heart Liver
Gariani 2016 Hepatology	2016	Gariani K, Menzies KJ, Ryu D, Wegner CJ, Wang X, Ropelle ER, Moullan N, Zhang H, Perino A, Lemos V, Kim B, Park YK, Piersigilli A, Pham TX, Yang Y, Ku SC, Koo SI, Fomitchova A, Cantó C, Schoonjans K, Sauve AA, Lee JY, Auwerx J (2016) Eliciting the mitochondrial unfolded protein response via NAD+ repletion reverses fatty liver disease. Hepatology 63:1190-204.	OXPHOS	N S	Permeabilized tissue	Mouse	Liver
Gregg 2016 Diabetes	2016	Gregg T, Poudel C, Schmidt BA, Dhillon RS, Sdao SM, Truchan NA, Baar EL, Fernandez LA, Denu JM, Eliceiri KW, Rogers JD, Kimple ME, Lamming DW, Merrins MJ (2016) Pancreatic β cells from mice offset age-associated mitochondrial deficiency with reduced K_ATP channel activity. Diabetes 65:2700-10.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Human Mouse	Islet cell;pancreas;thymus Other cell lines
Camacho-Pereira 2016 Cell Metab	2016	Camacho-Pereira J, Tarragó MG, Chini CC, Nin V, Escande C, Warner GM, Puranik AS, Schoon RA, Reid JM, Galina A, Chini EN (2016) CD38 dictates age-related NAD decline and mitochondrial dysfunction through an SIRT3-dependent mechanism. Cell Metab 23:1127-39.	LEAK ROUTINE OXPHOS ET	S ROX	Isolated mitochondria Intact cells	Human Mouse	Liver Lung;gill Other cell lines
Ryan 2016 Diabetes	2016	Ryan TE, Schmidt CA, Green TD, Spangenburg EE, Neufer PD, McClung JM (2016) Targeted expression of catalase to mitochondria protects against ischemic myopathy in high fat fed mice. Diabetes 65:2553-68.	LEAK OXPHOS ET	N S CIV Other combinations ROX	Isolated mitochondria	Mouse	Skeletal muscle
Tam 2016 Eur J Appl Physiol	2016	Tam E, Bruseghini P, Calabria E, Sacco LD, Doria C, Grassi B, Pietrangelo T, Pogliaghi S, Reggiani C, Salvadego D, Schena F, Toniolo L, Verratti V, Vernillo G, Capelli C (2016) Gokyo Khumbu/Ama Dablam Trek 2012: effects of physical training and high-altitude exposure on oxidative metabolism, muscle composition, and metabolic cost of walking in women. Eur J Appl Physiol 116:129-44.	LEAK OXPHOS	N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Lim 2016 FASEB J	2016	Lim SC, Hroudová J, Van Bergen NJ, Lopez Sanchez MI, Trounce IA, McKenzie M (2016) Loss of mitochondrial DNA-encoded protein ND1 results in disruption of complex I biogenesis during early stages of assembly. FASEB J 30:2236-48.	OXPHOS ET	N S NS ROX	Permeabilized cells	Human	Other cell lines
Wang 2016 Toxicol Sci	2016	Wang L, Espinoza HM, MacDonald JW, Bammler TK, Williams CR, Yeh A, Louie KW, Marcinek DJ, Gallagher EP (2016) Olfactory Transcriptional Analysis of Salmon Exposed to Mixtures of Chlorpyrifos and Malathion Reveal Novel Molecular Pathways of Neurobehavioral Injury. Toxicol Sci 149:145-57.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized tissue	Fishes	Endothelial;epithelial;mesothelial cell
Farsijani 2016 J Clin Invest	2016	Farsijani NM, Liu Q, Kobayashi H, Davidoff O, Sha F, Fandrey J, Ikizler TA, O'Connor PM, Haase VH (2016) Renal epithelium regulates erythropoiesis via HIF-dependent suppression of erythropoietin. J Clin Invest 126:1425-37.	LEAK OXPHOS	N S CIV ROX	Permeabilized tissue	Mouse	Nervous system
Cannon 2016 Lung	2016	Cannon DT, Liu J, Sakurai R, Rossiter HB, Rehan VK (2016) Impaired lung mitochondrial respiration following perinatal nicotine exposure in rats. Lung 194:325-8.	LEAK OXPHOS ET	N S CIV NS	Permeabilized tissue	Rat	Lung;gill
Hamilton 2016 Am J Physiol Heart Circ Physiol	2016	Hamilton DJ, Zhang A, Li S, Cao TN, Smith JA, Vedula I, Cordero-Reyes AM, Youker KA, Torre-Amione G, Gupte AA (2016) Combination of angiotensin II and l-NG-nitroarginine methyl ester exacerbates mitochondrial dysfunction and oxidative stress to cause heart failure. Am J Physiol Heart Circ Physiol 310:H667-80.	LEAK OXPHOS	F N S NS Other combinations ROX	Permeabilized tissue Isolated mitochondria	Mouse	Heart
Du 2016 J Exp Biol	2016	Du SN, Mahalingam S, Borowiec BG, Scott GR (2016) Mitochondrial physiology and reactive oxygen species production are altered by hypoxia acclimation in killifish (Fundulus heteroclitus). J Exp Biol 219:1130-8.	LEAK OXPHOS ET	N S CIV NS	Isolated mitochondria	Fishes	Liver
Ehinger 2016 Mov Disord	2016	Ehinger JK, Morota S, Hansson MJ, Gesine P, Elmér E (2016) Mitochondrial respiratory function in peripheral blood cells from Huntington’s disease patients. Mov Disord doi:10.1002/mdc3.12308.	LEAK ROUTINE OXPHOS ET	N S CIV NS Other combinations ROX	Permeabilized cells Intact cells	Human	Blood cells Lymphocyte Platelet
Lores-Arnaiz 2016 Neurochem Res	2016	Lores-Arnaiz S, Lombardi P, Karadayian AG, Orgambide F, Cicerchia D, Bustamante J (2016) Brain cortex mitochondrial bioenergetics in synaptosomes and non-synaptic mitochondria during aging. Neurochem Res 41:353-63.	LEAK ROUTINE OXPHOS ET	N S	Isolated mitochondria Intact cells	Mouse	Nervous system
Amaral 2016 J Neurochem	2016	Amaral AU, Cecatto C, Castilho RF, Wajner M (2016) 2-methylcitric acid impairs glutamate metabolism and induces permeability transition in brain mitochondria. J Neurochem 137:62-75.	LEAK OXPHOS ET	N S NS	Isolated mitochondria	Rat	Nervous system
Pamenter 2016 Biol Lett	2016	Pamenter ME, Gomez CR, Richards JG, Milsom WK (2016) Mitochondrial responses to prolonged anoxia in brain of red-eared slider turtles. Biol Lett 12. pii: 20150797.	LEAK OXPHOS ET	N S CIV ROX	Permeabilized tissue	Reptiles	Nervous system
Schoepf 2016 FEBS J	2016	Schöpf B, Schäfer G, Weber A, Talasz H, Eder IE, Klocker H, Gnaiger E (2016) Oxidative phosphorylation and mitochondrial function differ between human prostate tissue and cultured cells. https://doi.org/10.1111/febs.13733	LEAK OXPHOS ET	F N S NS Other combinations ROX	Permeabilized cells Permeabilized tissue	Human	Endothelial;epithelial;mesothelial cell Genital Other cell lines Fibroblast
Strifler 2016 PLOS ONE	2016	Strifler G, Tuboly E, Szél E, Kaszonyi E, Cao C, Kaszaki J, Mészáros A, Boros M, Hartmann P (2016) Inhaled methane limits the mitochondrial electron transport chain dysfunction during experimental liver ischemia-reperfusion injury. PLOS ONE 11:e0146363.	LEAK OXPHOS	N S CIV NS ROX	Homogenate Isolated mitochondria	Rat	Liver
Li 2016 Neurochem Int	2016	Li H, Liu Y, Lin LT, Wang XR, Du SQ, Yan CQ, He T, Yang JW, Liu CZ (2016) Acupuncture reversed hippocampal mitochondrial dysfunction in vascular dementia rats. Neurochem Int 92:35-42.	LEAK OXPHOS	S	Isolated mitochondria	Rat	Nervous system
Krischek 2016 Mol Reprod Dev	2016	Krischek C, Janisch S, Naraballobh W, Brunner R, Wimmers K, Wicke M (2016) Altered incubation temperatures between embryonic Days 7 and 13 influence the weights and the mitochondrial respiratory and enzyme activities in breast and leg muscles of broiler embryos. Mol Reprod Dev 83:71-8.	LEAK OXPHOS	N S	Permeabilized tissue	Chicken	Skeletal muscle
Johnson 2016 Diabetes	2016	Johnson ML, Distelmaier K, Lanza IR, Irving BA, Robinson MM, Konopka AR, Shulman GI, Nair KS (2016) Mechanism by which caloric restriction improves insulin sensitivity in sedentary obese adults. Diabetes 65:74-84.	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Human	Skeletal muscle
Yamada 2016 J Physiol	2016	Yamada T, Takakura H, Jue T, Hashimoto T, Ishizawa R, Furuichi Y, Kato Y, Iwanaka N, Masuda K (2016) Myoglobin and the regulation of mitochondrial respiratory chain complex IV. J Physiol 594:483-95.	LEAK OXPHOS	N S CIV Other combinations ROX		Mouse	Skeletal muscle Other cell lines
Mills 2016 Cell Metab	2016	Mills KF, Yoshida S, Stein LR, Uchida K, Yoshino J, Imai SI (2016) Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice. Cell Metab 24:1–12.	OXPHOS LEAK ET	N S NS	Permeabilized tissue	Mouse	Skeletal muscle
Doerrier 2016 Mitochondrion	2016	Doerrier C, García JA, Volt H, Díaz-Casado ME, Luna-Sánchez M, Fernández-Gil B, Escames G, López LC, Acuña-Castroviejo D (2016) Permeabilized myocardial fibers as model to detect mitochondrial dysfunction during sepsis and melatonin effects without disruption of mitochondrial network. Mitochondrion 27:56-63.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Mouse	Heart
Berger 2016 Nat Commun	2016	Berger E, Rath E, Yuan D, Waldschmitt N, Khaloian S, Allgäuer M, Staszewski O, Lobner EM, Schöttl T, Giesbertz P, Coleman OI, Prinz M, Weber A, Gerhard M, Klingenspor M, Janssen KP, Heikenwalder M, Haller D (2016) Mitochondrial function controls intestinal epithelial stemness and proliferation. Nat Commun 7:13171.	LEAK OXPHOS	S ROX		Mouse	Endothelial;epithelial;mesothelial cell
Cacabelos 2016 Acta Neuropathol Commun	2016	Cacabelos D, Ramírez-Núñez O, Granado-Serrano AB, Torres P, Ayala V, Moiseeva V, Povedano M, Ferrer I, Pamplona R, Portero-Otin M, Boada J (2016) Early and gender-specific differences in spinal cord mitochondrial function and oxidative stress markers in a mouse model of ALS. Acta Neuropathol Commun 4:3.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized tissue Intact cells	Mouse	Nervous system Other cell lines
Cagnone 2016 Sci Rep	2016	Cagnone GL, Tsai TS, Makanji Y, Matthews P, Gould J, Bonkowski MS, Elgass KD, Wong AS, Wu LE, McKenzie M, Sinclair DA, John JC (2016) Restoration of normal embryogenesis by mitochondrial supplementation in pig oocytes exhibiting mitochondrial DNA deficiency. Sci Rep 6:23229.	LEAK OXPHOS ET	S ROX	Isolated mitochondria	Pig	Genital
Munro 2016 Free Radic Biol Med	2016	Munro D, Banh S, Sotiri E, Tamanna N, Treberg JR (2016) The thioredoxin and glutathione-dependent H₂O₂ consumption pathways in muscle mitochondria: Involvement in H₂O₂ metabolism and consequence to H₂O₂ efflux assays. Free Radic Biol Med 96:334-46.	LEAK OXPHOS	N S	Isolated mitochondria	Rat	Skeletal muscle
Morad 2016 J Lipid Res	2016	Morad SA, Ryan TE, Neufer PD, Zeczycki TN, Davis TS, MacDougall MR, Fox TE, Tan SF, Feith DJ, Loughran TP Jr, Kester M, Claxton DF, Barth BM, Deering TG, Cabot MC (2016) Ceramide-tamoxifen regimen targets bioenergetic elements in acute myelogenous leukemia. J Lipid Res 57:1231-42.	LEAK OXPHOS	N S NS	Permeabilized cells	Human	Blood cells Other cell lines
Distefano 2016 J Gerontol A Biol Sci Med Sci	2016	Distefano G, Standley RA, Dubé JJ, Carnero EA, Ritov VB, Stefanovic-Racic M, Toledo FG, Piva SR, Goodpaster BH, Coen PM (2016) Chronological age does not influence ex-vivo mitochondrial respiration and quality control in skeletal muscle. J Gerontol A Biol Sci Med Sci 72:535-42.	LEAK OXPHOS ET	N S NS	Permeabilized tissue	Human	Skeletal muscle
Reynolds 2016 Am J Physiol Endocrinol Metab	2016	Reynolds MS, Hancock CR, Ray JD, Kener KB, Draney C, Garland K, Hardman J, Bikman BT, Tessem JS (2016) β-cell deletion of Nr4a1 and Nr4a3 nuclear receptors impedes mitochondrial respiration and insulin secretion. Am J Physiol Endocrinol Metab 311:E186-201.	LEAK ROUTINE OXPHOS ET	N S ROX	Permeabilized cells Intact cells	Rat	Islet cell;pancreas;thymus
Kimball 2016 Thesis	2016	Kimball RL (2016) The role of hypoxia on pyruvate kinase M2, mammalian target of rapamycin, mitochondrial function, and cell invasion in the trophoblast. Master Thesis p55.	LEAK OXPHOS ET	N S NS ROX	Permeabilized cells	Human	Genital Other cell lines
Viola 2016 J Physiol	2016	Viola H, Johnstone V, Szappanos HC, Richman T, Tsoutsman T, Filipovska A, Semsarian C, Hool L (2016) The L-type Ca²⁺ channel facilitates abnormal metabolic activity in the cTnI-G203S mouse model of hypertrophic cardiomyopathy. J Physiol 594:4051-70.		N S CIV	Isolated mitochondria	Mouse	Heart
Hagl 2016 Nutr Neurosci	2016	Hagl S, Berressem D, Grewal R, Grebenstein N, Frank J, Eckert GP (2016) Rice bran extract improves mitochondrial dysfunction in brains of aged NMRI mice. Nutr Neurosci 19:1-10.	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Mouse	Nervous system
Santos 2016 Insect Biochem Mol Biol	2016	Santos DE, Alberici LC, Hartfelder K (2016) Mitochondrial structure and dynamics as critical factors in honey bee (Apis mellifera L.) caste development. Insect Biochem Mol Biol 73:1-11.	LEAK OXPHOS ET	S	Permeabilized tissue	Hexapods	Fat
Lund 2016 J Physiol	2016	Lund MT, Kristensen M, Hansen M, Tveskov L, Floyd AK, Støckel M, Vainer B, Poulsen SS, Helge JW, Prats C, Dela F (2016) Hepatic mitochondrial oxidative phosphorylation is normal in obese patients with and without type 2 diabetes. J Physiol 594:4351-8.	LEAK OXPHOS ET	F N S CIV NS ROX	Permeabilized tissue	Human	Liver
Shrum 2016 J Kidney	2016	Shrum S, MacMillan-Crow LA, Parajuli N (2016) Cold storage exacerbates renal and mitochondrial dysfunction following transplantation. J Kidney 2 pii: 114.	OXPHOS	N S CIV	Permeabilized tissue	Rat	Kidney
Bai 2016 PLOS ONE	2016	Bai F, Fink BD, Yu L, Sivitz WI (2016) Voltage-dependent regulation of Complex II energized mitochondrial oxygen flux. PLOS ONE 11:e0154982.	LEAK OXPHOS ET	N S CIV NS	Isolated mitochondria	Mouse	Heart Skeletal muscle Nervous system Liver
Xiong 2016 Hypertension	2016	Xiong S, Wang P, Ma L, Gao P, Gong L, Li L, Li Q, Sun F, Zhou X, He H, Chen J, Yan Z, Liu D, Zhu Z (2016) Ameliorating endothelial mitochondrial dysfunction restores coronary function via transient receptor potential vanilloid 1-mediated protein kinase A/uncoupling protein 2 pathway. Hypertension 67:451-60.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Intact cells Permeabilized cells	Human	Endothelial;epithelial;mesothelial cell Other cell lines
LaBarge 2016 FASEB J	2016	LaBarge SA, Migdal CW, Buckner EH, Okuno H, Gertsman I, Stocks B, Barshop BA, Nalbandian SR, Philp A, McCurdy CE, Schenk S (2016) p300 is not required for skeletal muscle metabolic adaptation to endurance exercise training. FASEB J 30:1623-33.	LEAK OXPHOS ET	F N NS ROX S Other combinations	Permeabilized tissue	Mouse	Skeletal muscle
Zabielski 2016 Diabetes	2016	Zabielski P, Lanza IR, Gopala S, Holtz Heppelmann CJ, Bergen HR 3rd, Dasari S, Nair KS (2016) Altered skeletal muscle mitochondrial proteome as the basis of disruption of mitochondrial function in diabetic mice. Diabetes 65:561-73.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized cells	Mouse	Skeletal muscle
Nemeth 2016 FASEB J	2016	Németh B, Doczi J, Csete D, Kacso G, Ravasz D, Adams D, Kiss G, Nagy AM, Horvath G, Tretter L, Mócsai A, Csépányi-Kömi R, Iordanov I, Adam-Vizi V, Chinopoulos C (2016) Abolition of mitochondrial substrate-level phosphorylation by itaconic acid produced by LPS-induced Irg1 expression in cells of murine macrophage lineage. FASEB J 30:286-300.	LEAK OXPHOS	S	Isolated mitochondria	Mouse	Liver
Salin 2016 J Exp Biol	2016	Salin K, Auer SK, Anderson GJ, Selman C, Metcalfe NB (2016) Inadequate food intake at high temperatures is related to depressed mitochondrial respiratory capacity. J Exp Biol 219:1356-62.	LEAK OXPHOS	N S CIV NS Other combinations ROX	Permeabilized tissue	Fishes	Skeletal muscle Liver
Viola 2016 JACC: Basic to Translational Science	2016	Viola HM, Johnstone VPA, Szappanos HC, Richman TR, Tsoutsman T, Filipovska A, Semsarian C, Seidman JG, Seidman CE, Hool LC (2016) The role of the L-type Ca²⁺ channel in altered metabolic activity in a murine model of hypertrophic cardiomyopathy. JACC: Basic to Translational Science 1: 61–72.	OXPHOS	N S CIV	Isolated mitochondria	Mouse	Heart
Liepinsh 2016 Biochem J	2016	Liepinsh E, Makrecka-Kuka M, Volska K, Kuka J, Makarova E, Antone U, Sevostjanovs E, Vilskersts R, Strods A, Tars K, Dambrova M (2016) Long-chain acylcarnitines determine ischaemia/reperfusion-induced damage in heart mitochondria. Biochem J 473:1191-202.	LEAK OXPHOS	S NS	Isolated mitochondria	Rat	Heart
Jacobs 2016 J Physiol	2016	Jacobs RA, Lundby AM, Fenk S, Gehrig S, Siebenmann C, Flück D, Kirk N, Hilty MP, Lundby C (2016) Twenty-eight days of exposure to 3,454 m increases mitochondrial volume density in human skeletal muscle. J Physiol 594:1151-66.	LEAK OXPHOS ET	F N S CIV NS ROX	Permeabilized tissue	Human	Skeletal muscle
Chu 2016 World J Gastroenterol	2016	Chu MJ, Premkumar R, Hickey AJ, Jiang Y, Delahunt B, Phillips AR, Bartlett A (2016) Steatotic livers are susceptible to normothermic ischemia-reperfusion injury from mitochondrial Complex-I dysfunction. World J Gastroenterol 22:4673-84.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Rat	Liver

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