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• 4th edition Metabolism & Cancer 2021 Virtual  + (4th edition Metabolism & Cancer, Virtu … 4th edition Metabolism & Cancer, Virtual, 2021 </br></br></br>== Program ==</br>:::: [https://www.metabolism-cancer.com/program/ here]</br></br>== Organizers ==</br>:::: The list of organizers can be found [https://www.metabolism-cancer.com/under-construction/ here]</br></br>== Registration ==</br>:::: [https://www.metabolism-cancer.com/registration/ Registration and more information]</br></br>== Oroboros at MetaboCancer 2021==</br>:::: [[Gnaiger Erich]]: Oroboros Instruments innovations - NextGen-O2k and Bioenergetics Communications, ''May 28th at 11:25''</br></br>=== Booth ===</br>:::: The Oroboros team is looking forward to welcome you at our Oroboros booth which will be available at this conference.</br></br></br>== Support ==</br>[[File:Template NextGen-O2k.jpg|right|350px|link=NextGen-O2k]]</br></br>[[Category:NextGen-O2k]]</br>:::: Supported by project NextGen-O2k which has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 859770.</br><br/></br><br/></br><br/></br><br/> agreement No. 859770. <br/> <br/> <br/> <br/>)
• MacPherson 2016 Am J Physiol Cell Physiol  + (5'-AMP-activated protein kinase (AMPK) is … 5'-AMP-activated protein kinase (AMPK) is activated as a consequence of lipolysis and has been shown to play a role in regulation of adipose tissue mitochondrial content. Conversely, the inhibition of lipolysis has been reported to potentiate the induction of protein kinase A (PKA)-targeted genes involved in the regulation of oxidative metabolism. The purpose of the current study was to address these apparent discrepancies and to more fully examine the relationship between lipolysis, AMPK, and the β-adrenergic-mediated regulation of gene expression. In 3T3-L1 adipocytes, the adipose tissue triglyceride lipase (ATGL) inhibitor ATGListatin attenuated the Thr(172) phosphorylation of AMPK by a β3-adrenergic agonist (CL 316,243) independent of changes in PKA signaling. Similarly, CL 316,243-induced increases in the Thr(172) phosphorylation of AMPK were reduced in adipose tissue from whole body ATGL-deficient mice. Despite reductions in the activation of AMPK, the induction of PKA-targeted genes was intact or, in some cases, increased. Similarly, markers of mitochondrial content and respiration were increased in adipose tissue from ATGL knockout mice independent of changes in the Thr(172) phosphorylation of AMPK. Taken together, our data provide evidence that AMPK is not required for the regulation of adipose tissue oxidative capacity in conditions of reduced fatty acid release.</br></br>Copyright © 2016 the American Physiological Society.© 2016 the American Physiological Society.)
• Stride 2012 Front Physiol  + (5'-adenosine monophosphate-activated prote … 5'-adenosine monophosphate-activated protein kinase (AMPK) is considered central in regulation of energy status and substrate utilization within cells. In heart failure the energetic state is compromised and substrate metabolism is altered. We hypothesized that this could be linked to changes in AMPK activity and we therefore investigated mitochondrial oxidative phosphorylation capacity from the oxidation of long- and medium-chain fatty acids (LCFA and MCFA) in cardiomyocytes from young and old mice expressing a dominant negative AMPKα2 (AMPKα2-KD) construct and their wildtype (WT) littermates. We found a 35-45% (P < 0.05) lower mitochondrial capacity for oxidizing MCFA in AMPKα2-KD of both age-groups, compared to WT. This coincided with marked decreases in protein expression (19/29%, P < 0.05) and activity (14/21%, P < 0.05) of 3-hydroxyacyl-CoA-dehydrogenase (HAD), in young and old AMPKα2-KD mice, respectively, compared to WT. Maximal LCFA oxidation capacity was similar in AMPKα2-KD and WT mice independently of age implying that LCFA-transport into the mitochondria was unaffected by loss of AMPK activity or progressing age. Expression of regulatory proteins of glycolysis and glycogen breakdown showed equivocal effects of age and genotype. These results illustrate that AMPK is necessary for normal mitochondrial function in the heart and that decreased AMPK activity may lead to an altered energetic state as a consequence of reduced capacity to oxidize MCFA. We did not identify any clear aging effects on mitochondrial function. any clear aging effects on mitochondrial function.)
• Hanley 2005 J Physiol  + (5-Hydroxydecanoate (5-HD) blocks pharmacol … 5-Hydroxydecanoate (5-HD) blocks pharmacological and ischaemic preconditioning, and has been postulated to be a specific inhibitor of mitochondrial ATP-sensitive K+ (KATP) channels. However, recent work has shown that 5-HD is activated to 5-hydroxydecanoyl-CoA (5-HD-CoA), which is a substrate for the first step of β-oxidation. We have now analysed the complete β-oxidation of 5-HD-CoA using specially synthesised (and purified) substrates and enzymes, as well as isolated rat liver and heart mitochondria, and compared it with the metabolism of the physiological substrate decanoyl-CoA. At the second step of β-oxidation, catalysed by enoyl-CoA hydratase, enzyme kinetics were similar using either decenoyl-CoA or 5-hydroxydecenoyl-CoA as substrate. The last two steps were investigated using l-3-hydroxyacyl-CoA dehydrogenase (HAD) coupled to 3-ketoacyl-CoA thiolase. ''V''max for the metabolite of 5-HD (3,5-dihydroxydecanoyl-CoA) was fivefold slower than for the corresponding metabolite of decanoate (l-3-hydroxydecanoyl-CoA). The slower kinetics were not due to accumulation of d-3-hydroxyoctanoyl-CoA since this enantiomer did not inhibit HAD. Molecular modelling of HAD complexed with 3,5-dihydroxydecanoyl-CoA suggested that the 5-hydroxyl group could decrease HAD turnover rate by interacting with critical side chains. Consistent with the kinetic data, 5-hydroxydecanoyl-CoA alone acted as a weak substrate in isolated mitochondria, whereas addition of 100 μm 5-HD-CoA inhibited the metabolism of decanoyl-CoA or lauryl-carnitine. In conclusion, 5-HD is activated, transported into mitochondria and metabolised via β-oxidation, albeit with rate-limiting kinetics at the penultimate step. This creates a bottleneck for β-oxidation of fatty acids. The complex metabolic effects of 5-HD invalidate the use of 5-HD as a blocker of mitochondrial KATP channels in studies of preconditioning.TP channels in studies of preconditioning.)
• Mitchell 2011 Biochim Biophys Acta  + (50 years ago Peter Mitchell proposed the c … 50 years ago Peter Mitchell proposed the chemiosmotic hypothesis for which he was awarded the Nobel Prize for Chemistry in 1978. His comprehensive review on chemiosmotic coupling known as the first “Grey Book”, has been reprinted here with permission, to offer an electronic record and easy access to this important contribution to the biochemical literature. This remarkable account of Peter Mitchell's ideas originally published in 1966 is a landmark and must-read publication for any scientist in the field of bioenergetics. As far as was possible, the wording and format of the original publication have been retained. Some changes were required for consistency with BBA formats though these do not affect scientific meaning. A scanned version of the original publication is also provided as a downloadable file in Supplementary Information. See also Editorial in this issue by Peter R. Rich. Original title: CHEMIOSMOTIC COUPLING IN OXIDATIVE AND PHOTOSYNTHETIC PHOSPHORYLATION, by Peter Mitchell, Glynn Research Laboratories, Bodmin, Cornwall, England.h Laboratories, Bodmin, Cornwall, England.)
• ESCI 2021 Virtual  + (55^th ESCI meeting, Virtual, 2021)
• ESCI 2022 Bari IT  + (56^th ESCI meeting, Bari, Italy, 2022)
• ESCI 2023 Prague CZ  + (57^th ESCI meeting, Prague, Czech Republic, 2023)
• Targeting Mitochondria World Congress 2014  + (5^th Targeting Mitochondria World Congress - [http://www.targeting-mitochondria.com/ Targeting Mitochondria], Berlin DE)
• 5th Academic Symposium of Metabolic Biology Branch of Chinese Biophysical Society 2022 Zunyi CN  + (5th Academic Symposium of Metabolic Biology Branch of Chinese Biophysical Society, Zunyi, China, 2022)

• 5th International Conference of Mitochondrial Medicine  + (5th International Mitochondrial Medicine Conference Mitochondrial, Online, 2021)
• NHLBI Mitochondrial Biology Symposium 2019 Bethesda US  + (5th NHLBI Mitochondrial Biology Symposium, … 5th NHLBI Mitochondrial Biology Symposium, Bethesda, Maryland, USA, 2019 </br></br></br>== General information == </br>::::On September 26-27, 2019, experts from around the world will gather on the NIH Campus in Bethesda, Maryland to review advances in our understanding of how mitochondrial structure, function, and interactions within the cell contribute to diseases and aging; and to highlight recent progress made with animal models and therapeutic interventions.</br></br>== Venue == </br>:::: William H. Natcher Conference Center – Building 45</br>:::: National Institutes of Health</br>:::: 45 Center Drive</br>:::: Bethesda, MD 20814</br>:::: [https://2019mbs.com/meeting-venue/ How to get there]</br></br>== Organizer ==</br>:::: [https://2019mbs.com/organizers/ Information available here]</br></br>== Programme ==</br>:::: [https://2019mbs.com/agenda/ Agenda]</br></br>== Speakers == </br>:::: List of speakers can be found [https://2019mbs.com/featured-speakers/ here]</br></br>== Registration ==</br></br>:::: [https://www.eventbrite.com/e/the-2019-nhlbi-mitochondrial-biology-symposium-registration-54765893261 Registration and more information]</br></br>:::: The abstracts submission deadline is Friday, June 28, 2019, at 11:59PM EST. </br>:::: All submissions must be made through the abstract submission portal. </br>:::: Abstracts should be no longer than 500 words and include four clearly identifiable components: Background, Methods, Results, and Conclusion. </br>:::: Abstracts will be reviewed by the Organizing Committee. Acceptance will be based on the quality of the abstract and availability of space. Four high-quality abstracts will be selected for oral presentation.ts will be selected for oral presentation.)
• 5th edition Metabolism & Cancer 2023 Nice FR  + (5th edition Metabolism & Cancer, Nice, … 5th edition Metabolism & Cancer, Nice, France, 2023 </br></br>== Venue ==</br>:::: [https://www.metabolism-cancer.com/?utm_source=altemail&utm_medium=email&utm_campaign=2023-01-04%20METABO%202023%201 How to get there]</br></br>== Program ==</br>:::: Program available [https://www.metabolism-cancer.com/?utm_source=altemail&utm_medium=email&utm_campaign=2023-01-04%20METABO%202023%201 here]</br></br>== Organizers ==</br>:::: The list of organizers can be found [https://www.metabolism-cancer.com/?utm_source=altemail&utm_medium=email&utm_campaign=2023-01-04%20METABO%202023%201 here]</br></br>== Registration ==</br>:::: [https://www.metabolism-cancer.com/?utm_source=altemail&utm_medium=email&utm_campaign=2023-01-04%20METABO%202023%201 Registration and more information]utm_campaign=2023-01-04%20METABO%202023%201 Registration and more information])
• BPS19 2019 Baltimore US  + (63rd Annual Meeting of the Biophysical Soc … 63rd Annual Meeting of the Biophysical Society, Baltimore, Maryland USA, 2019 </br></br></br></br>== General information==</br>:::: The Biophysical Society meeting is the only major scientific meeting in the United States that routinely includes bioenergetics and mitochondrial topics. The Bioenergetics, Mitochondria, and Metabolism Subgroup has its two symposia on the first day of the meeting, March 2nd, and these two symposia have a distinguished group of speakers who are leaders in the field of bioenergetics. </br></br>== Venue == </br>:::: Baltimore Convention Center</br>:::: 1 W. Pratt Street</br>:::: Baltimore, Maryland 21201</br>::::[https://www.biophysics.org/2019meeting/hotel-travel Hotel and Travel]</br></br>== Programme ==</br>:::: [https://www.biophysics.org/2019meeting/program here]</br></br></br>== Registration ==</br>:::: [https://www.biophysics.org/2019meeting/registration Registration and more information]tration Registration and more information])
• AMI 2023 Jhansi IN  + (64^th Annual International Conference of the Associate of Microbiologists of India, Jhansi, India, 2023)
• BPS2023 San Diego US  + (67th Annual Meeting of the Biophysical Society, San Diego, California, USA, 2023)
• ISOTT 2017 Halle/Saale DE  + (6^th 45th Annual Meeting of the International Society on Oxygen Transport to Tissue (ISOTT), Halle/Saale, Germany.)
• 6th Annual Conference of Chinese Society for Neurobiological Control of Metabolism 2024 Quanzhou CN  + (6^th Annual Conference of Chinese Society for Neurobiological Control of Metabolism, Quanzhou, China, 2024)
• SMRM2017 New Delhi IN  + (6^th Annual Conference of the Society for Mitochondrial Research and Medicine, New Delhi, India.)
• MiPschool Copenhagen DK 2013  + (6^th MiP''summer school'' on Mitochondrial Physiology, 2013 August 26-30, Copenhagen, Denmark.)