Prosthetic group

From Bioblast

high-resolution terminology - matching measurements at high-resolution

Prosthetic group


A prosthetic group is a cofactor that is attached permanently and tightly or even covalently to an enzyme and that is regenerated in each enzymatic turnover. Thus a prostethic group is distinguished from a coenzyme or cosubstrate that is attached loosely and transiently. Like a coenzyme, the prosthetic group is required by an enzyme for its activity. A prosthetic group is 'a tightly bound, specific nonpolypeptide unit in a protein determining and involved in its biological activity' (IUPAC definition).

FMN/FMNH2 and FAD/FADH2 are prosthetic groups of Complex I and Complex II, respectively.



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Β» Substrate
Β» Product
Β» Substrates as electron donors
Β» Cellular substrates
Β» MitoPedia: Substrates and metabolites
Β» Substrate-uncoupler-inhibitor titration
Β» Cofactor
Β» Coenzyme, cosubstrate
Β» Nicotinamide adenine dinucleotide
Β» Coenzyme Q2
Β» Prosthetic group
Β» Flavin adenine dinucleotide
Β» Gnaiger E (2023) Complex II ambiguities ― FADH2 in the electron transfer system. MitoFit Preprints 2023.3.v6.

MitoPedia topics: Enzyme, Substrate and metabolite 

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