E-L net ET capacity: Difference between revisions

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E-L net ET capacity

Description

The Free ET capacity, ≈E, is the ET capacity corrected for LEAK respiration, ≈E = E-L. ≈E is the respiratory capacity potentially available for ion transport and phosphorylation of ADP to ATP. Oxygen consumption in the ET-pathway state, therefore, is partitioned into the free ET capacity, ≈E, and LEAK respiration, L_P, compensating for proton leaks, slip and cation cycling: E = ≈E+L_P (see free OXPHOS capacity).

Abbreviation: ≈E

Reference: Gnaiger 2014 MitoPathways

MitoPedia concepts: Respiratory state, Recommended, Ergodynamics

MitoPedia topics: EAGLE

Communicated by Gnaiger E 2014-09-21, edited 2015-01-19.

The Blue Book 2014: Fig. 2.4.

Coupling control states for ≈E

» Respiratory state

Reference state, Z_X: ET capacity; E = E´-Rox
Background state, Y_X: LEAK respiration; L = L´-Rox
Metabolic control variable, X=Z_X-Y_X: Scope of uncoupler stimulation, Free ET capacity; ≈E = E-L

Flux control factor

» Flux control factor, FCF

Coupling control factor, 1-Y_X/Z_X: E-L coupling control factor, ET-coupling efficiency: j_≈E = ≈E/E =(E-L)/E = 1-L/E

Compare

mt-Preparations Free OXPHOS capacity, ≈P = P-L
Intact cells Free ROUTINE activity, ≈R = R-L

@@ Line 1: / Line 1: @@
 {{MitoPedia
 |abbr=''≈E''
-|description=[[Image:E-L.jpg|50 px|Free ET-capacity]] The '''Free ET-capacity''', ''≈E'', is the [[ET-capacity]] corrected for [[LEAK respiration]], ''≈E'' = ''E-L''. ''≈E'' is the respiratory capacity potentially available for ion transport and phosphorylation of ADP to ATP. Oxygen consumption in the ET-pathway state, therefore, is partitioned into the free ET-capacity, ''≈E'', and LEAK respiration, ''L<sub>P</sub>'', compensating for proton leaks, slip and cation cycling: ''E'' = ''≈E''+''L<sub>P</sub>'' (see [[free OXPHOS capacity]]).
+|description=[[Image:E-L.jpg|50 px|Free ET capacity]] The '''Free ET capacity''', ''≈E'', is the [[ET capacity]] corrected for [[LEAK respiration]], ''≈E'' = ''E-L''. ''≈E'' is the respiratory capacity potentially available for ion transport and phosphorylation of ADP to ATP. Oxygen consumption in the ET-pathway state, therefore, is partitioned into the free ET capacity, ''≈E'', and LEAK respiration, ''L<sub>P</sub>'', compensating for proton leaks, slip and cation cycling: ''E'' = ''≈E''+''L<sub>P</sub>'' (see [[free OXPHOS capacity]]).
 |info=[[Gnaiger 2014 MitoPathways]]
 }}
@@ Line 17: / Line 17: @@
 == Coupling control states for ''≈E'' ==
 ::» [[Respiratory state]]
-* [[Reference state]], ''Z<sub>X</sub>'': [[Image:E.jpg|link=ET-capacity|ET-capacity]] [[ET-capacity]]; ''E'' = ''E´''-''Rox''
+* [[Reference state]], ''Z<sub>X</sub>'': [[Image:E.jpg|link=ET capacity|ET capacity]] [[ET capacity]]; ''E'' = ''E´''-''Rox''
 * [[Background state]], ''Y<sub>X</sub>'': [[Image:L.jpg|link=LEAK respiration|LEAK]] [[LEAK respiration]]; ''L'' = ''L´''-''Rox''
-* [[Metabolic control variable]], ''X=Z<sub>X</sub>-Y<sub>X</sub>'': [[Image:E-L.jpg|50 px|link=Free ET-capacity |Free ET-capacity]] Scope of uncoupler stimulation, [[Free ET-capacity]]; ''≈E'' = ''E-L''
+* [[Metabolic control variable]], ''X=Z<sub>X</sub>-Y<sub>X</sub>'': [[Image:E-L.jpg|50 px|link=Free ET capacity |Free ET capacity]] Scope of uncoupler stimulation, [[Free ET capacity]]; ''≈E'' = ''E-L''