E-L net ET capacity: Difference between revisions
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{{MitoPedia | {{MitoPedia | ||
|abbr=''โE'' | |abbr=''โE'' | ||
|description=[[Image:E-L.jpg|50 px|Free | |description=[[Image:E-L.jpg|50 px|Free ET-capacity]] The '''Free ET-capacity''', ''โE'', is the [[ET capacity]] corrected for [[LEAK respiration]], ''โE'' = ''E-L''. ''โE'' is the respiratory capacity potentially available for ion transport and phosphorylation of ADP to ATP. Oxygen consumption in the ET-pathway state, therefore, is partitioned into the free ET capacity, ''โE'', and LEAK respiration, ''L<sub>P</sub>'', compensating for proton leaks, slip and cation cycling: ''E'' = ''โE''+''L<sub>P</sub>'' (see [[free OXPHOS capacity]]). | ||
|info=[[Gnaiger 2014 MitoPathways]] | |info=[[Gnaiger 2014 MitoPathways]] | ||
}} | }} | ||
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== Coupling control states for ''โE'' == | == Coupling control states for ''โE'' == | ||
::ยป [[Respiratory state]] | ::ยป [[Respiratory state]] | ||
* [[Reference state]], ''Z<sub>X</sub>'': [[Image:E.jpg|link= | * [[Reference state]], ''Z<sub>X</sub>'': [[Image:E.jpg|link=ET capacity|ET capacity]] [[ET capacity]], ''E'' = ''Eยด''-ROX | ||
* [[Background state]], ''Y<sub>X</sub>'': [[Image:L.jpg|link=LEAK respiration|LEAK]] [[LEAK respiration]], ''L'' = ''Lยด''-ROX | * [[Background state]], ''Y<sub>X</sub>'': [[Image:L.jpg|link=LEAK respiration|LEAK]] [[LEAK respiration]], ''L'' = ''Lยด''-ROX | ||
* [[Metabolic control variable]], ''X=Z<sub>X</sub>-Y<sub>X</sub>'': [[Image:E-L.jpg|50 px|link=Free | * [[Metabolic control variable]], ''X=Z<sub>X</sub>-Y<sub>X</sub>'': [[Image:E-L.jpg|50 px|link=Free ET-capacity |Free ET-capacity]] Scope of uncoupler stimulation, [[Free ET-capacity]], ''โE'' = ''E-L'' | ||
== Flux control factor == | == Flux control factor == | ||
::ยป [[Flux control factor]], ''FCF'' | ::ยป [[Flux control factor]], ''FCF'' | ||
* [[Coupling control factor]], 1-''Y<sub>X</sub>/Z<sub>X</sub>'': [[Image:j--E.jpg|50 px|link= | * [[Coupling control factor]], 1-''Y<sub>X</sub>/Z<sub>X</sub>'': [[Image:j--E.jpg|50 px|link=ET-pathway coupling efficiency |ET-pathway coupling efficiency]] ''E-L'' coupling control factor, [[ET-pathway coupling efficiency]]: ''j<sub>โE</sub>'' = ''โE/E'' =(''E-L'')/''E'' = 1-''L/E'' | ||
Revision as of 16:28, 16 October 2017
Description
The Free ET-capacity, โE, is the ET capacity corrected for LEAK respiration, โE = E-L. โE is the respiratory capacity potentially available for ion transport and phosphorylation of ADP to ATP. Oxygen consumption in the ET-pathway state, therefore, is partitioned into the free ET capacity, โE, and LEAK respiration, LP, compensating for proton leaks, slip and cation cycling: E = โE+LP (see free OXPHOS capacity).
Abbreviation: โE
Reference: Gnaiger 2014 MitoPathways
MitoPedia concepts:
Respiratory state,
Recommended
MitoPedia topics:
EAGLE
Communicated by Gnaiger E 2014-09-21, edited 2015-01-19.
Coupling control states for โE
- Reference state, ZX: ET capacity, E = Eยด-ROX
- Background state, YX: LEAK respiration, L = Lยด-ROX
- Metabolic control variable, X=ZX-YX: Scope of uncoupler stimulation, Free ET-capacity, โE = E-L
Flux control factor
- ยป Flux control factor, FCF
- Coupling control factor, 1-YX/ZX: E-L coupling control factor, ET-pathway coupling efficiency: jโE = โE/E =(E-L)/E = 1-L/E
Compare
- mt-Preparations Free OXPHOS capacity, โP = P-L
- Intact cells Free ROUTINE activity, โR = R-L