Difference between revisions of "MitoEAGLE data: muscle"
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:::: The aim of WG2 will be to provide access to complete data sets for post-study statistical analysis and use harmonization tools (WG1) for standardized documentation, to initiate a data repository on muscle tissue from humans and model organisms in health and disease. Data sets shall be obtained from already published and new studies, prompting participating labs to report experimental details beyond those already published as far as possible (using tools such as PubMed Commons). As a result, specific protocols will be summarized for handling muscle tissue. Depending on specific interests, WG2 may decide to extend their focus to other tissue types. | :::: The aim of WG2 will be to provide access to complete data sets for post-study statistical analysis and use harmonization tools (WG1) for standardized documentation, to initiate a data repository on muscle tissue from humans and model organisms in health and disease. Data sets shall be obtained from already published and new studies, prompting participating labs to report experimental details beyond those already published as far as possible (using tools such as PubMed Commons). As a result, specific protocols will be summarized for handling muscle tissue. Depending on specific interests, WG2 may decide to extend their focus to other tissue types. | ||
== WG2 Participants == | |||
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== WG2 Management == | |||
=== Tasks === | === Tasks === | ||
Revision as of 14:52, 27 April 2016
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News and Events |  |
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Working Groups | Short-Term Scientific Missions | Management Committee | Members |  |
COST Action CA15203 (2016-2021): MitoEAGLE
Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping
MitoEAGLE data: muscle
WG2
- MITOEAGLE data repository in muscle and other tissues
WG2 Description
- During the past 10 years, a dramatically increasing number of studies report respirometric data on human muscle tissue (e.g. Christiansen 2015 Am J Physiol). Muscle mitochondrial function is particularly studied in genetically engineered mouse models of human diseases (e.g. Jelenik 2014 Diabetes). However, despite the many published data, lack of consistency often precludes quantitative comparison among data sets with permeabilized or homogenized muscle fibres or isolated mitochondria, normalized to either tissue wet weight, dry weight, protein content, citrate synthase activity or other mitochondrial markers. In the absence of validated conversion factors, these data remain largely unconnected and can only be qualitatively linked.
- The aim of WG2 will be to provide access to complete data sets for post-study statistical analysis and use harmonization tools (WG1) for standardized documentation, to initiate a data repository on muscle tissue from humans and model organisms in health and disease. Data sets shall be obtained from already published and new studies, prompting participating labs to report experimental details beyond those already published as far as possible (using tools such as PubMed Commons). As a result, specific protocols will be summarized for handling muscle tissue. Depending on specific interests, WG2 may decide to extend their focus to other tissue types.
WG2 Participants
| Country | City | Contact |
|---|---|---|
| Australia | Melbourne | Bishop David J |
| Austria | Innsbruck | Gnaiger Erich |
| Austria | Salzburg | Mayr JA |
| Austria | Innsbruck | Doerrier Carolina |
| Austria | Innsbruck | Laner Verena |
| Belgium | Leuven | Bird Matthew |
| Belgium | Liege | Votion Dominique-Marie |
| Brazil | São Paulo | Ferreira Julio Cesar B |
| Brazil | Jaboticabal, SP | Garcia Geovana S |
| Canada | Vancouver | Boushel Robert C |
| Canada | Edmonton (Alberta) | Lemieux Helene |
| Canada | Rimouski | Vandermeeren E |
| Canada | Antigonish | Kane Daniel A |
| Canada | Rimouski | Blier Pierre U |
| Croatia | Zagreb | Saric A |
| Croatia | Split | Mihanovic I |
| Czech Republic | Hradec Králové | Waldauf P |
| Czech Republic | Pilsen | Markova Michaela |
| Czech Republic | Prague 10 | Krajcova Adela |
| Czech Republic | Prague | Elkalaf Moustafa |
| Czech Republic | Pilsen | Kuncova J |
| Denmark | Copenhagen N | Mortensen OH |
| Denmark | Copenhagen | Dela Flemming |
| Denmark | Copenhagen | Larsen Steen |
| Denmark | Hvidovre | Nehlin Jan O |
| Denmark | Copenhagen | Gonzalez-Franquesa Alba |
| Denmark | Malov | Hey-Mogensen M |
| Estonia | Tallinn | Aid-Vanakova Jekaterina |
| Estonia | Tallinn | Truu Laura |
| Estonia | Tallinn | Karro N |
| Estonia | Tallinn | Kaambre Tuuli |
| Estonia | Tartu | Paju Kalju |
| Estonia | Tallinn | Tepp Kersti |
| Estonia | Tallinn | Vendelin Marko |
| Estonia | Tallinn | Puurand Marju |
| Finland | Jyvaeskylae | Lehti Maarit |
| Finland | Helsinki | Pirinen E |
| France | Grenoble cedex 9 | Dubouchaud Herve |
| France | Bordeaux cedex | Mourier A |
| France | Grenoble Cedex 9 | Schlattner Uwe |
| France | Montpellier | Cortade F |
| France | Montpellier Cedex 1 | Chabi Beatrice |
| France | Paris | Armand Anne-Sophie |
| France | Paris | Petit Patrice X |
| France | Paris | Ventura-Clapier R |
| Germany | Leipzig | Ost Mario |
| Germany | Cologne | Pesta Dominik |
| Germany | Rostock | Haider F |
| Germany | Köln | Kimoloi Sammy |
| Germany | Nuthetal | Klaus S |
| Germany | Munich | Jastroch M |
| Germany | Bochum | Platen P |
| Germany | Bremerhaven | Mark Felix Christopher |
| Germany | Düsseldorf | Granata Cesare |
| Germany | Duesseldorf | Roden Michael |
| Germany | Duesseldorf | Jelenik T |
| Greece | Heraklio | Sidiropoulou K |
| Greece | Heraklion | Tavernarakis Nektarios |
| Greece | Athens | Trougakos Ioannis P |
| India | Haryana | Sharma Vipin |
| Ireland | Dublin | O'Gorman Donal |
| Ireland | Dublin | Porter Richard K |
| Ireland | Sligo | Murphy J |
| Israel | Rishon Le Zion | Hachmo Yafit |
| Israel | Zrifin | Sova Marina |
| Israel | Jerusalem | Saada Reisch Ann |
| Italia | Udine | Salvadego Desy |
| Italy | Novara | Reano Simone |
| Italy | Bologna | Genova Maria Luisa |
| Italy | Rome | Scatena Roberto |
| Italy | Milan | De Palma Clara |
| Italy | Pisa | Gastaldelli Amalia |
| Italy | Milan | Giovarelli Matteo |
| Japan | Sapporo | Shirakawa R |
| Japan | Sapporo | Nambu H |
| Japan | Sapporo | Maekawa S |
| Latvia | Riga | Inashkina I |
| Latvia | Riga | Kuka Janis |
| Latvia | Riga | Liepins Edgars |
| Latvia | Riga | Zvejniece Liga |
| Luxembourg | Strassen | Devaux Yvan |
| Malta | Msida | Vella Joanna |
| Netherlands | Maastricht | Hoeks Joris |
| Netherlands | Maastricht | Grevendonk L |
| Netherlands | Wageningen | Keijer Jaap |
| Netherlands | Maastricht | Van Polanen N |
| Netherlands | Amsterdam | De Goede Paul |
| Netherlands | BT Amsterdam | Jaspers Richard T |
| Niederlande | ER Masstricht | De Theije C |
| Niederlande | ER Masstricht | De Wit-Verheggen V |
| Norway | Tromsoe | Schots Pauke C |
| Norway | Ullevål | Heiestad Christina |
| Norway | Oslo | Rustan AC |
| Norway | Oslo | Eide L |
| Norway | Oslo | Lund Jenny |
| Norway | Bergen | Tronstad Karl Johan |
| Norway | Oslo | Torp May-Kristin |
| Norway | Tromsoe | Larsen Terje S |
| Norway | Tromsoe | Jansen Kirsten M |
| Norway | Tromsoe | Aasum E |
| Norway | Oslo | Nikolic N |
| Poland | Lodz | Watala Cezary |
| Poland | Warsaw | Kampa Rafal Pawel |
| Poland | Lodz | Labieniec-Watala Magdalena |
| Poland | Warsaw | Dymkowska Dorota |
| Poland | Warsaw | Sek Aleksandra |
| Portugal | Porto | Coxito Pedro |
| Portugal | Porto | Magalhaes Jose |
| Portugal | Coimbra | Pereira Susana P |
| Portugal | Coimbra | Palmeira Carlos |
| Portugal | Porto | Beleza Jorge |
| Portugal | Coimbra | Carvalho Eugenia |
| Portugal | Cantanhede | Martins Joao D |
| Portugal | Cantanhede | Ferreira LL |
| Portugal | Coimbra | Martins Marques T |
| Romania | Timisoara | Lighezan R |
| Romania | Timisoara | Muntean Danina M |
| Singapore | Singapore | Hausenloy Derek J |
| Slovakia | Bratislava | Ukropcova B |
| Slovakia | Bratislava | Maderova D |
| Slovakia | Bratislava | Nemec Michal |
| Slovakia | Bratislava | Ukropec J |
| Slovakia | Bratislava | Sumbalova Zuzana |
| Slovenia | Ljubljana | Pirkmajer Sergej |
| Slovenia | Ljubljana | Dolinar K |
| Slovenia | Ljubljana | Mars T |
| South Africa | Smith James | |
| Spain | A Coruña | Blanco FJ |
| Spain | Barcelona | Guitart M |
| Spain | Barcelona | De la Torre Lara J |
| Spain | Sevilla | Bustos Matilde |
| Spain | Granada | Lopez Garcia Luis Carlos |
| Spain | Barcelona | Batlle M |
| Spain | Armilla (Granada) | Fernandez-Ortiz Marisol |
| Spain | Madrid | Cadenas S |
| Spain | Madrid | Moran M |
| Spain | Barcelona | Sebastian D |
| Spain | Barcelona | Zorzano Antonio |
| Spain | Barcelona | Garcia-Roves Pablo Miguel |
| Spain | Barcelona | Catalan M |
| Spain | Armilla (Granada) | Acuna-Castroviejo Dario |
| Spain | Barcelona | Gama Perez Pau |
| Spain | Armilla, Granada | Escames Germaine |
| Sweden | Stockholm | Cardinale Daniele A |
| Sweden | Linköping | Fontes-Oliveira CC |
| Switzerland | Lausanne | Weger M |
| Switzerland | Lausanne | Zalachoras I |
| Switzerland | Lausanne | Gebara E |
| Switzerland | Bern | Nuoffer Jean-Marc |
| Switzerland | Lausanne | Morato Fornaguera L |
| Switzerland | Lausanne | Sandi Carmen |
| The Netherlands | BT Amsterdam | Wuest Rob CI |
| The Netherlands | Wageningen | Van der Ende Miranda |
| Turkey | Ankara | Tuncay Erkan |
| USA | Gainesville | Neyroud D |
| USA | College Station | Latham C |
| USA | Gainesville | Wohlgemuth Stephanie E |
| USA | Baton Rouge | Irving Brian A |
| USA | Orlando | Coen Paul M |
| USA | Torrance | Rossiter Harry B |
| USA | Fort Collins | Chicco Adam J |
| USA | Boca Raton | Khamoui Andy V |
| USA | Colorado Springs | Jacobs RA |
| USA | Norfolk | Lai Nicola |
| USA | Baton Rouge | Axelrod Christopher L |
| USA | Seattle | Marcinek DJ |
| USA | Gainesville | Hepple Russell T |
| USA | Baltimore | Fang Evandro F |
| USA | Orlando | Distefano Giovanna |
| USA | Chicago | Dayanidhi Sudarshan |
| USA | Ann Arbor | Beard Daniel A |
| USA | Fairbanks | O'Brien Kristin |
| USA | Baltimore | Gonzalez-Freire Marta |
| USA | Little Rock | Porter Craig |
| USA | St Louis | Welch R |
| USA | College Station | White-Springer Sarah H |
| United Kingdom | Cambridge | Shiroma Jonathan G |
| United Kingdom | Brighton | Moore Anthony L |
| United Kingdom | Cambridge | Murray Andrew James |
| United Kingdom | London | Szabadkai Gyorgy |
| United Kingdom | Leeds | Boyle JP |
| United Kingdom | Birmingham | Thakker A |
| United Kingdom | Nottingham | Chakrabarti Lisa |
| United Kingdom | Manchester | Giakoumaki I |
| United Kingdom | Birmingham | Ashcroft S |
| United Kingdom | Oxford | Makrecka-Kuka Marina |
| United Kingdom | Birmingham | Joanisse S |
| United Kingdom | Loughborough | Ebanks Brad |
| United Kingdom | Birmingham | Garten Antje |
| United Kingdom | Plymouth, Devon | McKenna Helen T |
| United States | Providence | Siamwala J |
WG2 Management
Tasks
- Call for participating labs to deliver relevant experimental data on already published studies and to report them in a standardized format.
- Collection and indexing of the data sets as required for statistical analysis.
- Discussion of procedures, protocols and general guidelines.
- Draft a comprehensive review on mt-function in muscle tissue (registration at PROSPERO, link with EQUATOR).
- Opening of the database to the research public for data search and moderated entry of new data sets.
Milestones
- Call for data report delivered.
- Data sets entered in standardized format.
- Summary, interpretation and discussion of data for review.
Deliverables
- A MITOEAGLE database on muscle tissue from humans and model organisms.
- A set of guidelines for future studies on mitochondrial bioenergetics in muscle tissue.
- Draft of review manuscript.
Projects in progress
- » MiPMap
