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Difference between revisions of "Oroboros Laboratory"

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{{Template:OROBOROS header page name}}
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[[File:OROBOROS MitoFit-Lab.jpg|left|240px |MitoFit Laboratory]]
{{Template:OROBOROS Slogan}}
[[Image:Logo MitoFit.jpg|right|180px|link=http://www.mitofit.org/index.php/MitoFit|MitoFit]]
__TOC__
== About us ==


The OROBOROS MitoFit Laboratory (MitoFit Lab, 'Mitochondriales Forschungslabor') is a scientific research laboratory in Innsbruck, Austria, that is probably the world-wide best equipped lab for high-resolution respirometry. The MitoFit Lab was opened during the course of the K-Regio project [[MitoCom_O2k-Fluorometer| MitoCom Tyrol]], starting in June 2013. It comprises 140 sqm which are divided into the office and research areas.
:::: <big>'''Scientists with a gentle touch of entrepreneurship'''</big>
[[File:Lab in action.jpg|right|500px|Oroboros Laboratory]]


=== O2k instruments ===
'''24 O2k-Chambers (twelve O2k)'''


* Twelve O2k instruments (24 chambers) equipped with automatic Titration-Injection microPumps and the newest O2k-MultiSensor Modules or the NextGen-O2k configuration are available for research and biomedical applications. The newest instrumental designs are used for rigorous testing of our innovations.


* Two additional O2ks are devoted to instrumental development.
<!--[[File:OROBOROS MitoFit-Lab.jpg|left|240px |Oroboros O2k-Laboratory]]-->
 
 
''More details:'' [[O2k-technical_support_and_open_innovation|OROBOROS Support]]
 
 
=== OXPHOS analysis ===
 
SUIT protocols are applied in tissue samples from animal models and human patients. Using cultured cells or cells extracted from blood samples, the effects of genotypic variations or of various drugs are studied on OXPHOS parameters, using
 
* a phosphorylation control protocol in intact cells to evaluate effects on ROUTINE respiration, biochemical coupling efficiency and extracellular ROS production under physiological conditions;
 
* various substrate-uncoupler-inhibitor titration (SUIT) protocols in permeabilized cells for deep OXPHOS phenotyping ([[Cell_ergometry|cell ergometry]]).
 
 
=== The MitoFit Centre of Excellence ===
 
OROBOROS INSTRUMENTS collaborates closely with research labs of the Medical University of Innsbruck, the Ludwig-Franzens University of Innsbruck, and with visiting scientists from numerous internation research institutions.
 
According to the concept of open innovation, the Mitochondrial Research Laboratory welcomes visiting researchers from all over the world.
 
[[File:ORO Lab 1.jpg|250px]] [[File:ORO Lab 2.jpg|250px]] [[File:ORO Lab 3.jpg|250px]] [[File:ORO Lab 4.jpg|250px]]


__TOC__


== Oroboros O2k-Laboratory ==
:::: '''42 O2k-Chambers (21 O2k)'''


== Current projects and collaborators ==
:::: The '''Oroboros O2k-Laboratory''' ('Mitochondriales Forschungslabor') is a scientific research laboratory in Innsbruck, Austria, and likely the best equipped lab for high-resolution respirometry (HRR) worldwide. The O2k-Lab was opened during the course of the K-Regio project [[MitoCom_O2k-Fluorometer| MitoCom Tyrol]] in June 2013. It comprises 140 sqm which are divided into the office and research areas.
:: '''The [[OROBOROS_Company#The_OROBOROS-Team |OROBOROS-Team]] collaborates with:'''


=== MitoFit project ===
::::* Twenty-one O2k instruments for HRR (42 chambers) equipped with automatic Titration-Injection microPumps and the newest O2k-MultiSensor Modules or the NextGen-O2k configuration are available for research and biomedical applications. The newest instrumental designs are used for rigorous testing of our innovations.


[[Image:HoppelF.jpg|left|90px]]
::::* Two additional O2ks (4 chambers) are devoted to instrumental development.


:::: '''[[Hoppel F|Florian Hoppel]]''', MSc. - [mailto:florian.hoppel@oroboros.at florian.hoppel@oroboros.at]
::::* According to the concept of open innovation, the Oroboros O2k-Laboratory welcomes visiting researchers from all over the world.
:::: PhD student
:::: Institute for Sports Science and OROBOROS: [[O2k-MitoFit]]
[[Image:O2k-MitoFit.jpg|100px|link=http://www.mitofit.org/index.php/O2k-MitoFit|O2k-MitoFit]]
<br/><br/>


::::» ''More details:'' [[O2k-technical_support_and_open_innovation|Oroboros Support]]


=== Oncotyrol ===
:::: '''Prostate cancer'''
:::: The [[Oncotyrol| Oncotyrol]] research project has its focus on functional differences of mitochondria in human prostate tumor versus benign tissue, and comparison of primary tissue with cultured cells. - [http://oroboros.at/index.php?id=oncotyrol Oncotyrol]
:::: Project leader: A.Univ. Prof. Mag. Dr. Helmut Klocker, Dept. Urology, Medical University Innsbruck, Austria


::::'''[[Weber A| Anja Weber]]''', Mag., PhD student - [mailto:anja.weber@i-med.ac.at anja.weber@i-med.ac.at]
=== Joint projects ===
{| style="color: black;  width: 90%"
|-
| style="text-align: left;  background-color: #EFF5FB" | '''[[Functional Mitochondrial Diagnostics]]''' (VASCage)
| style="text-align: center;  background-color: #ffffff" |
<gallery heights="165px" mode="nolines" perrow="4" widths="192px">
File:Hardorp Rebecka.jpg|'''[[Hardorp Rebecka|Rebecka Hardorp]]'''
File:Romero Martinez Alejandra.jpeg|'''[[Romero Martinez Alejandra|Alejandra Romero-Martinez, Dr.]]'''
File:Wieser-Insole J.jpg|'''[[Wieser-Insole Joshua|Joshua Wieser-Insole]]'''
</gallery>
|-
| style="text-align: left;  background-color: #ffffff" | '''[[ALAS]]'''
| style="text-align: center;  background-color: #EFF5FB" |
<gallery heights="165px" mode="nolines" perrow="4" widths="192px">
File:Profile-icon-9.png|'''[[Pfleger Ana|Ana Pfleger, Mag. ]]'''
File:Roach_T.jpg|'''[[Roach Thomas|Thomas Roach, PhD ]]'''
</gallery>
|-
| style="text-align: left; background-color: #EFF5FB" | '''[[TissueModels]]'''
| style="text-align: center;  background-color: #ffffff" |
<gallery heights="165px" mode="nolines" perrow="4" widths="192px">


[[Image:SchoepfB.jpg|left|90px]]
File:Keller M.PNG|'''[[Keller Markus A| Markus Keller, Dr.]]'''
:: '''[[Schoepf B|Bernd Schoepf]]''', Mag., PhD student -
File:IOC 2366 cropped.jpg|'''[[Smaling Anna|Anna Smaling, MRes]]'''
<br/>
<br/>
<br/>


</gallery>
|-
| style="text-align: left;  background-color: #ffffff" | '''[[MitoKIN]]'''
| style="text-align: center;  background-color: #EFF5FB" |
<gallery heights="165px" mode="nolines" perrow="4" widths="192px">
File:Stefan E.jpg|'''[[Stefan Eduard|Eduard Stefan, PhD]]'''
File:Profile-icon-9.png|'''[[Strich Sophie|Sophie Strich]]'''
File:Torres-QuesadaO.jpg|'''[[Torres-Quesada O|Omar Torres-Quesada, PhD]]'''
</gallery>
|-
| style="text-align: left;  background-color: #EFF5FB" | '''[[CureMILS]]'''
| style="text-align: center;  background-color: #ffffff" |
<gallery heights="165px" mode="nolines" perrow="4" widths="192px">


:::: '''Oncotyrol phasing out'''
File:Suarez.png|'''[[Suarez-Cubero Marta|Marta Suarez-Cubero]]'''
:::: Project leader: Univ.-Prof. Dr. Zlatko Trajanoski, Biozentrum Innsbruck - Sektion für Bioinformatik, Medical University Innsbruck, Austria


</gallery>
|}




[[Image:WeberB.JPG|left|90px]]
== OXPHOS analysis ==
::::'''[[Weber B| Benno Weber]]''', Mag., Scientific assistant - [mailto:benno.weber@oncotyrol.at benno.weber@oncotyrol.at]
<br/> <br/> <br/> <br/> <br/>


[[Image:LaschoberG.JPG|left|90px]]
:::: SUIT protocols are applied in tissue samples from animal models and human patients. Using cultured cells or cells extracted from blood samples, the effects of genotypic variations or of various drugs are studied on OXPHOS parameters, using
::::'''[[Laschober G| Gerhard Laschober]]''', Mag., PhD, Postdoc - [mailto:gerhard.laschober@i-med.ac.at gerhard.laschober@i-med.ac.at]
<br/> <br/> <br/> <br/> <br/>


=== Pharmacology: mitochondrial function in brain tissues ===
::::* coupling control protocols (CCP) in intact cells to evaluate effects on ROUTINE respiration, biochemical coupling efficiency and extracellular ROS production under physiological conditions;
[[Image:Johannes.jpg|left|90px|Johannes Burtscher]]
::::* various substrate-uncoupler-inhibitor titration (SUIT) protocols in permeabilized cells for deep OXPHOS phenotyping ([[Cell_ergometry|cell ergometry]]).
:: '''[[Burtscher J|Johannes Burtscher]]''', Mag., PhD student
:: FWF projects W1206-B05 and I-977-B24.
:: Project leader: A.Univ. Prof. Dr. Christian Schwarzer, Dept. Pharmacology, Medical University Innsbruck, Austria
<br />




=== Internal Medicine ===
::::» [[Projects|'''Current projects''']]
:::: '''[[Volani C| Chiara Volani]]''', [mailto:c_volani@yahoo.com c_volani@yahoo.com]
::::» '''[[Partners in the Oroboros Ecosystem]]'''
:::: Project leader: Prof. Dr. Günther Weiss, Dept. of Internal Medicine, Medical University Innsbruck, Austria
::::» [[Oroboros Laboratories: visiting scientists |'''Visiting scientists''']]


=== Visiting scientists ===
== Keywords ==
:::: [[OROBOROS_MitoFit_lab:_visiting_scientists |'''» Visiting scientists in the MitoFit lab''']]
{{Keywords: Oroboros Laboratories}}

Latest revision as of 16:58, 15 February 2024

                

Oroboros Laboratory

Mitochondria and Cell Research - the Oroboros Ecosystem
Scientists with a gentle touch of entrepreneurship
Oroboros Laboratory



Oroboros O2k-Laboratory

42 O2k-Chambers (21 O2k)
The Oroboros O2k-Laboratory ('Mitochondriales Forschungslabor') is a scientific research laboratory in Innsbruck, Austria, and likely the best equipped lab for high-resolution respirometry (HRR) worldwide. The O2k-Lab was opened during the course of the K-Regio project MitoCom Tyrol in June 2013. It comprises 140 sqm which are divided into the office and research areas.
  • Twenty-one O2k instruments for HRR (42 chambers) equipped with automatic Titration-Injection microPumps and the newest O2k-MultiSensor Modules or the NextGen-O2k configuration are available for research and biomedical applications. The newest instrumental designs are used for rigorous testing of our innovations.
  • Two additional O2ks (4 chambers) are devoted to instrumental development.
  • According to the concept of open innovation, the Oroboros O2k-Laboratory welcomes visiting researchers from all over the world.
» More details: Oroboros Support


Joint projects

Functional Mitochondrial Diagnostics (VASCage)
ALAS
TissueModels
MitoKIN
CureMILS


OXPHOS analysis

SUIT protocols are applied in tissue samples from animal models and human patients. Using cultured cells or cells extracted from blood samples, the effects of genotypic variations or of various drugs are studied on OXPHOS parameters, using
  • coupling control protocols (CCP) in intact cells to evaluate effects on ROUTINE respiration, biochemical coupling efficiency and extracellular ROS production under physiological conditions;
  • various substrate-uncoupler-inhibitor titration (SUIT) protocols in permeabilized cells for deep OXPHOS phenotyping (cell ergometry).


» Current projects
» Partners in the Oroboros Ecosystem
» Visiting scientists

Keywords


Questions.jpg


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