Rohlena Jakub

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COST Action CA15203 (2016-2021): MitoEAGLE
Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping

Rohlena Jakub

MitoPedia topics: EAGLE

COST: Member COST WG1: WG1

Name	Rohlena Jakub, Dr.
Institution	Molecular Therapy Group, Institute of Biotechnology CAS, BIOCEV, CZ
Address	Prumyslova 595, 25250
City	Vestec
State/Province
Country	Czech Republic
Email	Jakub.Rohlena@img.cas.cz
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O2k-Network Lab	CZ Prague Neuzil J

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Publications

	Published	Reference
BEC 2020.1 doi10.26124bec2020-0001.v1	2020	Gnaiger E et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenerg Commun 2020.1. https://doi.org/10.26124/bec:2020-0001.v1
Boukalova 2020 Biochim Biophys Acta Mol Basis Dis	2020	Boukalova S, Hubackova S, Milosevic M, Ezrova Z, Neuzil J, Rohlena J (2020) Dihydroorotate dehydrogenase in oxidative phosphorylation and cancer. Biochim Biophys Acta Mol Basis Dis 1866:165759. https://doi.org/10.1016/j.bbadis.2020.165759
Bajzikova 2019 Cell Metab	2019	Bajzikova M, Kovarova J, Coelho AR, Boukalova S, Oh S, Rohlenova K, Svec D, Hubackova S, Endaya B, Judasova K, Bezawork-Geleta A, Kluckova K, Chatre L, Zobalova R, Novakova A, Vanova K, Ezrova Z, Maghzal GJ, Magalhaes Novais S, Olsinova M, Krobova L, An YJ, Davidova E, Nahacka Z, Sobol M, Cunha-Oliveira T, Sandoval-Acuña C, Strnad H, Zhang T, Huynh T, Serafim TL, Hozak P, Sardao VA, Koopman Werner JH, Ricchetti M, Oliveira PJ, Kolar F, Kubista M, Truksa J, Dvorakova-Hortova K, Pacak K, Gurlich R, Stocker R, Zhou Y, Berridge MV, Park S, Dong L, Rohlena J, Neuzil J (2019) Reactivation of dihydroorotate dehydrogenase-driven pyrimidine biosynthesis restores tumor growth of respiration-deficient cancer cells. Cell Metab 29:399-416. 10.1016/j.cmet.2018.10.014
Blecha 2017 Free Radic Biol Med	2017	Blecha J, Novais SM, Rohlenova K, Novotna E, Lettlova S, Schmitt S, Zischka H, Neuzil J, Rohlena J (2017) Antioxidant defense in quiescent cells determines selectivity of electron transport chain inhibition-induced cell death. Free Radic Biol Med 112:253-66.
Rohlenova 2016 Antioxid Redox Signal	2016	Rohlenova K, Sachaphibulkij K, Stursa J, Bezawork-Geleta A, Blecha J, Endaya B, Werner L, Cerny J, Zobalova R, Goodwin J, Spacek T, Alisadeh E, Yan B, Nguyen M, Vondrusova M, Sobol M, Jezek P, Hozak P, Truksa J, Rohlena J, Dong L, Neuzil J (2016) Selective disruption of respiratory supercomplexes as a new strategy to suppress Her2^high breast cancer. Antioxid Redox Signal 26:84-103.
Tan 2015 Cell Metab	2015	Tan AS, Baty JW, Dong L, Bezawork-Geleta A, Endaya B, Goodwin J, Bajzikova M, Kovarova J, Peterka M, Yan B, Pesdar EA, Sobol M, Filimonenko A, Stuart S, Vondrusova M, Kluckova K, Sachaphibulkij K, Rohlena J, Hozak P, Truksa J, Eccles D, Haupt LM, Griffiths LR, Neuzil J, Berridge MV (2015) Mitochondrial genome acquisition restores respiratory function and tumorigenic potential of cancer cells without mitochondrial DNA. Cell Metab 21:81-94.
Truksa 2015 Antioxid Redox Signal	2015	Truksa J, Dong L, Rohlena J, Stursa J, Vondrusova M, Goodwin J, Nguyen M, Kluckova K, Rychtarcikova Z, Lettlova S, Spacilova J, Stapelberg M, Zoratti M, Neuzil J (2015) Mitochondrially targeted vitamin E succinate modulates expression of mitochondrial DNA transcripts and mitochondrial biogenesis. Antioxid Redox Signal 22:883-900.
Kluckova 2015 Methods Mol Biol	2015	Kluckova K, Dong L, Bajzikova M, Rohlena J, Neuzil J (2015) Evaluation of respiration of mitochondria in cancer cells exposed to mitochondria-targeted agents. Methods Mol Biol 1265:181-94.
Kluckova 2015 Cell Death Dis	2015	Kluckova K, Sticha M, Cerny J, Mracek T, Dong L, Drahota Z, Gottlieb E, Neuzil J, Rohlena J (2015) Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation. Cell Death Dis 6:e1749.

Abstracts

	Published	Reference
Rohlena 2017 MiP2017	2017	Reactivation of dihydroorotate dehydrogenase by respiration restores tumor growth of mitochondrial DNA-depleted cancer cells.
Blecha 2015 Abstract MiP2015	2015	Modulation of mitochondrial electron transport chain activity differentially regulates cell death in proliferating and quiescent cells.
Rohlena 2015 Abstract MiP2015	2015	Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation.
Rohlenova 2015 Abstract MiP2015	2015	Mitochondrial targeting of tamoxifen enhances its activity against Her2^high breast cancer.
Kluckova 2014 Abstract MiP2014	2014	Proximal ubiquinone binding site in mitochondrial respiratory Complex II is a target for vitamin E analog MitoVES, an experimental anti-cancer agent. Mitochondr Physiol Network 19.13.

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