EE Tallinn Kaambre T

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Oroboros Instruments

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EE Tallinn Kaambre T

Oroboros O2k-Network

O2k-Network Lab Laboratory of Bioenergetics

National Institute of Chemical Physics and Biophysics

Address Akadeemia 23, 12618,
City Tallinn
Country Estonia
Contact Kaambre Tuuli
Team Chekulayev Vladimir, Klepinin Aleksandr, Koit Andre, Maedo Kati, Shevchuk Igor, Tepp Kersti, Timohhina Natalja, Truu Laura, Klepinina Lyudmila, Puurand Marju
Team previous Kandashvili Manana, Saks Valdur A, Varikmaa Minna
Status 4 Power-O2k 2006- ; previous: EE Tallinn Saks VA
Oroboros Events MiPschool 2018, MitoEAGLE 2018 LV, MitoEAGLE 2017 CZ, IOC122, MitoEAGLE 2017 ES, MitoEAGLE 2016 IT, MiP2015, MiP2014, IOC88, MiP2013, IOC77, IOC46, IOC36, IOC35


Puurand 2019 Cells2019Puurand M, Tepp K, Timohhina N, Aid J, Shevchuk I, Chekulayev V, Kaambre T (2019) Tubulin βII and βIII isoforms as the regulators of VDAC channel permeability in health and disease. Cells 8:E239.
Puurand 2018 Int J Mol Sci2018Puurand M, Tepp K, Klepinin A, Klepinina L, Shevchuk I, Kaambre T (2018) Intracellular energy-transfer networks and high-resolution respirometry: a convenient approach for studying their function. Int J Mol Sci 19:e2933.
Klepinin 2018 J Bioenerg Biomembr2018Klepinin A, Ounpuu L, Mado K, Truu L, Chekulayev V, Puurand M, Shevchuk I, Tepp K, Planken A, Kaambre T (2018) The complexity of mitochondrial outer membrane permeability and VDAC regulation by associated proteins. J Bioenerg Biomembr 50:339-54.
Koit 2018 US Patent2018Koit A, Kaambre T (2018) Method for selecting patients responsive for cancer treatments. US Patent US20180017547A1.
Ounpuu 2018 Biochem Cell Biol2018Ounpuu L, Truu L, Shevchuk I, Chekulayev V, Klepinin A, Koit A, Tepp K, Puurand M, Rebane-Klemm E, Käämbre T (2018) Comparative analysis of the bioenergetics of human adenocarcinoma Caco-2 cell line and postoperative tissue samples from colorectal cancer patients. Biochem Cell Biol [Epub ahead of print].
Tepp 2017 Mol Cell Biochem2017Tepp K, Puurand M, Timohhina N, Adamson J, Klepinin A, Truu L, Shevchuk I, Chekulayev V, Kaambre T (2017) Changes in the mitochondrial function and in the efficiency of energy transfer pathways during cardiomyocyte aging. Mol Cell Biochem 432:141-58.
Koit 2017 Oxid Med Cell Longev2017Koit A, Shevchuk I, Ounpuu L, Klepinin A, Chekulayev V, Timohhina N, Tepp K, Puurand M,Truu L, Heck K, Valvere V, Guzun R, Kaambre T (2017) Mitochondrial respiration in human colorectal and breast cancer clinical material is regulated differently. Oxid Med Cell Longev 2017:1372640.
Ounpuu 2017 Biochim Biophys Acta2017Ounpuu L, Klepinin A, Pook M, Teino I, Peet N, Paju K, Tepp K, Chekulayev V, Shevchuk I, Koks S, Maimets T, Kaambre T (2017) 2102Ep embryonal carcinoma cells have compromised respiration and shifted bioenergetic profile distinct from H9 human embryonic stem cells. Biochim Biophys Acta 1861:2146-54.
Klepinin 2016 J Bioenerg Biomembr2016Klepinin A, Ounpuu L, Guzun R, Chekulayev V, Timohhina N, Tepp K, Shevchuk I, Schlattner U, Kaambre T (2016) Simple oxygraphic analysis for the presence of adenylate kinase 1 and 2 in normal and tumor cells. J Bioenerg Biomembr 48:531-48.
Bagur 2016 Biochim Biophys Acta2016Bagur R, Tanguy S, Foriel S, Grichine A, Sanchez C, Pernet-Gallay K, Kaambre T, Kuznetsov AV, Usson Y, Boucher F, Guzun R (2016) The impact of cardiac ischemia/reperfusion on the mitochondria-cytoskeleton interactions. Biochim Biophys Acta 1862:1159-71.
Guzun 2015 Acta Physiol (Oxf)2015Guzun R, Kaambre T, Bagur R, Grichine A, Usson Y, Varikmaa M, Anmann T, Tepp K, Timohhina N, Shevchuk I, Chekulayev V, Boucher F, Dos Santos P, Schlattner U, Wallimann T, Kuznetsov AV, Dzeja P, Aliev M, Saks V (2015) Modular organization of cardiac energy metabolism:energy conversion, transfer and feedback regulation. Acta Physiol (Oxf) 213:84-106.
Chekulayev 2015 Biochem Biophys Rep2015Chekulayev V, Mado K, Shevchuk I, Koit A, Kaldma A, Klepinin A, Timohhina N, Tepp K, Kandashvili M, Ounpuu L, Heck K, Truu L, Planken A, Valvere V, Kaambre T (2015) Metabolic remodeling in human colorectal cancer and surrounding tissues: alterations in regulation of mitochondrial respiration and metabolic fluxes. Biochem Biophys Rep 4:111-25.
Klepinin 2014 J Bioenerg Biomembr2014Klepinin A, Chekulayev V, Timohhina N, Shevchuk I, Tepp K, Kaldma A, Koit A, Saks V, Kaambre T (2014) Comparative analysis of some aspects of mitochondrial metabolism in differentiated and undifferentiated neuroblastoma cells. J Bioenerg Biomembr 46:17-31.
Anmann 2014 Biochim Biophys Acta2014Anmann T, Varikmaa M, Timohhina N, Tepp K, Shevchuk I, Chekulayev V, Saks V, Kaambre T (2014) Formation of highly organized intracellular structure and energy metabolism in cardiac muscle cells during postnatal development of rat heart. Biochim Biophys Acta 1837:1350-61.
Kaldma 2014 Int J Biochem Cell Biol2014Kaldma A, Klepinin A, Chekulayev V, Mado K, Shevchuk I, Timohhina N, Tepp K, Kandashvili M, Varikmaa M, Koit A, Planken M, Heck K, Truu L, Planken A, Valvere V, Rebane E, Kaambre T (2014) An in situ study of bioenergetic properties of human colorectal cancer: The regulation of mitochondrial respiration and distribution of flux control among the components of ATP synthasome. Int J Biochem Cell Biol 55C:171-86.
Varikmaa 2014 Biochim Biophys Acta2014Varikmaa M, Bagur R, Kaambre T, Grichine A, Timohhina N, Tepp K, Shevchuk I, Chekulayev V, Metsis M, Boucher F, Saks V, Kuznetsov AV, Guzun R (2014) Role of mitochondria-cytoskeleton interactions in respiration regulation and mitochondrial organization in striated muscles. Biochim Biophys Acta 1837:232-45.
Varikmaa 2013 J Bioenerg Biomembr2013Varikmaa M, Guzun R, Grichine A, Gonzalez-Granillo M, Usson Y, Boucher F, Kaambre T, Saks V (2013) Matters of the heart in bioenergetics: mitochondrial fusion into continuous reticulum is not needed for maximal respiratory activity. J Bioenerg Biomembr 45:319-31.
Kaambre 2013 Front Physiol2013Kaambre T, Chekulayev V, Shevchuk I, Tepp K, Timohhina N, Varikmaa M, Bagur R, Klepinin A, Anmann T, Koit A, Kaldma A, Guzun R, Valvere V, Saks V (2013) Metabolic control analysis of respiration in human cancer tissue. Front Physiol 4:151.
Kaambre 2012 J Bioenerg Biomembr2012Kaambre T, Chekulayev V, Shevchuk I, Karu-Varikmaa M, Timohhina N, Tepp K, Bogovskaja J, Kütner R, Valvere V, Saks V (2012) Metabolic control analysis of cellular respiration in situ in intraoperational samples of human breast cancer. J Bioenerg Biomembr 44:539-58.
Kuznetsov 2012 Biochem J2012Kuznetsov AV, Guzun R, Boucher F, Bagur R, Kaambre T, Saks V (2012) Mysterious Ca2+-independent muscular contraction: déjà vu. Biochem J 445:333-6.
Gonzalez-Granillo 2012 J Mol Cell Cardiol2012Gonzalez-Granillo M, Grichine A, Guzun R, Usson Y, Tepp K, Chekulayev V, Shevchuk I, Karu-Varikmaa M, Kuznetsov AV, Grimm M, Saks V, Kaambre T (2012) Studies of the role of tubulin beta II isotype in regulation of mitochondrial respiration in intracellular energetic units in cardiac cells. J Mol Cell Cardiol 52:437-47.
Guzun 2011 Biochim Biophys Acta2011Guzun R, Karu-Varikmaa M, Gonzalez-Granillo M, Kuznetsov AV, Michel L, Cottet-Rousselle C, Saaremäe M, Kaambre T, Metsis M, Grimm M, Auffray C, Saks V (2011) Mitochondria–cytoskeleton interaction: Distribution of β-tubulins in cardiomyocytes and HL-1 cells. Biochim Biophys Acta 1807:458-69.
Tepp 2011 Biochim Biophys Acta2011Tepp K, Shevchuk I, Chekulayev V, Timohhina N, Kuznetsov AV, Guzun R, Saks V, Kaambre T (2011) High efficiency of energy flux controls within mitochondrial interactosome in cardiac intracellular energetic units. Biochim Biophys Acta 1807: 1549-1561.
Guerrero 2010 Mol Cell Biochem2010Guerrero K, Monge C, Brückner A, Puurand U, Kadaja L, Käämbre T, Seppet E, Saks V (2010) Study of possible interactions of tubulin, microtubular network, and STOP protein with mitochondria in muscle cells. Mol Cell Biochem 337:239-49.
Sepp 2010 Biophys J2010Sepp M, Vendelin M, Vija H, Birkedal R (2010) ADP compartmentation analysis reveals coupling between pyruvate kinase and ATPases in heart muscle. Biophys J 98:2785-93.
Guzun 2009 Biochim Biophys Acta2009Guzun R, Timohhina N, Tepp K, Monge C, Kaambre T, Sikk P, Kuznetsov AV, Pison C, Saks V (2009) Regulation of respiration controlled by mitochondrial creatine kinase in permeabilized cardiac cells in situ. Importance of system level properties. Biochim Biophys Acta 1787:1089-105.
Monge 2009 Can J Physiol Pharmacol 87:318-326.2009Monge C, Beraud N, Tepp K, Pelloux S, Chahboun S, Kaambre T, Kadaja L, Roosimaa M, Piirsoo A, Tourneur Y, Kuznetsov AV, Saks V, Seppet E (2009) Comparative analysis of the bioenergetics of adult cardiomyocytes and nonbeating HL-1 cells: respiratory chain activities, glycolytic enzyme profiles, and metabolic fluxes. Can J Physiol Pharmacol 87:318-26.
Timohhina 2009 J Bioenerg Biomembr2009Timohhina N, Guzun R, Tepp K, Monge C, Varikmaa M, Vija H, Sikk P, Kaambre T, Sackett D, Saks V (2009) Direct measurement of energy fluxes from mitochondria into cytoplasm in permeabilized cardiac cells in situ: some evidence for mitochondrial interactosome. J Bioenerg Biomembr 41:259-75.
Eimre 2008 Biochim Biophys Acta2008Eimre M, Paju K, Pelloux S, Beraud N, Roosimaa M, Kadaja L, Gruno M, Peet N, Orlova E, Remmelkoor R, Piirsoo A, Saks V, Seppet E (2008) Distinct organization of energy metabolism in HL-1 cardiac cell line and cardiomyocytes. Biochim Biophys Acta 1777:514-24.
Kuznetsov 2008 Nat Protoc2008Kuznetsov AV, Veksler V, Gellerich FN, Saks V, Margreiter R, Kunz WS (2008) Analysis of mitochondrial function in situ in permeabilized muscle fibers, tissues and cells. Nat Protoc 3:965-76.
Monge 2008 Mol Cell Biochem2008Monge C, Beraud N, Kuznetsov AV, Rostovtseva T, Sackett D, Schlattner U, Vendelin M, Saks V (2008) Regulation of respiration in brain mitochondria and synaptosomes: restrictions of ADP diffusion in situ, roles of tubulin, and mitochondrial creatine kinase. Mol Cell Biochem 318:147-65.
Rostovtseva 2008 Proc Natl Acad Sci U S A2008Rostovtseva TK, Sheldon KL, Hassanzadeh E, Monge C, Saks V, Bezrukov SM, Sackett DL (2008) Tubulin binding blocks mitochondrial voltage-dependent anion channel and regulates respiration. Proc Natl Acad Sci U S A 105:18746-51.
Anmann 2005 FEBS J2005Anmann T, Eimre M, Kuznetsov AV, Andrienko T, Kaambre T, Sikk P, Seppet E, Tiivel T, Vendelin M, Seppet EK, Saks VA (2005) Calcium-induced contraction of sarcomeres changes the regulation of mitochondrial respiration in permeabilized cardiac cells. FEBS J 272:3145-61.
Guerrero 2005 Am J Physiol Regul Integr Comp Physiol2005Guerrero K, Wuyam B, Mezin P, Vivodtzev I, Vendelin M, Borel JC, Hacini R, Chavanon O, Imbeaud S, Saks V, Pison C (2005) Functional coupling of adenine nucleotide translocase and mitochondrial creatine kinase is enhanced after exercise training in lung transplant skeletal muscle. Am J Physiol Regul Integr Comp Physiol 289:R1144-54.
Seppet 2005 Mol Cell Biochem2005Seppet E, Eimre M, Peet N, Paju K, Orlova E, Ress M, Kovask S, Piirsoo A, Saks VA, Gellerich FN, Zierz S, Seppet EK (2005) Compartmentation of energy metabolism in atrial myocardium of patients undergoing cardiac surgery. Mol Cell Biochem 270:49-61.
Kuznetsov 2004 Am J Physiol Heart Circ Physiol2004Kuznetsov AV, Schneeberger S, Seiler R, Brandacher G, Mark W, Steurer W, Saks V, Usson Y, Margreiter R, Gnaiger E (2004) Mitochondrial defects and heterogeneous cytochrome c release after cardiac cold ischemia and reperfusion. Am J Physiol Heart Circ Physiol 286:H1633–41.
Andrienko 2003 J Exp Biol2003Andrienko T, Kuznetsov AV, Kaambre T, Usson Y, Orosco A, Appaix F, Tiivel T, Sikk P, Vendelin M, Margreiter R, Saks VA (2003) Metabolic consequences of functional complexes of mitochondria, myofibrils and sarcoplasmic reticulum in muscle cells. J Exp Biol 206:2059-72.
Appaix 2003 Exp Physiol2003Appaix F, Kuznetsov AV, Usson Y, Kay L, Andrienko T, Olivares J, Kaambre T, Sikk P, Margreiter R, Saks V (2003) Possible role of cytoskeleton in intracellular arrangement and regulation of mitochondria. Exp Physiol 88:175-90.
Saks 2003 Biophys J2003Saks V, Kuznetsov A, Andrienko T, Usson Y, Appaix F, Guerrero K, Kaambre T, Sikk P, Lemba M, Vendelin M (2003) Heterogeneity of ADP diffusion and regulation of respiration in cardiac cells. Biophys J 84:3436-56.
Appaix 2002 Biochim Biophys Acta2002Appaix F, Guerrero K, Rampal D, Izikki M, Kaambre T, Sikk P, Brdiczka D, Riva-Lavieille C, Olivares J, Longuet M, Antonsson B, Saks VA (2002) Bax and heart mitochondria: uncoupling and inhibition of respiration without permeability transition. Biochim Biophys Acta 1556:155-67.
Seppet 2001 Biochim Biophys Acta2001Seppet EK, Kaambre T, Sikk P, Tiivel T, Vija H, Tonkonogi M, Sahlin K, Kay L, Appaix F, Braun U, Eimre M, Saks VA (2001) Functional complexes of mitochondria with Ca,Mg ATPases of myofibrils and sarcoplasmic reticulum in muscle cells. Biochim Biophys Acta 1504:379-95.
Saks 2001 Biochem J2001Saks VA, Kaambre T, Sikk P, Eimre M, Orlova E, Paju K, Piirsoo A, Appaix F, Kay L, Regitz-Zagrosek V, Fleck E, Seppet E (2001) Intracellular energetic units in red muscle cells. Biochem J 356:643-57.
Kay 1997 Biochim Biophys Acta1997Kay L, Li Z, Mericskay M, Olivares J, Tranqui L, Fontaine E, Tiivel T, Sikk P, Kaambre T, Samuel JL Rappaport L, Usson Y, Leverve X, Paulin D, Saks VA (1997) Study of regulation of mitochondrial respiration in vivo. An analysis of influence of ADP diffusion and possible role of cytoskeleton. Biochim Biophys Acta 1322:41-59.


Ounpuu 2018 MiP20182018
Lyudmila Ounpuu
Metabolic plasticity of cancer stem-like cells.
Garcia-Roves 2018 MiP2018b2018
Pablo Garcia-Roves
Generating mitochondrial respirometry reference values from permeabilized mouse soleus muscle fibers. Working Group 2 report. Garcia-Roves_Presentation
Puurand 2018 MiPschool Tromso E22018
Intracellular energy-transfer networks in health and disease – the results of oxygraphic studies.
Puurand 2017 MiP20172017
Cellular phosphotransfer networks as a target of bioenergetic research – methods of oxygraphic study.
Truu 2017 MiP20172017
Laura Truu
Bioenergetic comparison of human colorectal and breast cancer clinical patients.
Truu 2017 Abstract IOC1222017Bioenergetics of colorectal cancer.
Klepinin 2017 MiP20172017
Novel method to study the role of the adenylate kinase network in health and disease.
Ounpuu 2017 MiP20172017
Ljudmila Ounpuu
The role of dietary fibers in the energy metabolism of human colon cancer cells.
Shevchuk 2015 Abstract MiP20152015Analysis of energy fluxes in colorectal cancer saponin skinned tissues and Caco-2 cells.
Tepp 2015 Abstract MiP20152015Changes in energy transfer regulation during development and aging.
Kaambre 2015 Abstract MiP20152015Quantitative characterization of respiratory parameters of human colorectal and breast cancer clinical material.
Kandashvili 2014 Abstract MiP20142014Regulation of energy metabolism in human colorectal cancer cells in situ.
Maedo 2014 Abstract IOC 2014-04 Schroecken2014Maedo K, Kaldma A, Planken A, Klepinin A, Chekulayev V, Varikmaa M, Tepp K, Chevchuk I, Kaambre T (2014) Regulation of mitochondrial respiration in human colorectal cancer cells in situ: the possible role of beta-tubulins. Mitochondr Physiol Network 19.02.
Tepp 2013 Abstract MiP20132013Tepp K, Anmann T, Varikmaa M, Timohhina N, Shevchuk I, Chekulayev V, Saks V, Kaambre T (2013) Bioenergetic aspects of postnatal development of cardiac cells: Formation of structure-function relationship. Mitochondr Physiol Network 18.08.

Further references