O2k-PublicationAlert2023 Archive

From Bioblast
Mitochondria and Cell Research - the Oroboros Ecosystem
» Listed in Oroboros Ecosystem Agenda 2023 Archive

Dec 2023

  • Dec- 29 Fr
O2k-Publications in the MiPMap "Leptin receptor signaling in Schwann cells adjusts catabolic processes, including mitochondrial respiration and autophagy, facilitating nerve repair."
  • Sundaram VK, Schütza V, Schröter NH, Backhaus A, Bilsing A, Joneck L, Seelbach A, Mutschler C, Gomez-Sanchez JA, Schäffner E, Sánchez EE, Akkermann D, Paul C, Schwagarus N, Müller S, Odle A, Childs G, Ewers D, Kungl T, Sitte M, Salinas G, Sereda MW, Nave KA, Schwab MH, Ost M, Arthur-Farraj P, Stassart RM, Fledrich R (2023) Adipo-glial signaling mediates metabolic adaptation in peripheral nerve regeneration. »Bioblast link«
from the O2k-Network »DE_Leipzip_Ost_M«

  • Dec- 20 We
O2k-Publications in the MiPMap "SIRT4 [Sirtuin 4] knockdown increases mitochondrial capacity to oxidize fatty acids, decreasing LEAK respiration and further increasing mitochondrial elongation via its regulation of mitochondrial fusion."
  • Noone J, Rochfort KD, O'Sullivan F, O'Gorman DJ (2023) SIRT4 is a regulator of human skeletal muscle fatty acid metabolism influencing inner and outer mitochondrial membrane-mediated fusion. »Bioblast link«
from the O2k-Network »US FL Orlando Goodpaster BH« and »IE Dublin O Gorman D«

  • Dec- 14 Th
O2k-Publications in the MiPMap "HCR [High capacity runner rats] showed a consistent and robust trend of higher maximal oxygen consumption compared to LCR [low capacity runner rats], especially for long chain FAs [fatty acids]."
  • Fleischman JY, Van den Bergh F, Collins NL, Bowers M, Beard DA, Burant CF (2023) Higher mitochondrial oxidative capacity is the primary molecular differentiator in muscle of rats with high and low intrinsic cardiorespiratory fitness. »Bioblast link«
from the O2k-Network »US MI Ann Arbor Beard DA«

  • Dec- 12 Tu
MitoFit pdf From preprint to Gold Open Access publication in J Biol Chem
  • Gnaiger E (2023) Complex II ambiguities ― FADH2 in the electron transfer system. »Bioblast link«

  • Dec- 07 Th
O2k-Publications in the MiPMap "(…) L-Erg [L-Ergothioneine] treatment prevented and delayed cystine lithiasis in a cystinuria mouse model by increasing urinary cystine solubility and restored kidney GSH content and OXPHOS function."
  • Mayayo-Vallverdú C, López de Heredia M, Prat E, González L, Espino Guarch M, Vilches C, Muñoz L, Asensi MA, Serra C, Llebaria A, Casado M, Artuch R, Garrabou G, Garcia-Roves PM, Pallardó FV, Nunes V (2023) The antioxidant l-Ergothioneine prevents cystine lithiasis in the Slc7a9-/- mouse model of cystinuria »Bioblast link«
from the O2k-Network »ES Barcelona Moren C« and »ES Barcelona Garcia-Roves PM«

  • Dec- 06 We
MitoFit pdf "The capacity of FA oxidative phosphorylation (F-OXPHOS) with palmitoylcarnitine was up to 4 times higher than respiration with octanoylcarnitine. The optimal concentration of palmitoylcarnitine was 10 μM which corresponds to the total concentration of LC acylcarnitines in the brain."
  • Cecatto C, Cardoso LHD, Ozola M, Korzh S, Zvejniece L, Gukalova B, Doerrier C, Dambrova M, Gnaiger E, Makrecka-Kuka M, Liepinsh E (2023) Fatty acid β-oxidation in brain mitochondria: Insights from high-resolution respirometry in mouse, rat and Drosophila brain, ischemia and aging models. MitoFit Preprints 2023.10. https://doi.org/10.26124/mitofit:2023-0010
from the O2k-Network »AT Innsbruck Oroboros« and »LV Riga Liepins E«

  • Dec- 01 Fr World AIDS day
O2k-Publications in the MiPMap "We therefore hypothesized that the susceptibility to HIV-1 infection of FOXO1-inhibited resting T cells could be due to an increased cell metabolism. (...) Results obtained by high-resolution respirometry experiments of [human peripheral blood T cells] PBT (...) showed that [ROUTINE] respiration at the steady state was increased by [FOXO1 inhibitor] AS1842856."
  • Roux A, Leroy H, De Muylder B, Bracq L, Oussous S, Dusanter-Fourt I, Chougui G, Tacine R, Randriamampita C, Desjardins D, Le Grand R, Bouillaud F, Benichou S, Margottin-Goguet F, Cheynier R, Bismuth G, Mangeney M (2019) FOXO1 transcription factor plays a key role in T cell-HIV-1 interaction. »Bioblast link«
from the O2k-Network »FR Paris Bouillaud F«

Nov 2023

  • Nov- 23 Th
O2k-Publications in the MiPMap "Thoughtful design and execution of O2k experiments result in data that become a powerhouse for addressing many mitochondrial respiration research questions. "
  • Walsh MA, Musci RV, Jacobs RA, Hamilton KL (2023) A practical perspective on how to develop, implement, execute, and reproduce high-resolution respirometry experiments: The physiologist's guide to an Oroboros O2k »Bioblast link«
from the O2k-Network »US CO Colorado Springs Jacobs RA« and »US CO Fort Collins Hamilton K«

  • Nov- 22 We
Oliveira 2023 BEC
“The cautionary note provided by these studies emphasizes the need for careful consideration of which probes and conditions can be used when assessing mitochondrial physiology in Drosophila.”
from the O2k-Network »BR Rio de Janeiro Oliveira MF«

  • Nov- 16 Th - World Pancreatic Cancer Day
O2k-Publications in the MiPMap "To the advantage of PDAC [pancreatic ductal adenocarcinoma] patients, innovative and more effective therapeutics will be possible with a greater understanding of how pancreatic cancer cells control mitochondrial metabolism."
  • Padinharayil H, Rai V, George A (2023) Mitochondrial metabolism in pancreatic ductal adenocarcinoma: from mechanism-based perspectives to therapy. »Bioblast link«

  • Nov- 14 Tu - World Diabetes Day
O2k-Publications in the MiPMap "Liver [mitochondria] (...) adapt to metabolic challenges by increasing FAO-derived mitochondrial respiration in OBES [obesity model] and NASH [non-alcoholic steatohepatitis model], but by increasing both FAO- and TCA-derived respiration in DIAB [diabetes model]."
  • Dewidar B, Mastrototaro L, Englisch C, Ress C, Granata C, Rohbeck E, Pesta D, Heilmann G, Wolkersdorfer M, Esposito I, Reina Do Fundo M, Zivehe F, Yavas A, Roden M (2023) Alterations of hepatic energy metabolism in murine models of obesity, diabetes and fatty liver diseases. »Bioblast link«
from the O2k-Network »DE Duesseldorf Roden M« and »DE Cologne Pesta D«

  • Nov- 03 Fr
O2k-Publications in the MiPMap "Peripheral impairments at the skeletal muscle level, namely reduced mitochondrial function and the presence of markers of impaired mitochondrial biogenesis emerged as major determinants of exercise intolerance and fatigue [in patients with post-acute sequelae of SARS-CoV-2 infection]"
  • Colosio M, Brocca L, Gatti M, Neri M, Crea E, Cadile F, Canepari M, Pellegrino MA, Polla B, Porcelli S, Bottinelli R (2023) Structural and functional impairments of skeletal muscle in patients with post-acute sequelae of SARS-CoV-2 infection. »Bioblast link«

Oct 2023

  • Oct- 26 Th
O2k-Publications in the MiPMap "In collegiate swimmers, (…) a maximal exercise bout (i.e., the bucket test) was associated with minimal changes in cellular-level IO2 [oxygen flow in isolated PBMCs]. In contrast, due to the robust mobilization of immune cells in response to the maximal exercise bout, the tissue-level IO2-Tissue [blood] was significantly elevated."
  • Stampley JE, Cho E, Wang H, Theall B, Johannsen NM, Spielmann G, Irving BA (2023) Impact of maximal exercise on immune cell mobilization and bioenergetics. »Bioblast link«
from the O2k-Network »US LA Baton Rouge Irving BA«

  • Oct- 24 Tu
MitoFit pdf A theoretical communication from Garcia Menendez on electromagnetic coupling hypothesis.
  • Garcia Menendez R (2023) Update and a new statement of the electromagnetic coupling hypothesis to explain the translocation of protons in mitochondria, bacteria and chloroplasts. MitoFit Preprints 2023.8. https://doi.org/10.26124/mitofit:2023-0008

  • Oct- 19 Th
O2k-Publications in the MiPMap "MDH2 is a metabolic switch rewiring [electron transfer system] and TCA fuelling"
  • Molinié T, Cougouilles E, David C, Cahoreau E, Portais JC, Mourier A (2022) MDH2 produced OAA is a metabolic switch rewiring the fuelling of respiratory chain and TCA cycle. »Bioblast link«
from the O2k-Network »FR Bordeaux Mourier A«

  • Oct- 12 Th - World Arthritis Day
O2k-Publications in the MiPMap “Mitochondrial dysfunction did not seem to be a major contributing factor for insulin resistance in RA [rheumatoid arthritis]”
  • Moellering DR, Smith-Johnston K, Kelley C, Sammy MJ, Benedict J, Brock G, Johnson J, Baskin KK, Jarjour WN, Belury MA, Reiser PJ, Nagareddy PR, Hanaoka BY (2023) Association between skeletal muscle mitochondrial dysfunction and insulin resistance in patients with rheumatoid arthritis: a case-control study. »Bioblast link«
from the O2k-Network »US AL Birmingham Moellering_DR«

  • Oct- 05 Th - Breast Cancer Awareness Month
O2k-Publications in the MiPMap "GK-1 [immunomodulatory peptide] inhibits cellular respiration and induces mitochondrial uncoupling in breast tumors."
  • Cruz-Gregorio A, Aranda-Rivera AK, Aparicio-Trejo OE, Medina-Campos ON, Sciutto E, Fragoso G, Pedraza-Chaverri J (2022) GK-1 Induces oxidative stress, mitochondrial dysfunction, decreased membrane potential, and impaired autophagy flux in a mouse model of breast cancer. »Bioblast link«
from the O2k-Network »MX Mexico City Pedraza Chaverri J«

Sep 2023

  • Sep- 28 Th
O2k-Publications in the MiPMap "... systemic transplantation of young MDSPCs [muscle-derived stem/progenitor cells] into progeroid ZMPSTE24-deficient mice preserves skeletal muscle mitochondrial function and fatigue-resistant fibers in a sex-specific manner"
  • Thompson SD, Barrett KL, Rugel CL, Redmond R, Rudofski A, Kurian J, Curtin JL, Dayanidhi S, Lavasani M (2023) Sex-specific preservation of neuromuscular function and metabolism following systemic transplantation of multipotent adult stem cells in a murine model of progeria. »Bioblast link«
from the O2k-Network »US IL Chicago Dayanidhi S«

  • Sep- 21 Th
O2k-Network.png The first mitochondrial DNA mutations associated with disease were described in 1988.

These discoveries were a game changer in the field of mitochondrial diseases. 

  • Holt IJ, Harding A E, Morgan-Hughes JA (1988) Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies. »Bioblast link«
  • Wallace DC, Singh G, Lott MT, Hodge JA, Schurr TG, Lezza AM, Elsas LJ 2nd, Nikoskelainen EK (1988) Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy. »Bioblast link«
  • Zeviani M, Moraes CT, DiMauro S, Nakase H, Bonilla E, Schon EA, Rowland LP (1988) Deletions of mitochondrial DNA in Kearns-Sayre syndrome. »Bioblast link«

  • Sep- 19 Tu
O2k-Publications in the MiPMap In 1962, the first report of a patient with a mitochondrial disease was published.
  • Luft R, Ikkos D, Palmieri G, Ernster L, Afzelius B (1962). A case of severe hypermetabolism of nonthyroid origin with a defect in the maintenance of mitochondrial respiratory control: a correlated clinical, biochemical, and morphological study. »Bioblast link«

  • Sep- 15 Fr - World Lymphoma Awareness Day
O2k-Publications in the MiPMap "Respirometry assays confirmed that OXPHOShigh Richter transformation cells had a 3.5-fold higher oxygen consumption at ROUTINE respiration and fivefold higher electron transfer system capacity compared to chronic lymphocytic leukemia"
  • Nadeu F, Royo R, Massoni-Badosa R, Playa-Albinyana H, Garcia-Torre B, et al (2022) Detection of early seeding of Richter transformation in chronic lymphocytic leukemia. »Bioblast link«
from the O2k-Network »ES Barcelona Garcia-Roves PM« and »ES Barcelona IDIBAPS Hospital Clinic«

  • Sep- 14 Th
O2k-Publications in the MiPMap "The higher ROS release rates observed in both the muscle and liver of older individuals may suggest that increased ROS release is evidence of mitochondrial dysfunction during ageing in finches."
  • Salmón P, Millet C, Selman C, Monaghan P, Dawson NJ (2023) Tissue-specific reductions in mitochondrial efficiency and increased ROS release rates during ageing in zebra finches, Taeniopygia guttata. »Bioblast link«
from the O2k-Network »DE Wilhelmshaven Salmon P«, »UK Glasgow Metcalfe NB«

  • Sep- 07 Th
O2k-Publications in the MiPMap "...enhancing mitochondrial function by either overexpressing parkin or bypassing defective mitochondrial complexes has significant beneficial effects in a fly model of HD [Huntington's disease], rescuing neurodegeneration and enhancing viability and lifespan."
  • Campesan S, Del Popolo I, Marcou K, Straatman-Iwanowska A, Repici M, Boytcheva KV, Cotton VE, Allcock N, Rosato E, Kyriacou CP, Giorgini F (2023) Bypassing mitochondrial defects rescues Huntington's phenotypes in Drosophila. »Bioblast link«
from the O2k-Network »UK Leicester Giorgini F«

Aug 2023

  • Aug- 31 Th
O2k-Publications in the MiPMap "Our study showed that salinity modulates the mitochondrial responses to long-term and acute hypoxia exposure in an euryhaline intertidal bivalve C. gigas."
  • Steffen JBM, Sokolov EP, Sokolova IM (2023) Combined effects of salinity and intermittent hypoxia on mitochondrial capacity and reactive oxygen species efflux in the Pacific oyster, Crassostrea gigas »Bioblast link«
from the O2k-Network »DE Rostock Sokolova I«

  • Aug- 29 Tu
MitoFit pdf "Altogether, our results show that chronic hypoxia optimizes the efficiency of mitochondrial ATP synthesis in the retrosplenial cortex of mice. Contrastingly, rats sustain the production of ATP only by increasing mitochondrial content and altering mitochondrial dynamics, suggesting drastic mitochondrial malfunctions."
  • Arias-Reyes C, Aliaga-Raduán F, Pinto-Aparicio R, Joseph V, Soliz J (2023) Mitochondrial plasticity in the retrosplenial cortex enhances ATP synthesis during acclimatization to hypoxia in mice but not in rats. MitoFit Preprints 2023.6. https://doi.org/10.26124/mitofit:2023-0006
from the O2k-Network »CA Quebec Soliz J«

  • Aug- 24 Th
FAT4BRAIN "Understanding acylcarnitine metabolic and signaling pathways provides a better rationale for selecting targets for therapeutic interventions."
  • Dambrova M, Makrecka-Kuka M, Kuka J, Vilskersts R, Nordberg D, Attwood MM, Smesny S, Sen ZD, Guo AC, Oler E, Tian S, Zheng J, Wishart DS, Liepinsh E, Schioth HB. (2022) Acylcarnitines: Nomenclature, Biomarkers, Therapeutic Potential, Drug Targets, and Clinical Trials. »Bioblast link«
from the O2k-Network »LV Riga Liepins E«

  • Aug- 17 Th
O2k-Publications in the MiPMap "... species-specific differences in cardiac metabolic capacity [...] may influence the acclimation potential of notothenioid fishes to changing environmental conditions."
  • Mandic M, Frazier AJ, Naslund AW, Todgham AE (2022) A comparative and ontogenetic examination of mitochondrial function in antarctic notothenioid species. »Bioblast link«

  • Aug- 10 Th
O2k-Publications in the MiPMap "Reducing lipid hydroxides by GPX4 overexpression ameliorates the majority of muscle atrophy and weakness phenotypes present in mouse models of sarcopenia"
  • Czyżowska A, Brown J, Xu H, Sataranatarajan K, Kinter M, Tyrell VJ, O'Donnell VB, Van Remmen H (2023) Elevated phospholipid hydroperoxide glutathione peroxidase (GPX4) expression modulates oxylipin formation and inhibits age-related skeletal muscle atrophy and weakness. »Bioblast link«
from the O2k-Network »US OK Oklahoma City Van Remmen H«

  • Aug- 08 Tu
Rodriguez 2023 BEC
An overview of the “do’s and don’ts” when it comes to assessing mitochondrial function in Drosophila
  • Rodríguez E, Bettinazzi S, Inwongwan S, Camus MF, Lane N (2023) Harmonizing protocols to measure Drosophila respiratory function in mitochondrial preparations. Bioenerg Commun 2023.3. https://doi.org/10.26124/bec:2023-0003
from the O2k-Network »UK London Lane N«

  • Aug- 03 Th
O2k-Publications in the MiPMap "Hepatocyte-derived cells maintain cellular and mitochondrial Ca2+ concentrations within strictly controlled ranges, maximizing electron transport capacity by promoting the Goldilocks Ca2+ “sweet spot” for oxidative phosphorylation activity: neither too much nor too little, but just right."
  • Vilas-Boas EA, Cabral-Costa JV, Ramos VM, Caldeira da Silva CC, Kowaltowski AJ (2023) Goldilocks calcium concentrations and the regulation of oxidative phosphorylation: too much, too little, or just right. »Bioblast link«
from the O2k-Network »BR Sao Paulo Kowaltowski AJ«

Jul 2023

  • Jul- 27 Th
O2k-brief repository Mitochondrial function abnormalities in patients with heart failure with preserved ejection fraction are associated with exercise intolerance and represent novel therapeutic targets.
  • Scandalis L, Kitzman DW, Nicklas BJ, Lyles M, Brubaker P, Nelson MB, Gordon M, Stone J, Bergstrom J, Neufer PD, Gnaiger E, Molina AJA (2023) Skeletal muscle mitochondrial respiration and exercise intolerance in patients with heart failure with preserved ejection fraction. »Bioblast link«

  • Jul- 20 Th
O2k-Publications in the MiPMap "A cancer-selective Na+ increase correlated with HCC [hepatocellular carcinoma] cell killing, and a slower growth rate of HCC xenograft tumors."
  • Clemente N, Baroni S, Fiorilla S, Tasso F, Reano S, Borsotti C, Ruggiero MR, Alchera E, Corrazzari M, Walker G, Follenzi A, Crich SG, Carini R (2023) Boosting intracellular sodium selectively kills hepatocarcinoma cells and induces hepatocellular carcinoma tumor shrinkage in mice. »Bioblast link«
from the O2k-Network »IT Novara Filigheddu N«

  • Jul- 13 Th
O2k-brief repository Triplefin fish species have different ROS production and electron leakage according to their tolerance to hypoxia.
  • Devaux JBL, Hedges CP, Birch N, Herbert N, Renshaw GMC, Hickey AJR (2023) Electron transfer and ROS production in brain mitochondria of intertidal and subtidal triplefin fish (Tripterygiidae). »Bioblast link«

  • Jul- 06 Th
O2k-Publications in the MiPMap "G3 MB [Group 3 medulloblastoma] cells demonstrate exquisite sensitivity towards inhibitors of complex-I in the electron transport [system (ETS)] but not to other metabolism-targeting agents, including glycolytic inhibitors."
  • Martell E, Kuzmychova H, Kaul E, Senthil H, Chowdhury SR, Morrison LC, Fresnoza A, Zagozewski J, Venugopal C, Anderson CM, Singh SK, Banerji V, Werbowetski-Ogilvie TE, Sharif T (2023) Metabolism-based targeting of MYC via MPC-SOD2 axis-mediated oxidation promotes cellular differentiation in group 3 medulloblastoma. »Bioblast link«
from the O2k-Network »CA Winnipeg Banerji V«

Jun 2023

  • Jun- 29 Th
O2k-Publications in the MiPMap "This study reinforces the strict aerobic status of M. tuberculosis and indicates that the therapeutic value of inhibiting the terminal oxidases is relevant even under nano-oxic conditions found in TB [tuberculosis] lung granulomas."
  • Kalia NP, Singh S, Hards K, Cheung CY, Sviriaeva E, Banaei-Esfahani A, Aebersold R, Berney M, Cook GM, Pethe K (2023) M. tuberculosis relies on trace oxygen to maintain energy homeostasis and survive in hypoxic environments. »Bioblast link«

  • Jun- 22 Th
O2k-Publications in the MiPMap "BAM15 is a tolerable and efficacious protonophore that protects against diet‐induced obesity."
  • Axelrod CL, King WT, Davuluri G, Noland RC, Hall J, Hull M, Dantas WS, Zunica ER, Alexopoulos SJ, Hoehn KL, Langohr I, Stadler K, Doyle H, Schmidt E, Nieuwoudt S, Fitzgerald K, Pergola K, Fujioka H, Mey JT, Fealy C, Mulya A, Beyl R, Hoppel CL, Kirwan JP (2021) BAM15-mediated mitochondrial uncoupling protects against obesity and improves glycemic control. »Bioblast link«
from the O2k-Network »US LA Baton Rouge Noland RC« and »US OH Cleveland Hoppel CL«

  • Jun- 15 Th
O2k-Publications in the MiPMap "Obesity has an opposing association with mitochondrial respiration in adipose- and liver tissue with no overall association with NAFLD (nonalcoholic fatty liver disease) severity."
  • Pedersen JS, Rygg MO, Chrøis K, Sustarsic EG, Gerhart-Hines Z, Wever Albrechtsen NJ, Serizawa RR, Kristiansen VB, Basse AL, Boilesen AEB, Olsen BH, Hansen T, Gluud LL, Madsbad S, Larsen S, Bendtsen F, Dela F (2022) Influence of NAFLD and bariatric surgery on hepatic and adipose tissue mitochondrial biogenesis and respiration. »Bioblast link«
from the O2k-Network »DK Copenhagen Gerhart-Hines Z« and »DK Copenhagen Larsen S«

May 2023

  • May- 25 Th
O2k-Publications in the MiPMap "Such markers [of mitochondrial function] could help to identify metabolic changes before the disease becomes irreversible and at a stage where therapeutic and lifestyle intervention could be more effective, thus reducing the burden of the health and economic costs of this epidemic."
  • Calabria E, Muollo V, Cavedon V, Capovin T, Saccenti L, Passarotti F, Ghiotto L, Milanese C, Gelati M, Rudi D, Salvagno GL, Lippi G, Tam E, Schena F, Pogliaghi S (2023) Type 2 diabetes related mitochondrial defects in peripheral mononucleated blood cells from overweight postmenopausal women. »Bioblast link«
from the O2k-Network »IT Verona Venturelli M«

  • May- 02 Tu
O2k-Publications in the MiPMap "Mitochondria–nucleus communication and its integration within the maintenance of cellular homeostasis constitute key determinants of cellular fate and organism health in the context of cellular stress, homeostasis perturbation, and disease"
  • Temelie M, Talpur R, Dominguez-Prieto M, Dantas Silva A, Cenusa C, Craciun L, Savu DI, Moisoi N (2023) Impaired integrated stress response and mitochondrial integrity modulate genotoxic stress impact and lower the threshold for immune signalling. »Bioblast link«
from the O2k-Network »UK Leicester Moisoi N«

Apr 2023

  • Apr- 25 Tu
MitoFit pdf “The variety of approaches to studying Drosophila mitochondrial function in the circa 60 studies surveyed over a 12-year period calls for a more careful consideration of the methodological approach tailored to the research questions.”
  • Rodríguez E, Bettinazzi S, Inwongwan S, Camus MF, Lane N (2023) Harmonising protocols to measure Drosophila respiratory function in mitochondrial preparations. MitoFit Preprints 2023.4. https://doi.org/10.26124/mitofit:2023-0004
from the O2k-Network »UK London Lane N«

  • Apr- 17 Mo
MitoFit pdf “The ambiguities surrounding Complex II in the literature call for quality control, to secure scientific standards in current communications on bioenergetics and support adequate clinical applications.”
from the O2k-Network »AT Innsbruck Oroboros«

  • Apr- 11 Tu
MitoFit pdf "Our findings suggest that O2 control of mitochondrial oxidative phosphorylation can relay changes in respiration and reduce mitochondrial Ca2+ uptake... [which] may influence how muscle mitochondria adapt after contractions in conditions of hypoxia."
  • Donnelly C, Komlódi T, Cecatto C, Cardoso LHD, Compagnion AC, Matera A, Tavernari D, Zanou N, Kayser B, Gnaiger E, Place N (2023) Functional hypoxia reduces mitochondrial calcium uptake. MitoFit Preprints 2023.2. https://doi.org/10.26124/mitofit:2023-0002
from the O2k-Network »AT Innsbruck Oroboros«, »CH Lausanne Place N«, »HU Budapest Tretter L«
  • Apr- 06 Th
MitoFit pdf Oliveira and Couto-Lima provide evidence for the importance of local stock centers in sustaining the substantial increase in the output of Drosophila mitochondrial research worldwide in recent decades.
from the O2k-Network »BR Jaboticabal Oliveira MT«

Mar 20223

  • Mar- 24 Fr - World Tuberculosis Day-
O2k-Publications in the MiPMap "The molecular structure of the bd oxidase from M. tuberculosis provides the long-sought atomic framework for the design of highly specific drugs to target this respiratory enzyme"
  • Safarian S, Opel-Reading HK, Wu D, Mehdipour AR, Hards K, Harold LK, Radloff M, Stewart I, Welsch S, Hummer G, Cook GM, Krause KL, Michel H (2021) The cryo-EM structure of the bd oxidase from M. tuberculosis reveals a unique structural framework and enables rational drug design to combat TB. »Bioblast link«

  • Mar- 10 Fr - World Kidney Day
O2k-Publications in the MiPMap "...subcapsular administration of MSC-derived EVs [extracellular vesicles secreted by adipose tissue mesenchymal cells] at the moment of reperfusion after ischemia totally recovers the normal ROS formation by mitochondria from renal proximal tubule cells in all functional respiratory states"
  • Lopes JA, Collino F, Rodrigues-Ferreira C, Sampaio LDS, Costa-Sarmento G, Wendt CHC, Almeida FP, Miranda KR, Kasai-Brunswick TH, Lindoso RS, Vieyra A (2022) Early effects of extracellular vesicles secreted by adipose tissue mesenchymal cells in renal ischemia followed by reperfusion: mechanisms rely on a decrease in mitochondrial anion superoxide production »Bioblast link«
from the O2k-Network »BR Rio de Janeiro Vieyra A«

  • Mar- 06 Mo
Bellissimo 2022 BEC
Natural cycling of ADP with ATP attenuates mitochondrial permeability transition in permeabilized muscle fibres: can repeating mtPT assessments with and without adenylates provide new insights?
  • Bellissimo CA, Soendergaard S, Hughes MC, Ramos SV, Larsen S, Perry CGR (2022) The influence of adenylate cycling on mitochondrial calcium-induced permeability transition in permeabilized skeletal muscle fibers. Bioenerg Commun 2023.1. https://doi.org/10.26124/bec:2023-0001
from the O2k-Network »CA Toronto Perry CG« and »DK Copenhagen Larsen S«

  • Mar- 03 Fr - World Wildlife Day
O2k-Publications in the MiPMap "[...]adaptive changes in the physiology of specific mitochondrial fractions can help overcome the metabolic challenges of life in the harsh environment at high altitude."
  • Dawson NJ, Scott GR (2022) Adaptive increases in respiratory capacity and O2 affinity of subsarcolemmal mitochondria from skeletal muscle of high-altitude deer mice. »Bioblast link«
from the O2k-Network »CA Hamilton Scott GR«

Feb 20223

  • Feb- 28 Tu - Rare Disease Day
Balbaisi 2022 BEC
Balbaisi and Stiban review the current knowledge on Barth Syndrome, a rare disease affecting the production of cardiolipin, the only phospholipid specific to mitochondria.

  • Feb- 15 We - International Childhood Cancer Day
O2k-Publications in the MiPMap Mitochondrial respiratory dysfunction present in platelets from 10- to 11-year-old children with acute lymphoblastic leukemia
  • Lelcu T, Bînă AM, Dănilă MD, Popoiu CM, Aburel OM, Arghirescu ST, Borza C, Muntean DM (2021) Assessment of platelet mitochondrial respiration in a pediatric population: A pilot study in healthy children and children with acute lymphoblastic leukemia. »Bioblast link«
from the O2k-Network »RO Timisoara Muntean DM«

  • Feb- 13 Mo - International Epilepsy Day
O2k-Publications in the MiPMap "NAC [N-acetylcysteine] modulates neuronal excitability and the appearance or propagation of seizures through its antioxidant capacity and ability to reduce glycolytic/lactic metabolism in WAR [Wistar Audiogenic Rat – a genetic model of epilepsy]"
  • Dechandt CRP, Ferrari GD, Dos Santos JR, de Oliveira JAC, da Silva-Jr RMP, Cunha AOS, Garcia-Cairasco N, Alberici LC (2019) Energy metabolism and redox state in brains of wistar audiogenic rats, a genetic model of epilepsy. Front Neurol 10:1007. »Bioblast link«
from the O2k-Network »BR Ribeirao Preto Alberici LC«

  • Feb- 11 Sa - International Day of Women and Girls in Science
Gentle Science “While progress has been made, women (particularly women of color) remain underrepresented in many scientific, engineering, and medical fields, and at many levels in education and career stages.”

Read this report for actionable recommendations to promote participation of females in STEM fields:

  • National Academies of Sciences, Engineering, and Medicine (2020) Promising practices for addressing the underrepresentation of women in science, engineering, and medicine: opening doors. The National Academies Press, Washington DC . »Bioblast link«

  • Feb- 07 Tu
O2k-brief repository Antitumoral properties of triterpenic acid functionalized gold nanoparticles arise from decreasing mitochondrial respiration
  • Mioc M, Mioc A, Racoviceanu R, Ghiulai R, Prodea A, Milan A, Barbu Tudoran L, Oprean C, Ivan V, Șoica C (2023) The antimelanoma biological assessment of triterpenic acid functionalized gold nanoparticles. »Bioblast link«

Jan 2023

  • Jan- 24 Tu - International Day of Education
Gnaiger 2021 BEC
Restricted access to academic research produces problems of social inequality in education: A re-evaluation of scientific communication and value of science is needed. Open access to research is essential, together with a bigger demand on quality control to ensure reproducibility of the results and prevent an avalanche of new publications that may go into oblivion.

  • Jan- 03 Tu
Bombaca 2022 BEC
Bionenerg Commun 2022.20

Bombaça and Menna-Barreto discuss data on mitochondrial susceptibility and adaptative processes obtained by their group in the last 17 years.

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