Difference between revisions of "Oroboros Ecosystem Agenda 2021 Archive"

Revision as of 09:16, 1 February 2021

Oroboros Ecosystem Agenda 2021 Archive

Mitochondria and Cell Research - the Oroboros Ecosystem

Last week

2021 Week 4

Jan-25 Mo

Jan-26 Tu- ÖGMBT Life Science Tuesdays

Jan-27 We

Cell-permeable succinate prodrug NV118 improves statin-induced mitochondrial dysfunction in human platelets

from the O2k-Network »RO Timisoara Muntean DM« and »SE Lund Elmer E«

Avram VF, Chamkha I, Åsander-Frostner E, Ehinger JK, Timar RZ, Hansson MJ, Muntean DM, Elmér E (2021) Cell-permeable succinate rescues mitochondrial respiration in cellular models of statin toxicity. Int J Mol Sci 22:424. »Bioblast link«

Jan-28 Th

A quote from MitoPathways Chapter 6. Convergent electron transfer at the Q-junction:

The concept on convergent electron transfer at the Q-junction (ETS) challenges conventional OXPHOS analysis based on the ETC terminology and a way of thinking about the mitochondrial ‘electron transfer chain’ - »Gnaiger 2020 BEC MitoPathways«.

Jan-29 Fr

SUIT protocols with Magnesium Green™ (MgG) can be used to study respiration and ATP production P»

MgG dye does not affect respiration of cardiac isolated mitochondria.

Cardoso LHD, Doerrier C, Gnaiger E (2021) Magnesium Green for fluorometric measurement of ATP production does not interfere with mitochondrial respiration. MitoFit Preprints 2021.1. doi:10.26124/mitofit:2021-0001.

Jan 2021

Jan-01 Fr

Happy New Year!

 2021 Week 1

Jan-04 Mo

The Oroboros office is enjoying a break from December 24th to January 6th.

Jan-05 Tu

Jan-06 We

Jan-07 Th

Oroboros Instruments is pleased to be a collaborator on the CureMILS project that has recently been approved for EJP-RD funding.

Led by O2k-Network member, Alessandro Prigione, the project aims to employ a novel approach to enable drug discovery of Mitochondrial DNA (mtDNA)-associated Leigh syndrome (MILS).

- Read more »CureMILS«

Jan-08 Fr

Liver mitochondrial adaptation in a mouse model of NAFLD induced by a Western-style diet

from the O2k-Network »CZ Hradec Kralove Cervinkova Z«

Staňková P, Kučera O, Peterová E, Lotková H, Maseko TE, Nožičková K, Červinková Z (2020) Adaptation of mitochondrial substrate flux in a mouse model of nonalcoholic fatty liver disease. Int J Mol Sci 21:E1101. »Bioblast link«

2021 Week 2

Jan-11 Mo

Are you a beginner or need a refresher on using SUIT protocols with DatLab7.4?

- » O2k-Videosupport: How to perform an experiment with a SUIT DL-Protocol« and » Run DL-Protocol/Set O2 limit in DatLab «
- communicated by »Komlodi Timea« and Schmitt Sabine«

Jan-12 Tu - ÖGMBT Life Science Tuesdays

Jan-13 We

Positive effect of regular physical activity on mitochondrial respiration in burnout syndrome

from the O2k-Network »CH Basel Eckert A«

Brand S, Ebner K, Mikoteit T, Lejri I, Gerber M, Beck J, Holsboer-Trachsler E, Eckert A (2020) Influence of regular physical activity on mitochondrial activity and symptoms of burnout-an interventional pilot study. J Clin Med 9:E667.»Bioblast link«

Jan-14 Th

Jan-15 Fr

2021 Week 3

Jan-18 Mo

Jan-19 Tu

Complex III is essential in mitochondrial electron transfer system maturation and supercomplex formation

from the O2k-Network »US FL Miami Moraes CT«

Protasoni M, Pérez-Pérez R, Lobo-Jarne T, Harbour ME, Ding S, Peñas A, Diaz F, Moraes CT, Fearnley IM, Zeviani M, Ugalde C, Fernández-Vizarra E (2020) Respiratory supercomplexes act as a platform for complex III-mediated maturation of human mitochondrial complexes I and IV. EMBO J 39:e102817. »Bioblast link«

Jan-20 We

A quote from MitoPathways Chapter 3. Normalization:

Respiratory OXPHOS capacity P in human skeletal muscle ranges from 60 to 160 pmol∙s^-1∙mg^-1 based on wet muscle mass of permeabilized fibers. By comparison, mass-specific electron transfer capacity E is approximately 25 pmol∙s^-1∙mg^-1 in platelets and senescent fibroblasts and 40 to 80 pmol∙s^-1∙mg^-1 in PBMC, HEK, CEM, HUVEC, and young fibroblasts. ― Are these values comparable? - »Gnaiger 2020 BEC MitoPathways«.

Jan-21 Th

Measuring ATP production with Magnesium Green – which sample preparations work?

Magnesium Green (MgG) can be used with mitochondrial preparations: isolated mitochondria, tissue homogenates, and permeabilized cells and tissues.
- »MgG« and »Publications MgG«
- communicated by »Cardoso Luiza« and »Komlodi Timea«

Jan-22 Fr

Stay alert

Collections from Bioblast agenda

Bioblast alert 2024

MitoPedia alert

O2k-Publications alert

O2k-Open Support alert

Oroboros alert

@@ Line 8: / Line 8: @@
 == Last week ==
-Week 3
+Week 4
+*'''Jan-25 Mo'''
-*'''Jan-18 Mo'''
+----
+*'''Jan-26 Tu'''- [[12th_%C3%96GMBT_Annual_Meeting_2020_Virtual_Event#Programme|ÖGMBT Life Science Tuesdays]]
 ----
-*'''Jan-19 Tu'''
+*'''Jan-27 We'''
 :{|
 | width="100" align="center" |[[Image:O2k-Publications.jpg|70px|link=http://wiki.oroboros.at/index.php/O2k-Publications:_Topics |O2k-Publications in the MiPMap]]
-|'''Complex III is essential in mitochondrial electron transfer system maturation and supercomplex formation'''<br>
+|'''Cell-permeable succinate prodrug NV118 improves statin-induced mitochondrial dysfunction in human platelets '''<br>
-:from the O2k-Network »[[US FL Miami Moraes CT]]«
+:from the O2k-Network »[[RO Timisoara Muntean DM]]« and »[[SE Lund Elmer E]]«
-*Protasoni M, Pérez-Pérez R, Lobo-Jarne T, Harbour ME, Ding S, Peñas A, Diaz F, Moraes CT, Fearnley IM, Zeviani M, Ugalde C, Fernández-Vizarra E (2020) Respiratory supercomplexes act as a platform for complex III-mediated maturation of human mitochondrial complexes I and IV. EMBO J 39:e102817. [[Protasoni 2020 EMBO J|»Bioblast link«]]
+*Avram VF, Chamkha I, Åsander-Frostner E, Ehinger JK, Timar RZ, Hansson MJ, Muntean DM, Elmér E (2021) Cell-permeable succinate rescues mitochondrial respiration in cellular models of statin toxicity. Int J Mol Sci 22:424. [[Avram 2021 Int J Mol Sci|»Bioblast link«]]
 |}
 ----
-*'''Jan-20 We'''
+*'''Jan-28 Th'''
 :{|
 | width="100" align="center" |[[File:Gnaiger 2020 BEC MitoPathways.jpg|70px|link=https://www.bioenergetics-communications.org/index.php/Gnaiger_2020_BEC_MitoPathways|Gnaiger 2020 BEC MitoPathways]]
-|'''A quote from ''MitoPathways Chapter 3. Normalization'': '''
+|'''A quote from ''MitoPathways Chapter 6. Convergent electron transfer at the Q-junction'': '''
-Respiratory OXPHOS capacity ''P'' in human skeletal muscle ranges from 60 to 160 pmol∙s<sup>-1</sup>∙mg<sup>-1</sup> based on wet muscle mass of permeabilized fibers. By comparison, mass-specific electron transfer capacity ''E'' is approximately 25 pmol∙s<sup>-1</sup>∙mg<sup>-1</sup> in platelets and senescent fibroblasts and 40 to 80 pmol∙s<sup>-1</sup>∙mg<sup>-1</sup> in PBMC, HEK, CEM, HUVEC, and young fibroblasts. ― Are these values comparable? - [[Gnaiger 2020 BEC MitoPathways|»Gnaiger 2020 BEC MitoPathways«]].
+The concept on convergent electron transfer at the Q-junction (ETS) challenges conventional OXPHOS analysis based on the ETC terminology and a way of thinking about the mitochondrial ‘electron transfer chain’ - [[Gnaiger 2020 BEC MitoPathways|»Gnaiger 2020 BEC MitoPathways«]].
 |}
 ----
-*'''Jan-21 Th'''
+*'''Jan-29 Fr'''
 :{|
-| width="110" align="center" | [[File:MitoPedia.jpg|left|80px|MitoPedia|link=MitoPedia]]
-| '''Measuring ATP production with Magnesium Green – which sample preparations work?'''<br>
+| width="100" align="center" |[[File:MitoFit Preprints pdf.png|100px|link=https://wiki.oroboros.at/index.php/Cardoso_2021_MitoFit_MgG |MitoFit pdf]]
-Magnesium Green (MgG) can be used with mitochondrial preparations: isolated mitochondria, tissue homogenates, and permeabilized cells and tissues. <br>
+|'''SUIT protocols with Magnesium Green™ (MgG) can be used to study respiration and ATP production P» '''<br>
-- »'''[[Magnesium_Green|MgG]]'''« and »'''[[Magnesium_Green#Publications:_MgG|Publications MgG]]'''« <br>
+MgG dye does not affect respiration of cardiac isolated mitochondria.  <br>
-- communicated by »[[Cardoso Luiza]]« and »[[Komlodi Timea]]«
+* Cardoso LHD, Doerrier C, Gnaiger E (2021) Magnesium Green for fluorometric measurement of ATP production does not interfere with mitochondrial respiration. MitoFit Preprints 2021.1. [https://wiki.oroboros.at/index.php/Cardoso_2021_MitoFit_MgG doi:10.26124/mitofit:2021-0001].
 |}
-----
-*'''Jan-22 Fr'''
 ----
@@ Line 99: / Line 102: @@
 ----
 *'''Jan-15 Fr'''
+Week 3
+*'''Jan-18 Mo'''
+----
+*'''Jan-19 Tu'''
+:{|
+| width="100" align="center" |[[Image:O2k-Publications.jpg|70px|link=http://wiki.oroboros.at/index.php/O2k-Publications:_Topics |O2k-Publications in the MiPMap]]
+|'''Complex III is essential in mitochondrial electron transfer system maturation and supercomplex formation'''<br>
+:from the O2k-Network »[[US FL Miami Moraes CT]]«
+*Protasoni M, Pérez-Pérez R, Lobo-Jarne T, Harbour ME, Ding S, Peñas A, Diaz F, Moraes CT, Fearnley IM, Zeviani M, Ugalde C, Fernández-Vizarra E (2020) Respiratory supercomplexes act as a platform for complex III-mediated maturation of human mitochondrial complexes I and IV. EMBO J 39:e102817. [[Protasoni 2020 EMBO J|»Bioblast link«]]
+|}
+----
+*'''Jan-20 We'''
+:{|
+| width="100" align="center" |[[File:Gnaiger 2020 BEC MitoPathways.jpg|70px|link=https://www.bioenergetics-communications.org/index.php/Gnaiger_2020_BEC_MitoPathways|Gnaiger 2020 BEC MitoPathways]]
+|'''A quote from ''MitoPathways Chapter 3. Normalization'': '''
+Respiratory OXPHOS capacity ''P'' in human skeletal muscle ranges from 60 to 160 pmol∙s<sup>-1</sup>∙mg<sup>-1</sup> based on wet muscle mass of permeabilized fibers. By comparison, mass-specific electron transfer capacity ''E'' is approximately 25 pmol∙s<sup>-1</sup>∙mg<sup>-1</sup> in platelets and senescent fibroblasts and 40 to 80 pmol∙s<sup>-1</sup>∙mg<sup>-1</sup> in PBMC, HEK, CEM, HUVEC, and young fibroblasts. ― Are these values comparable? - [[Gnaiger 2020 BEC MitoPathways|»Gnaiger 2020 BEC MitoPathways«]].
+|}
+----
+*'''Jan-21 Th'''
+:{|
+| width="110" align="center" | [[File:MitoPedia.jpg|left|80px|MitoPedia|link=MitoPedia]]
+| '''Measuring ATP production with Magnesium Green – which sample preparations work?'''<br>
+Magnesium Green (MgG) can be used with mitochondrial preparations: isolated mitochondria, tissue homogenates, and permeabilized cells and tissues. <br>
+- »'''[[Magnesium_Green|MgG]]'''« and »'''[[Magnesium_Green#Publications:_MgG|Publications MgG]]'''« <br>
+- communicated by »[[Cardoso Luiza]]« and »[[Komlodi Timea]]«
+|}
+----
+*'''Jan-22 Fr'''
 == Stay alert ==
 {{Oroboros Ecosystem Agenda list}}