Noncoupled respiration: Difference between revisions
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Noncoupled respiration is maximum [[electron flow]] in an open-transmembrane proton circuit mode of operation (see [[ET-capacity]]). | Noncoupled respiration is maximum [[electron flow]] in an open-transmembrane proton circuit mode of operation (see [[ET-capacity]]). | ||
|info=[[Gnaiger 2014 MitoPathways]], [[MitoPedia: Respiratory states]] | |info=[[Gnaiger 2014 MitoPathways]], [[MitoPedia: Respiratory states]] | ||
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Contributed by [[Gnaiger E]] 2010-08-15, edited 2015-01-19. | Contributed by [[Gnaiger E]] 2010-08-15, edited 2015-01-19. | ||
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::::» [[Noncoupled respiration]] | ::::» [[Noncoupled respiration]] | ||
::::» [[Uncoupler#Is_respiration_uncoupled_-_noncoupled_-_dyscoupled.3F |Is respiration uncoupled - noncoupled - dyscoupled?]] | ::::» [[Uncoupler#Is_respiration_uncoupled_-_noncoupled_-_dyscoupled.3F |Is respiration uncoupled - noncoupled - dyscoupled?]] | ||
{{Keywords: Uncoupling}} | |||
{{MitoPedia concepts | |||
|mitopedia concept=Respiratory state, Recommended | |||
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{{MitoPedia methods | |||
|mitopedia method=Respirometry | |||
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{{MitoPedia topics | |||
|mitopedia topic=EAGLE | |||
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Revision as of 07:16, 19 February 2020
Description
Noncoupled respiration is distinguished from general (pharmacological or mechanical) uncoupled respiration, to give a label to an effort to reach the state of maximum uncoupler-activated respiration without inhibiting respiration. Noncoupled respiration, therefore, yields an estimate of ET-capacity. Experimentally uncoupled respiration may fail to yield an estimate of ET-capacity, due to inhibition of respiration above optimum uncoupler concentrations or insufficient stimulation by sub-optimal uncoupler concentrations. Optimum uncoupler concentrations for evaluation of (noncoupled) ET-capacity require inhibitor titrations (Steinlechner-Maran 1996 Am J Physiol Cell Physiol; Huetter 2004 Biochem J; Gnaiger 2008 POS).
Noncoupled respiration is maximum electron flow in an open-transmembrane proton circuit mode of operation (see ET-capacity).
Abbreviation: E
Reference: Gnaiger 2014 MitoPathways, MitoPedia: Respiratory states
Contributed by Gnaiger E 2010-08-15, edited 2015-01-19.
Is respiration uncoupled - noncoupled - dyscoupled?
- » More details: Uncoupler
Biochemical coupling efficiency: from 0 to <1
- » More details: OXPHOS coupling efficiency and ET-coupling efficiency
Related MitoPedia pages
- Electron transfer-pathway, ET-pathway
- Electron transfer-pathway states
- Coupling control state E
- Bioblast links: Uncoupling - >>>>>>> - Click on [Expand] or [Collapse] - >>>>>>>
- Specific
- » Artefacts by single dose uncoupling
- » ATP synthase
- » CCCP
- » Coupling-control protocol
- » DNP
- » Dyscoupled respiration
- » FCCP
- » Is respiration uncoupled - noncoupled - dyscoupled?
- » Noncoupled respiration: Discussion
- » Uncoupler
- » Uncoupled respiration - see » Noncoupled respiration
- » Uncoupling proteins
- » Uncoupling protein 1
- » Uncoupler titrations - Optimum uncoupler concentration
- Specific
- Respiratory states and control ratios
- » Biochemical coupling efficiency
- » Coupling-control state
- » Electron-transfer-pathway state
- » Electron-transfer pathway
- ET capacity
- » E-L coupling efficiency
- » Flux control efficiency
- » Flux control ratio
- » LEAK-control ratio
- » LEAK respiration
- » Noncoupled respiration
- » OXPHOS
- » OXPHOS capacity; » State 3
- » OXPHOS-control ratio, P/E ratio
- » Respiratory acceptor control ratio
- » ROUTINE-control ratio
- » ROUTINE respiration
- » ROUTINE state
- » State 3u
- » State 4
- » Uncoupling-control ratio UCR
- Respiratory states and control ratios
- Gnaiger E et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenerg Commun 2020.1. https://doi.org/10.26124/bec:2020-0001.v1
- Gnaiger E (2020) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 5th ed. Bioenerg Commun 2020.2. https://doi.org/10.26124/bec:2020-0002
- General (alphabetical order)
- Other keyword lists
MitoPedia concepts:
Respiratory state,
Recommended
MitoPedia methods:
Respirometry
MitoPedia topics:
EAGLE