O2k-Publications: Fibroblast
NIH3T3 mouse embryonic fibroblast cells come from a cell line isolated and initiated in 1962 at the New York University School of Medicine Department of Pathology. 3T3 refers to the cell transfer and inoculation protocol for the line, and means 3-day transfer, inoculum 3 x 105 cells. Using this protocol, the immortal cell line begins to thrive and stabilize in cell culture after about 20-30 generations of in vitro growth. George Todaro and Howard Green, the scientists who first cultured this cell line, obtained the cells from desegregated NIH Swiss mouse embryo fibroblasts. The cell line has since become a standard fibroblast cell line.
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Was published in year | Reference | Organism | Tissue;cell | |
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MiPNet18.10 O2k-Specifications | 2024-03-26 | O2k-specifications for respirometry and comprehensive OXPHOS analysis. | Human | Fibroblast |
Shi 2024 Clin Sci (Lond) | 2024 | Shi L, Yang J, Tao Z, Zheng L, Bui TF, Alonso RL, Yue F, Cheng Z (2024) Loss of FoxO1 activates an alternate mechanism of mitochondrial quality control for healthy adipose browning. Clin Sci (Lond) 138:371-85. https://doi.org/10.1042/cs20230973 | Mouse | Fibroblast |
Meldau 2024 Mol Genet Metab Rep | 2024 | Meldau S, Ackermann S, Riordan G, van der Watt GF, Spencer C, Raga S, Khan K, Blackhurst DM, van der Westhuizen FH (2024) A novel mitochondrial DNA variant in MT-ND6: m.14430A>C p.(Trp82Gly) identified in a patient with Leigh syndrome and complex I deficiency. Mol Genet Metab Rep 39:101078. https://doi.org/10.1016/j.ymgmr.2024.101078 | Human | Fibroblast |
Ciccone 2024 J Exp Biol | 2024 | Ciccone C, Kante F, Folkow LP, Hazlerigg DG, West AC, Wood SH (2024) Circadian coupling of mitochondria in a deep-diving mammal. J Exp Biol 227:jeb24699. https://doi.org/10.1242/jeb.246990 | Other mammals | Fibroblast |
Bassot 2023 Cell Rep | 2023 | Bassot A, Chen J, Takahashi-Yamashiro K, Yap MC, Gibhardt CS, Le GNT, Hario S, Nasu Y, Moore J, Gutiérrez T, Mina L, Mast H, Moses A, Bhat R, Ballanyi K, Lemieux H, Sitia R, Zito E, Bogeski I, Campbell RE, Simmen T (2023) The endoplasmic reticulum kinase PERK interacts with the oxidoreductase ERO1 to metabolically adapt mitochondria. Cell Rep 42:111899. https://doi.org/10.1016/j.celrep.2022.111899 | Human Mouse | HEK Fibroblast |
Kamienieva 2023 Biochim Biophys Acta Mol Basis Dis | 2023 | Kamienieva I, CharzyĆska A, DuszyĆski J, MaliĆska D, Szczepanowska J (2023) In search for mitochondrial biomarkers of Parkinson's disease: Findings in parkin-mutant human fibroblasts. https://doi.org/10.1016/j.bbadis.2023.166787 | Human | Fibroblast |
Tian 2023 Redox Biol | 2023 | Tian G, Zhou J, Quan Y, Kong Q, Li J, Xin Y, Wu W, Tang X, Liu X (2023) Voltage-dependent anion channel 1 (VDAC1) overexpression alleviates cardiac fibroblast activation in cardiac fibrosis via regulating fatty acid metabolism. https://doi.org/10.1016/j.redox.2023.102907 | Mouse | Heart Fibroblast |
Gaudo 2023 Free Radic Biol Med | 2023 | GaudĂł P, de TomĂĄs-Mateo E, Garrido-PĂ©rez N, Santana A, Ruiz-Pesini E, Montoya J, Bayona-Bafaluy P (2023) "ATAD3C regulates ATAD3A assembly and function in the mitochondrial membrane". https://doi.org/10.1016/j.freeradbiomed.2023.12.006 | Human | Fibroblast |
Robertson 2023 J Cell Sci | 2023 | Robertson GL, Riffle S, Patel M, Bodnya C, Marshall A, Beasley HK, Garza-Lopez E, Shao J, Vue Z, Hinton A, Stoll MS, de Wet S, Theart RP, Chakrabarty RP, Loos B, Chandel NS, Mears JA, Gama V (2023) DRP1 mutations associated with EMPF1 encephalopathy alter mitochondrial membrane potential and metabolic programs. https://doi.org/10.1242/jcs.260370 | Human | Fibroblast |
Curtabbi 2023 Redox Biol | 2023 | Curtabbi A, GuarĂĄs A, Cabrera-AlarcĂłn JL, Rivero M, Calvo E, Rosa-Moreno M, VĂĄzquez J, Medina M, EnrĂquez JA (2023) Regulation of respiratory complex I assembly by FMN cofactor targeting. https://doi.org/10.1016/j.redox.2023.103001 | Mouse | Fibroblast Kidney |
Temelie 2023 Int J Mol Sci | 2023 | Temelie M, Talpur R, Dominguez-Prieto M, Dantas Silva A, Cenusa C, Craciun L, Savu DI, Moisoi N (2023) Impaired integrated stress response and mitochondrial integrity modulate genotoxic stress impact and lower the threshold for immune signalling. https://doi.org/10.3390/ijms24065891 | Mouse | Fibroblast |
Kataura 2022 Dev Cell | 2022 | Kataura T, Sedlackova L, Otten EG, Kumari R, Shapira D, Scialo F, Stefanatos R, Ishikawa KI, Kelly G, Seranova E, Sun C, Maetzel D, Kenneth N, Trushin S, Zhang T, Trushina E, Bascom CC, Tasseff R, Isfort RJ, Oblong JE, Miwa S, Lazarou M, Jaenisch R, Imoto M, Saiki S, Papamichos-Chronakis M, Manjithaya R, Maddocks ODK, Sanz A, Sarkar S, Korolchuk VI (2022) Autophagy promotes cell survival by maintaining NAD levels. https://doi.org/10.1016/j.devcel.2022.10.008 | Mouse | Fibroblast |
Gschwind 2022 Ann Clin Transl Neurol | 2022 | Gschwind M, Garcia Segarra N, Schaller A, Bolognini R, Nuoffer JM, Hourez R, Deprez M, Lhermitte B, Maeder P, Tran C, Kuntzer T (2022) Early-onset leukoencephalomyelopathy due to a biallelic NDUFV1 variant in a mid-forties patient. https://doi.org/10.1002/acn3.51556 | Human | Skeletal muscle Fibroblast |
Schober 2022 Hum Mol Genet | 2022 | Schober FA, Tang JX, Sergeant K, Moedas MF, Zierz CM, Moore D, Smith C, Lewis D, Guha N, Hopton S, Falkous G, Lam A, Pyle A, Poulton J, Gorman GS, Taylor RW, Freyer C, Wredenberg A (2022) Pathogenic SLC25A26 variants impair SAH transport activity causing mitochondrial disease. https://doi.org/10.1093/hmg/ddac002 | Mouse Drosophila | Fibroblast |
Munoz-Pujol 2022 Brain Pathol | 2022 | Muñoz-Pujol G, Ortigoza-Escobar JD, Paredes-Fuentes AJ, Jou C, Ugarteburu O, Gort L, Yubero D, GarcĂa-Cazorla A, O'Callaghan M, Campistol J, Muchart J, YĂ©pez VA, Gusic M, Gagneur J, Prokisch H, Artuch R, Ribes A, Urreizti R, Tort F (2022) Leigh syndrome is the main clinical characteristic of PTCD3 deficiency. https://doi.org/10.1111/bpa.13134 | Human | Fibroblast |
Lee 2022 Hum Mol Genet | 2022 | Lee RG, Balasubramaniam S, Stentenbach M, Kralj T, McCubbin T, Padman B, Smith J, Riley LG, Priyadarshi A, Peng L, Nuske MR, Webster R, Peacock K, Roberts P, Stark Z, Lemire G, Ito YA; Care4Rare Canada Consortium, Boycott KM, Geraghty MT, van Klinken JB, Ferdinandusse S, Zhou Y, Walsh R, Marcellin E, Thorburn DR, Rosciolli T, Fletcher J, Rackham O, Vaz FM, Reid GE, Filipovska A (2022) Deleterious variants in CRLS1 lead to cardiolipin deficiency and cause an autosomal recessive multi-system mitochondrial disease. https://doi.org/10.1093/hmg/ddac040 | Human | Fibroblast |
Zdrazilova 2022 PLOS ONE | 2022 | Zdrazilova L, Hansikova H, Gnaiger E (2022) Comparable respiratory activity in attached and suspended human fibroblasts. PLoS ONE 17:e0264496. https://doi.org/10.1371/journal.pone.0264496 | Human | Fibroblast |
Adant 2022 Mol Metab | 2022 | Adant I, Bird M, Decru B, Windmolders P, Wallays M, de Witte P, Rymen D, Witters P, Vermeersch P, Cassiman D, GhesquiĂšre B (2022) Pyruvate and uridine rescue the metabolic profile of OXPHOS dysfunction. https://doi.org/10.1016/j.molmet.2022.101537 | Human | Fibroblast |
Giordano 2021 Gene Ther | 2021 | Giordano L, Aneja MK, Sommer N, Alebrahimdehkordi N, Seraji A, Weissmann N, Rudolph C, Plank C, Jacobs HT, Szibor M (2021) Alternative oxidase encoded by sequence-optimized and chemically-modified RNA transfected into mammalian cells is catalytically active. https://doi.org/10.1038/s41434-021-00235-z | Mouse | Fibroblast |
Gnaiger 2021 MitoFit BCA | 2021 | Gnaiger E (2021) Bioenergetic cluster analysis â mitochondrial respiratory control in human fibroblasts. MitoFit Preprints 2021.08. https://doi.org/10.26124/mitofit:2021-0008 | Human | Fibroblast |
Brito 2021 BMC Cancer | 2021 | Brito A, Merle C, Lagarde P, Faustin B, Devin A, Lartigue L, Chibon F (2021) Cell fusion enhances energy metabolism of mesenchymal tumor hybrid cells to sustain their proliferation and invasion. BMC Cancer 21:863. | Human | Fibroblast |
Baldini 2021 Life Sci | 2021 | Baldini F, Fabbri R, Eberhagen C, Voci A, Portincasa P, Zischka H, Vergani L (2021) Adipocyte hypertrophy parallels alterations of mitochondrial status in a cell model for adipose tissue dysfunction in obesity. Life Sci 265:118812. | Mouse | Fibroblast |
Hesse 2021 FASEB J | 2021 | Hesse J, Groterath W, Owenier C, Steinhausen J, Ding Z, Steckel B, Czekelius C, Alter C, Marzoq A, Schrader J (2021) Normoxic induction of HIF-1α by adenosine-A2B R signaling in epicardial stromal cells formed after myocardial infarction. FASEB J 35:21517. | Rat | Heart Fibroblast |
Kripnerova 2021 J Clin Med | 2021 | KripnerovĂĄ M, Parmar HS, Ć ĂĄna J, KopkovĂĄ A, RadovĂĄ L, Sopper S, Biernacki K, JedliÄka J, KohoutovĂĄ M, KuncovĂĄ J, Peychl J, Rudolf E, Äervinka M, Houdek Z, DvoĆĂĄk P, HoufkovĂĄ K, PeĆĄta M, TĆŻma Z, DolejĆĄovĂĄ M, TichĂĄnek F, BabuĆĄka V, Leba M, SlabĂœ O, Hatina J (2021) Complex interplay of genes underlies invasiveness in fibrosarcoma progression model. J Clin Med 10:2297. | Mouse | Fibroblast |
Correia 2021 Hum Mutat | 2021 | Correia SP, Moedas MF, Naess K, Bruhn H, Maffezzini C, Calvo-Garrido J, Lesko N, Wibom R, Schober FA, Jemt A, Stranneheim H, Freyer C, Wedell A, Wredenberg A (2021) Severe congenital lactic acidosis and hypertrophic cardiomyopathy caused by an intronic variant in NDUFB7. Hum Mutat 42:378-84. | Human | Fibroblast |
Cretin 2021 EMBO Mol Med | 2021 | Cretin E, Lopes P, Vimont E, Tatsuta T, Langer T, Gazi A, Sachse M, Yu-Wai-Man P, Reynier P, Wai T (2021) High-throughput screening identifies suppressors of mitochondrial fragmentation in OPA1 fibroblasts. EMBO Mol Med 13:13579. | Mouse | Fibroblast |
Friederich 2021 Mol Genet Metab | 2021 | Friederich MW, Geddes GC, Wortmann SB, Punnoose A, Wartchow E, Knight KM, Prokisch H, Creadon-Swindell G, Mayr JA, Van Hove JLK (2021) Pathogenic variants in MRPL44 cause infantile cardiomyopathy due to a mitochondrial translation defect. Mol Genet Metab 133:362-71. | Human | Fibroblast |
Burska 2021 Biochim Biophys Acta Mol Basis Dis | 2021 | Burska D, Stiburek L, Krizova J, Vanisova M, Martinek V, Sladkova J, Zamecnik J, Honzik T, Zeman J, Hansikova H, Tesarova M (2021) Homozygous missense mutation in UQCRC2 associated with severe encephalomyopathy, mitochondrial complex III assembly defect and activation of mitochondrial protein quality control. Biochim Biophys Acta Mol Basis Dis 1867:166147. | Human | Fibroblast |
Pelaez Coyotl 2020 Pharmaceutics | 2020 | Pelåez Coyotl EA, Barrios Palacios J, Muciño G, Moreno-Blas D, Costas M, Montiel Montes T, Diener C, Uribe-Carvajal S, Massieu L, Castro-Obregón S, Espinosa OR, Mata Espinosa D, Barrios-Payan J, León Contreras JC, Corzo G, Hernåndez-Pando R, Del Rio G (2020) Antimicrobial peptide against Mycobacterium tuberculosis that activates autophagy is an effective treatment for tuberculosis. Pharmaceutics 12:E1071. | Mouse | Fibroblast |
Ugarteburu 2020 J Clin Med | 2020 | Ugarteburu O, SĂĄnchez-VilĂ©s M, Ramos J, Barcos-RodrĂguez T, Garrabou G, GarcĂa-Villoria J, Ribes A, Tort F (2020) Physiopathological bases of the disease caused by HACE1 mutations: alterations in autophagy, mitophagy and oxidative stress response. J Clin Med 9:E913. | Human | Fibroblast |
Alston 2020 Am J Hum Genet | 2020 | Alston CL, Veling MT, Heidler J, Taylor LS, Alaimo JT, Sung AY, He L, Hopton S, Broomfield A, Pavaine J, Diaz J, Leon E, Wolf P, McFarland R, Prokisch H, Wortmann SB, Bonnen PE, Wittig I, Pagliarini DJ, Taylor RW (2020) Pathogenic bi-allelic mutations in NDUFAF8 cause Leigh syndrome with an isolated complex I deficiency. Am J Hum Genet 106:92-101. | Human | Fibroblast |
Gnaiger 2020 BEC MitoPathways | 2020 | Gnaiger E (2020) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 5th ed. Bioenerg Commun 2020.2. https://doi.org/10.26124/bec:2020-0002 | Human Mouse | Heart Skeletal muscle Fibroblast |
Catalan-Garcia 2020 J Clin Med | 2020 | CatalĂĄn-GarcĂa M, GarcĂa-GarcĂa FJ, Moreno-Lozano PJ, Alcarraz-VizĂĄn G, Tort-Merino A, Milisenda JC, CantĂł-Santos J, Barcos-RodrĂguez T, Cardellach F, LladĂł A, Novials A, Garrabou G, Grau-Junyent JM (2020) Mitochondrial dysfunction: A common hallmark underlying comorbidity between sIBM and other degenerative and age-related diseases. J Clin Med 9:E1446. | Human | Fibroblast |
Cornelissen 2020 Hum Mol Genet | 2020 | Cornelissen T, Spinazzi M, Martin S, Imberechts D, Vangheluwe P, Bird M, De Strooper B, Vandenberghe W (2020) CHCHD2 harboring the Parkinson's disease-linked T61I mutation precipitates inside mitochondria and induces precipitation of wild-type CHCHD2. Hum Mol Genet 29:1096-106. | Human | Fibroblast |
Robledo-Cadena 2020 Pharmaceuticals (Basel) | 2020 | Robledo-Cadena DX, Gallardo-PĂ©rez JC, DĂĄvila-Borja V, Pacheco-VelĂĄzquez SC, Belmont-DĂaz JA, Ralph SJ, Blanco-Carpintero BA, Moreno-SĂĄnchez R, RodrĂguez-EnrĂquez S (2020) Non-steroidal anti-inflammatory drugs increase cisplatin, paclitaxel, and doxorubicin efficacy against human cervix cancer cells. Pharmaceuticals (Basel) 13:463. | Human | Endothelial;epithelial;mesothelial cell HeLa Fibroblast |
Beninca 2020 J Med Genet | 2020 | Beninca C, Zanette V, Brischigliaro M, Johnson M, Reyes A, Valle DAD, Robinson AJ, Degiorgi A, Yeates A, Telles BA, Prudent J, Baruffini E, Santos ML, de Souza RL, Fernandez-Vizarra E, Whitworth A, Zeviani M (2020) Mutation in the MICOS subunit gene APOO (MIC26) associated with an X-linked recessive mitochondrial myopathy, lactic acidosis, cognitive impairment and autistic features. J Med Genet 58:155-67. | Human | Fibroblast |
Cassereau 2020 Exp Neurol | 2020 | Cassereau J, Chevrollier A, Codron P, Goizet C, Gueguen N, Verny C, Reynier P, Bonneau D, Lenaers G, Procaccio V (2020) Oxidative stress contributes differentially to the pathophysiology of Charcot-Marie-Tooth disease type 2K. Exp Neurol 323:113069. | Human | Fibroblast |
Gutierrez 2020 Sci Signal | 2020 | Gutiérrez T, Qi H, Yap MC, Tahbaz N, Milburn LA, Lucchinetti E, Lou PH, Zaugg M, LaPointe PG, Mercier P, Overduin M, Bischof H, Burgstaller S, Malli R, Ballanyi K, Shuai J, Simmen T (2020) The ER chaperone calnexin controls mitochondrial positioning and respiration . Sci Signal 13:eaax6660. | Mouse | Fibroblast |
Xia 2020 Biomed Res Int | 2020 | Xia W, Wang Q, Lu Y, Hu Y, Zhang X, Zhang J, Liu D, Song J, Zhu Z, Liu D, Zhang H (2020) Transient receptor potential channel canonical type 3 deficiency antagonizes myofibroblast transdifferentiation in vivo. Biomed Res Int 2020:1202189. | Human | Fibroblast |
Kawamura 2021 Mol Ther Nucleic Acids | 2020 | Kawamura E, Maruyama M, Abe J, Sudo A, Takeda A, Takada S, Yokota T, Kinugawa S, Harashima H, Yamada Y (2021) Validation of gene therapy for mutant mitochondria by delivering mitochondrial RNA using a MITO-porter. Mol Ther Nucleic Acids 20:687-98. | Human | Fibroblast |
Alahmad 2020 EMBO Mol Med | 2020 | Alahmad A, Nasca A, Heidler J, Thompson K, OlĂĄhovĂĄ M, Legati A, Lamantea E, Meisterknecht J, Spagnolo M, He L, Alameer S, Hakami F, Almehdar A, Ardissone A, Alston CL, McFarland R, Wittig I, Ghezzi D, Taylor RW (2020) Bi-allelic pathogenic variants in NDUFC2 cause early-onset Leigh syndrome and stalled biogenesis of complex I. EMBO Mol Med 12:e12619. | Human | Fibroblast |
Juarez-Flores 2020 Antioxidants (Basel) | 2020 | Juarez-Flores DL, Ezquerra M, Gonzalez-Casacuberta I, Ormazabal A, Moren C, Tolosa E, Fucho R, Guitart-Mampel M, Casado M, Valldeoriola F, de la Torre-Lara J, Munoz E, Tobias E, Compta Y, Garcia-Garcia FJ, Garcia-Ruiz C, Fernandez-Checa JC, Marti MJ, Grau JM, Cardellach F, Artuch R, Fernandez-Santiago R, Garrabou G (2020) Disrupted mitochondrial and metabolic plasticity underlie comorbidity between age-related and degenerative disorders as Parkinson disease and type 2 diabetes mellitus. Antioxidants (Basel) 9:1063. | Human | Fibroblast |
Germain 2019 Int J Med Sci | 2019 | Germain N, Dessein AF, Vienne JC, Dobbelaere D, Mention K, Joncquel M, Dekiouk S, Laine W, Kluza J, Marchetti P (2019) First-line screening of OXPHOS deficiencies using microscale oxygraphy in human skin fibroblasts: A preliminary study. Int J Med Sci 16:931-38. | Human | Fibroblast |
Richter 2019 Life Sci Alliance | 2019 | Richter U, Ng KY, Suomi F, Marttinen P, Turunen T, Jackson C, Suomalainen A, Vihinen H, Jokitalo E, Nyman TA, Isokallio MA, Stewart JB, Mancini C, Brusco A, Seneca S, LombĂšs A, Taylor RW, Battersby BJ (2019) Mitochondrial stress response triggered by defects in protein synthesis quality control. Life Sci Alliance 2:e201800219. | Human | Fibroblast |
Gustafson 2019 PLoS One | 2019 | Gustafson MA, McCormick EM, Perera L, Longley MJ, Bai R, Kong J, Dulik M, Shen L, Goldstein AC, McCormack SE, Laskin BL, Leroy BP, Ortiz-Gonzalez XR, Ellington MG, Copeland WC, Falk MJ (2019) Mitochondrial single-stranded DNA binding protein novel de novo SSBP1 mutation in a child with single large-scale mtDNA deletion (SLSMD) clinically manifesting as Pearson, Kearns-Sayre, and Leigh syndromes. PLoS One 14:e0221829. | Human | Fibroblast Lymphocyte |
Itkis 2019 Mitochondrion | 2019 | Itkis Y, Krylova T, Pechatnikova NL, De Grassi A, Tabakov VY, Pierri CL, Aleshin V, Boyko A, Bunik VI, Zakharova EY (2019) A novel variant m.641A>T in the mitochondrial MT-TF gene is associated with epileptic encephalopathy in adolescent. Mitochondrion 47:10-17. | Human | Fibroblast |
Wang H 2019 J Biol Chem | 2019 | Wang H, Lu J, Kulkarni S, Zhang W, Gorka JE, Mandel JA, Goetzman ES, Prochownik EV (2019) Metabolic and oncogenic adaptations to pyruvate dehydrogenase inactivation in fibroblasts. J Biol Chem 294:5466-86. | Rat | Fibroblast |
Veyrat-Durebex 2019 Mol Neurobiol | 2019 | Veyrat-Durebex C, Bris C, Codron P, Bocca C, Chupin S, Corcia P, Vourc'h P, Hergesheimer R, Cassereau J, Funalot B, Andres CR, Lenaers G, Couratier P, Reynier P, Blasco H (2019) Metabo-lipidomics of fibroblasts and mitochondrial-endoplasmic reticulum extracts from ALS patients shows alterations in purine, pyrimidine, energetic, and phospholipid metabolisms. Mol Neurobiol 56:5780-91. | Human | Fibroblast |
Gaudo 2019 Neurogenetics | 2019 | GaudĂł P, Emperador S, Garrido-PĂ©rez N, Ruiz-Pesini E, Yubero D, GarcĂa-Cazorla A, Artuch R, Montoya J, Bayona-Bafaluy MP (2019) Infectious stress triggers a POLG-related mitochondrial disease. Neurogenetics 21:19-27. | Human | Fibroblast |
Zhao 2019 Basic Res Cardiol | 2019 | Zhao J, Gao JL, Zhu JX, Zhu HB, Peng X, Jiang M, Fu Y, Xu J, Mao XH, Hu N, Ma MH, Dong DL (2019) The different response of cardiomyocytes and cardiac fibroblasts to mitochondria inhibition and the underlying role of STAT3. Basic Res Cardiol 114:12. | Rat | Heart Fibroblast |
Friederich 2019 Mol Genet Metab | 2019 | Friederich MW, Perez FA, Knight KM, Van Hove RA, Yang SP, Saneto RP, Van Hove JLK (2019) Pathogenic variants in NUBPL result in failure to assemble the matrix arm of complex I and cause a complex leukoencephalopathy with thalamic involvement. Mol Genet Metab 129:236-42. | Human | Fibroblast |
Desquiret-Dumas 2019 Biochim Biophys Acta Mol Basis Dis | 2019 | Desquiret-Dumas V, Leman G, Wetterwald C, Chupin S, Lebert A, Khiati S, Le Mao M, Geffroy G, Kane MS, Chevrollier A, Goudenege D, Gadras C, Tessier L, Barth M, Leruez S, Amati-Bonneau P, Henrion D, Bonneau D, Procaccio V, Reynier P, Lenaers G, Gueguen N (2019) Warburg-like effect is a hallmark of complex I assembly defects. Biochim Biophys Acta Mol Basis Dis 1865:2475-89. | Human | Fibroblast |
Wolf 2019 Cells | 2019 | Wolf C, Zimmermann R, Thaher O, Bueno D, WĂŒllner V, SchĂ€fer MKE, Albrecht P, Methner A (2019) The Charcot-Marie tooth disease mutation R94Q in MFN2 decreases ATP production but increases mitochondrial respiration under conditions of mild oxidative stress. Cells 8:E1289. | Mouse | Fibroblast |
Silva Ramos 2019 PLoS Genet | 2019 | Silva Ramos E, Motori E, BrĂŒser C, KĂŒhl I, Yeroslaviz A, Ruzzenente B, Kauppila JHK, Busch JD, Hultenby K, Habermann BH, Jakobs S, Larsson NG, Mourier A (2019) Mitochondrial fusion is required for regulation of mitochondrial DNA replication. PLoS Genet 15:e1008085. | Mouse | Heart Fibroblast |
Krylova 2019 Mitochondrion | 2019 | Krylova TD, Sheremet NL, Tabakov VY, Lyamzaev KG, Itkis YS, Tsygankova PG, Andreeva NA, Shmelkova MS, Nevinitsyna TA, Kadyshev VV, Zakharova EY (2019) Three rare pathogenic mtDNA substitutions in LHON patients with low heteroplasmy. Mitochondrion 50:139-144. | Human | Fibroblast |
Giordano 2018 Am J Respir Cell Mol Biol | 2018 | Giordano L, Farnham A, Dhandapani PK, Salminen L, Bhaskaran J, Voswinckel R, Rauschkolb P, Scheibe S, Sommer N, Beisswenger C, Weissmann N, Braun T, Jacobs HT, Bals R, Herr C, Szibor M (2018) Alternative oxidase attenuates cigarette smoke-induced lung dysfunction and tissue damage. Am J Respir Cell Mol Biol 60:515-22. | Mouse | Fibroblast |
Nacarelli 2018 Geroscience | 2018 | Nacarelli T, Azar A, Altinok O, Orynbayeva Z, Sell C (2018) Rapamycin increases oxidative metabolism and enhances metabolic flexibility in human cardiac fibroblasts. Geroscience 40:243-56. | Human | Heart Fibroblast |
Boutoual 2018 Scientific Reports | 2018 | Boutoual, R., Meseguer, S., Villarroya, M., Martin-Hernandez, E., Errami, M., Martin, M. A., Casado, M., and Armengod, M. E. (2018) Defects in the mitochondrial-tRNA modification enzymes MTO1 and GTPBP3 promote different metabolic reprogramming through a HIF-PPARgamma-UCP2-AMPK axis. Scientific reports 8, 1163 | Human | Other cell lines Fibroblast |
Alston 2018 Am J Hum Genet | 2018 | Alston CL, Heidler J, Dibley MG, Kremer LS, Taylor LS, Fratter C, French CE, Glasgow RIC, Feichtinger RG, Delon I, Pagnamenta AT, Dolling H, Lemonde H, Aiton N, BjĂžrnstad A, Henneke L, GĂ€rtner J, Thiele H, Tauchmannova K, Quaghebeur G, Houstek J, Sperl W, Raymond FL, Prokisch H, Mayr JA, McFarland R, Poulton J, Ryan MT, Wittig I, Henneke M, Taylor RW (2018) Bi-allelic mutations in NDUFA6 establish its role in early-onset isolated mitochondrial complex I deficiency. Am J Hum Genet 103:592-601. | Human | Fibroblast |
Liu 2018 J Periodontol | 2018 | Liu J, Zeng J, Wang X, Zheng M, Luan Q (2018) P53 mediates lipopolysaccharide-induced inflammation in human gingival fibroblasts. J Periodontol 89:1142-51. | Human | Fibroblast |
Temelie 2018 Oxid Med Cell Longev | 2018 | Temelie M, Savu DI, Moisoi N (2018) Intracellular and intercellular signalling mechanisms following DNA damage are modulated by PINK1. Oxid Med Cell Longev 1391387. | Human Mouse | Nervous system Other cell lines Fibroblast |
Isohanni 2018 Neurogenetics | 2018 | Isohanni P, Carroll CJ, Jackson CB, Pohjanpelto M, Lönnqvist T, Suomalainen A (2018) Defective mitochondrial ATPase due to rare mtDNA m.8969G>A mutation-causing lactic acidosis, intellectual disability, and poor growth. Neurogenetics 19:49-53. | Human | Skeletal muscle Blood cells Fibroblast |
Lee 2018 Neurol Genet | 2018 | Lee RG, Sedghi M, Salari M, Shearwood AJ, Stentenbach M, Kariminejad A, Goullee H, Rackham O, Laing NG, Tajsharghi H, Filipovska A (2018) Early-onset Parkinson disease caused by a mutation in CHCHD2 and mitochondrial dysfunction. Neurol Genet 4:e276. | Human | Fibroblast |
Dejmek 2018 Physiol Res | 2018 | Dejmek J, KohoutovĂĄ M, KripnerovĂĄ M, ÄedĂkovĂĄ M, TĆŻma Z, BabuĆĄka V, Bolek L, KuncovĂĄ J (2018) Repeated exposure to hyperbaric hyperoxia affects mitochondrial functions of the lung fibroblasts. Physiol Res 67(Suppl 4):S633-S643. | Human | Lung;gill Fibroblast |
Juarez-Flores 2018 J Transl Med | 2018 | JuĂĄrez-Flores DL, GonzĂĄlez-Casacuberta I, Ezquerra M, Bañó M, Carmona-Pontaque F, CatalĂĄn-GarcĂa M, Guitart-Mampel M, Rivero JJ, Tobias E, Milisenda JC, Tolosa E, Marti MJ, FernĂĄndez-Santiago R, Cardellach F, MorĂ©n C, Garrabou G (2018) Exhaustion of mitochondrial and autophagic reserve may contribute to the development of LRRK2G2019S -Parkinson's disease. J Transl Med 16:160. | Human | Fibroblast |
Friederich 2018 Nat Commun | 2018 | Friederich MW, Timal S, Powell CA, Dallabona C, Kurolap A, Palacios-Zambrano S, Bratkovic D, Derks TGJ, Bick D, Bouman K, Chatfield KC, Damouny-Naoum N, Dishop MK, Falik-Zaccai TC, Fares F, Fedida A, Ferrero I, Gallagher RC, Garesse R, Gilberti M, GonzĂĄlez C, Gowan K, Habib C, Halligan RK, Kalfon L, Knight K, Lefeber D, Mamblona L, Mandel H, Mory A, Ottoson J, Paperna T, Pruijn GJM, Rebelo-Guiomar PF, Saada A, Sainz B Jr, Salvemini H, Schoots MH, Smeitink JA, Szukszto MJ, Ter Horst HJ, van den Brandt F, van Spronsen FJ, Veltman JA, Wartchow E, Wintjes LT, Zohar Y, FernĂĄndez-Moreno MA, Baris HN, Donnini C, Minczuk M, Rodenburg RJ, Van Hove JLK (2018) Pathogenic variants in glutamyl-tRNAGln amidotransferase subunits cause a lethal mitochondrial cardiomyopathy disorder. Nat Commun 9:4065. | Human Fungi | Fibroblast |
Boutoual 2018 Sci Rep | 2018 | Boutoual R, Meseguer S, Villarroya M, MartĂn-HernĂĄndez E, Errami M, MartĂn MA, Casado M, Armengod ME (2018) Defects in the mitochondrial-tRNA modification enzymes MTO1 and GTPBP3 promote different metabolic reprogramming through a HIF-PPARÎł-UCP2-AMPK axis. Sci Rep 8:1163. | Human | Fibroblast |
Angebault 2018 Sci Signal | 2018 | Angebault C, Fauconnier J, Patergnani S, Rieusset J, Danese A, Affortit CA, Jagodzinska J, MĂ©gy C, Quiles M, Cazevieille C, Korchagina J, Bonnet-Wersinger D, Milea D, Hamel C, Pinton P, Thiry M, Lacampagne A, Delprat B, Delettre C (2018) ER-mitochondria cross-talk is regulated by the Ca2+ sensor NCS1 and is impaired in Wolfram syndrome. Sci Signal 11:eaaq1380. | Human | Fibroblast |
Barca 2018 Hum Mol Genet | 2018 | Barca E, Ganetzky RD, Potluri P, Juanola-Falgarona M, Gai X, Li D, Jalas C, Hirsch Y, Emmanuele V, Tadesse S, Ziosi M, Akman HO, Chung WK, Tanji K, McCormick E, Place E, Consugar M, Pierce EA, Hakonarson H, Wallace DC, Hirano M, Falk MJ (2018) USMG5 Ashkenazi Jewish founder mutation impairs mitochondrial complex V dimerization and ATP synthesis. Hum Mol Genet 27:3305-12. | Human | Fibroblast |
Harmuth 2018 Front Mol Neurosci | 2018 | Harmuth T, Prell-Schicker C, Weber JJ, Gellerich F, Funke C, DrieĂen S, Magg JCD, Krebiehl G, Wolburg H, Hayer SN, Hauser S, KrĂŒger R, Schöls L, Riess O, HĂŒbener-Schmid J (2018) Mitochondrial morphology, function and homeostasis are impaired by expression of an N-terminal calpain cleavage fragment of Ataxin-3. Front Mol Neurosci 11:368. | Mouse | Fibroblast |
Szelechowski 2018 Sci Rep | 2018 | Szelechowski M, Amoedo N, Obre E, LĂ©ger C, Allard L, Bonneu M, Claverol S, Lacombe D, Oliet S, Chevallier S, Le Masson G, Rossignol R (2018) Metabolic reprogramming in amyotrophic lateral sclerosis. Sci Rep 8:3953. | Human | Endothelial;epithelial;mesothelial cell Fibroblast |
Reyes 2018 EMBO Mol Med | 2018 | Reyes A, Melchionda L, Burlina A, Robinson AJ, Ghezzi D, Zeviani M (2018) Mutations in TIMM50 compromise cell survival in OxPhos-dependent metabolic conditions. EMBO Mol Med 10:e8698. | Human | Fibroblast |
Monzio Compagnoni 2018 Biochim Biophys Acta Mol Basis Dis | 2018 | Monzio Compagnoni G, Kleiner G, Bordoni A, Fortunato F, Ronchi D, Salani S, Guida M, Corti C, Pichler I, Bergamini C, Fato R, Pellecchia MT, Vallelunga A, Del Sorbo F, Elia A, Reale C, Garavaglia B, Mora G, Albanese A, Cogiamanian F, Ardolino G, Bresolin N, Corti S, Comi GP, Quinzii CM, Di Fonzo A (2018) Mitochondrial dysfunction in fibroblasts of multiple system atrophy. Biochim Biophys Acta Mol Basis Dis 1864:3588-97. | Human | Fibroblast |
Walczak 2018 FASEB J | 2018 | Walczak J, DÄbska-Vielhaber G, Vielhaber S, SzymaĆski J, CharzyĆska A, DuszyĆski J, Szczepanowska J (2018) Distinction of sporadic and familial forms of ALS based on mitochondrial characteristics. FASEB J 33:4388-403. | Human | Fibroblast |
Sant'Anna-Silva 2018 Front Oncol | 2018 | Sant'Anna-Silva ACB, Santos GC, Campos SPC, Oliveira Gomes AM, PĂ©rez-Valencia JA, Rumjanek FD (2018) Metabolic profile of oral squamous carcinoma cell lines relies on a higher demand of lipid metabolism in metastatic cells. Front Oncol 8:13. | Human | Other cell lines Fibroblast |
Chen 2018 Hum Mol Genet | 2018 | Chen A, Tiosano D, Guran T, Baris HN, Bayram Y, Mory A, Shapiro-Kulnane L, Hodges CA, Coban Akdemir Z, Turan S, Jhangiani SN, van den Akker F, Hoppel CL, Salz HK, Lupski JR, Buchner DA (2018) Mutations in the mitochondrial ribosomal protein MRPS22 lead to primary ovarian insufficiency. Hum Mol Genet 27:1913-26. | Human | Endothelial;epithelial;mesothelial cell Fibroblast |
Pfeiffer 2017 Free Radic Biol Med | 2017 | Pfeiffer A, Schneider J, Bueno D, Dolga A, Voss TD, Lewerenz J, WĂŒllner V, Methner A (2017) Bcl-xL knockout attenuates mitochondrial respiration and causes oxidative stress that is compensated by pentose phosphate pathway activity. Free Radic Biol Med 112:350-9. | Mouse | Fibroblast |
Victor 2017 Thesis | 2017 | Victor L (2017) Investigating the possible cytoprotective effects of melatonin isomer against simulated ischemic injury. Master's Thesis 76. | Rat | Fibroblast |
Uzhachenko 2017 Aging (Albany NY) | 2017 | Uzhachenko R, Boyd K, Olivares-Villagomez D, Zhu Y, Goodwin JS, Rana T, Shanker A, Tan WJ, Bondar T, Medzhitov R, Ivanova AV (2017) Mitochondrial protein Fus1/Tusc2 in premature aging and age-related pathologies: critical roles of calcium and energy homeostasis. Aging (Albany NY) 9:627-49. | Mouse | Kidney Endothelial;epithelial;mesothelial cell Fibroblast |
Pravenec 2017 Physiol Res | 2017 | Pravenec M1, ZĂdek V, Landa V, Mlejnek P, Ć ilhavĂœ J, Ć imĂĄkovĂĄ M, TrnovskĂĄ J, Ć kop V, MarkovĂĄ I, MalĂnskĂĄ H, HĂŒttl M, KazdovĂĄ L, BardovĂĄ K, TauchmannovĂĄ K, VrbackĂœ M, NĆŻskovĂĄ H, MrĂĄÄek T, KopeckĂœ J, HouĆĄtÄk J (2017) Mutant Wars2 gene in spontaneously hypertensive rats impairs brown adipose tissue function and predisposes to visceral obesity. Physiol Res 66:917-24. | Rat | Endothelial;epithelial;mesothelial cell Fibroblast |
Uppala 2017 Biochem Biophys Res Commun | 2017 | Uppala R, Dudiak B, Beck ME, Bharathi SS, Zhang Y, Stolz DB, Goetzman ES (2017) Aspirin increases mitochondrial fatty acid oxidation. Biochem Biophys Res Commun 482:346-51. | Human Mouse | HEK Fibroblast |
Ruiz 2017 Brain Pathol | 2017 | Ruiz M, Bégou M, Launay N, Ranea-Robles P, Bianchi P, López-Erauskin J, Morató L, Guilera C, Petit B, Vaurs-Barriere C, Guéret-Gonthier C, Bonnet-Dupeyron MN, Fourcade S, Auwerx J, Boespflug-Tanguy O, Pujol A (2017) Oxidative stress and mitochondrial dynamics malfunction are linked in Pelizaeus-Merzbacher disease. Brain Pathol 28:611-30. | Human Mouse | Nervous system Fibroblast |
Thaher 2017 Neurochem Int | 2017 | Thaher O, Wolf C, Dey PN, Pouya A, WĂŒllner V, Tenzer S, Methner A (2017) The thiol switch C684 in Mitofusin-2 mediates redox-induced alterations of mitochondrial shape and respiration. Neurochem Int 117:167-73. | Mouse | Fibroblast |
Friederich 2017 Hum Mol Genet | 2017 | Friederich MW, Erdogan AJ, Coughlin CR 2nd, Elos MT, Jiang H, O'Rourke CP, Lovell MA, Wartchow E, Gowan K, Chatfield KC, Chick WS, Spector EB, Van Hove JLK, Riemer J (2017) Mutations in the accessory subunit NDUFB10 result in isolated complex I deficiency and illustrate the critical role of intermembrane space import for complex I holoenzyme assembly. Hum Mol Genet 26:702-16. | Human | Fibroblast |
Kane 2017 J Cell Mol Med | 2017 | Kane MS, Alban J, Desquiret-Dumas V, Gueguen N, Ishak L, Ferre M, Amati-Bonneau P, Procaccio V, Bonneau D, Lenaers G, Reynier P, Chevrollier A (2017) Autophagy controls the pathogenicity of OPA1 mutations in dominant optic atrophy. J Cell Mol Med 21:2284-97. | Human | Fibroblast |
Krylova 2017 Biomed Khim | 2017 | Krylova TD, Tsygankova PG, Itkis YS, Sheremet NL, Nevinitsyna TA, Mikhaylova SV, Zakharova EY (2017) High resolution respirometry in diagnostic of mitochondrial disorders caused by mitochondrial complex I deficiency. Biomed Khim 63:327-33. | Human | Endothelial;epithelial;mesothelial cell Fibroblast |
Rohde 2017 Cell Death Differ | 2017 | Rohde K, Kleinesudeik L, Roesler S, Löwe O, Heidler J, Schröder K, Wittig I, Dröse S, Fulda S (2017) A Bak-dependent mitochondrial amplification step contributes to Smac mimetic/glucocorticoid-induced necroptosis. Cell Death Differ 24:83-97. | Mouse | Fibroblast |
Theisen 2017 Am J Med Genet A | 2017 | Theisen BE, Rumyantseva A, Cohen JS, Alcaraz WA, Shinde DN, Tang S, Srivastava S, Pevsner J, Trifunovic A, Fatemi A (2017) Deficiency of WARS2, encoding mitochondrial tryptophanyl tRNA synthetase, causes severe infantile onset leukoencephalopathy. Am J Med Genet A 173:2505-10. | Human | Endothelial;epithelial;mesothelial cell Fibroblast |
Beresewicz 2017 PLoS One | 2017 | Beresewicz M, Boratynska-Jasinska A, Charzewski L, Kawalec M, Kabzinska D, Kochanski A, Krzysko KA, Zablocka B (2017) The effect of a novel c.820C>T (Arg274Trp) mutation in the mitofusin 2 gene on fibroblast metabolism and clinical manifestation in a patient. PLoS One 12:0169999. | Human | Fibroblast Endothelial;epithelial;mesothelial cell |
Gerber 2017 Brain | 2017 | Gerber S, Charif M, Chevrollier A, Chaumette T, Angebault C, Kane MS, Paris A, Alban J, Quiles M, Delettre C, Bonneau D, Procaccio V, Amati-Bonneau P, Reynier P, Leruez S, Calmon R, Boddaert N, Funalot B, Rio M, Bouccara D, Meunier I, Sesaki H, Kaplan J, Hamel CP, Rozet JM, Lenaers G (2017) Mutations in DNM1L, as in OPA1, result indominant optic atrophy despite opposite effects on mitochondrial fusion and fission. Brain 140:2586-96. | Human | Endothelial;epithelial;mesothelial cell Fibroblast |
Jang 2017 Biol Open | 2017 | Jang DH, Seeger SC, Grady ME, Shofer FC, Eckmann DM (2017) Mitochondrial dynamics and respiration within cells with increased open pore cytoskeletal meshes. Biol Open 6:1831-9. | Human | Endothelial;epithelial;mesothelial cell Fibroblast |
Boutant 2017 EMBO J | 2017 | Boutant M, Kulkarni SS, Joffraud M, Ratajczak J, Valera-Alberni M, Combe R, Zorzano A, CantĂł C (2017) Mfn2 is critical for brown adipose tissue thermogenic function. EMBO J 36:1543-58. | Mouse | Fat Fibroblast |
Beresewicz 2017 PLOS ONE | 2017 | BerÄsewicz M, BoratyĆska-JasiĆska A, Charzewski Ć, Kawalec M, KabziĆska D, KochaĆski A, KrzyĆko KA, ZabĆocka B (2017) The effect of a novel c.820C>T (Arg274Trp) mutation in the mitofusin 2 gene on fibroblast metabolism and clinical manifestation in a patient. PLOS ONE 12:e0169999. | Human | Endothelial;epithelial;mesothelial cell Fibroblast |
Elmer 2017 US Patent | 2017 | Elmer E, Hansson MJ, Ehinger JK, Piel S, Moss S (2017) Succinate prodrugs for use in the treatment of lactic acidosis or drug-induced side-effects due to complex I-related impairment of mitochondrial oxidative phosphorylation. US Patent US20170100359 A1. | Human | Heart Blood cells Fibroblast Macrophage-derived Platelet |
Zhou 2017 Biochim Biophys Acta | 2017 | Zhou L, Wang W, Hoppel C, Liu J, Zhu X (2017) Parkinson's disease-associated pathogenic VPS35 mutation causes complex I deficits. Biochim Biophys Acta 1863:2791-5. | Human | Fibroblast |
Wetzel 2017 Thesis | 2017 | Wetzel MD (2017) Mechanism of metformin action in dermal fibroblasts. PhD Thesis 125. | Human | Fibroblast |
Porras 2017 Stem Cells | 2017 | Porras DP, Abbaszadeh M, Bhattacharya D, D'Souza NC, Edjiu NR, Perry CG, ScimĂš A (2017) p107 determines a metabolic checkpoint required for adipocyte lineage fates. Stem Cells 35:1378-91. | Mouse | Fat Fibroblast |
Scrima 2017 PLOS ONE | 2017 | Scrima R, Menga M, Pacelli C, Agriesti F, Cela O, Piccoli C, Cotoia A, De Gregorio A, Gefter JV, Cinnella G, Capitanio N (2017) Para-hydroxyphenylpyruvate inhibits the pro-inflammatory stimulation of macrophage preventing LPS-mediated nitro-oxidative unbalance and immunometabolic shift. PLOS ONE 12:e0188683. | Human Mouse | Endothelial;epithelial;mesothelial cell Blood cells Fibroblast Macrophage-derived |
Macheiner 2016 Sci Rep | 2016 | Macheiner T, Fengler VH, Agreiter M, Eisenberg T, Madeo F, Kolb D, Huppertz B, Ackbar R, Sargsyan K (2016) Magnetomitotransfer: An efficient way for direct mitochondria transfer into cultured human cells. Sci Rep 6:35571. | Human | Fibroblast Lung;gill |
Ehinger 2016 Nat Commun | 2016 | Ehinger JK, Piel S, Ford R, Karlsson M, Sjövall F, Frostner Eà , Morota S, Taylor RW, Turnbull DM, Cornell C, Moss SJ, Metzsch C, Hansson MJ, Fliri H, Elmér E (2016) Cell-permeable succinate prodrugs bypass mitochondrial Complex I deficiency. Nat Commun 7:12317. https://doi.org/10.1038/ncomms12317 | Heart Blood cells Fibroblast | |
Scrima 2016 Biochim Biophys Acta | 2016 | Scrima R, Cela O, Merla G, Augello B, Rubino R, Quarato G, Fugetto S, Menga M, Fuhr L, RelĂłgio A, Piccoli C, Mazzoccoli G, Capitanio N (2016) Clock-genes and mitochondrial respiratory activity: Evidence of a reciprocal interplay. Biochim Biophys Acta 1857:1344-51. | Human | Liver Endothelial;epithelial;mesothelial cell Other cell lines Fibroblast |
Sengupta 2016 Free Radic Biol Med | 2016 | Sengupta S, Yang G, O'Donnell JC, Hinson MD, McCormack SE, Falk MJ, La P, Robinson MB, Williams ML, Yohannes MT, Polyak E, Nakamaru-Ogiso E, Dennery PA (2016) The circadian gene Rev-erbα improves cellular bioenergetics and provides preconditioning for protection against oxidative stress. Free Radic Biol Med 93:177-89. | Mouse | Lung;gill Fibroblast |
Sheremet 2016 Biochemistry (Moscow) | 2016 | Sheremet NL, Nevinitsyna TA, Zhorzholadze NV, Ronzina IA, Itkis YS, Krylova TD, Tsygankova PG, Malakhova VA, Zakharova EY, Tokarchuk AV, Panteleeva AA, Karger EM, Lyamzaev KG, Avetisov SE (2016) Previously unclassified mutation of mtDNA m.3472T>C: evidence of pathogenicity in Leberâs hereditary optic neuropathy. Biochemistry (Moscow) BM16-078. | Human | Endothelial;epithelial;mesothelial cell Fibroblast Platelet |
Torres 2016 Redox Biol | 2016 | Torres S, MatĂas N, Baulies A, Nuñez S, Alarcon-Vila C, Martinez L, Nuño N, Fernandez A, Caballeria J, Levade T, Gonzalez-Franquesa A, Garcia-RovĂ©s P, Balboa E, Zanlungo S, FabrĂas G, Casas J, Enrich C, Garcia-Ruiz C, FernĂĄndez-Checa JC (2016) Mitochondrial GSH replenishment as a potential therapeutic approach for Niemann Pick type C disease. Redox Biol 11:60-72. | Human Mouse | Nervous system Liver Endothelial;epithelial;mesothelial cell Fibroblast |
Peruzzo 2016 Cell Cycle | 2016 | Peruzzo P, Comelli M, Di Giorgio E, Franforte E, Mavelli I, Brancolini C (2016) Transformation by different oncogenes relies on specific metabolic adaptations. Cell Cycle 15:2656-68. | Mouse | Fibroblast |
Franko 2016 Diabetes | 2016 | Franko A, Huypens P, Neschen S, Irmler M, Rozman J, Rathkolb B, Neff F, Prehn C, Dubois G, Baumann M, Massinger R, Gradinger D, Przemeck GK, Repp B, Aichler M, Feuchtinger A, Schommers P, Stöhr O, Sanchez-Lasheras C, Adamski J, Peter A, Prokisch H, Beckers J, Walch AK, Fuchs H, Wolf E, Schubert M, Wiesner RJ, HrabÄ de Angelis M (2016) Bezafibrate improves insulin sensitivity and metabolic flexibility in STZ-treated diabetic mice. Diabetes 65:2540-52. | Human | Skeletal muscle Fibroblast |
Gerber 2016 J Med Genet | 2016 | Gerber S, Ding MG, GĂ©rard X, Zwicker K, Zanlonghi X, Rio M, Serre V, Hanein S, Munnich A, Rotig A, Bianchi L, Amati-Bonneau P, Elpeleg O, Kaplan J, Brandt U, Rozet JM (2016) Compound heterozygosity for severe and hypomorphic NDUFS2 mutations cause non-syndromic LHON-like optic neuropathy. J Med Genet 54:346-56. | Human | Endothelial;epithelial;mesothelial cell Fibroblast |
Chubanov 2016 Elife | 2016 | Chubanov V, Ferioli S, Wisnowsky A, Simmons DG, Leitzinger C, Einer C, Jonas W, Shymkiv Y, Bartsch H, Braun A, Akdogan B, Mittermeier L, Sytik L, Torben F, Jurinovic V, van der Vorst EP, Weber C, Yildirim ĂA, Sotlar K, SchĂŒrmann A, Zierler S, Zischka H, Ryazanov AG, Gudermann T (2016) Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival. Elife 5. pii: e20914. | Human | Fibroblast Other cell lines |
Hartmannova 2016 Hum Mol Genet | 2016 | HartmannovĂĄ H, PiherovĂĄ L, TauchmannovĂĄ K, Kidd K, Acott PD, Crocker JF, Oussedik Y, Mallet M, HodaĆovĂĄ K, StrĂĄneckĂœ V, PĆistoupilovĂĄ A, BareĆĄovĂĄ V, JedliÄkovĂĄ I, ĆœivnĂĄ M, SovovĂĄ J, HĆŻlkovĂĄ H, Robins V, VrbackĂœ M, Pecina P, KaplanovĂĄ V, HouĆĄtÄk J, MrĂĄÄek T, Thibeault Y, Bleyer AJ, Kmoch S (2016) Acadian variant of Fanconi syndrome is caused by mitochondrial respiratory chain complex I deficiency due to a non-coding mutation in complex I assembly factor NDUFAF6. Hum Mol Genet 25:4062-79. | Human | Fibroblast |
Wos 2016 Arch Biochem Biophys | 2016 | WoĆ M, Szczepanowska J, PikuĆa S, Tylki-SzymaĆska A, ZabĆocki K, Bandorowicz-PikuĆa J (2016) Mitochondrial dysfunction in fibroblasts derived from patients with Niemann-Pick type C disease. Arch Biochem Biophys 593:50-9. | Human | Endothelial;epithelial;mesothelial cell Fibroblast |
Zelenka 2016 Oxid Med Cell Longev | 2016 | Zelenka J, DvoĆĂĄk A, AlĂĄn L, ZadinovĂĄ M, HaluzĂk M, VĂtek L (2016) Hyperbilirubinemia protects against aging-associated inflammation and metabolic deterioration. Oxid Med Cell Longev ID 6190609:10p. | Rat | Liver Kidney Fibroblast |
Silva Ramos 2016 Biochim Biophys Acta | 2016 | Silva Ramos E, Larsson NG, Mourier A (2016) Bioenergetic roles of mitochondrial fusion. Biochim Biophys Acta 1857:1277-83. | Mouse | Fibroblast |
Kawalec 2016 Praca doktorska | 2016 | Kawalec MM (2016) Badanie komĂłrkowych skutkĂłw mutacji w genie mitofuzyny 2. PrĂłba zaproponowania testu patogennoĆci mutacji. Praca doktorska p86. | Mouse | Fibroblast |
Heimer 2016 Am J Hum Genet | 2016 | Heimer G, KerÀtÀr JM, Riley LG, Balasubramaniam S, Eyal E, PietikÀinen LP, Hiltunen JK, Marek-Yagel D, Hamada J, Gregory A, Rogers C, Hogarth P, Nance MA, Shalva N, Veber A, Tzadok M, Nissenkorn A, Tonduti D, Renaldo F, Kraoua I, Panteghini C, Valletta L, Garavaglia B, Cowley MJ, Gayevskiy V, Roscioli T, Silberstein JM, Hoffmann C, Raas-Rothschild A, Tiranti V, Anikster Y, Christodoulou J, Kastaniotis AJ, Ben-Zeev B, Hayflick SJ (2016) MECR mutations cause childhood-onset dystonia and optic atrophy, a mitochondrial fatty acid synthesis disorder. Am J Hum Genet 99:1229-44. | Human | Fibroblast |
Schoepf 2016 FEBS J | 2016 | Schöpf B, SchÀfer G, Weber A, Talasz H, Eder IE, Klocker H, Gnaiger E (2016) Oxidative phosphorylation and mitochondrial function differ between human prostate tissue and cultured cells. https://doi.org/10.1111/febs.13733 | Human | Endothelial;epithelial;mesothelial cell Genital Other cell lines Fibroblast |
Alvarez-Mora 2016 Mol Neurobiol | 2016 | Alvarez-Mora MI, Rodriguez-Revenga L, Madrigal I, Guitart-Mampel M, Garrabou G, MilĂ M (2016) Impaired mitochondrial function and dynamics in the pathogenesis of FXTAS. Mol Neurobiol 54:6896-902. | Human | Fibroblast |
Garama 2015 Mol Cell Biol | 2015 | Garama DJ, Harris TJ, White CL, Rossello FJ, Abdul-Hay M, Gough DJ, Levy DE (2015) A synthetic lethal interaction between glutathione synthesis and mitochondrial reactive oxygen species provides a tumor-specific vulnerability dependent on STAT3. Mol Cell Biol 35:3646-56. | Mouse | Endothelial;epithelial;mesothelial cell Fibroblast |
Seillier 2015 EMBO Mol Med | 2015 | Seillier M, Pouyet L, N'Guessan P, Nollet M, Capo F, Guillaumond F, Peyta L, Dumas JF, Varrault A, Bertrand G, Bonnafous S, Tran A, Meur G, Marchetti P, Ravier MA, Dalle S, Gual P, Muller D, Rutter GA, Servais S, Iovanna JL, Carrier A (2015) Defects in mitophagy promote redox-driven metabolic syndrome in the absence of TP53INP1. EMBO Mol Med 7:802-18. | Human Mouse | Fibroblast |
Kishita 2015 Am J Hum Genet | 2015 | Kishita Y, Pajak A, Bolar NA, Marobbio CM, Maffezzini C, Miniero DV, Monné M, Kohda M, Stranneheim H, Murayama K, Naess K, Lesko N, Bruhn H, Mourier A, Wibom R, Nennesmo I, Jespers A, Govaert P, Ohtake A, Van Laer L, Loeys BL, Freyer C, Palmieri F, Wredenberg A, Okazaki Y, Wedell A (2015) Intra-mitochondrial methylation deficiency due to mutations in SLC25A26. Am J Hum Genet 97:761-8. | Human | Skeletal muscle Fibroblast |
Kluckova 2015 Cell Death Dis | 2015 | Kluckova K, Sticha M, Cerny J, Mracek T, Dong L, Drahota Z, Gottlieb E, Neuzil J, Rohlena J (2015) Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation. Cell Death Dis 6:e1749. | Other mammals | Lung;gill Other cell lines Fibroblast |
Angebault 2015 Am J Hum Genet | 2015 | Angebault C, Guichet PO, Talmat-Amar Y, Charif M, Gerber S, Fares-Taie L, Gueguen N, Halloy F, Moore D, Amati-Bonneau P, Manes G, Hebrard M, Bocquet B, Quiles M, Piro-MĂ©gy C, Teigell M, Delettre C, Rossel M, Meunier I, Preising M, Lorenz B, Carelli V, Chinnery PF, Yu-Wai-Man P, Kaplan J, Roubertie A, Barakat A, Bonneau D, Reynier P, Rozet JM, Bomont P, Hamel CP, Lenaers G (2015) Recessive mutations in RTN4IP1 cause isolated and syndromic optic neuropathies. Am J Hum Genet 97:754-60. | Human | Endothelial;epithelial;mesothelial cell Fibroblast |
Zelenka 2015 Oxid Med Cell Longev | 2015 | Zelenka J, DvoĆĂĄk A, AlĂĄn L (2015) L-lactate protects skin fibroblasts against aging-associated mitochondrial dysfunction via mitohormesis. Oxid Med Cell Longev 2015:351698. | Rat | Liver Endothelial;epithelial;mesothelial cell Fibroblast |
Abou-Hamdan 2015 Methods Enzymol | 2015 | Abou-Hamdan A, Guedouari-Bounihi H, Lenoir V, Andriamihaja M, Blachier F, Bouillaud F (2015) Oxidation of H2S in mammalian cells and mitochondria. Methods Enzymol 554:201-28. | Human Pig Mouse Rat | Heart Nervous system Liver Kidney Genital CHO Neuroblastoma Fibroblast |
Leman 2015 Int J Biochem Cell Biol | 2015 | Leman G, Gueguen N, Desquiret-Dumas V, Kane MS, Wettervald C, Chupin S, Chevrollier A, Lebre AS, Bonnefont JP, Barth M, Amati-Bonneau P, Verny C, Henrion D, Bonneau D, Reynier P, Procaccio V (2015) Assembly defects induce oxidative stress in inherited mitochondrial complex I deficiency. Int J Biochem Cell Biol 65:91-103. | Human | Endothelial;epithelial;mesothelial cell Fibroblast |
Mourier 2015 J Cell Biol | 2015 | Mourier A, Motori E, Brandt T, Lagouge M, Atanassov I, Galinier A, Rappl G, Brodesser S, Hultenby K, Dieterich C, Larsson NG (2015) Mitofusin 2 is required to maintain mitochondrial coenzyme Q levels. J Cell Biol 208:429-42. | Mouse | Heart Fibroblast |
Plecita-Hlavata 2015 Am J Respir Cell Mol Biol | 2015 | PlecitĂĄ-HlavatĂĄ L, Tauber J, Li M, Zhang H, Flockton AR, Pullamsetti SS, Chelladurai P, D'alessandro A, El Kasmi KC, JeĆŸek P, Stenmark KR (2015) Constitutive reprogramming of fibroblast mitochondrial metabolism in pulmonary hypertension. Am J Respir Cell Mol Biol 55:47-57. | Human Bovines | Endothelial;epithelial;mesothelial cell Fibroblast |
Kawalec 2015 PLoS One | 2015 | Kawalec M, BoratyĆska-JasiĆska A, BerÄsewicz M, Dymkowska D, ZabĆocki K, ZabĆocka B (2015) Mitofusin 2 deficiency affects energy metabolism and mitochondrial biogenesis in MEF cells. PLoS One 10:e0134162. | Mouse | Fibroblast |
Lim 2015 Am J Cancer Res | 2015 | Lim SC, Carey KT, McKenzie M (2015) Anti-cancer analogues ME-143 and ME-344 exert toxicity by directly inhibiting mitochondrial NADH: ubiquinone oxidoreductase (Complex I). Am J Cancer Res 5:689-701. | Human | Kidney Other cell lines HEK HeLa Fibroblast |
Logan 2014 Nat Genet | 2014 | Logan CV, Szabadkai G, Sharpe JA, Parry DA, Torelli S, Childs AM, Kriek M, Phadke R, Johnson CA, Roberts NY, Bonthron DT, Pysden KA, Whyte T, Munteanu I, Foley AR, Wheway G, Szymanska K, Natarajan S, Abdelhamed ZA, Morgan JE, Roper H, Santen GW, Niks EH, van der Pol WL, Lindhout D, Raffaello A, De Stefani D, den Dunnen JT, Sun Y, Ginjaar I, Sewry CA, Hurles M, Rizzuto R. UK10K Consortium, Duchen MR, Muntoni F, Sheridan E (2014) Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling. Nat Genet 46:188-93. | Human | Fibroblast |
Jackson 2014 J Med Genet | 2014 | Jackson CB, Nuoffer JM, Hahn D, Prokisch H, Haberberger B, Gautsch M, HĂ€berli A, Gallati S, Schaller A (2014) Mutations in SDHD lead to autosomal recessive encephalomyopathy and isolated mitochondrial Complex II deficiency. J Med Genet 51:170-5. | Human | Fibroblast |
Gnaiger 2014 MitoPathways | 2014 | Gnaiger E (2014) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 4th ed. Mitochondr Physiol Network 19.12. Oroboros MiPNet Publications, Innsbruck:80 pp. â see 5th edition: Gnaiger 2020 BEC MitoPathways. | Human Mouse | Heart Skeletal muscle Fibroblast |
Ye 2013 Anal Biochem | 2013 | Ye F, Hoppel CL (2013) Measuring oxidative phosphorylation in human skin fibroblasts. https://doi.org/10.1016/j.ab.2013.02.010 | Human | Skeletal muscle Fibroblast |
Zhang 2013 PLoS One | 2013 | Zhang Z, Tsukikawa M, Peng M, Polyak E, Nakamaru-Ogiso E, Ostrovsky J, McCormack S, Place E, Clarke C, Reiner G, McCormick E, Rappaport E, Haas R, Baur JA, Falk MJ (2013) Primary respiratory chain disease causes tissue-specific dysregulation of the global transcriptome and nutrient-sensing signaling network. PLoS One 8:e69282. | Human | Fibroblast |
Huai 2013 J Cell Sci | 2013 | Huai J, Vögtle FN, Jöckel L, Li Y, Kiefer T, Ricci JE, Borner C (2013) TNFα-induced lysosomal membrane permeability (LMP) is downstream of MOMP and triggered by caspase-mediated p75 cleavage and ROS formation. J Cell Sci 126:4015-25. | Human Mouse | HeLa Fibroblast |
El-Bacha 2012 Int J Biochem Cell Biol | 2012 | El-Bacha T, Da Poian AT (2012) Virus-induced changes in mitochondrial bioenergetics as potential targets for therapy. Int J Biochem Cell Biol 45:41-6. | Human Mouse | Nervous system Liver Fibroblast |
Pesta 2012 Methods Mol Biol | 2012 | Pesta D, Gnaiger E (2012) High-resolution respirometry. OXPHOS protocols for human cells and permeabilized fibers from small biopsies of human muscle. Methods Mol Biol 810:25-58. https://doi.org/10.1007/978-1-61779-382-0_3 | Human | Skeletal muscle Other cell lines HEK Fibroblast HUVEC |
Goo 2012 PLoS One | 2012 | Goo CK, Lim HY, Ho QS, Too HP, Clement MV, Wong KP (2012) PTEN/Akt signaling controls mitochondrial respiratory capacity through 4E-BP1. PLoS One 7:e45806. | Mouse | Fibroblast |
Iyer 2012 Hum Gene Ther | 2012 | Iyer S, Bergquist K, Young K, Gnaiger E, Rao RR, Bennett JP Jr (2012) Mitochondrial gene therapy improves respiration, biogenesis and transcription in G11778A Leberâs hereditary optic neuropathy and T8993G Leighâs syndrome cells. Hum Gene Ther 23:647-57. | Human | Fibroblast |
Tello 2011 Cell Metab | 2011 | Tello D, Balsa E, Acosta-Iborra B, Fuertes-Yebra E, Elorza A, Ordóñez Ă, Corral-Escariz M, Soro I, LĂłpez-Bernardo E, Perales-Clemente E, MartĂnez-Ruiz A, EnrĂquez JA, AragonĂ©s J, Cadenas S, LandĂĄzuri MO (2011) Induction of the mitochondrial NDUFA4L2 protein by HIF-1α decreases oxygen consumption by inhibiting Complex I activity. Cell Metab 14:768-79. | Mouse | Fibroblast |
Ye 2011 J Biol Chem | 2011 | Ye F, Lemieux H, Hoppel CL, Hanson RW, Hakimi P, Croniger CM, Puchowicz M, Anderson VE, Fujioka H, Stavnezer E (2011) Peroxisome proliferator-activated receptor Îł (PPARÎł) mediates a Ski-induced shift from glycolysis to oxidative energy metabolism. J Biol Chem 286:40013-24. | Chicken | Fibroblast |
Thomas 2011 Mitochondrion | 2011 | Thomas RR, Khan SM, Portell FR, Smigrodzki RM, Bennett JP Jr (2011) Recombinant human mitochondrial transcription factor A stimulates mitochondrial biogenesis and ATP synthesis, improves motor function after MPTP, reduces oxidative stress and increases survival after endotoxin. Mitochondrion 11:108-18. | Human Mouse | Heart Skeletal muscle Nervous system Fibroblast |
Remor 2011 Biochim Biophys Acta | 2011 | Remor AP, de Matos FJ, Ghisoni K, da Silva TL, Eidt G, BĂșrigo M, de Bem AF, Silveira PC, de LeĂłn A, Sanchez MC, Hohl A, Glaser V, Saraiva-Gonçalves CA, Quincozes-Santos A, Borba Rosa R, Latini A (2011) Differential effects of insulin on peripheral diabetes-related changes in mitochondrial bioenergetics: Involvement of advanced glycosylated end products. Biochim Biophys Acta 1812:1460-71. | Rat | Endothelial;epithelial;mesothelial cell Fibroblast |
KozieĆ 2011 J Invest Dermatol | 2011 | KozieĆ R, Greussing R, Maier AB, Declercq L, Jansen-DĂŒrr P (2011) Functional interplay between mitochondrial and proteasome activity in skin aging. J Invest Dermatol 131:594-603. | Human | Fibroblast |
Quarato 2011 Biochim Biophys Acta | 2011 | Quarato G, Piccoli C, Scrima R, Capitanio N (2011) Variation of flux control coefficient of cytochrome c oxidase and of the other respiratory chain complexes at different values of protonmotive force occurs by a threshold mechanism. Biochim Biophys Acta 1807: 1114-1124. | Human Mouse | Liver Fibroblast |
Paulsen 2011 Cell Transplant | 2011 | Paulsen BD, Maciel RD, Galina A, da Silveira MS, Souza CD, Drummond H, Pozzato EN, Junior HS, Chicaybam L, Massuda R, Setti-PerdigĂŁo P, Bonamino M, Belmonte-de-Abreu PS, Castro NG, Brentani H, Rehen SK (2011) Altered oxygen metabolism associated to neurogenesis of induced pluripotent stem cells derived from a schizophrenic patient. Cell Transplant 21:1547-59 | Human | Fibroblast |
Fornuskova 2010 Thesis | 2010 | FornĆŻskovĂĄ D (2010) Biochemical and molecular studies of cytochrome c oxidase and ATP synthase deficiencies. PhD Thesis p93. | Human | Heart Skeletal muscle Nervous system Liver HEK Fibroblast |
Kotarsky 2010 Mitochondrion | 2010 | Kotarsky H, Karikoski R, Mörgelin M, Marjavaara S, Bergman P, Zhang DL, Smet J, van Coster R, Fellman V (2010) Characterization of complex III deficiency and liver dysfunction in GRACILE syndrome caused by a BCS1L mutation. Mitochondrion 10:497-509. | Human | Fibroblast |
Guillet 2010 neurogenetics | 2010 | Guillet V, Gueguen N, Verny C, Ferre M, Homedan C, Loiseau D, Procaccio V, Amati-Bonneau P, Bonneau D, Reynier P, Chevrollier A (2010) Adenine nucleotide translocase is involved in a mitochondrial coupling defect in MFN2-related Charcot-Marie-Tooth type 2A disease. Neurogenetics 11:127-33. | Human | Fibroblast |
Baron 2010 Thesis | 2010 | Baron M (2010) Copy number variations of the mitochondrial DNA as potential cause of mitochondrial diseases. Thesis Rheinischen Friedrich-Wilhelms-Universitaet Bonn, Mathematisch-Naturwissenschaftlichen FakultÀt, 110pp. | Human | Endothelial;epithelial;mesothelial cell Fibroblast |
Yang 2010 Cancer Biol Ther | 2010 | Yang D, Wang MT, Tang Yong, Chen Y, Jiang H, Jones TT, Rao K, Brewer GJ, Singh KK, Nie D (2010) Impairment of mitochondrial respiration in mouse fibroblasts by oncogenic H-RAS(Q61L). Canc Biol Ther 9:122-33. | Mouse | Fibroblast |
Haack 2010 Nat Genet | 2010 | Haack TB, Danhauser K, Haberberger B, Hoser J, Strecker V, Boehm D, Uziel G, Lamantea E, Invernizzi F, Poulton J, Rolinski B, Iuso A, Biskup S, Schmidt T, Mewes HW, Wittig I, Meitinger T, Zeviani M, Prokisch H (2010) Exome sequencing identifies ACAD9 mutations as a cause of Complex I deficiency. Nat Genet 42:1131-4. | Fibroblast | |
Dikov 2010 Exp Gerontol | 2010 | Dikov D, Aulbach A, Muster B, Dröse S, Jendrach M, Bereiter-Hahn J (2010) Do UCP2 and mild uncoupling improve longevity? Exp Gerontol 45:586-95. | HeLa Fibroblast HUVEC | |
Smolkova 2010 J Bioenerg Biomembr | 2010 | SmolkovĂĄ K, Bellance N, Scandurra F, GĂ©not E, Gnaiger E, PlecitĂĄ-HlavatĂĄ L, JeĆŸek P, Rossignol R (2010) Mitochondrial bioenergetic adaptations of breast cancer cells to aglycemia and hypoxia. https://doi.org/10.1007/s10863-009-9267-x | Human | Fibroblast |
Guillet 2010 Mitochondrion | 2010 | Guillet V, Chevrollier A, Cassereau J, Letournel F, Gueguen N, Richard L, Desquiret V, Verny C, Procaccio V, Amati-Bonneau P, Reynier P, Bonneau D (2010) Ethambutol-induced optic neuropathy linked to OPA1 mutation and mitochondrial toxicity. Mitochondrion 10:115-24. | Human | Fibroblast |
Krebiehl 2010 PLoS One | 2010 | Krebiehl G, Ruckerbauer S, Burbulla LF, Kieper N, Maurer B, Waak J, Wolburg H, Gizatullina Z, Gellerich FN, Woitalla D, Riess O, Kahle PJ, Proikas-Cezanne T, Krueger R (2010) Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1. PLoS One 5:e9367. | Mouse | Fibroblast |
Casasnovas 2009 J Med Genet | 2010 | Casasnovas C, Banchs I, Cassereau J, Gueguen N, Chevrollier A, MartĂnez-Matos JA, Bonneau D, Volpini V (2010) Phenotypic spectrum of MFN2 mutations in the Spanish population. J Med Genet 47:249-56. | Human | Nervous system Fibroblast |
Nochez 2009 Mol Vis | 2009 | Nochez Y, Arsene S, Gueguen N, Chevrollier A, Ferré M, Guillet V, Desquiret V, Toutain A, Bonneau D, Procaccio V, Amati-Bonneau P, Pisella PJ, Reynier P (2009) Acute and late-onset optic atrophy due to a novel OPA1 mutation leading to a mitochondrial coupling defect. Mol Vis 15:598-608. | Human | Fibroblast |
Haendeler 2009 Arterioscler Thromb Vasc Biol | 2009 | Haendeler J, Dröse S, BĂŒchner N, Jakob S, Altschmied J, Goy C, Spyridopoulos I, Zeiher AM, Brandt U, Dimmeler S (2009) Mitochondrial telomerase reverse transcriptase binds to and protects mitochondrial DNA and function from damage. Arterioscler Thromb Vasc Biol 29:929-35. | Human Mouse | Heart Endothelial;epithelial;mesothelial cell Fibroblast |
Bellance 2009 Int J Biochem Cell Biol | 2009 | Bellance N, Benard G, Furt F, Begueret H, SmolkovĂĄ K, Passerieux E, Delage JP, Baste JM, Moreau P, Rossignol R (2009) Bioenergetics of lung tumors: Alteration of mitochondrial biogenesis and respiratory capacity. Int J Biochem Cell Biol 41:2566-77. | Human | Fibroblast |
Mufazalov 2009 Mol Biol (Mosk) | 2009 | Mufazalov IA, Pen'kov DN, Cherniak BV, Pletiushkina OIu, Vysokikh MIu, Kirpichnikov MP, Dolgikh DA, Kruglov AA, Kuprash DV, Skulachev VP, Nedospasov SA (2009) Preparation and characterization of mouse embryonic fibroblasts with K72W mutation in somatic cytochrome c gene. Mol Biol (Mosk) 43:648-56. | Mouse | Fibroblast |
Hoepken 2007 Neurobiol Dis | 2007 | Hoepken HH, Gispert S, Morales B, Wingerter O, Del Turco D, MĂŒlsch A, Nussbaum RL, MĂŒller K, Dröse S, Brandt U, Deller T, Wirth B, Kudin AP, Kunz WS, Auburger G (2007) Mitochondrial dysfunction, peroxidation damage and changes in glutathione metabolism in PARK6. Neurobiol Dis 25:401-11. | Human | Fibroblast |
Rodriguez-Juarez 2007 Biochem J | 2007 | Rodriguez-Juarez F, Aguirre E, Cadenas S (2007) Relative sensitivity of soluble guanylate cyclase and mitochondrial respiration to endogenous nitric oxide at physiological oxygen concentration. Biochem J 405:223-31. | Rat | Fibroblast |
Blakely 2006 Pediatr Res | 2006 | Blakely EL, Rennie KJ, Jones L, Elstner M, Chrzanowska-Lightowlers ZMA, White CB, Shield JPH, Pilz DT, Turnbull DM, Poulton J, Taylor RW (2006) Sporadic intragenic inversion of the mitochondrial DNA MTND1 gene causing fatal infantile lactic acidosis. Pediatr Res 59:440-4. | Human | Fibroblast |
Deschauer 2006 Mol Genet Metab | 2006 | Deschauer M, Gizatullina Z, Schulze A, Pritsch M, Knöppel C, Knape M, Zierz S, Gellerich FN (2006) Molecular and biochemical investigations in fumarase deficiency. Mol Genet Metab 88:146-52. | Human | Fibroblast |
Garedew 2005 Eur Shock Soc | 2005 | Garedew A, HĂŒtter E, Haffner B, Gradl P, Gradl L, Jansen-DĂŒrr P, Gnaiger E (2005) High-resolution respirometry for the study of mitochondrial function in health and disease. The Oroboros O2k. Proc 11th Congress Eur Shock Soc, Vienna, Austria (Redl H, ed) Medimond, Bologna:107-11. | Human | Fibroblast |
Oezen 2005 Hum Mol Genet | 2005 | Oezen I, Rossmanith W, Forss-Petter S, Kemp S, Voigtlander T, Moser-Thier K, Wanders RJA, Bittner RE, Berger J (2005) Accumulation of very long-chain fatty acids does not affect mitochondrial function in adrenoleukodystrophy protein deficiency. Hum Mol Genet 14:1127-37. | Human Mouse | Skeletal muscle Nervous system Fibroblast |
Huetter 2004 Biochem J | 2004 | HĂŒtter E, Renner K, Pfister G, Stöckl P, Jansen-DĂŒrr P, Gnaiger E (2004) Senescence-associated changes in respiration and oxidative phosphorylation in primary human fibroblasts. https://doi.org/10.1042/BJ20040095 | Human | Fibroblast |
Jesina 2004 Biochem J | 2004 | Jesina P, Tesarova M, Fornuskova D, Vojtiskova A, Pecina P, Kaplanova V, Hansikova H, Zeman J, Houstek J (2004) Diminished synthesis of subunit a (ATP6) and altered function of ATP synthase and cytochrome c oxidase due to the mtDNA 2 bp microdeletion of TA at positions 9205 and 9206. Biochem J 383:561-71. | Human | Fibroblast |
Pecina 2004 Am J Physiol Cell Physiol | 2004 | Pecina P, Gnaiger E, Zeman J, Pronicka E, Houstek J (2004) Decreased affinity to oxygen of cytochrome c oxidase in Leigh syndrome caused by SURF1 mutations. Am J Physiol Cell Physiol 287:C1384-8. | Human | Fibroblast |
Mayr 2004 Pediatr Res | 2004 | Mayr JA, Paul J, Pecina P, Kurnik P, Forster H, Fotschl U, Sperl W, Houstek J (2004) Reduced respiratory control with ADP and changed pattern of respiratory chain enzymes as a result of selective deficiency of the mitochondrial ATP synthase. Pediatr Res 55:988-94. | Human | Heart Skeletal muscle Fibroblast |
Pecina 2004 Physiol Res | 2004 | Pecina P, Houstkova H, Hansikova H, Zeman J, Houstek J (2004) Genetic defects of cytochrome c oxidase assembly. Physiol Res 53 Suppl 1:S213-23. | Human | Skeletal muscle Fibroblast |
Winkler-Stuck 2004 J Neurol Sci | 2004 | Winkler-Stuck K, Wiedemann FR, Wallesch CW, Kunz WS (2004) Effect of coenzyme Q10 on the mitochondrial function of skin fibroblasts from Parkinson patients. J Neurol Sci 220:41-8. | Human | Fibroblast |
Gnaiger 2003 Adv Exp Med Biol | 2003 | Gnaiger E (2003) Oxygen conformance of cellular respiration. A perspective of mitochondrial physiology. https://doi.org/10.1007/978-1-4419-8997-0_4 | Human Rat | Heart Liver Endothelial;epithelial;mesothelial cell Fibroblast |
Pecina 2003 Biochim Biophys Acta | 2003 | Pecina P, Capkova M, Chowdhury SK, Drahota Z, Dubot A, Vojtiskova A, Hansikova H, Houstekova H, Zeman J, Godinot C, Houstek J (2003) Functional alteration of cytochrome c oxidase by SURF1 mutations in Leigh syndrome. Biochim Biophys Acta 1639:53-63. | Human | Endothelial;epithelial;mesothelial cell Fibroblast |
Huetter 2002 Mol Biol Rep | 2002 | HĂŒtter E, Renner K, Jansen-DĂŒrr P, Gnaiger E (2002) Biphasic oxygen kinetics of cellular respiration and linear oxygen dependence of antimycin A inhibited oxygen consumption. Mol Biol Rep 29:83-7. | Human | Fibroblast |
Messer 2000 J Biomed Materials Res | 2000 | Messer RLW, Doeller JE, Kraus DW, Lucas LC (2000) An investigation of fibroblast mitochondria enzyme activity and respiration in response to metallic ions released from dental alloys. J Biomed Materials Res 50:598-604. | Human | Fibroblast |
Chowdhury 2000 Clin Chim Acta | 2000 | Chowdhury SK, Drahota Z, Floryk D, Calda P, Houstek J (2000) Activities of mitochondrial oxidative phosphorylation enzymes in cultured amniocytes. Clin Chim Acta 298:157-73. | Human | Endothelial;epithelial;mesothelial cell Fibroblast |
O2k-Publications: Fibroblast - Abstracts
Sort in ascending/descending order by a click on one of the small symbols in squares below.
Was submitted in year | Reference | Organism | Tissue;cell | |
---|---|---|---|---|
Gnaiger 2022 ESCI Bari | 2022 | Gnaiger E (2022) Bioenergetic cluster analysis â diagnostic evaluation of mitochondrial respiratory control in human fibroblasts. 56th Annual Scientific Meeting of the European Society for Clinical Investigation. | Human | Fibroblast |
Gnaiger 2019 NatureConference | 2019 | Gnaiger E, Passrugger M, Gallee L, Felipe F Garcia-Souza, Zdrazilova L, Doerrier C (2019) High-resolution respirometry and innovations in the Oroboros O2k-technology. | Human | Blood cells HEK Fibroblast Platelet |
Zdrazilova 2018 MiPschool Tromso C4 | 2018 | Bioenergetic characterization of skin fibroblasts from patients with congenital disorders of glycosylation. | Human | Fibroblast |
Luis-Garcia 2018 Am J Respir Crit Care Med | 2018 | Contribution of the mitochondrial intrinsic pathway to the apoptosis resistance exhibited by fibroblasts from idiopathic pulmonary fibrosis. | Human | Lung;gill Fibroblast |
Gnaiger 2017 Abstract EUROMIT2017 Cologne | 2017 | Again not a Warburg effect - mitochondrial function in primary prostate cancer. | Human | Endothelial;epithelial;mesothelial cell Genital Fibroblast |
Krylova 2017 MiPschool Obergurgl | 2017 | High-resolution respirometry in diagnostic of mitochondrial complex I deficiency. | Endothelial;epithelial;mesothelial cell Fibroblast | |
Iyer 2017 MiP2017 | 2017 | Bioenergetic profiling of patient derived human fibroblasts for mitochondrial diseases. Iyer_Presentation | Human | Fibroblast |
Aasander Frostner 2017 MiP2017 | 2017 | Cell-permeable succinate and malonate as research tools. Aasander Frostner_Poster | Human | Heart Liver Blood cells Fibroblast |
Gnaiger 2016 Abstract UMDF2016 | 2016 | Schöpf B, SchÀfer G, Weber A, Talasz H, Eder IE, Klocker H, Gnaiger E (2016) Oxidative phosphorylation and mitochondrial function differ between human prostate tissue and cultured cells. | Human | Endothelial;epithelial;mesothelial cell Genital Other cell lines Fibroblast |
Hoppel 2016c Abstract MitoFit Science Camp 2016 | 2016 | Mitochondrial respiration in permeabilized skin fibroblasts. | Human | Endothelial;epithelial;mesothelial cell Fibroblast |
Bird 2016 Abstract IOC115 | 2016 | High-resolution respirometry for the diagnosis of mitochondrial disease. | Human | Skeletal muscle Liver Fibroblast |
Ost 2015 Abstract IOC100 | 2015 | Ost M (2015) âMitokinesâ and the organismal role of mitochondrial function in energy homeostasis & metabolism. Mitochondr Physiol Network 20.01. | Mouse | Skeletal muscle Fibroblast |
Ehinger 2015 Abstract MiPschool London 2015 | 2015 | Cell-permeable mitochondrial complex II substrates â a new compound class for treatment of complex I-linked mitochondrial disease. | Human | Heart Blood cells Fibroblast |
Logan 2015 Abstract MiPschool London 2015 | 2015 | Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signalling. | Human | Endothelial;epithelial;mesothelial cell Fibroblast |
Wagenaars 2014 Abstract IOC 2014-04 Schroecken | 2014 | Wagenaars J, Willems PHGM, Koopman WJ (2014) Oxygen consumption in OXPHOS-deficient cells. Mitochondr Physiol Network 19.02. | Human Mouse | Skeletal muscle Fibroblast |
Bristot 2014 Abstract MiP2014 | 2014 | High-resolution respirometry and bioenergetics evaluation in fibroblasts derived from patients with TP53 germline mutations. | Human | Fibroblast |
Dohlmann 2014 Abstract MiP2014 | 2014 | Mitochondrial adaptations to high-intensity training in young and elderly men and women. | Human | Skeletal muscle HeLa Fibroblast |
Felser 2014 Abstract MiP2014 | 2014 | Assessing mitochondrial dysfunction in fibroblast cells â a comparison between O2k and multiwell respirometry. | Human | Endothelial;epithelial;mesothelial cell HeLa Fibroblast |
Hahn 2014 Abstract MiP2014 | 2014 | Validation of oxygen consumption measurements in muscle and fibroblasts from patients with mitochondrial diseases. | Human | Skeletal muscle Fibroblast |
Wieckowski 2013 Abstract MiP2013 | 2013 | Wieckowski MR, Karkucinska-Wieckowska A, Wojtala A, Lebiedzinska M, Pronicki M, Duszynski J (2013) Mitochondrial bioenergetic parameters, reactive oxygen species production and the status of antioxidant defense system can be used to differentiate mitochondrial defects studied in the fibroblasts from patients with various mitochondrial disorders. Mitochondr Physiol Network 18.08. | Human Mouse | Fibroblast |
Kallijarvi 2013 Abstract IOC75 | 2013 | Kallijarvi J (2013) Respiratory chain dysfunction in the Complex III assembly disorder GRACILE. Mitochondr Physiol Network 18.03. | Human Mouse | Liver Kidney Fibroblast |
Skulachev 2013 Abstract MiP2013 | 2013 | Skulachev VP (2013) SkQ1, the first mitochondria-targeted medicine available in drugstores. Mitochondr Physiol Network 18.08. | Human Mouse Horse Dog Rabbit Fishes Other invertebrates Fungi Plants | Heart Skeletal muscle Nervous system Kidney Islet cell;pancreas;thymus Other cell lines HeLa Fibroblast Stem cells |
Iyer 2012 Abstract Bioblast | 2012 | Iyer S (2012) Gentle Science in the real world of mitochondrial physiology and genetics. Mitochondr Physiol Network 17.12. | Human | Fibroblast |
Labieniec-Watala 2012 Abstract Bioblast | 2012 | Labieniec-Watala M, Siewiera K, Watala C (2012) Seasonal fluctuations affect the physiology of laboratory animals â facts and artifacts from the perspective of heart mitochondrial respiratory response to tested compounds. Mitochondr Physiol Network 17.12. | Mouse Rat | Heart Liver Fibroblast |
Nuskova 2011 Abstract IOC61 | 2011 | Nuskova H, Pecina P, Kovarova N, DellâAgnello C, Zeviani M, Houstek J (2011) Cytochrome c oxidase with decreased H+/eâ ratio in SURF1 knockout mice. MiPNet16.01. | Mouse | Endothelial;epithelial;mesothelial cell Fibroblast |
Marelsson 2011 Abstract IOC61 | 2011 | Marelsson S (2011) Mitochondrial dysfunction in children with unknown encephalopathy. MiPNet16.01. | Human | Blood cells Fibroblast |
Gnaiger Abstract MiP2010 2-01 | 2010 | Gnaiger E (2010) Measuring the upper limit of mitochondrial performance - how and why? | Human | Fibroblast |
Itkis 2010 Abstract IOC60 | 2010 | Itkis YS (2010) Respirometry application in Leigh disease diagnostic and treatment. MiPNet15.10. | Human | Fibroblast |
Amoedo 2010 Abstract MiP2010 | 2010 | AmoĂȘdo ND, Rodrigues MF, Pezutto P, Lourenço MVC, Madeiro da Costa RF, Oliveira MF, Galina A, Rumjanek FD, El-Bacha T (2010) Metabolic reprogramming of lung cancer cell induced by sodium butyrate: Studies on mitochondrial physiology and bioenergetics. Mitochondr Physiol Network 15.06. | Human | Endothelial;epithelial;mesothelial cell Fibroblast |