Difference between revisions of "Gnaiger 2019 MitoFit Preprint Arch"

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|authors=''Author affiliations in hyperlinks:'', Gnaiger E, Aasander Frostner E, Abdul Karim N, Abumrad NA, Acuna-Castroviejo D, Adiele RC, Ahn B, Ali SS, Almeida A, Alton L, Alves MG, Amati F, Amoedo ND, Andreadou I, Antunes D, Arago M, Aral C, Arandarcikaite O, Armand AS, Arnould T, Avram VF, Bach de Courtade SM, Bailey DM, Bajpeyi S, Bajzikova M, Bakker BM, Bardal T, Barlow J, Bastos Sant'Anna Silva AC, Batterson P, Battino M, Bazil J, Beard DA, Bednarczyk P, Bello F, Ben-Shachar D, Bento G, Bergdahl A, Berge RK, Bergmeister L, Bernardi P, Berridge MV, Bettinazzi S, Bishop D, Blier PU, Blindheim DF, Boardman NT, Boetker HE, Borchard S, Boros M, Borsheim E, Borutaite V, Botella J, Bouillaud F, Bouitbir J, Boushel RC, Bovard J, Breton S, Brown DA, Brown GC, Brown RA, Brozinick JT, Buettner GR, Burtscher J, Calabria E, Calbet JA, Calzia E, Cannon DT, Cano Sanchez M, Canto AC, Cardoso LHD, Carvalho E, Casado Pinna M, Cassar S, Cassina AM, Castelo MP, Castro L, Cavalcanti-de-Albuquerque JP, Cervinkova Z, Chabi B, Chakrabarti L, Chakrabarti S, Chaurasia B, Chen Q, Chicco AJ, Chinopoulos C, Chowdhury SK, Cizmarova B, Clementi E, Coen PM, Cohen BH, Coker RH, Collin A, Crisostomo L, Crossland H, Dahdah N, Dalgaard LT, Dambrova M, Danhelovska T, Darveau CA, Das AM, Dash RK, Davidova E, Davis MS, De Goede P, De Palma C, Decker S, Dembinska-Kiec A, Detraux D, Devaux Y, Di Marcello M, Di Paola FJ, Dias TR, Diederich M, Distefano G, Doermann N, Doerrier C, Dong L, Donnelly C, Drahota Z, Duarte FV, Dubouchaud H, Duchen MR, Dumas JF, Durham WJ, Dymkowska D, Dyrstad SE, Dyson A, Dzialowski EM, Eaton S, Ehinger J, Elmer E, Endlicher R, Engin AB, Escames G, Ezrova Z, Falk MJ, Fell DA, Ferdinandy P, Ferko M, Ferreira JCB, Ferreira R, Ferri A, Fessel JP, Filipovska A, Fisar Z, Fischer C, Fischer M, Fisher G, Fisher JJ, Ford E, Fornaro M, Fulton M, Galina A, Galkin A, Gallee L, Galli GL, Gama Perez P, Gan Z, Ganetzky R, Garcia-Rivas G, Garcia-Roves PM, Garcia-Souza LF, Garipi E, Garlid KD, Garrabou G, Garten A, Gastaldelli A, Gayen J, Genders AJ, Genova ML, Giovarelli M, Goncalo Teixeira da Silva R, Goncalves DF, Gonzalez-Armenta JL, Gonzalez-Freire M, Gonzalo H, Goodpaster BH, Gorr TA, Gourlay CW, Grams B, Granata C, Grefte S, Guarch ME, Gueguen N, Gumeni S, Haas CB, Haavik J, Haendeler J, Haider M, Hamann A, Han J, Han WH, Hancock CR, Hand SC, Handl J, Hargreaves IP, Harper ME, Harrison DK, Hassan H, Hausenloy DJ, Heales SJR, Hecker M, Heiestad C, Hellgren KT, Hepple RT, Hernansanz-Agustin P, Hewakapuge S, Hickey AJ, Ho DH, Hoehn KL, Hoel F, Holland OJ, Holloway GP, Hoppel CL, Hoppel F, Houstek J, Huete-Ortega M, Hyrossova P, Iglesias-Gonzalez J, Irving BA, Isola R, Iyer S, Jackson CB, Jadiya P, Jana PF, Jang DH, Jang YC, Janowska J, Jansen K, Jansen-Duerr P, Jansone B, Jarmuszkiewicz W, Jaskiewicz A, Jedlicka J, Jespersen NR, Jha RK, Jones JG, Joseph V, Jurczak MJ, Jurk D, Jusic A, Kaambre T, Kaczor JJ, Kainulainen H, Kampa RP, Kandel SM, Kane DA, Kapferer W, Kappler L, Karabatsiakis A, Karavaeva I, Karkucinska-Wieckowska A, Kaur S, Keijer J, Keller MA, Keppner G, Khamoui AV, Kidere D, Kilbaugh T, Kim HK, Kim JKS, Klepinin A, Klepinina L, Klingenspor M, Klocker H, Komlodi T, Koopman WJH, Kopitar-Jerala N, Kowaltowski AJ, Kozlov AV, Krajcova A, Krako Jakovljevic N, Kristal BS, Krycer JR, Kuang J, Kucera O, Kuka J, Kwak HB, Kwast K, Kwon OS, Laasmaa M, Labieniec-Watala M, Lagarrigue S, Lai N, Land JM, Lane N, Laner V, Lanza IR, Laranjinha J, Larsen TS, Lavery GG, Lazou A, Lee HK, Leeuwenburgh C, Leffler M, Lehti M, Lemieux H, Lenaz G, Lerfall J, Li PA, Li Puma L, Liang L, Liepins E, Liu J, Lopez LC, Lucchinetti E, Ma T, Macedo MP, Maciej S, MacMillan-Crow LA, Majtnerova P, Makarova E, Makrecka-Kuka M, Malik AN, Markova M, Martin DS, Martins AD, Martins JD, Maseko TE, Maull F, Mazat JP, McKenna HT, McKenzie M, Menze MA, Merz T, Meszaros AT, Methner A, Michalak S, Mihanovic I, Mila Guasch M, Moellering DR, Moisoi N, Molina AJA, Montaigne D, Moore AL, Moore C, Moreau K, Moreira BP, Moreno-Sanchez R, Mracek T, Muccini AM, Munro D, Muntane J, Muntean DM, Murray AJ, Musiol E, Nabben M, Nair KS, Nehlin JO, Nemec M, Neufer PD, Neuzil J, Neviere R, Newsom SA, Norman J, Nozickova K, O'Brien K, O'Brien KA, O'Gorman D, Olgar Y, Oliveira B, Oliveira MF, Oliveira MT, Oliveira PF, Oliveira PJ, Olsen RE, Orynbayeva Z, Osiewacz HD, Paez H, Pak YK, Pallotta ML, Palmeira CM, Parajuli N, Passos JF, Passrugger M, Patel HH, Pavlova N, Pecina P, Pedersen TM, Pereira da Silva Grilo da Silva F, Pereira SP, Perez Valencia JA, Perks KL, Pesta D, Petit PX, Pettersen IKN, Pichaud N, Pichler I, Piel S, Pietka TA, Pino MF, Pirkmajer S, Plangger M, Porter C, Porter RK, Prigione A, Procaccio V, Prochownik EV, Prola A, Pulinilkunnil T, Puskarich MA, Puurand M, Radenkovic F, Ramzan R, Rattan SIS, Reboredo P, Rees BB, Renner-Sattler K, Rial E, Robinson MM, Roden M, Rodriguez E, Rodriguez-Enriquez S, Roesland GV, Rohlena J, Rolo AP, Ropelle ER, Roshanravan B, Rossignol R, Rossiter HB, Rubelj I, Rybacka-Mossakowska J, Saada A, Safaei Z, Saharnaz S, Salin K, Salvadego D, Sandi C, Saner N, Sanz A, Sazanov LA, Scaife P, Scatena R, Schartner M, Scheibye-Knudsen M, Schilling JM, Schlattner U, Schoenfeld P, Schots PC, Schulz R, Schwarzer C, Scott GR, Selman C, Sendon PM, Shabalina IG, Sharma P, Sharma V, Shevchuk I, Shirazi R, Shiroma JG, Siewiera K, Silber AM, Silva AM, Sims CA, Singer D, Singh BK, Skolik R, Smenes BT, Smith J, Soares FAA, Sobotka O, Sokolova I, Sommer N, Sonkar VK, Sowton AP, Sparagna GC, Sparks LM, Spinazzi M, Stankova P, Starr J, Stary C, Stelfa G, Stepto NK, Stiban J, Stier A, Stocker R, Storder J, Sumbalova Z, Suomalainen A, Suravajhala P, Svalbe B, Swerdlow RH, Swiniuch D, Szabo I, Szewczyk A, Szibor M, Tanaka M, Tandler B, Tarnopolsky MA, Tausan D, Tavernarakis N, Tepp K, Thakkar H, Thapa M, Thyfault JP, Tomar D, Ton R, Torp MK, Towheed A, Tretter L, Trewin AJ, Trifunovic A, Trivigno C, Tronstad KJ, Trougakos IP, Truu L, Tuncay E, Turan B, Tyrrell DJ, Urban T, Valentine JM, Van Bergen NJ, Van Hove J, Varricchio F, Vella J, Vendelin M, Vercesi AE, Victor VM, Vieira Ligo Teixeira C, Vidimce J, Viel C, Vieyra A, Vilks K, Villena JA, Vincent V, Vinogradov AD, Viscomi C, Vitorino RMP, Vlachaki Walker J, Vogt S, Volani C, Volska K, Votion DM, Vujacic-Mirski K, Wagner BA, Ward ML, Warnsmann V, Wasserman DH, Watala C, Wei YH, Weissig V, Whitfield J, Wickert A, Wieckowski MR, Wiesner RJ, Williams CM, Winwood-Smith H, Wohlgemuth SE, Wohlwend M, Wolff JN, Wrutniak-Cabello C, Wuest RCI, Yokota T, Zablocki K, Zanon A, Zanou N, Zaugg K, Zaugg M, Zdrazilova L, Zhang Y, Zhang Yizhu, Zikova A, Zischka H, Zorzano A, Zvejniece L
+
|authors=''Author affiliations in hyperlinks:'', Gnaiger E, Aasander Frostner E, Abdul Karim N, Abumrad NA, Acuna-Castroviejo D, Adiele RC, Ahn B, Ali SS, Almeida A, Alton L, Alves MG, Amati F, Amoedo ND, Andreadou I, Antunes D, Arago M, Aral C, Arandarcikaite O, Armand AS, Arnould T, Avram VF, Bach de Courtade SM, Bailey DM, Bajpeyi S, Bajzikova M, Bakker BM, Bardal T, Barlow J, Bastos Sant'Anna Silva AC, Batterson P, Battino M, Bazil J, Beard DA, Bednarczyk P, Bello F, Ben-Shachar D, Bento G, Bergdahl A, Berge RK, Bergmeister L, Bernardi P, Berridge MV, Bettinazzi S, Bishop D, Blier PU, Blindheim DF, Boardman NT, Boetker HE, Borchard S, Boros M, Borsheim E, Borutaite V, Botella J, Bouillaud F, Bouitbir J, Boushel RC, Bovard J, Breton S, Brown DA, Brown GC, Brown RA, Brozinick JT, Buettner GR, Burtscher J, Calabria E, Calbet JA, Calzia E, Cannon DT, Cano Sanchez M, Canto AC, Cardoso LHD, Carvalho E, Casado Pinna M, Cassar S, Cassina AM, Castelo MP, Castro L, Cavalcanti-de-Albuquerque JP, Cervinkova Z, Chabi B, Chakrabarti L, Chakrabarti S, Chaurasia B, Chen Q, Chicco AJ, Chinopoulos C, Chowdhury SK, Cizmarova B, Clementi E, Coen PM, Cohen BH, Coker RH, Collin A, Crisostomo L, Crossland H, Dahdah N, Dalgaard LT, Dambrova M, Danhelovska T, Darveau CA, Das AM, Dash RK, Davidova E, Davis MS, De Goede P, De Palma C, Decker S, Dembinska-Kiec A, Detraux D, Devaux Y, Di Marcello M, Di Paola FJ, Dias TR, Diederich M, Distefano G, Doermann N, Doerrier C, Dong L, Donnelly C, Drahota Z, Duarte FV, Dubouchaud H, Duchen MR, Dumas JF, Durham WJ, Dymkowska D, Dyrstad SE, Dyson A, Dzialowski EM, Eaton S, Ehinger J, Elmer E, Endlicher R, Engin AB, Escames G, Ezrova Z, Falk MJ, Fell DA, Ferdinandy P, Ferko M, Ferreira JCB, Ferreira R, Ferri A, Fessel JP, Filipovska A, Fisar Z, Fischer C, Fischer M, Fisher G, Fisher JJ, Ford E, Fornaro M, Fulton M, Galina A, Galkin A, Gallee L, Galli GL, Gama Perez P, Gan Z, Ganetzky R, Garcia-Rivas G, Garcia-Roves PM, Garcia-Souza LF, Garipi E, Garlid KD, Garrabou G, Garten A, Gastaldelli A, Gayen J, Genders AJ, Genova ML, Giovarelli M, Glatz JFC, Goncalo Teixeira da Silva R, Goncalves DF, Gonzalez-Armenta JL, Gonzalez-Freire M, Gonzalo H, Goodpaster BH, Gorr TA, Gourlay CW, Grams B, Granata C, Grefte S, Guarch ME, Gueguen N, Gumeni S, Haas CB, Haavik J, Haendeler J, Haider M, Hamann A, Han J, Han WH, Hancock CR, Hand SC, Handl J, Hargreaves IP, Harper ME, Harrison DK, Hassan H, Hausenloy DJ, Heales SJR, Hecker M, Heiestad C, Hellgren KT, Hepple RT, Hernansanz-Agustin P, Hewakapuge S, Hickey AJ, Ho DH, Hoehn KL, Hoel F, Holland OJ, Holloway GP, Hoppel CL, Hoppel F, Houstek J, Huete-Ortega M, Hyrossova P, Iglesias-Gonzalez J, Irving BA, Isola R, Iyer S, Jackson CB, Jadiya P, Jana PF, Jang DH, Jang YC, Janowska J, Jansen K, Jansen-Duerr P, Jansone B, Jarmuszkiewicz W, Jaskiewicz A, Jedlicka J, Jespersen NR, Jha RK, Jones JG, Joseph V, Jurczak MJ, Jurk D, Jusic A, Kaambre T, Kaczor JJ, Kainulainen H, Kampa RP, Kandel SM, Kane DA, Kapferer W, Kappler L, Karabatsiakis A, Karavaeva I, Karkucinska-Wieckowska A, Kaur S, Keijer J, Keller MA, Keppner G, Khamoui AV, Kidere D, Kilbaugh T, Kim HK, Kim JKS, Klepinin A, Klepinina L, Klingenspor M, Klocker H, Komlodi T, Koopman WJH, Kopitar-Jerala N, Kowaltowski AJ, Kozlov AV, Krajcova A, Krako Jakovljevic N, Kristal BS, Krycer JR, Kuang J, Kucera O, Kuka J, Kwak HB, Kwast K, Kwon OS, Laasmaa M, Labieniec-Watala M, Lagarrigue S, Lai N, Land JM, Lane N, Laner V, Lanza IR, Laranjinha J, Larsen TS, Lavery GG, Lazou A, Lee HK, Leeuwenburgh C, Leffler M, Lehti M, Lemieux H, Lenaz G, Lerfall J, Li PA, Li Puma L, Liang L, Liepins E, Liu J, Lopez LC, Lucchinetti E, Ma T, Macedo MP, Maciej S, MacMillan-Crow LA, Majtnerova P, Makarova E, Makrecka-Kuka M, Malik AN, Markova M, Martin DS, Martins AD, Martins JD, Maseko TE, Maull F, Mazat JP, McKenna HT, McKenzie M, Menze MA, Merz T, Meszaros AT, Methner A, Michalak S, Mihanovic I, Mila Guasch M, Moellering DR, Moisoi N, Molina AJA, Montaigne D, Moore AL, Moore C, Moreau K, Moreira BP, Moreno-Sanchez R, Mracek T, Muccini AM, Munro D, Muntane J, Muntean DM, Murray AJ, Musiol E, Nabben M, Nair KS, Nehlin JO, Nemec M, Neufer PD, Neuzil J, Neviere R, Newsom SA, Norman J, Nozickova K, O'Brien K, O'Brien KA, O'Gorman D, Olgar Y, Oliveira B, Oliveira MF, Oliveira MT, Oliveira PF, Oliveira PJ, Olsen RE, Orynbayeva Z, Osiewacz HD, Paez H, Pak YK, Pallotta ML, Palmeira CM, Parajuli N, Passos JF, Passrugger M, Patel HH, Pavlova N, Pecina P, Pedersen TM, Pereira da Silva Grilo da Silva F, Pereira SP, Perez Valencia JA, Perks KL, Pesta D, Petit PX, Pettersen IKN, Pichaud N, Pichler I, Piel S, Pietka TA, Pino MF, Pirkmajer S, Plangger M, Porter C, Porter RK, Prigione A, Procaccio V, Prochownik EV, Prola A, Pulinilkunnil T, Puskarich MA, Puurand M, Radenkovic F, Ramzan R, Rattan SIS, Reboredo P, Rees BB, Renner-Sattler K, Rial E, Robinson MM, Roden M, Rodriguez E, Rodriguez-Enriquez S, Roesland GV, Rohlena J, Rolo AP, Ropelle ER, Roshanravan B, Rossignol R, Rossiter HB, Rubelj I, Rybacka-Mossakowska J, Saada A, Safaei Z, Saharnaz S, Salin K, Salvadego D, Sandi C, Saner N, Sanz A, Sazanov LA, Scaife P, Scatena R, Schartner M, Scheibye-Knudsen M, Schilling JM, Schlattner U, Schoenfeld P, Schots PC, Schulz R, Schwarzer C, Scott GR, Selman C, Sendon PM, Shabalina IG, Sharma P, Sharma V, Shevchuk I, Shirazi R, Shiroma JG, Siewiera K, Silber AM, Silva AM, Sims CA, Singer D, Singh BK, Skolik R, Smenes BT, Smith J, Soares FAA, Sobotka O, Sokolova I, Sommer N, Sonkar VK, Sowton AP, Sparagna GC, Sparks LM, Spinazzi M, Stankova P, Starr J, Stary C, Stelfa G, Stepto NK, Stiban J, Stier A, Stocker R, Storder J, Sumbalova Z, Suomalainen A, Suravajhala P, Svalbe B, Swerdlow RH, Swiniuch D, Szabo I, Szewczyk A, Szibor M, Tanaka M, Tandler B, Tarnopolsky MA, Tausan D, Tavernarakis N, Tepp K, Thakkar H, Thapa M, Thyfault JP, Tomar D, Ton R, Torp MK, Towheed A, Tretter L, Trewin AJ, Trifunovic A, Trivigno C, Tronstad KJ, Trougakos IP, Truu L, Tuncay E, Turan B, Tyrrell DJ, Urban T, Valentine JM, Van Bergen NJ, Van Hove J, Varricchio F, Vella J, Vendelin M, Vercesi AE, Victor VM, Vieira Ligo Teixeira C, Vidimce J, Viel C, Vieyra A, Vilks K, Villena JA, Vincent V, Vinogradov AD, Viscomi C, Vitorino RMP, Vlachaki Walker J, Vogt S, Volani C, Volska K, Votion DM, Vujacic-Mirski K, Wagner BA, Ward ML, Warnsmann V, Wasserman DH, Watala C, Wei YH, Weissig V, Whitfield J, Wickert A, Wieckowski MR, Wiesner RJ, Williams CM, Winwood-Smith H, Wohlgemuth SE, Wohlwend M, Wolff JN, Wrutniak-Cabello C, Wuest RCI, Yokota T, Zablocki K, Zanon A, Zanou N, Zaugg K, Zaugg M, Zdrazilova L, Zhang Y, Zhang Yizhu, Zikova A, Zischka H, Zorzano A, Zvejniece L
 
|year=2019
 
|year=2019
 
|journal=MitoFit Preprint Arch
 
|journal=MitoFit Preprint Arch
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:::::: T +43 512 566796 15, F +43 512 566796 20
 
:::::: T +43 512 566796 15, F +43 512 566796 20
 
:::::: mitoeagle@i-med.ac.at | www.mitoeagle.org  
 
:::::: mitoeagle@i-med.ac.at | www.mitoeagle.org  
:::* '''Coauthors''' (listed in alphabetical order); number of coauthors (2019-06-24): '''566'''
+
:::* '''Coauthors''' (listed in alphabetical order); number of coauthors (2019-06-24): '''567'''
 
:::::: ''Many coauthors have made significant additions and suggestions for improvement of the manuscript. All coauthors confirm to have read the final manuscript, and to agree to implement the recommendations into future manuscripts, presentations and teaching materials.''         
 
:::::: ''Many coauthors have made significant additions and suggestions for improvement of the manuscript. All coauthors confirm to have read the final manuscript, and to agree to implement the recommendations into future manuscripts, presentations and teaching materials.''         
 
:::::: Disclaimer: This article was prepared while Joshua P. Fessel was employed at Vanderbilt University Medical Center. The opinions expressed in this article are the author's own and do not reflect the view of the National Institutes of Health, the Department of Health and Human Services, or the United States government.
 
:::::: Disclaimer: This article was prepared while Joshua P. Fessel was employed at Vanderbilt University Medical Center. The opinions expressed in this article are the author's own and do not reflect the view of the National Institutes of Health, the Department of Health and Human Services, or the United States government.

Revision as of 15:16, 24 June 2019


MitoFit Preprint Arch         MitoFit Preprint Archives         Editorial mitofit:190002.v2         States and rates mitofit:190001.v6         MitoPedia: Preprints         MitoFit DOI Data Center


Gnaiger 2019 MitoFit Preprint Arch

Publications in the MiPMap
Gnaiger E, Aasander Frostner E, Abdul Karim N, Abumrad NA, Acuna-Castroviejo D, Adiele RC, et al (2019) Mitochondrial respiratory states and rates. MitoFit Preprint Arch doi:10.26124/mitofit:190001.v4.
»
MitoFit pdf
Mitochondrial respiratory states and rates



Author affiliations in hyperlinks:, Gnaiger E, Aasander Frostner E, Abdul Karim N, Abumrad NA, Acuna-Castroviejo D, Adiele RC, Ahn B, Ali SS, Almeida A, Alton L, Alves MG, Amati F, Amoedo ND, Andreadou I, Antunes D, Arago M, Aral C, Arandarcikaite O, Armand AS, Arnould T, Avram VF, Bach de Courtade SM, Bailey DM, Bajpeyi S, Bajzikova M, Bakker BM, Bardal T, Barlow J, Bastos Sant'Anna Silva AC, Batterson P, Battino M, Bazil J, Beard DA, Bednarczyk P, Bello F, Ben-Shachar D, Bento G, Bergdahl A, Berge RK, Bergmeister L, Bernardi P, Berridge MV, Bettinazzi S, Bishop D, Blier PU, Blindheim DF, Boardman NT, Boetker HE, Borchard S, Boros M, Borsheim E, Borutaite V, Botella J, Bouillaud F, Bouitbir J, Boushel RC, Bovard J, Breton S, Brown DA, Brown GC, Brown RA, Brozinick JT, Buettner GR, Burtscher J, Calabria E, Calbet JA, Calzia E, Cannon DT, Cano Sanchez M, Canto AC, Cardoso LHD, Carvalho E, Casado Pinna M, Cassar S, Cassina AM, Castelo MP, Castro L, Cavalcanti-de-Albuquerque JP, Cervinkova Z, Chabi B, Chakrabarti L, Chakrabarti S, Chaurasia B, Chen Q, Chicco AJ, Chinopoulos C, Chowdhury SK, Cizmarova B, Clementi E, Coen PM, Cohen BH, Coker RH, Collin A, Crisostomo L, Crossland H, Dahdah N, Dalgaard LT, Dambrova M, Danhelovska T, Darveau CA, Das AM, Dash RK, Davidova E, Davis MS, De Goede P, De Palma C, Decker S, Dembinska-Kiec A, Detraux D, Devaux Y, Di Marcello M, Di Paola FJ, Dias TR, Diederich M, Distefano G, Doermann N, Doerrier C, Dong L, Donnelly C, Drahota Z, Duarte FV, Dubouchaud H, Duchen MR, Dumas JF, Durham WJ, Dymkowska D, Dyrstad SE, Dyson A, Dzialowski EM, Eaton S, Ehinger J, Elmer E, Endlicher R, Engin AB, Escames G, Ezrova Z, Falk MJ, Fell DA, Ferdinandy P, Ferko M, Ferreira JCB, Ferreira R, Ferri A, Fessel JP, Filipovska A, Fisar Z, Fischer C, Fischer M, Fisher G, Fisher JJ, Ford E, Fornaro M, Fulton M, Galina A, Galkin A, Gallee L, Galli GL, Gama Perez P, Gan Z, Ganetzky R, Garcia-Rivas G, Garcia-Roves PM, Garcia-Souza LF, Garipi E, Garlid KD, Garrabou G, Garten A, Gastaldelli A, Gayen J, Genders AJ, Genova ML, Giovarelli M, Glatz JFC, Goncalo Teixeira da Silva R, Goncalves DF, Gonzalez-Armenta JL, Gonzalez-Freire M, Gonzalo H, Goodpaster BH, Gorr TA, Gourlay CW, Grams B, Granata C, Grefte S, Guarch ME, Gueguen N, Gumeni S, Haas CB, Haavik J, Haendeler J, Haider M, Hamann A, Han J, Han WH, Hancock CR, Hand SC, Handl J, Hargreaves IP, Harper ME, Harrison DK, Hassan H, Hausenloy DJ, Heales SJR, Hecker M, Heiestad C, Hellgren KT, Hepple RT, Hernansanz-Agustin P, Hewakapuge S, Hickey AJ, Ho DH, Hoehn KL, Hoel F, Holland OJ, Holloway GP, Hoppel CL, Hoppel F, Houstek J, Huete-Ortega M, Hyrossova P, Iglesias-Gonzalez J, Irving BA, Isola R, Iyer S, Jackson CB, Jadiya P, Jana PF, Jang DH, Jang YC, Janowska J, Jansen K, Jansen-Duerr P, Jansone B, Jarmuszkiewicz W, Jaskiewicz A, Jedlicka J, Jespersen NR, Jha RK, Jones JG, Joseph V, Jurczak MJ, Jurk D, Jusic A, Kaambre T, Kaczor JJ, Kainulainen H, Kampa RP, Kandel SM, Kane DA, Kapferer W, Kappler L, Karabatsiakis A, Karavaeva I, Karkucinska-Wieckowska A, Kaur S, Keijer J, Keller MA, Keppner G, Khamoui AV, Kidere D, Kilbaugh T, Kim HK, Kim JKS, Klepinin A, Klepinina L, Klingenspor M, Klocker H, Komlodi T, Koopman WJH, Kopitar-Jerala N, Kowaltowski AJ, Kozlov AV, Krajcova A, Krako Jakovljevic N, Kristal BS, Krycer JR, Kuang J, Kucera O, Kuka J, Kwak HB, Kwast K, Kwon OS, Laasmaa M, Labieniec-Watala M, Lagarrigue S, Lai N, Land JM, Lane N, Laner V, Lanza IR, Laranjinha J, Larsen TS, Lavery GG, Lazou A, Lee HK, Leeuwenburgh C, Leffler M, Lehti M, Lemieux H, Lenaz G, Lerfall J, Li PA, Li Puma L, Liang L, Liepins E, Liu J, Lopez LC, Lucchinetti E, Ma T, Macedo MP, Maciej S, MacMillan-Crow LA, Majtnerova P, Makarova E, Makrecka-Kuka M, Malik AN, Markova M, Martin DS, Martins AD, Martins JD, Maseko TE, Maull F, Mazat JP, McKenna HT, McKenzie M, Menze MA, Merz T, Meszaros AT, Methner A, Michalak S, Mihanovic I, Mila Guasch M, Moellering DR, Moisoi N, Molina AJA, 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Trougakos IP, Truu L, Tuncay E, Turan B, Tyrrell DJ, Urban T, Valentine JM, Van Bergen NJ, Van Hove J, Varricchio F, Vella J, Vendelin M, Vercesi AE, Victor VM, Vieira Ligo Teixeira C, Vidimce J, Viel C, Vieyra A, Vilks K, Villena JA, Vincent V, Vinogradov AD, Viscomi C, Vitorino RMP, Vlachaki Walker J, Vogt S, Volani C, Volska K, Votion DM, Vujacic-Mirski K, Wagner BA, Ward ML, Warnsmann V, Wasserman DH, Watala C, Wei YH, Weissig V, Whitfield J, Wickert A, Wieckowski MR, Wiesner RJ, Williams CM, Winwood-Smith H, Wohlgemuth SE, Wohlwend M, Wolff JN, Wrutniak-Cabello C, Wuest RCI, Yokota T, Zablocki K, Zanon A, Zanou N, Zaugg K, Zaugg M, Zdrazilova L, Zhang Y, Zhang Yizhu, Zikova A, Zischka H, Zorzano A, Zvejniece L (2019) MitoFit Preprint Arch

Abstract: Version 5 2019-06-24 in preparation - for discussion

Version 4 (v4) 2019-05-20 doi:10.26124/mitofit:190001.v4
Versions (v3) 2019-04-24 doi:10.26124/mitofit:190001.v3; (v2) 2019-03-15 doi:10.26124/mitofit:190001.v2; (v1) 2019-02-12 doi:10.26124/mitofit:190001 - »Link to all versions«

As the knowledge base and importance of mitochondrial physiology to human health expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow guidelines of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols to the nomenclature of classical bioenergetics. We endeavour to provide a balanced view on mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of databases of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery.

Keywords: Mitochondrial respiratory control, coupling control, mitochondrial preparations, protonmotive force, uncoupling, oxidative phosphorylation, OXPHOS, efficiency, electron transfer, ET; proton leak, LEAK, residual oxygen consumption, ROX, State 2, State 3, State 4, normalization, flow, flux, O2 Bioblast editor: Gnaiger E

Authors: MitoEAGLE Task Group

Figure 1. Internal and external respiration. Mitochondrial respiration is the oxidation of fuel substrates (electron donors) and reduction of O2 catalysed by the electron transfer system, ETS: (mt) mitochondrial catabolic respiration; (ce) total cellular O2 consumption; and (ext) external respiration. All chemical reactions, r, that consume O2 in the cells of an organism, contribute to cell respiration, JrO2. In addition to mitochondrial catabolic respiration, O2 is consumed by: (1) Mitochondrial residual oxygen consumption, Rox. (2) Non-mitochondrial O2 consumption by catabolic reactions, particularly peroxisomal oxidases and microsomal cytochrome P450 systems. (3) Non-mitochondrial Rox by reactions unrelated to catabolism. (4) Extracellular Rox. (5) Aerobic microbial respiration. Bars are not at a quantitative scale.
  • Corresponding author
Erich Gnaiger
Chair COST Action CA15203 MitoEAGLE
T +43 512 566796 15, F +43 512 566796 20
mitoeagle@i-med.ac.at | www.mitoeagle.org
  • Coauthors (listed in alphabetical order); number of coauthors (2019-06-24): 567
Many coauthors have made significant additions and suggestions for improvement of the manuscript. All coauthors confirm to have read the final manuscript, and to agree to implement the recommendations into future manuscripts, presentations and teaching materials.
Disclaimer: This article was prepared while Joshua P. Fessel was employed at Vanderbilt University Medical Center. The opinions expressed in this article are the author's own and do not reflect the view of the National Institutes of Health, the Department of Health and Human Services, or the United States government.
  • Copyright: © 2019 Gnaiger et al.
This is an Open Access preprint (not peer-reviewed) distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited. © remains with the authors, who have granted MitoFit an Open Access preprint licence in perpetuity.
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From Version 4 to 5

On World Metrology Day (2019-05-20) the redefinition of the SI units came into force. At this occasion, Version 4 of the MitoEAGLE preprint on 'Mitochondrial respiratory rates and states' was released, in line with our emphasis on SI units for reporting data on mitochondrial respiratory physiology.

Version 5 2019-06-24 in preparation - for discussion


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» 2019-03-12 Circular to coauthors
» 2019-02-12 Circular to coauthors


Linking COST Actions and MiPsociety

COST Action MitoEAGLE e-COST MitoEAGLE e-COST MitoEAGLE countries MiPsociety


The MitoFit preprint


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» Manuscript phases and versions

Manuscript phases and versions - an open-access apporach

COST Action MitoEAGLE
This manuscript on ‘Mitochondrial respiratory states and rates’ is a position statement in the frame of COST Action CA15203 MitoEAGLE. The list of coauthors evolved beyond phase 1 in the bottom-up spirit of COST.
The global MitoEAGLE network made it possible to collaborate with a large number of coauthors to reach consensus on the present manuscript. Nevertheless, we do not consider scientific progress to be supported by ‘declaration’ statements (other than on ethical or political issues). Our manuscript aims at providing arguments for further debate rather than pushing opinions. We hope to initiate a much broader process of discussion and want to raise the awareness on the importance of a consistent terminology for reporting of scientific data in the field of bioenergetics, mitochondrial physiology and pathology. Quality of research requires quality of communication. Some established researchers in the field may not want to re-consider the use of jargon which has become established despite deficiencies of accuracy and meaning. In the long run, superior standards will become accepted. We hope to contribute to this evolutionary process, with an emphasis on harmonization rather than standardization.
  • Phase 1: The protonmotive force and respiratory control
» The protonmotive force and respiratory control - Discussion
» MitoEAGLE preprint 2017-09-21 - Discussion
  • Phase 2: Mitochondrial respiratory states and rates: Building blocks of mitochondrial physiology Part 1
» MitoEAGLE Task Group States and rates - Discussion
  • Phase 4: Journal submission
  • Target: CELL METABOLISM, aiming at indexing by The Web of Science and PubMed.
Coauthors
  • 2017-09-21 Version 01: 105 coauthors
  • 2017-10-15 Version 10: 131 coauthors
  • 2018-01-18 Version 20: 168 coauthors
  • 2018-02-26 Version 30: 225 coauthors
  • 2018-08-20 Version 40: 350 coauthors - EBEC Poster
  • 2018-10-17 Version 44: 426 coauthors - MiPschool Tromso-Bergen 2018
  • 2018-12-12 Version 50: 517 coauthors - Submission to the preprint server bioRxiv not successful
  • 2019-02-12 Preprint version 1: 530 coauthors
  • 2019-03-15 Preprint version 2: 533 coauthors
  • 2019-04-24 Preprint version 3: 533 coauthors
  • 2019-05-20 Preprint version 4: 542 coauthors
  • 2019-07-24 Preprint version 5: 612 coauthors
  • 2019-08-30 Preprint version 6: 622 coauthors - Preprint publication doi:10.26124/mitofit:190001.v6



Labels: MiParea: Respiration, mt-Awareness 



Preparation: Permeabilized cells, Permeabilized tissue, Homogenate, Isolated mitochondria  Enzyme: Marker enzyme  Regulation: Coupling efficiency;uncoupling, Flux control, mt-Membrane potential, Uncoupler  Coupling state: LEAK, OXPHOS, ET  Pathway: F, N, S, Gp, DQ, CIV, NS, Other combinations, ROX 


MitoFitPublication, MitoEAGLEPublication