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Hamilton Microsyringe\100 mm³ 51/0.41 mm for manual titrations, 100 mm³ volume; fixed needle with rounded tip: 51 mm length, 0.41 mm inner diameter. It is recommended for injections of suspensions of isolated mitochondria.

Hamilton Microsyringe\25 mm³ 51/0.15 mm for manual titrations, 25 mm³ volume; fixed needle with rounded tip: 51 mm length, 0.15 mm inner diameter.

Microsyringe\500 mm3\TIP2k: Microinjection syringe for Titration-Injection microPump, 500 mm³ (µl), fixed injection needle with rounded tip, with spacers.

The MitoCanada Foundation.

The MitoCanada Foundation is Canada’s only not-for-profit organization focused on mitochondrial disease. Since its founding in 2010, MitoCanada has dedicated over $1 million to fund the work of leading Canadian scientists and to support national awareness and support programs.

The MitoCanada Foundation is committed to ensuring that those who live with mitochondrial disease are able to enjoy the best possible quality of life until there is a cure.

MitoFit Preprints is an Open Access preprint server for mitochondrial physiology and bioenergetics.

Cell permeable prodrugs, composed of MitoKit-CII/Succinate-nv and MitoKit-CII/Malonate-nv, stimulates (Snv) or inhibits (Mnanv) mitochondrial respiration in CI-deficient human blood cells, fibroblasts and heart fibres, acting on Complex II of the electron transfer system.

MitoSOX^TM is the version of the hydroetidine designed to target mitochondria in live cells for the detection of superoxide (O₂^•-). The oxidation of the compound by O₂^•- is easily detected in the red spectrum. One of the advantages of MitoSOX^TM is its selectivity for O₂^•- but not for other reactive oxygen species or reactive nitrogen species.

• Readily oxidized by superoxide but not by other ROS- or RNS-generating systems

• Absorption/emission maxima: ~510/580 nm

• Use for live cell imaging

• Rapidly and selectively targeted to the mitochondria

MitoSOX^TM has been widely used in life cell imaging but it is not free of problems and should be used cautiously. For example, it has been highlighted that the use of potentiometric dyes which accumulates into the mitochondria due to its moiety with Tetraphenylphosphonium, confers a membrane potential sensitivity that creates a series of artifacts and problems not often considered.

The Mitochondria Interest Group (MIG) is an Inter-Institute Interest Group at the National Institutes of Health (NIH), with members worldwide! MIG is concerned with all aspects of the mitochondrion and diseases in which the mitochondrion is involved. We hold monthly meetings, usually on the second Monday of the month (except when it is a Federal holiday or other special exceptions).

MITOCHONDRIA-L@LIST.NIH.GOV is an Email list moderated by Ph.D. Steven Zullo as an interactive information platform, with free subscritpion to this mitochondrial network. List members are reminded of their responsibility to critically evaluate the content of the postings. The information, opinions, data, and statements contained herein are not necessarily those of the U. S. Government, the National Institutes of Health (NIH), or MIG and should not be interpreted, acted on or represented as such.

The Mitochondria-Targeted Drug Development Summit was first established in 2021, as an online conference. Due to its success and unmatched focus, the 2^nd edition returns to Boston this March 2022. This is the only industry-led meeting that unites key stakeholders under a mutual and ambitious objective of accelerating the discovery and development of novel drugs that target mitochondrial functions for chronic, primary mitochondrial diseases, muscular dystrophy, metabolic disorders, and neurodegenerative diseases. Join our speakers from GenSight Biologics, Abliva, Reneo Pharma, Mito BioPharma, Mitokinin and more with exciting networking opportunities, panel discussions and dedicated roundtables.