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	Year	Reference	Coupling	Pathway	Preparation	Organism	Tissue;cell
Kawalec 2016 Praca doktorska	2016	Kawalec MM (2016) Badanie komórkowych skutków mutacji w genie mitofuzyny 2. Próba zaproponowania testu patogenności mutacji. Praca doktorska p86.	LEAK ROUTINE ET		Intact cells	Mouse	Fibroblast
Du 2016 Aquat Toxicol	2016	Du X, Crawford DL, Nacci DE, Oleksiak MF (2016) Heritable oxidative phosphorylation differences in a pollutant resistant Fundulus heteroclitus population. Aquat Toxicol 177:44-50.	LEAK OXPHOS ET	N S CIV Other combinations ROX	Permeabilized cells	Fishes	Liver
Christensen 2016 J Appl Physiol (1985)	2016	Christensen PM, Jacobs RA, Bonne T, Flück D, Bangsbo J, Lundby C (2016) A short period of high-intensity interval training improves skeletal muscle mitochondrial function and pulmonary oxygen uptake kinetics. J Appl Physiol (1985) 120:1319-27.	LEAK OXPHOS ET	F N S CIV NS Other combinations ROX	Permeabilized tissue	Human	Skeletal muscle
Dias 2016 Neurobiol Aging	2016	Dias C, Lourenço CF, Ferreiro E, Barbosa RM, Laranjinha J, Ledo A (2016) Age-dependent changes in the glutamate-nitric oxide pathway in the hippocampus of the triple transgenic model of Alzheimer's disease: implications for neurometabolic regulation. Neurobiol Aging 46:84-95.	LEAK ET	N S ROX	Permeabilized tissue	Mouse	Nervous system
Ojuka 2016 Am J Physiol Endocrinol Metab	2016	Ojuka E, Andrew B, Bezuidenhout N, George S, Maarman G, Madlala HP, Mendham A, Osiki PO (2016) Measurement of β-oxidation capacity of biological samples by respirometry: a review of principles and substrates. Am J Physiol Endocrinol Metab 310:E715-23. https://doi.org/10.1152/ajpendo.00475.2015	LEAK OXPHOS ET	F	Permeabilized tissue Isolated mitochondria	Human Mouse Rat	Skeletal muscle Liver
Scrima 2016 Biochim Biophys Acta	2016	Scrima R, Cela O, Merla G, Augello B, Rubino R, Quarato G, Fugetto S, Menga M, Fuhr L, Relógio A, Piccoli C, Mazzoccoli G, Capitanio N (2016) Clock-genes and mitochondrial respiratory activity: Evidence of a reciprocal interplay. Biochim Biophys Acta 1857:1344-51.	LEAK ROUTINE ET	ROX	Intact cells	Human	Liver Endothelial;epithelial;mesothelial cell Other cell lines Fibroblast
Price 2016 J Thermal Biol	2016	Price ER, Sirsat TS, Sirsat SKG, Kang G, Keereetaweep J, Aziz M, Chapman KD, Dzialowski EM (2016) Thermal acclimation in American alligators: Effects of temperature regime on growth rate, mitochondrial function, and membrane composition. J Thermal Biol p11.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized tissue	Reptiles	Heart Skeletal muscle
Cecatto 2016 Thesis	2016	Cecatto C (2016) Efeitos de acidos graxos hidroxilados de cadeia longa acumulados nas deficiencias da 3-hidroxiacil CoA desidrogenase de cadeia longa e da proteina trifunctional mitocondrial sobre a homeostase energetica mitochondrial nos musculos cardiaco e esqueletico de ratos jovens. Dissertation p103.	LEAK OXPHOS ET	N S	Permeabilized tissue Isolated mitochondria	Rat	Heart Skeletal muscle
Anand 2016 PLOS ONE	2016	Anand R, Strecker V, Urbach J, Wittig I, Reichert AS (2016) Mic13 is essential for formation of crista junctions in mammalian cells. PLOS ONE 11:e0160258.	LEAK ROUTINE OXPHOS ET	N CIV NS Other combinations ROX	Permeabilized cells Intact cells		HEK
Cecatto 2016 Toxicol In Vitro	2016	Cecatto C, Godoy KD, da Silva JC, Amaral AU, Wajner M (2016) Disturbance of mitochondrial functions provoked by the major long-chain 3-hydroxylated fatty acids accumulating in MTP and LCHAD deficiencies in skeletal muscle. Toxicol In Vitro 36:1-9.	LEAK OXPHOS ET	N	Permeabilized tissue Isolated mitochondria	Rat	Skeletal muscle
Jiroutkova 2016 JPEN J Parenter Enteral Nutr	2016	Jiroutková K, Krajčová A, Žiak J, Fric M, Gojda J, Džupa V, Kalous M, Tůmová J, Trnka J, Duška F (2016) Mitochondrial function in an in vitro model of skeletal muscle of patients with protracted critical illness and intensive care unit-acquired weakness. JPEN J Parenter Enteral Nutr 41:1213-21.	LEAK ET	F ROX		Human	Skeletal muscle Other cell lines
Sheremet 2016 Biochemistry (Moscow)	2016	Sheremet NL, Nevinitsyna TA, Zhorzholadze NV, Ronzina IA, Itkis YS, Krylova TD, Tsygankova PG, Malakhova VA, Zakharova EY, Tokarchuk AV, Panteleeva AA, Karger EM, Lyamzaev KG, Avetisov SE (2016) Previously unclassified mutation of mtDNA m.3472T>C: evidence of pathogenicity in Leber’s hereditary optic neuropathy. Biochemistry (Moscow) BM16-078.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Endothelial;epithelial;mesothelial cell Fibroblast Platelet
Schoenenberger 2016 Cancer Res	2016	Schönenberger D, Harlander S, Rajski M, Jacobs RA, Lundby AK, Adlesic M, Hejhal T, Wild PJ, Lundby C, Frew IJ (2016) Formation of renal cysts and tumors in Vhl/Trp53-deficient mice requires HIF1α and HIF2α. Cancer Res 76:2025-36.	OXPHOS ET	F N S CIV NS ROX	Permeabilized tissue	Mouse	Nervous system
Holandino 2016 Bioelectrochemistry	2016	Holandino C, Teixeira CA, de Oliveira FA, Barbosa GM, Siqueira CM, Messeder DJ, de Aguiar FS, da Veiga VF, Girard-Dias W, Miranda K, Galina A, Capella MA, Morales MM (2016) Direct electric current treatment modifies mitochondrial function and lipid body content in the A549 cancer cell line. Bioelectrochemistry 111:83-92.	LEAK ROUTINE ET	ROX	Intact cells	Human	Lung;gill Other cell lines
Bratic 2016 PLoS Genet	2016	Bratic A, Clemente P, Calvo-Garrido J, Maffezzini C, Felser A, Wibom R, Wedell A, Freyer C, Wredenberg A (2016) Mitochondrial polyadenylation is a one-step process required for mRNA integrity and tRNA maturation. PLoS Genet 12:e1006028.	LEAK OXPHOS ET	N CIV NS	Permeabilized tissue	Drosophila
Seiferling 2016 EMBO Rep	2016	Seiferling D, Szczepanowska K, Becker C, Senft K, Hermans S, Maiti P, König T, Kukat A, Trifunovic A (2016) Loss of CLPP alleviates mitochondrial cardiomyopathy without affecting the mammalian UPRmt. EMBO Rep 17:953-64.	LEAK OXPHOS ET	N NS	Isolated mitochondria	Mouse	Heart
Radovic 2016 Diabetologia	2016	Radović B, Vujić N, Leopold C, Schlager S, Goeritzer M, Patankar JV, Korbelius M, Kolb D, Reindl J, Wegscheider M, Tomin T, Birner-Gruenberger R, Schittmayer M, Groschner L, Magnes C, Diwoky C, Frank S, Steyrer E, Du H, Graier WF, Madl T, Kratky D (2016) Lysosomal acid lipase regulates VLDL synthesis and insulin sensitivity in mice. Diabetologia 59:1743-52.	LEAK OXPHOS ET	N S NS	Isolated mitochondria	Mouse	Liver
Assmann 2016 Cell Rep	2016	Assmann N, Dettmer K, Simbuerger JM, Broeker C, Nuernberger N, Renner K, Courtneidge H, Klootwijk ED, Duerkop A, Hall A, Kleta R, Oefner PJ, Reichold M, Reinders J (2016) Renal fanconi syndrome is caused by a mistargeting-based mitochondriopathy. Cell Rep 15:1423-9.	LEAK OXPHOS ET	F N S NS Other combinations ROX	Intact cells	Pig	Kidney Other cell lines
Bai 2016 PLOS ONE	2016	Bai F, Fink BD, Yu L, Sivitz WI (2016) Voltage-dependent regulation of Complex II energized mitochondrial oxygen flux. PLOS ONE 11:e0154982.	LEAK OXPHOS ET	N S CIV NS	Isolated mitochondria	Mouse	Heart Skeletal muscle Nervous system Liver
Peruzzo 2016 Cell Cycle	2016	Peruzzo P, Comelli M, Di Giorgio E, Franforte E, Mavelli I, Brancolini C (2016) Transformation by different oncogenes relies on specific metabolic adaptations. Cell Cycle 15:2656-68.	LEAK ROUTINE ET	ROX	Intact cells	Mouse	Fibroblast
Yavari 2016 Cell Metab	2016	Yavari A, Stocker CJ, Ghaffari S, Wargent ET, Steeples V, Czibik G, Pinter K, Bellahcene M, Woods A, Martinez de Morentin PB, Cansell C, Lam BY, Chuster A, Petkevicius K, Nguyen-Tu MS, Martinez-Sanchez A, Pullen TJ, Oliver PL, Stockenhuber A, Nguyen C, Lazdam M, O'Dowd JF, Harikumar P, Toth M, Beall C, Kyriakou T, Parnis J, Sarma D, Katritsis G, Wortmann DD, Harper AR, Brown LA, Willows R, Gandra S, Poncio V, de Oliveira Figueiredo MJ, Qi NR, Peirson SN, McCrimmon RJ, Gereben B, Tretter L, Fekete C, Redwood C, Yeo GS, Heisler LK, Rutter GA, Smith MA, Withers DJ, Carling D, Sternick EB, Arch JR, Cawthorne MA, Watkins H, Ashrafian H (2016) Chronic activation of γ2 AMPK induces obesity and reduces β cell function. Cell Metab 23:821-36.	LEAK OXPHOS ET	N NS ROX	Homogenate	Mouse	Nervous system
Distefano 2016 J Gerontol A Biol Sci Med Sci	2016	Distefano G, Standley RA, Dubé JJ, Carnero EA, Ritov VB, Stefanovic-Racic M, Toledo FG, Piva SR, Goodpaster BH, Coen PM (2016) Chronological age does not influence ex-vivo mitochondrial respiration and quality control in skeletal muscle. J Gerontol A Biol Sci Med Sci 72:535-42.	LEAK OXPHOS ET	N S NS	Permeabilized tissue	Human	Skeletal muscle
Reynolds 2016 Am J Physiol Endocrinol Metab	2016	Reynolds MS, Hancock CR, Ray JD, Kener KB, Draney C, Garland K, Hardman J, Bikman BT, Tessem JS (2016) β-cell deletion of Nr4a1 and Nr4a3 nuclear receptors impedes mitochondrial respiration and insulin secretion. Am J Physiol Endocrinol Metab 311:E186-201.	LEAK ROUTINE OXPHOS ET	N S ROX	Permeabilized cells Intact cells	Rat	Islet cell;pancreas;thymus
Moore 2016 Cryobiology	2016	Moore DS, Hand SC (2016) Cryopreservation of lipid bilayers by LEA proteins from Artemia franciscana and trehalose. Cryobiology 73:240-7.	LEAK OXPHOS ET	S	Isolated mitochondria	Rat	Liver
Most 2016 Am J Clin Nutr	2016	Most J, Timmers S, Warnke I, Jocken JW, van Boekschoten M, de Groot P, Bendik I, Schrauwen P, Goossens GH, Blaak EE (2016) Combined epigallocatechin-3-gallate and resveratrol supplementation for 12 wk increases mitochondrial capacity and fat oxidation, but not insulin sensitivity, in obese humans: a randomized controlled trial. Am J Clin Nutr 104:215-27.	LEAK OXPHOS ET	F N NS	Permeabilized tissue	Human	Skeletal muscle
Davuluri 2016 Proc Natl Acad Sci U S A	2016	Davuluri G, Song P, Liu Z, Wald D, Sakaguchi TF, Green MR, Devireddy L (2016) Inactivation of 3-hydroxybutyrate dehydrogenase 2 delays zebrafish erythroid maturation by conferring premature mitophagy. Proc Natl Acad Sci U S A 113:E1460-9.	LEAK ROUTINE ET		Intact cells	Zebrafish	Blood cells
Saben 2016 Cell Rep	2016	Saben JL, Boudoures AL, Asghar Z, Thompson A, Drury A, Zhang W, Chi M, Cusumano A, Scheaffer S, Moley KH (2016) Maternal metabolic syndrome programs mitochondrial dysfunction via germline changes across three generations. Cell Rep 16:1-8.	LEAK OXPHOS ET	N NS	Permeabilized tissue	Mouse	Skeletal muscle
Vevera 2016 Physiol Res	2016	Vevera J, Fišar Z, Nekovářová T, Vrablík M, Zlatohlávek L, Hroudová J, Singh N, Raboch J, Valeš K (2016) Statin-induced changes in mitochondrial respiration in blood platelets in rats and human with dyslipidemia. Physiol Res 65:777-88.	LEAK ROUTINE OXPHOS ET	N S NS Other combinations ROX	Intact cells Permeabilized cells	Human Rat	Blood cells Platelet
Ehinger 2016 Nat Commun	2016	Ehinger JK, Piel S, Ford R, Karlsson M, Sjövall F, Frostner EÅ, Morota S, Taylor RW, Turnbull DM, Cornell C, Moss SJ, Metzsch C, Hansson MJ, Fliri H, Elmér E (2016) Cell-permeable succinate prodrugs bypass mitochondrial Complex I deficiency. Nat Commun 7:12317. https://doi.org/10.1038/ncomms12317	OXPHOS ET	S	Intact cells Permeabilized tissue		Heart Blood cells Fibroblast
Karlsson 2016 Shock	2016	Karlsson M, Hara N, Morata S, Sjövall F, Kilbaugh T, Hansson MJ, Uchino H, Elmér E (2016) Diverse and tissue-specific mitochondrial respiratory response in a mouse model of sepsis-induced multiple organ failure. Shock 45:404-10.	LEAK OXPHOS ET	N S CIV NS	Homogenate	Mouse	Nervous system Liver
Camacho-Pereira 2016 Cell Metab	2016	Camacho-Pereira J, Tarragó MG, Chini CC, Nin V, Escande C, Warner GM, Puranik AS, Schoon RA, Reid JM, Galina A, Chini EN (2016) CD38 dictates age-related NAD decline and mitochondrial dysfunction through an SIRT3-dependent mechanism. Cell Metab 23:1127-39.	LEAK ROUTINE OXPHOS ET	S ROX	Isolated mitochondria Intact cells	Human Mouse	Liver Lung;gill Other cell lines
Van Zutphen 2016 J Hepatol	2016	van Zutphen T, Ciapaite J, Bloks VW, Ackereley C, Gerding A, Jurdzinski A, Allgayer de Moraes R, Zhang L, Wolters JC, Bischoff R, Wanders RJA, Houten SM, Bronte-Tinkew D, Shatseva T, Lewis GF, Groen AK, Reijngoud DJ, Bakker BM, Jonker JW, Kim PK, Bandsma RH (2016) Malnutrition-associated liver steatosis and ATP depletion is caused by peroxisomal and mitochondrial dysfunction. J Hepatol 65:1198-1208.	LEAK OXPHOS ET	F N NS Other combinations	Isolated mitochondria	Rat	Liver
Hagl 2016 Neuromolecular Med	2016	Hagl S, Asseburg H, Heinrich M, Sus N, Blumrich EM, Dringen R, Frank J, Eckert GP (2016) Effects of long-term rice bran extract supplementation on survival, cognition and brain mitochondrial function in aged NMRI mice. Neuromolecular Med 18:347-63.	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Mouse	Nervous system
Ryan 2016 Diabetes	2016	Ryan TE, Schmidt CA, Green TD, Spangenburg EE, Neufer PD, McClung JM (2016) Targeted expression of catalase to mitochondria protects against ischemic myopathy in high fat fed mice. Diabetes 65:2553-68.	LEAK OXPHOS ET	N S CIV Other combinations ROX	Isolated mitochondria	Mouse	Skeletal muscle
Jang 2016 J Intensive Care Med	2016	Jang DH, Greenwood JC, Spyres MB, Eckmann D (2016) Measurement of mitochondrial respiration and motility in acute care: sepsis, trauma, and poisoning. J Intensive Care Med 32:86-94.	LEAK ROUTINE ET	ROX	Intact cells	Human	Blood cells Lymphocyte
Silva 2016 Thesis	2016	Silva Luana Caroline Schüeler da (2016) Fucoxantina inibe a oxidação de LDL e ativação de macrófagos in vitro. PhD Thesis:93 pp.	LEAK ROUTINE ET	ROX	Intact cells	Human
Zhunussova 2016 PLOS ONE	2016	Zhunussova A, Vitol EA, Polyak B, Tuleukhanov S, Brooks AD, Sensenig R, Friedman G, Orynbayeva Z (2016) Mitochondria-mediated anticancer effects of non-thermal atmospheric plasma. PLOS ONE 11:e0156818.	LEAK ROUTINE ET		Intact cells	Human	Genital Other cell lines
Ryan 2016 J Mol Cell Cardiol	2016	Ryan TE, Schmidt CA, Alleman RJ, Tsang AM, Green TD, Neufer PD, Brown DA, McClung JM (2016) Mitochondrial therapy improves limb perfusion and myopathy following hindlimb ischemia. J Mol Cell Cardiol 97:191-6.	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Mouse	Skeletal muscle
Boeck 2016 Mitochondrion	2016	Boeck C, Koenig AM, Schury K, Geiger ML, Karabatsiakis A, Wilker S, Waller C, Gündel H, Fegert JM, Calzia E, Kolassa IT (2016) Inflammation in adult women with a history of child maltreatment: The involvement of mitochondrial alterations and oxidative stress. Mitochondrion 30:197-207.	LEAK ROUTINE ET	ROX	Intact cells	Human	Blood cells Lymphocyte
Heinonen 2016 Hum Exp Toxicol	2016	Heinonen JA, Schramko AA, Skrifvars MB, Litonius E, Backman JT, Mervaala E, Rosenberg PH (2016) The effects of intravenous lipid emulsion on hemodynamic recovery and myocardial cell mitochondrial function after bupivacaine toxicity in anesthetized pigs. Hum Exp Toxicol 36:365-75.	LEAK OXPHOS ET	F N S NS	Homogenate	Pig	Heart
Wijermars 2016 Am J Transplant	2016	Wijermars LG, Schaapherder AF, Kostidis S, Wüst RC, Lindeman JH (2016) Succinate accumulation and ischemia reperfusion injury: of mice but not men - A study in renal ischemia reperfusion. Am J Transplant 16:2741-6.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Human Pig Mouse Rat	Kidney
Gregg 2016 Diabetes	2016	Gregg T, Poudel C, Schmidt BA, Dhillon RS, Sdao SM, Truchan NA, Baar EL, Fernandez LA, Denu JM, Eliceiri KW, Rogers JD, Kimple ME, Lamming DW, Merrins MJ (2016) Pancreatic β cells from mice offset age-associated mitochondrial deficiency with reduced K_ATP channel activity. Diabetes 65:2700-10.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Human Mouse	Islet cell;pancreas;thymus Other cell lines
Barison 2016 J Bioenerg Biomembr	2016	Barisón MJ, Damasceno FS, Mantilla BS, Silber AM (2016) The active transport of histidine and its role in ATP production in Trypanosoma cruzi. J Bioenerg Biomembr 48:437-49.	LEAK ROUTINE ET		Intact cells	Protists
Lemieux 2016 Mitochondrion	2016	Lemieux H, Boemer F, van Galen G, Serteyn D, Amory H, Baise E, Cassart D, van Loon G, Marcillaud-Pitel C, Votion DM (2016) Mitochondrial function is altered in horse atypical myopathy. Mitochondrion 30:35-41.	OXPHOS ET	N S NS ROX	Permeabilized tissue	Horse	Skeletal muscle
Rohlenova 2016 Antioxid Redox Signal	2016	Rohlenova K, Sachaphibulkij K, Stursa J, Bezawork-Geleta A, Blecha J, Endaya B, Werner L, Cerny J, Zobalova R, Goodwin J, Spacek T, Alisadeh E, Yan B, Nguyen M, Vondrusova M, Sobol M, Jezek P, Hozak P, Truksa J, Rohlena J, Dong L, Neuzil J (2016) Selective disruption of respiratory supercomplexes as a new strategy to suppress Her2^high breast cancer. Antioxid Redox Signal 26:84-103.	LEAK ROUTINE ET	N S Other combinations	Permeabilized cells Homogenate	Human Mouse	Liver Genital Other cell lines
Sengupta 2016 Free Radic Biol Med	2016	Sengupta S, Yang G, O'Donnell JC, Hinson MD, McCormack SE, Falk MJ, La P, Robinson MB, Williams ML, Yohannes MT, Polyak E, Nakamaru-Ogiso E, Dennery PA (2016) The circadian gene Rev-erbα improves cellular bioenergetics and provides preconditioning for protection against oxidative stress. Free Radic Biol Med 93:177-89.	LEAK ROUTINE ET	ROX	Intact cells	Mouse	Lung;gill Fibroblast
Peyta 2016 Biochim Biophys Acta	2016	Peyta L, Jarnouen K, Pinault M, Guimaraes C, Pais de Barros JP, Chevalier S, Dumas JF, Maillot F, Hatch GM, Loyer P, Servais S (2016) Reduced cardiolipin content decreases respiratory chain capacities and increases ATP synthesis yield in the human HepaRG cells. Biochim Biophys Acta 1857:443-53.	LEAK OXPHOS ET	N CIV NS ROX	Permeabilized cells	Human	Liver Other cell lines
Amaral 2016 Biochim Biophys Acta	2016	Amaral AU, Cecatto C, da Silva JC, Wajner A, Godoy KD, Ribeiro RT, Wajner M (2016) cis-4-Decenoic and decanoic acids impair mitochondrial energy, redox and Ca²⁺ homeostasis and induce mitochondrial permeability transition pore opening in rat brain and liver: Possible implications for the pathogenesis of MCAD deficiency. Biochim Biophys Acta 1857:1363-72.	LEAK OXPHOS ET	N	Isolated mitochondria	Rat	Nervous system Liver
Gomez 2016 Thesis	2016	Gomez CR (2016) Mitochondrial responses to anoxia exposure in red eared sliders (Trachemys scripta). Master's Thesis p102.	LEAK OXPHOS ET	S	Permeabilized cells Isolated mitochondria	Reptiles	Heart Nervous system
Iglesias-Gonzalez 2016 Mol Neurobiol	2016	Iglesias-González J, Sánchez-Iglesias S, Beiras-Iglesias A, Méndez-Álvarez E, Soto-Otero R (2016) Effects of aluminium on rat brain mitochondria bioenergetics: an in vitro and in vivo study. Mol Neurobiol 54:563-70.	LEAK OXPHOS ET	N S NS	Isolated mitochondria	Rat	Nervous system
Kontro 2016 Thesis	2016	Kontro H (2016) Mitochondrial function and sirtuin expression in hippocampus of young and old high and low-capacity runner rats. Master's Thesis p35.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Rat	Nervous system
Wang 2016 Toxicol Sci	2016	Wang L, Espinoza HM, MacDonald JW, Bammler TK, Williams CR, Yeh A, Louie KW, Marcinek DJ, Gallagher EP (2016) Olfactory Transcriptional Analysis of Salmon Exposed to Mixtures of Chlorpyrifos and Malathion Reveal Novel Molecular Pathways of Neurobehavioral Injury. Toxicol Sci 149:145-57.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized tissue	Fishes	Endothelial;epithelial;mesothelial cell
Soendergaard 2016 Eur J Sport Sci	2016	Søndergård SD, Dela F, Helge JW, Larsen S (2016) Actovegin, a non-prohibited drug increases oxidative capacity in human skeletal muscle. Eur J Sport Sci 16:801-7.	LEAK OXPHOS ET	N NS	Permeabilized tissue	Human	Skeletal muscle
Siewiera 2016 Life Sci	2016	Siewiera K, Kassassir H, Talar M, Wieteska L, Watala C (2016) Higher mitochondrial potential and elevated mitochondrial respiration are associated with excessive activation of blood platelets in diabetic rats. Life Sci 148:293-304.	LEAK ROUTINE ET	ROX	Intact cells	Rat	Blood cells Platelet
Pamenter 2016 Biol Lett	2016	Pamenter ME, Gomez CR, Richards JG, Milsom WK (2016) Mitochondrial responses to prolonged anoxia in brain of red-eared slider turtles. Biol Lett 12. pii: 20150797.	LEAK OXPHOS ET	N S CIV ROX	Permeabilized tissue	Reptiles	Nervous system
Castellano-Gonzalez 2016 Oncotarget	2016	Castellano-González G, Pichaud N, Ballard JW, Bessede A, Marcal H, Guillemin GJ (2016) Epigallocatechin-3-gallate induces oxidative phosphorylation by activating cytochrome c oxidase in human cultured neurons and astrocytes. Oncotarget 7:7426-40	LEAK ROUTINE ET	ROX	Intact cells	Human	Nervous system
Sanchez-Calvo 2016 PLOS ONE	2016	Sánchez-Calvo B, Cassina A, Rios N, Peluffo G, Boggia J, Radi R, Rubbo H, Trostchansky A (2016) Nitro-arachidonic acid prevents Angiotensin II-induced mitochondrial dysfunction in a cell line of kidney proximal tubular cells. PLOS ONE 11:e0150459.	LEAK ROUTINE ET	ROX	Intact cells	Human	Kidney Other cell lines
Lesage 2016 Am J Hum Genet	2016	Lesage S, Drouet V, Majounie E, Deramecourt V, Jacoupy M, Nicolas A, Cormier-Dequaire F, Hassoun SM, Pujol C, Ciura S, Erpapazoglou Z, Usenko T, Maurage CA, Sahbatou M, Liebau S, Ding J, Bilgic B, Emre M, Erginel-Unaltuna N, Guven G, Tison F, Tranchant C, Vidailhet M, Corvol JC, Krack P, Leutenegger AL, Nalls MA, Hernandez DG, Heutink P, Gibbs JR, Hardy J, Wood NW, Gasser T, Durr A, Deleuze JF, Tazir M, Destée A, Lohmann E, Kabashi E, Singleton A, Corti O, Brice A (2016) Loss of VPS13C function in autosomal-recessive parkinsonism causes mitochondrial dysfunction and increases PINK1/Parkin-Dependent Mitophagy. Am J Hum Genet 98:500-13.	LEAK ROUTINE ET	ROX	Intact cells	Other mammals	Kidney Other cell lines
Sirsat 2016 Biol Open	2016	Sirsat SK, Sirsat TS, Price ER, Dzialowski EM (2016) Post-hatching development of mitochondrial function, organ mass and metabolic rate in two ectotherms, the American alligator (Alligator mississippiensis) and the common snapping turtle (Chelydra serpentina). Biol Open 5:443-51.	LEAK OXPHOS ET	N NS	Permeabilized tissue	Reptiles	Heart Skeletal muscle
Chu 2016 World J Gastroenterol	2016	Chu MJ, Premkumar R, Hickey AJ, Jiang Y, Delahunt B, Phillips AR, Bartlett A (2016) Steatotic livers are susceptible to normothermic ischemia-reperfusion injury from mitochondrial Complex-I dysfunction. World J Gastroenterol 22:4673-84.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Rat	Liver
Schoepf 2016 FEBS J	2016	Schöpf B, Schäfer G, Weber A, Talasz H, Eder IE, Klocker H, Gnaiger E (2016) Oxidative phosphorylation and mitochondrial function differ between human prostate tissue and cultured cells. https://doi.org/10.1111/febs.13733	LEAK OXPHOS ET	F N S NS Other combinations ROX	Permeabilized cells Permeabilized tissue	Human	Endothelial;epithelial;mesothelial cell Genital Other cell lines Fibroblast
Keller 2016 Oxid Med Cell Longev	2016	Keller AC, Knaub LA, McClatchey PM, Connon CA, Bouchard R, Miller MW, Geary KE, Walker LA, Klemm DJ, Reusch JE (2016) Differential mitochondrial adaptation in primary vascular smooth muscle cells from a diabetic rat model. Oxid Med Cell Longev 2016:8524267.	LEAK OXPHOS ET	N NS	Permeabilized cells	Rat	Endothelial;epithelial;mesothelial cell
Amaral 2016 J Neurochem	2016	Amaral AU, Cecatto C, Castilho RF, Wajner M (2016) 2-methylcitric acid impairs glutamate metabolism and induces permeability transition in brain mitochondria. J Neurochem 137:62-75.	LEAK OXPHOS ET	N S NS	Isolated mitochondria	Rat	Nervous system
Birkenmeier 2016 Int J Cancer	2016	Birkenmeier Katrin, Droese Stefan, Wittig Ilka, Winkelmann Ria, Kaefer Viktoria, Doering Claudia, Hartmann Sylvia, Wenz Tina, Reichert Andreas S, Brandt Ulrich, Hansmann Martin‐Leo (2016) Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma are highly dependent on oxidative phosphorylation. Int J Cancer 138:2231-46.	LEAK ROUTINE ET	ROX	Intact cells	Human	Other cell lines HeLa Macrophage-derived
Wolff 2016 J Evol Biol	2016	Wolff JN, Pichaud N, Camus MF, Côté G, Blier PU, Dowling DK (2016) Evolutionary implications of mitochondrial genetic variation: mitochondrial genetic effects on OXPHOS respiration and mitochondrial quantity change with age and sex in fruit flies. J Evol Biol 29:736-47.	LEAK OXPHOS ET	N Gp CIV Other combinations ROX	Permeabilized tissue	Drosophila	Skeletal muscle
Lores-Arnaiz 2016 Neurochem Res	2016	Lores-Arnaiz S, Lombardi P, Karadayian AG, Orgambide F, Cicerchia D, Bustamante J (2016) Brain cortex mitochondrial bioenergetics in synaptosomes and non-synaptic mitochondria during aging. Neurochem Res 41:353-63.	LEAK ROUTINE OXPHOS ET	N S	Isolated mitochondria Intact cells	Mouse	Nervous system
Shama 2016 Evol Appl	2016	Shama LNS, Mark FC, Strobel A, Lokmer A, John U, Wegner KM (2016) Transgenerational effects persist down the maternal line in marine sticklebacks: gene expression matches physiology in a warming ocean. Evol Appl 10013/epic.47323.	LEAK OXPHOS ET	NS ROX	Permeabilized tissue	Fishes	Heart
Boutant 2016 Cell Rep	2016	Boutant M, Kulkarni SS, Joffraud M, Raymond F, Métairon S, Descombes P, Cantó C (2016) SIRT1 gain of function does not mimic or enhance the adaptations to intermittent fasting. Cell Rep 14:2068-75.	OXPHOS ET	N NS	Permeabilized tissue Homogenate	Mouse	Skeletal muscle Liver Fat
Cannon 2016 Lung	2016	Cannon DT, Liu J, Sakurai R, Rossiter HB, Rehan VK (2016) Impaired lung mitochondrial respiration following perinatal nicotine exposure in rats. Lung 194:325-8.	LEAK OXPHOS ET	N S CIV NS	Permeabilized tissue	Rat	Lung;gill
Leucci 2016 Nature	2016	Leucci E, Vendramin R, Spinazzi M, Laurette P, Fiers M, Wouters J, Radaelli E, Eyckerman S, Leonelli C, Vanderheyden K, Rogiers A, Hermans E, Baatsen P, Aerts S, Amant F, Van Aelst S, van den Oord J, de Strooper B, Davidson I, Lafontaine DL, Gevaert K, Vandesompele J, Mestdagh P, Marine JC (2016) Melanoma addiction to the long non-coding RNA SAMMSON. Nature 531:518-22.	LEAK OXPHOS ET	N CIV NS ROX	Permeabilized cells	Human	Endothelial;epithelial;mesothelial cell Other cell lines
Bynum 2016 Transfusion	2016	Bynum JA, Adam Meledeo M, Getz TM, Rodriguez AC, Aden JK, Cap AP, Pidcoke HF (2016) Bioenergetic profiling of platelet mitochondria during storage: 4°C storage extends platelet mitochondrial function and viability. Transfusion 56 Suppl 1:S76-84.	LEAK ROUTINE ET	ROX	Intact cells	Human	Blood cells Platelet
Lim 2016 FASEB J	2016	Lim SC, Hroudová J, Van Bergen NJ, Lopez Sanchez MI, Trounce IA, McKenzie M (2016) Loss of mitochondrial DNA-encoded protein ND1 results in disruption of complex I biogenesis during early stages of assembly. FASEB J 30:2236-48.	OXPHOS ET	N S NS ROX	Permeabilized cells	Human	Other cell lines
Du 2016 J Exp Biol	2016	Du SN, Mahalingam S, Borowiec BG, Scott GR (2016) Mitochondrial physiology and reactive oxygen species production are altered by hypoxia acclimation in killifish (Fundulus heteroclitus). J Exp Biol 219:1130-8.	LEAK OXPHOS ET	N S CIV NS	Isolated mitochondria	Fishes	Liver
Gemmink 2016 Diabetologia	2016	Gemmink A, Bosma M, Kuijpers HJ, Hoeks J, Schaart G, van Zandvoort MA, Schrauwen P, Hesselink MK (2016) Decoration of intramyocellular lipid droplets with PLIN5 modulates fasting-induced insulin resistance and lipotoxicity in humans. Diabetologia 59:1040-8.	OXPHOS ET	F NS Other combinations	Permeabilized tissue	Human	Skeletal muscle
Sparks 2016 Diabetologia	2016	Sparks LM, Gemmink A, Phielix E, Bosma M, Schaart G, Moonen-Kornips E, Jörgensen JA, Nascimento EB, Hesselink MK, Schrauwen P, Hoeks J (2016) ANT1-mediated fatty acid-induced uncoupling as a target for improving myocellular insulin sensitivity. Diabetologia 59:1030-9.	LEAK OXPHOS ET	F N NS Other combinations	Permeabilized tissue Isolated mitochondria	Human Mouse Rat	Skeletal muscle Other cell lines
Ehinger 2016 Mov Disord	2016	Ehinger JK, Morota S, Hansson MJ, Gesine P, Elmér E (2016) Mitochondrial respiratory function in peripheral blood cells from Huntington’s disease patients. Mov Disord doi:10.1002/mdc3.12308.	LEAK ROUTINE OXPHOS ET	N S CIV NS Other combinations ROX	Permeabilized cells Intact cells	Human	Blood cells Lymphocyte Platelet
Baeder 2016 Int J Dent	2016	Baeder AC, Napa K, Richardson ST, Taylor OJ, Andersen SG, Wilcox SH, Winden DR, Reynolds PR, Bikman BT (2016) Oral gingival cell cigarette smoke exposure induces muscle cell metabolic disruption. Int J Dent 2016:2763160.	LEAK OXPHOS ET	N NS ROX	Permeabilized cells	Mouse	Skeletal muscle
Hagl 2016 Nutr Neurosci	2016	Hagl S, Berressem D, Grewal R, Grebenstein N, Frank J, Eckert GP (2016) Rice bran extract improves mitochondrial dysfunction in brains of aged NMRI mice. Nutr Neurosci 19:1-10.	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Mouse	Nervous system
Kimball 2016 Thesis	2016	Kimball RL (2016) The role of hypoxia on pyruvate kinase M2, mammalian target of rapamycin, mitochondrial function, and cell invasion in the trophoblast. Master Thesis p55.	LEAK OXPHOS ET	N S NS ROX	Permeabilized cells	Human	Genital Other cell lines
Tunholi 2016 J Invertebr Pathol	2016	Tunholi VM, Tunholi-Alves VM, Santos AT, Garcia Jda S, Maldonado A Jr, da-Silva WS, Rodrigues Mde L, Pinheiro J (2016) Evaluation of the mitochondrial system in the gonad-digestive gland complex of Biomphalaria glabrata (Mollusca, Gastropoda) after infection by Echinostoma paraensei (Trematoda, Echinostomatidae). J Invertebr Pathol 136:136-41.	LEAK OXPHOS ET	N NS ROX	Permeabilized tissue	Molluscs	Genital
Li 2016 J Appl Physiol (1985)	2016	Li C, White SH, Warren LK, Wohlgemuth SE (2016) Effects of aging on mitochondrial function in skeletal muscle of quarter horses. J Appl Physiol (1985) 121:299-311.	LEAK OXPHOS ET	N NS ROX	Permeabilized tissue	Horse	Skeletal muscle
Santos 2016 Insect Biochem Mol Biol	2016	Santos DE, Alberici LC, Hartfelder K (2016) Mitochondrial structure and dynamics as critical factors in honey bee (Apis mellifera L.) caste development. Insect Biochem Mol Biol 73:1-11.	LEAK OXPHOS ET	S	Permeabilized tissue	Hexapods	Fat
Lund 2016 J Physiol	2016	Lund MT, Kristensen M, Hansen M, Tveskov L, Floyd AK, Støckel M, Vainer B, Poulsen SS, Helge JW, Prats C, Dela F (2016) Hepatic mitochondrial oxidative phosphorylation is normal in obese patients with and without type 2 diabetes. J Physiol 594:4351-8.	LEAK OXPHOS ET	F N S CIV NS ROX	Permeabilized tissue	Human	Liver
Cagnone 2016 Sci Rep	2016	Cagnone GL, Tsai TS, Makanji Y, Matthews P, Gould J, Bonkowski MS, Elgass KD, Wong AS, Wu LE, McKenzie M, Sinclair DA, John JC (2016) Restoration of normal embryogenesis by mitochondrial supplementation in pig oocytes exhibiting mitochondrial DNA deficiency. Sci Rep 6:23229.	LEAK OXPHOS ET	S ROX	Isolated mitochondria	Pig	Genital
Cheng 2016 Nat Immunol	2016	Cheng SC, Scicluna BP, Arts RJ, Gresnigt MS, Lachmandas E, Giamarellos-Bourboulis EJ, Kox M, Manjeri GR, Wagenaars JA, Cremer OL, Leentjens J, van der Meer AJ, van de Veerdonk FL, Bonten MJ, Schultz MJ, Willems PH, Pickkers P, Joosten LA, van der Poll T, Netea MG (2016) Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis. Nat Immunol 17:406-13.	LEAK ROUTINE ET	ROX	Intact cells	Human	Blood cells Lymphocyte
Xiong 2016 Hypertension	2016	Xiong S, Wang P, Ma L, Gao P, Gong L, Li L, Li Q, Sun F, Zhou X, He H, Chen J, Yan Z, Liu D, Zhu Z (2016) Ameliorating endothelial mitochondrial dysfunction restores coronary function via transient receptor potential vanilloid 1-mediated protein kinase A/uncoupling protein 2 pathway. Hypertension 67:451-60.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Intact cells Permeabilized cells	Human	Endothelial;epithelial;mesothelial cell Other cell lines
LaBarge 2016 FASEB J	2016	LaBarge SA, Migdal CW, Buckner EH, Okuno H, Gertsman I, Stocks B, Barshop BA, Nalbandian SR, Philp A, McCurdy CE, Schenk S (2016) p300 is not required for skeletal muscle metabolic adaptation to endurance exercise training. FASEB J 30:1623-33.	LEAK OXPHOS ET	F N NS ROX S Other combinations	Permeabilized tissue	Mouse	Skeletal muscle
Power 2016 Am J Physiol Heart Circ Physiol	2016	Power AS, Pham T, Loiselle DS, Crossman DH, Ward ML, Hickey AJ (2016) Impaired ADP channeling to mitochondria and elevated reactive oxygen species in hypertensive hearts. https://doi.org/10.1152/ajpheart.00050.2016	LEAK OXPHOS ET	N CIV NS	Permeabilized tissue Homogenate	Rat	Heart
Osiki 2016 FASEB J	2016	Osiki PO, Ojuka E, Marmaan G (2016) An investigation of the suitability of using octanoylcarnitine together with malate as a substrate combination for assessing Beta-oxidation using High Resolution Respirometry. FASEB J 30: 1015.12 .	LEAK OXPHOS ET	F	Permeabilized tissue	Rat	Skeletal muscle
Bonifacio 2016 Arch Toxicol	2016	Bonifacio A, Mullen PJ, Mityko IS, Navegantes LC, Bouitbir J, Krähenbühl S (2016) Simvastatin induces mitochondrial dysfunction and increased atrogin-1 expression in H9c2 cardiomyocytes and mice in vivo. Arch Toxicol 90:203-15. doi: 10.1007/s00204-014-1378-4	LEAK OXPHOS ET	N S DQ CIV NS	Permeabilized cells Permeabilized tissue Intact cells	Rat	Heart
Snook 2016 Am J Physiol Regul Integr Comp Physiol	2016	Snook LA, MacPherson RE, Monaco CM, Frendo-Cumbo S, Castellani L, Peppler WT, Anderson ZG, Buzelle SL, LeBlanc PJ, Holloway GP, Wright DC (2016) Prior exercise training blunts short term highfat diet induced weight gain. Am J Physiol Regul Integr Comp Physiol 311:R315-24.	LEAK OXPHOS ET	N NS	Permeabilized tissue	Mouse	Fat
Chang 2016 Transl Res	2016	Chang JC, Wu SL, Liu KH, Chen YH, Chuang CS, Cheng FC, Su HL, Wei YH, Kuo SJ, Liu CS (2016) Allogeneic/xenogeneic transplantation of peptide-labeled mitochondria in Parkinson's disease: restoration of mitochondria functions and attenuation of 6-hydroxydopamine-induced neurotoxicity. Transl Res 170:40-56.	LEAK OXPHOS ET	N	Isolated mitochondria	Rat	Nervous system Other cell lines
Jacobs 2016 J Physiol	2016	Jacobs RA, Lundby AM, Fenk S, Gehrig S, Siebenmann C, Flück D, Kirk N, Hilty MP, Lundby C (2016) Twenty-eight days of exposure to 3,454 m increases mitochondrial volume density in human skeletal muscle. J Physiol 594:1151-66.	LEAK OXPHOS ET	F N S CIV NS ROX	Permeabilized tissue	Human	Skeletal muscle
Mizushima 2016 J Mol Cell Cardiol	2016	Mizushima W, Takahashi H, Watanabe M, Kinugawa S, Matsushima S, Takada S, Yokota T, Furihata T, Matsumoto J, Tsuda M, Chiba I, Nagashima S, Yanagi S, Matsumoto M, Nakayama KI, Tsutsui H, Hatakeyama S (2016) The novel heart-specific RING finger protein 207 is involved in energy metabolism in cardiomyocytes. J Mol Cell Cardiol 100:43-53.	LEAK OXPHOS ET		Permeabilized cells	Rat	Heart
Doerrier 2016 Mitochondrion	2016	Doerrier C, García JA, Volt H, Díaz-Casado ME, Luna-Sánchez M, Fernández-Gil B, Escames G, López LC, Acuña-Castroviejo D (2016) Permeabilized myocardial fibers as model to detect mitochondrial dysfunction during sepsis and melatonin effects without disruption of mitochondrial network. Mitochondrion 27:56-63.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Mouse	Heart
Zabielski 2016 Diabetes	2016	Zabielski P, Lanza IR, Gopala S, Holtz Heppelmann CJ, Bergen HR 3rd, Dasari S, Nair KS (2016) Altered skeletal muscle mitochondrial proteome as the basis of disruption of mitochondrial function in diabetic mice. Diabetes 65:561-73.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized cells	Mouse	Skeletal muscle
Cacabelos 2016 Acta Neuropathol Commun	2016	Cacabelos D, Ramírez-Núñez O, Granado-Serrano AB, Torres P, Ayala V, Moiseeva V, Povedano M, Ferrer I, Pamplona R, Portero-Otin M, Boada J (2016) Early and gender-specific differences in spinal cord mitochondrial function and oxidative stress markers in a mouse model of ALS. Acta Neuropathol Commun 4:3.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized tissue Intact cells	Mouse	Nervous system Other cell lines
Ruas 2016 PLOS ONE	2016	Ruas JS, Siqueira-Santos ES, Amigo I, Rodrigues-Silva E, Kowaltowski AJ, Castilho RF (2016) Underestimation of the maximal capacity of the mitochondrial electron transport system in oligomycin-treated cells. PLOS ONE 11:e0150967.	LEAK OXPHOS ET	N	Intact cells Permeabilized cells Isolated mitochondria	Human Rat	Nervous system Genital Other cell lines
Schinagl 2016 PLoS One	2016	Schinagl CW, Vrabl P, Burgstaller W (2016) Adapting high-resolution respirometry to glucose-limited steady state mycelium of the filamentous fungus Penicillium ochrochloron: method development and standardisation. PLoS One 11:e0146878.	ROUTINE ET		Intact cells	Fungi
Jang 2016 Clin Toxicol (Phila)	2016	Jang DH, Shofer FS, Weiss SL, Becker LB (2016) Impairment of mitochondrial respiration following ex vivo cyanide exposure in peripheral blood mononuclear cells. Clin Toxicol (Phila) 54:303-7.	LEAK ROUTINE ET	ROX	Intact cells	Human	Blood cells Lymphocyte
Volt 2016 J Pineal Res	2016	Volt H, García JA, Doerrier C, Díaz-Casado ME, Guerra-Librero A, López LC, Escames G, Tresguerres JA, Acuña-Castroviejo D (2016) Same molecule but different expression: aging and sepsis trigger NLRP3 inflammasome activation, a target of melatonin. J Pineal Res 60:193-205.	OXPHOS ET	N NS	Permeabilized tissue	Mouse	Heart
Johnson 2016 Diabetes	2016	Johnson ML, Distelmaier K, Lanza IR, Irving BA, Robinson MM, Konopka AR, Shulman GI, Nair KS (2016) Mechanism by which caloric restriction improves insulin sensitivity in sedentary obese adults. Diabetes 65:74-84.	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Human	Skeletal muscle
Puskarich 2016 J Crit Care	2016	Puskarich MA, Kline JA, Watts JA, Shirey K, Hosler J, Jones AE (2016) Early alterations in platelet mitochondrial function are associated with survival and organ failure in patients with septic shock. J Crit Care 31:63-7.	LEAK ROUTINE ET	ROX	Intact cells	Human	Blood cells Platelet
Baris 2016 Am J Physiol Regul Integr Comp Physiol	2016	Baris TZ, Blier PU, Pichaud N, Crawford DL, Oleksiak MF (2016) Gene by environmental interactions affecting oxidative phosphorylation and thermal sensitivity. Am J Physiol Regul Integr Comp Physiol 311:R157-65.	LEAK OXPHOS ET	CIV NS ROX S	Permeabilized tissue	Fishes	Heart
Nauta 2016 Thesis	2016	Nauta TD (2016) HIF-2α regulates in vitro neovascularization during hypoxia. Doctoral Dissertation p206.	LEAK ROUTINE ET	ROX	Intact cells	Human	Endothelial;epithelial;mesothelial cell
Bueno 2016 Thesis	2016	Bueno e Silva MM (2016) Alterações mitocondriais e reprogramação metabólica em células de glioblastoma após tratamento com temozolomida. Dissertation p71.	LEAK ROUTINE ET		Intact cells	Human	Nervous system Other cell lines
Shirey 2016 Biochemistry	2016	Shirey K, Stover KR, Cleary J, Hoang N, Hosler J (2016) Membrane-anchored cyclic peptides as effectors of mitochondrial oxidative phosphorylation. Biochemistry 55:2100-11.	LEAK OXPHOS ET	CIV NS N S	Isolated mitochondria SMP	Rat	Heart Liver
Berressem 2016 PLOS ONE	2016	Berressem D, Koch K, Franke N, Klein J, Eckert GP (2016) Intravenous treatment with a long-chain omega-3 lipid emulsion provides neuroprotection in a murine model of ischemic stroke - a pilot study. PLOS ONE 11:e0167329.	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Mouse	Nervous system
Scott 2016 Thesis	2016	Scott KY (2016) Evaluation of cardiac mitochondrial function in the fructose-fed rat. Master's Thesis p98.	LEAK OXPHOS ET	F N S CIV ROX	Isolated mitochondria	Rat	Heart
Schaefer 2016 PLOS ONE	2016	Schaefer PM, von Einem B, Walther P, Calzia E, von Arnim CA (2016) Metabolic characterization of intact cells reveals intracellular amyloid beta but not its precursor protein to reduce mitochondrial respiration. PLOS ONE 11:e0168157.	LEAK ROUTINE ET	CIV ROX	Intact cells	Human Mouse	Nervous system HEK
Chubanov 2016 Elife	2016	Chubanov V, Ferioli S, Wisnowsky A, Simmons DG, Leitzinger C, Einer C, Jonas W, Shymkiv Y, Bartsch H, Braun A, Akdogan B, Mittermeier L, Sytik L, Torben F, Jurinovic V, van der Vorst EP, Weber C, Yildirim ÖA, Sotlar K, Schürmann A, Zierler S, Zischka H, Ryazanov AG, Gudermann T (2016) Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival. Elife 5. pii: e20914.	ROUTINE ET	ROX	Intact cells	Human	Fibroblast Other cell lines
Van Hoose 2016 J Nutr Biochem	2016	Van Hoose PM, Kelm NQ, Piell KM, Cole MP (2016) Conjugated linoleic acid and nitrite attenuate mitochondrial dysfunction during myocardial ischemia. J Nutr Biochem 34:8-16.	LEAK OXPHOS ET	N ROX	Isolated mitochondria	Mouse	Heart
Bastow 2016 J Cell Sci	2016	Bastow EL, Peswani AR, Tarrant DS, Pentland DR, Chen X, Morgan A, Staniforth GL, Tullet JM, Rowe ML, Howard MJ, Tuite MF, Gourlay CW (2016) New links between SOD1 and metabolic dysfunction from a yeast model of amyotrophic lateral sclerosis. J Cell Sci 129:4118-29.	LEAK ROUTINE ET	ROX	Intact cells	Saccharomyces cerevisiae
Queliconi 2016 PLOS ONE	2016	Queliconi BB, Kowaltowski AJ, Gottlieb RA (2016) Bicarbonate increases ischemia-reperfusion damage by inhibiting mitophagy. PLOS ONE 11:e0167678.	LEAK OXPHOS ET	S ROX	Isolated mitochondria	Rat	Heart
Moll 2016 bioRxiv	2016	Moll CWI, Lindtner RA, Vogel GF, Brunner M, Gutleben K, Blauth M, Krumschnabel G, Ebner HL (2016) Bone marrow mesenchymal stem cells from osteoporotic patients do not show altered mitochondrial energetics or ultrastructure. bioRxiv doi.org/10.1101/046300.	LEAK ROUTINE OXPHOS ET	N S ROX	Intact cells Permeabilized cells	Human	Stem cells
Chakraborty 2016 Pancreatology	2016	Chakraborty M, Hickey AJ, Petrov MS, Macdonald JR, Thompson N, Newby L, Sim D, Windsor JA, Phillips AR (2016) Mitochondrial dysfunction in peripheral blood mononuclear cells in early experimental and clinical acute pancreatitis. Pancreatology 16:739-47.	LEAK OXPHOS ROUTINE ET	N Gp CIV NS ROX S	Permeabilized cells	Human Rat	Blood cells
Lark 2016 Am J Physiol Cell Physiol	2016	Lark DS, Torres MJ, Lin CT, Ryan TE, Anderson EJ, Neufer PD (2016) Direct real-time quantification of mitochondrial oxidative phosphorylation efficiency in permeabilized skeletal muscle myofibers. Am J Physiol Cell Physiol 311:C239-45.	LEAK OXPHOS ET	N Gp NS	Permeabilized tissue Isolated mitochondria	Mouse	Skeletal muscle
Roy 2016 Free Radic Biol Med	2016	Roy J, Fauconnier J, Oger C, Farah C, Angebault-Prouteau C, Thireau J, Bideaux P, Scheuermann V, Bultel-Poncé V, Demion M, Galano JM, Durand T, Lee JC, Le Guennec JY (2016) Non-enzymatic oxidized metabolite of DHA, 4(RS)-4-F_4t-neuroprostane protects the heart against reperfusion injury. Free Radic Biol Med 102:229-39.	OXPHOS ET	N S NS	Permeabilized cells	Rat	Heart
Witt 2016 Metab Brain Dis	2016	Witt AM, Larsen FS, Bjerring PN (2016) Accumulation of lactate in the rat brain during hyperammonaemia is not associated with impaired mitochondrial respiratory capacity. Metab Brain Dis 32:461-70.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Rat	Nervous system
Van Eunen 2016 BMC Biol	2016	van Eunen K, Volker-Touw CM, Gerding A, Bleeker A, Wolters JC, van Rijt WJ, Martines AM, Niezen-Koning KE, Heiner RM, Permentier H, Groen AK, Reijngoud DJ, Derks TG, Bakker BM (2016) Living on the edge: substrate competition explains loss of robustness in mitochondrial fatty-acid oxidation disorders. BMC Biol 14:107.	ET	F N	Isolated mitochondria	Mouse	Liver
Timpani 2016 Neurotherapeutics	2016	Timpani CA, Trewin AJ, Stojanovska V, Robinson A, Goodman CA, Nurgali K, Betik AC, Stepto N, Hayes A, McConell GK, Rybalka E (2016) Attempting to compensate for reduced neuronal nitric oxide synthase protein with nitrate supplementation cannot overcome metabolic dysfunction but rather has detrimental effects in Dystrophin-deficient mdx muscle. Neurotherapeutics 14:429-46.	LEAK OXPHOS ET	N CIV NS Other combinations ROX S	Permeabilized tissue	Mouse	Skeletal muscle
Briston 2016 Sci Rep	2016	Briston T, Lewis S, Koglin M, Mistry K, Shen Y, Hartopp N, Katsumata R, Fukumoto H, Duchen MR, Szabadkai G, Staddon JM, Roberts M, Powney B (2016) Identification of ER-000444793, a Cyclophilin D-independent inhibitor of mitochondrial permeability transition, using a high-throughput screen in cryopreserved mitochondria. Sci Rep 6:37798.	LEAK OXPHOS ET	N S ROX	Isolated mitochondria	Rat	Liver
Strifler 2016b PLOS ONE	2016	Strifler G, Tuboly E, Görbe A, Boros M, Pécz D, Hartmann P (2016) Targeting mitochondrial dysfunction with L-alpha glycerylphosphorylcholine. PLOS ONE 11:e0166682.	LEAK OXPHOS ET	N S NS Other combinations ROX	Homogenate	Rat	Liver
Torres 2016 Redox Biol	2016	Torres S, Matías N, Baulies A, Nuñez S, Alarcon-Vila C, Martinez L, Nuño N, Fernandez A, Caballeria J, Levade T, Gonzalez-Franquesa A, Garcia-Rovés P, Balboa E, Zanlungo S, Fabrías G, Casas J, Enrich C, Garcia-Ruiz C, Fernández-Checa JC (2016) Mitochondrial GSH replenishment as a potential therapeutic approach for Niemann Pick type C disease. Redox Biol 11:60-72.	LEAK ROUTINE OXPHOS ET	N S ROX	Homogenate Intact cells	Human Mouse	Nervous system Liver Endothelial;epithelial;mesothelial cell Fibroblast
Tsai 2016 Sci Rep	2016	Tsai HH, Chang SC, Chou CH, Weng TP, Hsu CC, Wang JS (2016) Exercise training alleviates hypoxia-induced mitochondrial dysfunction in the lymphocytes of sedentary males. Sci Rep 6:35170.	LEAK ROUTINE OXPHOS ET	F N S NS Other combinations ROX	Permeabilized cells Intact cells	Human	Lymphocyte Blood cells
Frey 2016 Biochim Biophys Acta	2016	Frey S, Geffroy G, Desquiret-Dumas V, Gueguen N, Bris C, Belal S, Amati-Bonneau P, Chevrollier A, Barth M, Henrion D, Lenaers G, Bonneau D, Reynier P, Procaccio V (2016) The addition of ketone bodies alleviates mitochondrial dysfunction by restoring complex I assembly in a MELAS cellular model. Biochim Biophys Acta 1863:284-91.	ROUTINE LEAK ET	N S NS	Permeabilized cells Intact cells	Human	Nervous system
Docherty 2016 Stem Cell Res Ther	2016	Docherty CK, Salt IP, Mercer JR (2016) Lin28A induces energetic switching to glycolytic metabolism in human embryonic kidney cells. Stem Cell Res Ther 7:78.	LEAK ET	ROX	Intact cells	Human	Kidney HEK
Raesaenen 2016 Proc Natl Acad Sci U S A	2016	Räsänen M, Degerman J, Nissinen TA, Miinalainen I, Kerkelä R, Siltanen A, Backman JT, Mervaala E, Hulmi JJ, Kivelä R, Alitalo K (2016) VEGF-B gene therapy inhibits doxorubicin-induced cardiotoxicity by endothelial protection. Proc Natl Acad Sci U S A 113:13144-49.	LEAK OXPHOS ET	N S NS	Homogenate	Mouse	Heart
Ferguson 2016 J Bioenerg Biomembr	2016	Ferguson MA, Sutton RM, Karlsson M, Sjövall F, Becker LB, Berg RA, Margulies SS, Kilbaugh TJ (2016) Increased platelet mitochondrial respiration after cardiac arrest and resuscitation as a potential peripheral biosignature of cerebral bioenergetic dysfunction. J Bioenerg Biomembr 48:269-79.	LEAK ROUTINE OXPHOS ET	N S CIV NS ROX	Permeabilized cells Homogenate Intact cells	Pig	Nervous system Platelet
Timmers 2016 Diabetes Care	2016	Timmers S, de Ligt M, Phielix E, van de Weijer T, Hansen J, Moonen-Kornips E, Schaart G, Kunz I, Hesselink MK, Schrauwen-Hinderling VB, Schrauwen P (2016) Resveratrol as add-on therapy in subjects with well-controlled type 2 diabetes: a randomized controlled trial. Diabetes Care 39:2211-17.	LEAK ET OXPHOS	F N NS	Permeabilized tissue	Human	Skeletal muscle
Hals 2016 Islets	2016	Hals IK, Singh R, Ma Z, Scholz H, Björklund A, Grill V (2016) Culture at low glucose up-regulates mitochondrial function in pancreatic β cells with accompanying effects on viability. Islets 8:165-76.	LEAK ET	ROX	Intact cells	Rat	Islet cell;pancreas;thymus
Karlsson 2016 Mitochondrion	2016	Karlsson M, Ehinger JK, Piel S, Sjövall F, Henriksnäs J, Höglund U, Hansson MJ, Elmér E (2016) Changes in energy metabolism due to acute rotenone-induced mitochondrial complex I dysfunction – an in vivo large animal model. Mitochondrion 31:56-62.	ET	N ROX	Intact cells	Pig	Skeletal muscle Platelet
Maarman 2016 J Appl Physiol (1985)	2016	Maarman GJ, Andrew BM, Blackhurst DM, Ojuka EO (2016) Melatonin protects against uric acid-induced mitochondrial dysfunction, oxidative stress, and triglyceride accumulation in C₂C₁₂ myotubes. J Appl Physiol (1985) 122:1003-10.	LEAK ROUTINE OXPHOS ET	N S CIV NS ROX	Permeabilized cells Intact cells	Mouse	Skeletal muscle
Kang 2016 Elife	2016	Kang Y, Baker MJ, Liem M, Louber J, McKenzie M, Atukorala I, Ang CS, Keerthikumar S, Mathivanan S, Stojanovski D (2016) Tim29 is a novel subunit of the human TIM22 translocase and is involved in complex assembly and stability. Elife 5:e17463.	ROUTINE ET	ROX	Intact cells	Human
Chowdhury 2015 Biosci Rep	2016	Chowdhury SK, Djordjevic J, Albensi B, Fernyhough P (2015) Simultaneous evaluation of substrate-dependent oxygen consumption rates and mitochondrial membrane potential by TMRM and safranin in cortical mitochondria. Biosci Rep 36:e00286.	LEAK OXPHOS ET	N S NS ROX	Homogenate Isolated mitochondria	Mouse	Nervous system
Hancock 2016 Amino Acids	2016	Hancock CN, Liu W, Alvord WG, Phang JM (2016) Co-regulation of mitochondrial respiration by proline dehydrogenase/oxidase and succinate. Amino Acids 48:859-72.	LEAK ROUTINE ET	S Other combinations ROX	Isolated mitochondria Oxidase;biochemical oxidation Intact cells	Mouse	Liver
Perna 2016 Amino Acids	2016	Perna MK, Kokenge AN, Miles KN, Udobi KC, Clark JF, Pyne-Geithman GJ, Khuchua Z, Skelton MR (2016) Creatine transporter deficiency leads to increased whole body and cellular metabolism. Amino Acids 48:2057-65.	LEAK OXPHOS ET	N NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Salvadego 2016 J Appl Physiol (1985)	2016	Salvadego D, Keramidas ME, Brocca L, Domenis R, Mavelli I, Rittweger J, Eiken O, Mekjavic IB, Grassi B (2016) Separate and combined effects of a 10-d exposure to hypoxia and inactivity on oxidative function in vivo and mitochondrial respiration ex vivo in humans. J Appl Physiol (1985) 121:154-63.	LEAK OXPHOS ET	N ROX	Permeabilized tissue	Human	Skeletal muscle
Fisar 2016a Folia Biol (Praha)	2016	Fisar Z, Hroudova J (2016) Pig brain mitochondria as a biological model for study of mitochondrial respiration. Folia Biol (Praha) 62:15-25.	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Pig	Nervous system
Liang 2016 J Biol Chem	2016	Liang X, Liu L, Fu T, Zhou Q, Zhou D, Xiao L, Liu L, Kong Y, Xie H, Yi F, Lai L, Vega RB, Kelly DP, Smith SR, Gan Z (2016) Exercise inducible lactate dehydrogenase B regulates mitochondrial function in skeletal muscle. J Biol Chem 291:25306-18.	LEAK OXPHOS ET	N	Permeabilized tissue	Mouse	Skeletal muscle
Fisar 2016 Curr Alzheimer Res	2016	Fišar Z, Hroudová J, Hansíková H, Spáčilová J, Lelková P, Wenchich L, Jirák R, Zvěřová M, Zeman J, Martásek P, Raboch J (2016) Mitochondrial respiration in the platelets of patients with Alzheimer's disease. Curr Alzheimer Res 13:930-41.	LEAK OXPHOS ET	N S NS ROX	Intact cells Permeabilized cells	Human	Blood cells Platelet
Fisar 2016b Folia Biol (Praha)	2016	Fisar Z, Hroudova J, Singh N, Koprivova A, Maceckova D (2016) Effect of simvastatin, coenzyme Q10, resveratrol, acetylcysteine and acetylcarnitine on mitochondrial respiration. Folia Biol (Praha) 62:53-66.	OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Pig	Nervous system
Grimm 2016 Methods Mol Biol	2016	Grimm A, Schmitt K, Eckert A (2016) Advanced mitochondrial respiration assay for evaluation of mitochondrial dysfunction in Alzheimer's disease. Methods Mol Biol 1303:171-83.	LEAK OXPHOS ET	N CIV ROX	Isolated mitochondria	Mouse	Nervous system
Schiffer 2016 Am J Physiol Cell Physiol	2016	Schiffer TA, Peleli M, Sundqvist ML, Ekblom B, Lundberg JO, Weitzberg E, Larsen FJ (2016) Control of human energy expenditure by cytochrome c oxidase subunit IV-2. Am J Physiol Cell Physiol 311:C452-61.	LEAK OXPHOS ET ROUTINE	N NS	Permeabilized cells Isolated mitochondria Intact cells	Human	Skeletal muscle HEK
Raturi 2016 J Cell Biol	2016	Raturi A, Gutiérrez T, Ortiz-Sandoval C, Ruangkittisakul A, Herrera-Cruz MS, Rockley JP, Gesson K, Ourdev D, Lou PH, Lucchinetti E, Tahbaz N, Zaugg M, Baksh S, Ballanyi K, Simmen T (2016) TMX1 determines cancer cell metabolism as a thiol-based modulator of ER-mitochondria Ca²⁺ flux. J Cell Biol 214:433-44.	LEAK ET ROUTINE		Permeabilized cells Intact cells	Mouse Human	HeLa Other cell lines
Strecker 2016 Biochim Biophys Acta	2016	Strecker V, Kadeer Z, Heidler J, Cruciat CM, Angerer H, Giese H, Pfeiffer K, Stuart RA, Wittig I (2016) Supercomplex-associated Cox26 protein binds to cytochrome c oxidase. Biochim Biophys Acta 1863:1643-52.	ROUTINE ET	ROX	Intact cells	Saccharomyces cerevisiae
Gerber 2016 J Med Genet	2016	Gerber S, Ding MG, Gérard X, Zwicker K, Zanlonghi X, Rio M, Serre V, Hanein S, Munnich A, Rotig A, Bianchi L, Amati-Bonneau P, Elpeleg O, Kaplan J, Brandt U, Rozet JM (2016) Compound heterozygosity for severe and hypomorphic NDUFS2 mutations cause non-syndromic LHON-like optic neuropathy. J Med Genet 54:346-56.	LEAK ROUTINE ET	ROX	Intact cells	Human	Endothelial;epithelial;mesothelial cell Fibroblast
Eisenberg 2016 Nat Med	2016	Eisenberg T, Abdellatif M, Schroeder S, Primessnig U, Stekovic S, Pendl T, Harger A, Schipke J, Zimmermann A, Schmidt A, Tong M, Ruckenstuhl C, Dammbrueck C, Gross AS, Herbst V, Magnes C, Trausinger G, Narath S, Meinitzer A, Hu Z, Kirsch A, Eller K, Carmona-Gutierrez D, Büttner S, Pietrocola F, Knittelfelder O, Schrepfer E, Rockenfeller P, Simonini C, Rahn A, Horsch M, Moreth K, Beckers J, Fuchs H, Gailus-Durner V, Neff F, Janik D, Rathkolb B, Rozman J, de Angelis MH, Moustafa T, Haemmerle G, Mayr M, Willeit P, von Frieling-Salewsky M, Pieske B, Scorrano L, Pieber T, Pechlaner R, Willeit J, Sigrist SJ, Linke WA, Mühlfeld C, Sadoshima J, Dengjel J, Kiechl S, Kroemer G, Sedej S, Madeo F (2016) Cardioprotection and lifespan extension by the natural polyamine spermidine. Nat Med 22:1428-38.	LEAK ET OXPHOS	N ROX	Isolated mitochondria	Mouse	Heart
Safiedeen 2016 Antioxid Redox Signal	2016	Safiedeen Z, Rodríguez-Gómez I, Vergori L, Soleti R, Vaithilingam D, Douma I, Agouni A, Leiber D, Dubois S, Simard G, Zibara K, Andriantsitohaina R, Martínez MC (2016) Temporal cross talk between endoplasmic reticulum and mitochondria regulates oxidative stress and mediates microparticle-induced endothelial dysfunction. Antioxid Redox Signal 26:15-27.	LEAK ET ROUTINE	ROX	Intact cells	Human	Endothelial;epithelial;mesothelial cell
Watala 2016 Int J Pharm	2016	Watala C, Karolczak K, Kassassir H, Siewiera K, Maczynska K, Pieniazek A, Labieniec-Watala M (2016) How do the full-generation poly(amido)amine (PAMAM) dendrimers activate blood platelets? Platelet membrane zeta potential and other membrane-associated phenomena. Int J Pharm 500:379-89.	LEAK ROUTINE ET	ROX	Intact cells	Human	Blood cells Platelet
Nissinen 2016 Sci Rep	2016	Nissinen TA, Degerman J, Räsänen M, Poikonen AR, Koskinen S, Mervaala E, Pasternack A, Ritvos O, Kivelä R, Hulmi JJ (2016) Systemic blockade of ACVR2B ligands prevents chemotherapy-induced muscle wasting by restoring muscle protein synthesis without affecting oxidative capacity or atrogenes. Sci Rep 6:32695.	LEAK OXPHOS ET	N S CIV NS ROX	Homogenate	Mouse	Skeletal muscle
Tyrrell 2016 Redox Biol	2016	Tyrrell DJ, Bharadwaj MS, Jorgensen MJ, Register TC, Molina AJ (2016) Blood cell respirometry is associated with skeletal and cardiac muscle bioenergetics: Implications for a minimally invasive biomarker of mitochondrial health. Redox Biol 10:65-77. https://doi.org/10.1016/j.redox.2016.09.009	OXPHOS LEAK ET	N NS ROX	Permeabilized tissue Isolated mitochondria Intact cells	Other mammals Human	Skeletal muscle Blood cells Platelet
Du 2016 Thesis	2016	Du X (2016) Anthropogenic pollution effects on mitochondrial energy metabolism, gene expression, and genotypes of natural Fundulus heteroclitus populations. Dissertation p175.	LEAK OXPHOS ET	S CIV ROX N NS	Permeabilized cells	Fishes	Liver
Chen 2016 Nat Chem Biol	2016	Chen YJ, Mahieu NG, Huang X, Singh M, Crawford PA, Johnson SL, Gross RW, Schaefer J, Patti GJ (2016) Lactate metabolism is associated with mammalian mitochondria. Nat Chem Biol 12:937-43.	LEAK OXPHOS ET	N NS ROX	Isolated mitochondria	Human	HeLa
Amigo 2016 Aging Cell	2016	Amigo I, Menezes-Filho SL, Luévano-Martínez LA, Chausse B, Kowaltowski AJ (2016) Caloric restriction increases brain mitochondrial calcium retention capacity and protects against excitotoxicity. Aging Cell 16:73-81.	LEAK OXPHOS ET	N S	Isolated mitochondria	Mouse	Nervous system
Drehmer 2016 Stem Cell Res	2016	Drehmer DL, de Aguiar AM, Brandt AP, Petiz L, Cadena SM, Rebelatto CK, Brofman PR, Filipak Neto F, Dallagiovanna B, Abud AP (2016) Metabolic switches during the first steps of adipogenic stem cells differentiation. Stem Cell Res 17:413-421.	LEAK ROUTINE ET	ROX	Intact cells	Human	Fat Stem cells
Smith 2016 Diabetes	2016	Smith BK, Ford RJ, Desjardins EM, Green AE, Hughes MC, Houde VP, Day EA, Marcinko K, Crane JD, Mottillo EP, Perry CG, Kemp BE, Tarnopolsky MA, Steinberg GR (2016) Salsalate (Salicylate) uncouples mitochondria, improves glucose homeostasis, and reduces liver lipids independent of AMPK β1. Diabetes 65:3352-61.	LEAK OXPHOS ET	F N NS Other combinations ROX	Permeabilized cells Isolated mitochondria Permeabilized tissue	Mouse	Skeletal muscle Liver Fat
Davuluri 2016 J Physiol	2016	Davuluri G, Allawy A, Thapaliya S, Rennison JH, Singh D, Kumar A, Sandlers Y, Van Wagoner DR, Flask CA, Hoppel C, Kasumov T, Dasarathy S (2016) Hyperammonaemia-induced skeletal muscle mitochondrial dysfunction results in cataplerosis and oxidative stress. J Physiol 594:7341-60.	LEAK ROUTINE ET	ROX	Intact cells	Mouse	Skeletal muscle Other cell lines
Galli 2016 Am J Physiol Regul Integr Comp Physiol	2016	Galli GL, Crossley J, Elsey RM, Dzialowski EM, Shiels HA, Crossley DA 2nd (2016) Developmental plasticity of mitochondrial function in American alligators, Alligator mississippiensis. Am J Physiol Regul Integr Comp Physiol 311:R1164-72.	LEAK OXPHOS ET	N S CIV Other combinations ROX	Isolated mitochondria	Reptiles	Heart
Berschneider 2016 Thesis	2016	Berschneider K (2016) Connecting the functions of the proteasome and mitochondria in the lung. Dissertation p161.	LEAK ROUTINE ET	ROX	Permeabilized cells	Mouse	Lung;gill
McFarlane 2016 Thesis	2016	McFarlane SV (2016) Temperature-dependent alterations of brown adipose tissue metabolism during hibernation in the thirteen-lined ground squirrel, Ictidomys tridecemlineatus. Dissertation p74.	LEAK ROUTINE OXPHOS ET	F N	Isolated mitochondria Intact cells	Other mammals	Fat
Stier 2016 Methods Ecol Evol	2016	Stier A, Romestaing C, Schull Q, Lefol E, Robin JP, Roussel D, Bize P (2016) How to measure mitochondrial function in birds using red blood cells: a case study in the king penguin and perspectives in ecology and evolution. Methods Ecol Evol doi:10.1111/2041-210X.12724.	LEAK ROUTINE OXPHOS ET	N S ROX	Permeabilized tissue Intact cells	Birds	Skeletal muscle Blood cells
Porter 2016 Cell Metab	2016	Porter C, Herndon DN, Chondronikola M, Chao T, Annamalai P, Bhattarai N, Saraf MK, Capek KD, Reidy PT, Daquinag AC, Kolonin MG, Rasmussen BB, Borsheim E, Toliver-Kinsky T, Sidossis LS (2016) Human and mouse brown adipose tissue mitochondria have comparable UCP1 function. Cell Metab 24:246-55.	LEAK OXPHOS ET	F N NS Other combinations	Permeabilized tissue	Human Mouse	Skeletal muscle Fat
Brandt 2016 Chem Biol Interact	2016	Brandt AP, Gozzi GJ, Pires Ado R, Martinez GR, Dos Santos Canuto AV, Echevarria A, Di Pietro A, Cadena SM (2016) Impairment of oxidative phosphorylation increases the toxicity of SYD-1 on hepatocarcinoma cells (HepG2). Chem Biol Interact 256:154-60.	LEAK ROUTINE ET	ROX	Intact cells	Human	Liver Other cell lines
Liu 2016 EMBO Mol Med	2016	Liu J, Liang X, Zhou D, Lai L, Xiao L, Liu L, Fu T, Kong Y, Zhou Q, Vega RB, Zhu MS, Kelly DP, Gao X, Gan Z (2016) Coupling of mitochondrial function and skeletal muscle fiber type by a miR-499/Fnip1/AMPK circuit. EMBO Mol Med 8:1212-1228.	LEAK OXPHOS ET	N ROX	Permeabilized cells Permeabilized tissue	Mouse	Skeletal muscle
Granata 2016 FASEB J	2016	Granata C, Oliveira RS, Little JP, Renner K, Bishop DJ (2016) Mitochondrial adaptations to high-volume exercise training are rapidly reversed after a reduction in training volume in human skeletal muscle. FASEB J 30:3413-23. https://doi.org/10.1096/fj.201500100R	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized tissue	Human	Skeletal muscle
Rackham 2016 Cell Rep	2016	Rackham O, Busch JD, Matic S, Siira SJ, Kuznetsova I, Atanassov I, Ermer JA, Shearwood AM, Richman TR, Stewart JB, Mourier A, Milenkovic D, Larsson NG, Filipovska A (2016) Hierarchical RNA processing is required for mitochondrial ribosome assembly. Cell Rep 16:1874-90.	LEAK OXPHOS ET	N S CIV NS Other combinations	Isolated mitochondria	Mouse	Heart
Hartmannova 2016 Hum Mol Genet	2016	Hartmannová H, Piherová L, Tauchmannová K, Kidd K, Acott PD, Crocker JF, Oussedik Y, Mallet M, Hodaňová K, Stránecký V, Přistoupilová A, Barešová V, Jedličková I, Živná M, Sovová J, Hůlková H, Robins V, Vrbacký M, Pecina P, Kaplanová V, Houštěk J, Mráček T, Thibeault Y, Bleyer AJ, Kmoch S (2016) Acadian variant of Fanconi syndrome is caused by mitochondrial respiratory chain complex I deficiency due to a non-coding mutation in complex I assembly factor NDUFAF6. Hum Mol Genet 25:4062-79.	LEAK OXPHOS ET	N S Gp CIV NS ROX	Permeabilized cells	Human	Fibroblast
Reich 2016 Thesis	2016	Reich V (2016) Pathophysiologie und Verfahrensentwicklung: Mechanismen der Metabolisierung von Schwefelwasserstoff im mitochondrialen Atmungskreislauf von Lungenalveolarmakrophagen. Dissertation p91.	LEAK OXPHOS ET	N S CIV NS ROX	Intact cells Permeabilized cells	Mouse	Macrophage-derived
Mills 2016 Cell Metab	2016	Mills KF, Yoshida S, Stein LR, Uchida K, Yoshino J, Imai SI (2016) Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice. Cell Metab 24:1–12.	OXPHOS LEAK ET	N S NS	Permeabilized tissue	Mouse	Skeletal muscle
McCourt 2016 PLOS ONE	2016	McCourt AC, Jakobsson L, Larsson S, Holm C, Piel S, Elmér E, Björkqvist M (2016) White adipose tissue browning in the R6/2 mouse model of Huntington's disease. PLOS ONE 11:e0159870.	LEAK OXPHOS ET	NS ROX	Permeabilized cells	Mouse	Fat
Kilbaugh 2016 Mitochondrion	2016	Kilbaugh TJ, Karlsson M, Duhaime AC, Hansson MJ, Elmer E, Margulies SS (2016) Mitochondrial response in a toddler-aged swine model following diffuse non-impact traumatic brain injury. Mitochondrion 26:19-25.	LEAK OXPHOS ET	N S CIV NS ROX	Homogenate	Pig	Nervous system
Khattar 2016 J Neurosci Methods	2016	Khattar NK, Yablonska S, Baranov SV, Baranova OV, Kretz ES, Larkin TM, Carlisle DL, Richardson RM, Friedlander RM (2016) Isolation of functionally active and highly purified neuronal mitochondria from human cortex. J Neurosci Methods 263:1-6.	LEAK OXPHOS ET	N	Isolated mitochondria	Human Mouse	Nervous system
Heimer 2016 Am J Hum Genet	2016	Heimer G, Kerätär JM, Riley LG, Balasubramaniam S, Eyal E, Pietikäinen LP, Hiltunen JK, Marek-Yagel D, Hamada J, Gregory A, Rogers C, Hogarth P, Nance MA, Shalva N, Veber A, Tzadok M, Nissenkorn A, Tonduti D, Renaldo F, Kraoua I, Panteghini C, Valletta L, Garavaglia B, Cowley MJ, Gayevskiy V, Roscioli T, Silberstein JM, Hoffmann C, Raas-Rothschild A, Tiranti V, Anikster Y, Christodoulou J, Kastaniotis AJ, Ben-Zeev B, Hayflick SJ (2016) MECR mutations cause childhood-onset dystonia and optic atrophy, a mitochondrial fatty acid synthesis disorder. Am J Hum Genet 99:1229-44.	LEAK ROUTINE ET	ROX	Intact cells	Human	Fibroblast
Brecht 2016 Toxicol In Vitro	2016	Brecht K, Riebel V, Couttet P, Paech F, Wolf A, Chibout SD, Pognan F, Krähenbühl S, Uteng M (2016) Mechanistic insights into selective killing of OXPHOS-dependent cancer cells by arctigenin. Toxicol In Vitro 40:55-65.	LEAK OXPHOS ET	N S CIV Other combinations ROX DQ	Permeabilized cells	Human	Islet cell;pancreas;thymus
Szczepanowska 2016 EMBO J	2016	Szczepanowska K, Maiti P, Kukat A, Hofsetz E, Nolte H, Senft K, Becker C, Ruzzenente B, Hornig-Do HT, Wibom R, Wiesner RJ, Krüger M, Trifunovic A (2016) CLPP coordinates mitoribosomal assembly through the regulation of ERAL1 levels. EMBO J 35:2566-83.	LEAK OXPHOS ET	N NS	Isolated mitochondria	Mouse	Heart
Duteil 2016 Cell Rep	2016	Duteil D, Tosic M, Lausecker F, Nenseth HZ, Müller JM, Urban S, Willmann D, Petroll K, Messaddeq N, Arrigoni L, Manke T, Kornfeld JW, Brüning JC, Zagoriy V, Meret M, Dengjel J, Kanouni T, Schüle R (2016) Lsd1 ablation triggers metabolic reprogramming of brown adipose tissue. Cell Rep 17:1008-21.	ET	F N S NS	Permeabilized tissue	Mouse	Fat
Valenzuela 2016 Cell Death Dis	2016	Valenzuela R, Costa-Besada MA, Iglesias-Gonzalez J, Perez-Costas E, Villar-Cheda B, Garrido-Gil P, Melendez-Ferro M, Soto-Otero R, Lanciego JL, Henrion D, Franco R, Labandeira-Garcia JL (2016) Mitochondrial angiotensin receptors in dopaminergic neurons. Role in cell protection and aging-related vulnerability to neurodegeneration. Cell Death Dis 7:e2427.	OXPHOS ET	N	Isolated mitochondria	Mouse Rat	Nervous system
Van Schaardenburgh 2016 PLOS ONE	2016	van Schaardenburgh M, Wohlwend M, Rognmo Ø, Mattsson EJ (2016) Mitochondrial respiration after one session of calf raise exercise in patients with peripheral vascular disease and healthy older adults. PLOS ONE 11:e0165038.	LEAK OXPHOS ET	F N S NS	Permeabilized tissue	Human	Skeletal muscle
Macheiner 2016 Sci Rep	2016	Macheiner T, Fengler VH, Agreiter M, Eisenberg T, Madeo F, Kolb D, Huppertz B, Ackbar R, Sargsyan K (2016) Magnetomitotransfer: An efficient way for direct mitochondria transfer into cultured human cells. Sci Rep 6:35571.	LEAK ROUTINE ET	ROX		Human	Fibroblast Lung;gill
McCurdy 2016 JCI Insight	2016	McCurdy CE, Schenk S, Hetrick B, Houck J, Drew BG, Kaye S, Lashbrook M, Bergman BC, Takahashi DL, Dean TA, Nemkov T, Gertsman I, Hansen KC, Philp A, Hevener AL, Chicco AJ, Aagaard KM, Grove KL, Friedman JE (2016) Maternal obesity reduces oxidative capacity in fetal skeletal muscle of Japanese macaques. JCI Insight 1:e86612.	LEAK OXPHOS ET	F N S NS	Permeabilized tissue	Other mammals	Skeletal muscle
Lukasiak 2016 Eur J Pharmacol	2016	Łukasiak A, Skup A, Chlopicki S, Łomnicka M, Kaczara P, Proniewski B, Szewczyk A, Wrzosek A (2016) SERCA, complex I of the respiratory chain and ATP-synthase inhibition are involved in pleiotropic effects of NS1619 on endothelial cells. Eur J Pharmacol 786:137-47.	ROUTINE ET	Other combinations	Intact cells	Human	Other cell lines Endothelial;epithelial;mesothelial cell
Pravenec 2016 Physiol Genomics	2016	Pravenec M, Mlejnek P, Zídek V, Landa V, Šimáková M, Šilhavý J, Strnad H, Eigner S, Eigner Henke K, Škop V, Malínská H, Trnovská J, Kazdová L, Drahota Z, Mráček T, Houštěk J (2016) Autocrine effects of transgenic resistin reduce palmitate and glucose oxidation in brown adipose tissue. Physiol Genomics 48:420-7.	ET	F N	Isolated mitochondria	Rat	Fat
Dechandt 2016 Anal Biochem	2016	Dechandt CRP, Couto-Lima CA, Alberici LC (2016) Triglyceride depletion of brown adipose tissue enables analysis of mitochondrial respiratory function in permeabilized biopsies. Anal Biochem 515:55-60.	LEAK OXPHOS ET	N S ROX	Permeabilized tissue	Rat	Fat
Wos 2016 Arch Biochem Biophys	2016	Woś M, Szczepanowska J, Pikuła S, Tylki-Szymańska A, Zabłocki K, Bandorowicz-Pikuła J (2016) Mitochondrial dysfunction in fibroblasts derived from patients with Niemann-Pick type C disease. Arch Biochem Biophys 593:50-9.	LEAK ROUTINE ET		Intact cells	Human	Endothelial;epithelial;mesothelial cell Fibroblast
Pohland 2016 Neurochem Res	2016	Pohland M, Hagl S, Pellowska M, Wurglics M, Schubert-Zsilavecz M, Eckert GP (2016) MH84: a novel γ-secretase modulator/PPARγ agonist-improves mitochondrial dysfunction in a cellular model of Alzheimer's disease. Neurochem Res 41:231-42.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized cells	Human	Kidney HEK
Asseburg 2016 Neuromolecular Med	2016	Asseburg H, Schäfer C, Müller M, Hagl S, Pohland M, Berressem D, Borchiellini M, Plank C, Eckert GP (2016) Effects of grape skin extract on age-related mitochondrial dysfunction, memory and life span in C57BL/6J mice. Neuromolecular Med 18:378-95.	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Mouse	Nervous system
Silva Ramos 2016 Biochim Biophys Acta	2016	Silva Ramos E, Larsson NG, Mourier A (2016) Bioenergetic roles of mitochondrial fusion. Biochim Biophys Acta 1857:1277-83.	LEAK OXPHOS ET	S Gp	Permeabilized cells	Mouse	Fibroblast
MiPNet17.03 Shredder vs Fibers	2015-06-18	Mitochondrial respiration in permeabilized fibers versus homogenate from fish liver and heart. An application study with the PBI-Shredder.	LEAK OXPHOS ET	N S NS	Homogenate	Fishes	Heart Liver
Dueregger 2015 PLoS One	2015	Dueregger A, Schöpf B, Eder T, Höfer J, Gnaiger E, Aufinger A, Kenner L, Perktold B, Ramoner R, Klocker H, Eder IE (2015) Differential utilization of dietary fatty acids in benign and malignant cells of the prostate. PLoS One 10(8):e0135704.	LEAK ROUTINE OXPHOS ET	F N NS ROX	Permeabilized cells Permeabilized tissue	Human	Genital Other cell lines
Hanssen 2015 Nat Med	2015	Hanssen MJ, Hoeks J, Brans B, van der Lans AA, Schaart G, van den Driessche JJ, Jörgensen JA, Boekschoten MV, Hesselink MK, Havekes B, Kersten S, Mottaghy FM, van Marken Lichtenbelt WD, Schrauwen P (2015) Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus. Nat Med 21:863-5.	LEAK OXPHOS ET	F N NS Other combinations	Permeabilized tissue	Human	Skeletal muscle
Zhunussova 2015 Am J Cancer Res	2015	Zhunussova A, Sen B, Friedman L, Tuleukhanov S, Brooks AD, Sensenig R, Orynbayeva Z (2015) Tumor microenvironment promotes dicarboxylic acid carrier-mediated transport of succinate to fuel prostate cancer mitochondria. Am J Cancer Res 5:1665-79.	ROUTINE ET	S	Permeabilized cells Intact cells	Human Rat	Endothelial;epithelial;mesothelial cell Genital Other cell lines
Khera 2015 Placenta	2015	Khera A, Dong LF, Holland OJ, Vanderlelie J, Pasdar EA, Neuzil J, Perkins AV (2015) Selenium supplementation induces mitochondrial biogenesis in trophoblasts. Placenta 36:863-9.	LEAK ROUTINE OXPHOS ET	N S CIV	Permeabilized cells Intact cells	Human	Genital Other cell lines
Kilbaugh 2015 Exp Neurol	2015	Kilbaugh TJ, Karlsson M, Byro M, Bebee A, Ralston J, Sullivan S, Duhaime AC, Hansson MJ, Elmér E, Margulies SS (2015) Mitochondrial bioenergetic alterations after focal traumatic brain injury in the immature brain. Exp Neurol 271:136-144.	LEAK ROUTINE OXPHOS ET	N S CIV NS ROX	Permeabilized tissue Homogenate	Pig	Nervous system
Du 2015 Aquat Toxicol	2015	Du X, Crawford DL, Oleksiak MF (2015) Effects of anthropogenic pollution on the oxidative phosphorylation pathway of hepatocytes from natural populations of Fundulus heteroclitus. Aquat Toxicol 165:231-40.	LEAK OXPHOS ET	N S CIV ROX	Permeabilized cells	Fishes	Liver
Kelly 2015 Biotechnol J	2015	Kelly PS, Breen L, Gallagher C, Kelly S, Henry M, Lao NT, Meleady P, O'Gorman D, Clynes M, Barron N (2015) Re-programming CHO cell metabolism using miR-23 tips the balance towards a highly productive phenotype. Biotechnol J 10:1029-40.	LEAK ROUTINE OXPHOS ET	N S CIV NS ROX	Intact cells Permeabilized cells		CHO
Hezel 2015 Redox Biol	2015	Hezel MP, Liu M, Schiffer TA, Larsen FJ, Checa A, Wheelock CE, Carlström M, Lundberg JO, Weitzberg E (2015) Effects of long-term dietary nitrate supplementation in mice. Redox Biol 5:234-42.	LEAK OXPHOS ET	N	Isolated mitochondria	Mouse	Skeletal muscle
Fouret 2015 Biochim Biophys Acta	2015	Fouret G, Tolika E, Lecomte J, Bonafos B, Aoun M, Murphy MP, Ferreri C, Chatgilialoglu C, Dubreucq E, Coudray C, Feillet-Coudray C (2015) The mitochondrial-targeted antioxidant, MitoQ, increases liver mitochondrial cardiolipin content in obesogenic diet-fed rats. Biochim Biophys Acta 1847:1025-35.	OXPHOS ET	NS	Isolated mitochondria	Rat	Liver
Orynbayeva 2015 Nanomedicine (Lond)	2015	Orynbayeva Z, Sensenig R, Polyak B (2015) Metabolic and structural integrity of magnetic nanoparticle-loaded primary endothelial cells for targeted cell therapy. Nanomedicine (Lond) 10:1555-68.	LEAK ROUTINE ET	ROX	Intact cells	Rat	Endothelial;epithelial;mesothelial cell
Senyilmaz 2015 Nature	2015	Senyilmaz D, Virtue S, Xu X, Tan CY, Griffin JL, Miller AK, Vidal-Puig A, Teleman AA (2015) Regulation of mitochondrial morphology and function by stearoylation of TFR1. Nature 525:124-8.	OXPHOS ET	N S CIV NS	Permeabilized tissue	Drosophila
Zelenka 2015 Oxid Med Cell Longev	2015	Zelenka J, Dvořák A, Alán L (2015) L-lactate protects skin fibroblasts against aging-associated mitochondrial dysfunction via mitohormesis. Oxid Med Cell Longev 2015:351698.	LEAK ROUTINE ET	N S	Isolated mitochondria Intact cells	Rat	Liver Endothelial;epithelial;mesothelial cell Fibroblast
Konopka 2015 Diabetes	2015	Konopka AR, Asante A, Lanza IR, Robinson MM, Johnson ML, Dalla Man C, Cobelli C, Amols MH, Irving BA, Nair KS (2015) Defects in mitochondrial efficiency and H₂O₂ emissions in obese women are restored to a lean phenotype with aerobic exercise training. Diabetes 64:2104-15.	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Human	Skeletal muscle
Li 2015 Sci Rep	2015	Li P, Wang B, Sun F, Li Y, Li Q, Lang H, Zhao Z, Gao P, Zhao Y, Shang Q, Liu D, Zhu Z (2015) Mitochondrial respiratory dysfunctions of blood mononuclear cells link with cardiac disturbance in patients with early-stage heart failure. Sci Rep 5:10229.	LEAK ROUTINE OXPHOS ET	N S NS	Intact cells	Human	Blood cells Lymphocyte
Schwarzkopf 2015 Neuroscience	2015	Schwarzkopf TM, Koch K, Klein J (2015) Reduced severity of ischemic stroke and improvement of mitochondrial function after dietary treatment with the anaplerotic substance triheptanoin. Neuroscience 300:201-9.	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Mouse	Nervous system
Labieniec-Watala 2015 Int J Pharm Sci Res	2015	Labieniec-Watala M, Przygodzki T, Siewiera K, Podsedek A, Watala C (2015) Facts and artifacts in the evaluation of the anti-diabetic activity of spent hop extract in rat hearts in the “experimental model of diabetes. Int J Pharm Sci Res 1:106.	LEAK OXPHOS ET	S ROX	Isolated mitochondria	Rat	Heart
Lourenco 2015 Front Aging Neurosci	2015	Lourenço CF, Ledo A, Dias C, Barbosa RM, Laranjinha J (2015) Neurovascular and neurometabolic derailment in aging and Alzheimer's disease. Front Aging Neurosci 7:103.	ROUTINE ET	ROX	Intact cells	Mouse	Nervous system
Yan 2015 BMC Cancer	2015	Yan B, Stantic M, Zobalova R, Bezawork-Geleta A, Stapelberg M, Stursa J, Prokopova K, Dong L, Neuzil J (2015) Mitochondrially targeted vitamin E succinate efficiently kills breast tumour-initiating cells in a complex II-dependent manner. BMC Cancer 15:401.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human Mouse	Genital Other cell lines
Kluckova 2015 Cell Death Dis	2015	Kluckova K, Sticha M, Cerny J, Mracek T, Dong L, Drahota Z, Gottlieb E, Neuzil J, Rohlena J (2015) Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation. Cell Death Dis 6:e1749.	OXPHOS ET	S ROX	Permeabilized cells Isolated mitochondria	Other mammals	Lung;gill Other cell lines Fibroblast
Pasdar 2015 PLoS One	2015	Pasdar EA, Smits M, Stapelberg M, Bajzikova M, Stantic M, Goodwin J, Yan B, Stursa J, Kovarova J, Sachaphibulkij K, Bezawork-Geleta A, Sobol M, Filimonenko A, Tomasetti M, Zobalova R, Hozak P, Dong LF, Neuzil J (2015) Characterisation of mesothelioma-initiating cells and their susceptibility to anti-cancer agents. PLoS One 10:e0119549.	LEAK ROUTINE OXPHOS ET	N S NS	Permeabilized cells Intact cells	Human Mouse	Endothelial;epithelial;mesothelial cell Other cell lines
Ramos-Filho 2015 PLoS One	2015	Ramos-Filho D, Chicaybam G, de-Souza-Ferreira E, Guerra Martinez C, Kurtenbach E, Casimiro-Lopes G, Galina A (2015) High intensity interval training (HIIT) induces specific changes in respiration and electron leakage in the mitochondria of different rat skeletal muscles. PLoS One 10:e0131766.	LEAK OXPHOS ET	F N S Gp NS ROX	Permeabilized tissue	Rat	Skeletal muscle
Smolkova 2015 Int J Biochem Cell Biol	2015	Smolková K, Dvořák A, Zelenka J, Vítek L, Ježek P (2015) Reductive carboxylation and 2-hydroxyglutarate formation by wild-type IDH2 in breast carcinoma cells. Int J Biochem Cell Biol 65:125-33.	LEAK ROUTINE ET	ROX	Intact cells	Human	Endothelial;epithelial;mesothelial cell Other cell lines
Koliaki 2015 Cell Metab	2015	Koliaki C, Szendroedi J, Kaul K, Jelenik T, Nowotny P, Jankowiak F, Herder C, Carstensen M, Krausch M, Knoefel WT, Schlensak M, Roden M (2015) Adaptation of hepatic mitochondrial function in humans with non-alcoholic fatty liver is lost in steatohepatitis. Cell Metab 21:739-46.	LEAK OXPHOS ET	F N NS Other combinations ROX	Homogenate Isolated mitochondria	Human	Liver
Ikaga 2015 Biochem Biophys Rep	2015	Ikaga R, Namekatac I, Kotiadisd VN, Ogawab H, Duchend MR, Tanakac H, Iida-Tanakab N (2015) Knockdown of aquaporin-8 induces mitochondrial dysfunction in 3T3-L1 cells. Biochem Biophys Rep 4:187–95.	LEAK ROUTINE ET	CIV ROX	Intact cells	Mouse	Fat Other cell lines
Cell ergometry	2015	Gnaiger E (2015) Cell ergometry and OXPHOS. Mitochondr Physiol Network 2015-01-18.	LEAK OXPHOS ET	N S NS ROX
Lehtola 2015 Master's Thesis	2015	Lehtola A (2015) Main protein component of high density lipoprotein, apolipoprotein A1, modulates leukocyte cell respiration. Master's Thesis 1-44.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Intact cells Permeabilized cells	Human	Blood cells Other cell lines Lymphocyte
Cassina 2015 Biol Reprod	2015	Cassina AM, Silveira P, Cantu L, Montes JM, Radi R, Sapiro R (2015) Defective human sperm cells are associated with mitochondrial dysfunction and oxidant production. Biol Reprod 93:119.	LEAK ROUTINE ET	ROX		Human	Genital
Kilbaugh 2015 J Am Heart Assoc	2015	Kilbaugh TJ, Sutton RM, Karlsson M, Hansson MJ, Naim MY, Morgan RW, Bratinov G, Lampe JW, Nadkarni VM, Becker LB, Margulies SS, Berg RA (2015) Persistently altered brain mitochondrial bioenergetics after apparently successful resuscitation from cardiac arrest. J Am Heart Assoc 4(9) pii: e002232.	LEAK OXPHOS ET	N S CIV NS ROX	Homogenate	Pig	Nervous system
Montero 2015 J Physiol	2015	Montero D, Cathomen A, Jacobs RA, Flück D, de Leur J, Keiser S, Bonne T, Kirk N, Lundby AK, Lundby C (2015) Haematological rather than skeletal muscle adaptations contribute to the increase in peak oxygen uptake induced by moderate endurance training. J Physiol 593:4677-88.	OXPHOS ET		Permeabilized tissue	Human	Skeletal muscle
Hagl 2015 Neurochem Int	2015	Hagl S, Kocher A, Schiborr C, Kolesova N, Frank J, Eckert GP (2015) Curcumin micelles improve mitochondrial function in neuronal PC12 cells and brains of NMRI mice - Impact on bioavailability. Neurochem Int 89:234-42.	LEAK OXPHOS ET	N S CIV	Isolated mitochondria	Mouse	Nervous system
Hagl 2015 Molecules	2015	Hagl S, Berressem D, Bruns B, Sus N, Frank J, Eckert GP (2015) Beneficial Effects of Ethanolic and Hexanic Rice Bran Extract on Mitochondrial Function in PC12 Cells and the Search for Bioactive Components. Molecules 20(9):16524-39.	LEAK ROUTINE OXPHOS ET	N S CIV NS ROX	Permeabilized cells	Rat	Nervous system Other cell lines
Negmadjanov 2015 PLOS ONE	2015	Negmadjanov U, Godic Z, Rizvi F, Emelyanova L, Ross G, Richards J, Holmuhamedov EL, Jahangir A (2015) TGF-β1-mediated differentiation of fibroblasts is associated with increased mitochondrial content and cellular respiration. PLOS ONE 10:e0123046. doi: 10.1371/journal.pone.0123046.	LEAK ROUTINE ET	ROX		Mouse	Fibroblast
Six 2015 Cell Death Dis	2015	Six E, Lagresle-Peyrou C, Susini S, De Chappedelaine C, Sigrist N, Sadek H, Chouteau M, Cagnard N, Fontenay M, Hermine O, Chomienne C, Reynier P, Fischer A, André-Schmutz I, Gueguen N, Cavazzana M (2015) AK2 deficiency compromises the mitochondrial energy metabolism required for differentiation of human neutrophil and lymphoid lineages. Cell Death Dis 6:e1856.	LEAK ROUTINE ET	ROX	Intact cells	Human	Blood cells Other cell lines
Garama 2015 Mol Cell Biol	2015	Garama DJ, Harris TJ, White CL, Rossello FJ, Abdul-Hay M, Gough DJ, Levy DE (2015) A synthetic lethal interaction between glutathione synthesis and mitochondrial reactive oxygen species provides a tumor-specific vulnerability dependent on STAT3. Mol Cell Biol 35:3646-56.	LEAK ROUTINE ET		Intact cells	Mouse	Endothelial;epithelial;mesothelial cell Fibroblast
Errea 2015 J Neuroinflammation	2015	Errea O, Moreno B, Gonzalez-Franquesa A, Garcia-Roves PM, Villoslada P (2015) The disruption of mitochondrial axonal transport is an early event in neuroinflammation. J Neuroinflammation 12:152.	LEAK OXPHOS ET	N S CIV NS ROX	Homogenate	Mouse	Nervous system
Sundstroem 2015 PhD Thesis	2015	Sundstrøm T (2015) Experimental modeling and novel therapeutic strategies in melanoma brain metastasis. PhD Thesis 1-146.	ET	N S NS ROX		Mouse	Nervous system
Cahill 2015 J Biol Chem	2015	Cahill TJ, Leo V, Kelly M, Stockenhuber A, Kennedy NW, Bao L, Cereghetti G, Harper AR, Czibik G, Lao C, Bellahcene M, Steeples V, Ghaffari S, Yavari A, Mayer A, Poulton J, Ferguson D, Scorrano L, Hettiarachchi NT, Peers C, Boyle J, Hill RB, Simmons A, Watkins H, Dear TN, Ashrafian H (2015) Resistance of dynamin-related protein 1 oligomers to disassembly impairs mitophagy resulting in myocardial inflammation and heart failure. J Biol Chem 290:25907-19.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Mouse	Heart
Imran 2015 J Neurochem	2015	Imran I, Hillert MH, Klein J (2015) Early metabolic responses to lithium/pilocarpine-induced status epilepticus in rat brain. J Neurochem 135:1007-18.	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Rat	Nervous system
Hwang 2015 EMBO Mol Med	2015	Hwang S, Disatnik MH, Mochly-Rosen D (2015) Impaired GAPDH-induced mitophagy contributes to the pathology of Huntington's disease. EMBO Mol Med 7:1307-26.	LEAK OXPHOS ET	ROX	Intact cells	Rat	Nervous system Other cell lines
Houben 2015 Mitochondrion	2015	Houben R, Leleu C, Fraipont A, Serteyn D, Votion DM (2015) Determination of muscle mitochondrial respiratory capacity in Standardbred racehorses as an aid to predicting exertional rhabdomyolysis. Mitochondrion 24:99-104.	OXPHOS ET	N S NS ROX	Permeabilized tissue	Horse	Skeletal muscle
Kawalec 2015 PLoS One	2015	Kawalec M, Boratyńska-Jasińska A, Beręsewicz M, Dymkowska D, Zabłocki K, Zabłocka B (2015) Mitofusin 2 deficiency affects energy metabolism and mitochondrial biogenesis in MEF cells. PLoS One 10:e0134162.	LEAK ROUTINE ET		Permeabilized cells	Mouse	Fibroblast
Schoettl 2015 Mol Metab	2015	Schöttl T, Kappler L, Fromme T, Klingenspor M (2015) Limited OXPHOS capacity in white adipocytes is a hallmark of obesity in laboratory mice irrespective of the glucose tolerance status. Mol Metab 4:631-42.	LEAK ROUTINE OXPHOS ET	F N S ROX	Isolated mitochondria Intact cells	Mouse	Fat Other cell lines
Madsen 2015 Nat Commun	2015	Madsen CT, Sylvestersen KB, Young C, Larsen SC, Poulsen JW, Andersen MA, Palmqvist EA, Hey-Mogensen M, Jensen PB, Treebak JT, Lisby M, Nielsen ML (2015) Biotin starvation causes mitochondrial protein hyperacetylation and partial rescue by the SIRT3-like deacetylase Hst4p. Nat Commun 6:7726.	ROUTINE ET		Intact cells	Saccharomyces cerevisiae
Ortiz 2015 J Pineal Res	2015	Ortiz F, Acuña-Castroviejo D, Doerrier C, Dayoub JC, López LC, Venegas C, García JA, López A, Volt H, Luna-Sánchez M, Escames G (2015) Melatonin blunts the mitochondrial/NLRP3 connection and protects against radiation-induced oral mucositis. J Pineal Res 58:34-49.	LEAK OXPHOS ET	N S	Homogenate Isolated mitochondria
Cagnone 2015 Methods Mol Biol	2015	Cagnone G, Vaghjiani V, Lee W, Sun C, Johnson J, Yeung KY, St John JC (2015) Analysis of the mitochondrial DNA and its replicative capacity in induced pluripotent stem cells. Methods Mol Biol 1357:231-67.	LEAK ROUTINE ET	ROX	Intact cells	Human	Stem cells
Tyrrell 2015 Exp Gerontol	2015	Tyrrell DJ, Bharadwaj MS, Van Horn CG, Marsh AP, Nicklas BJ, Molina AJ (2015) Blood-cell bioenergetics are associated with physical function and inflammation in overweight/obese older adults. Exp Gerontol 70:84-91.	LEAK ET		Intact cells	Human	Blood cells Lymphocyte
Ping 2015 Oxid Med Cell Longev	2015	Ping Z, Zhang LF, Cui YJ, Chang YM, Jiang CW, Meng ZZ, Xu P, Liu HY, Wang DY, Cao XB (2015) The protective effects of Salidroside from exhaustive exercise-induced heart injury by enhancing the PGC-1𝛼–NRF1/NRF2 pathway and mitochondrial respiratory function in rats. Oxid Med Cell Longev Article ID 876825.	OXPHOS ET	N S CIV ROX	Permeabilized tissue	Rat	Heart
Keane 2015 Clin Sci (Lond)	2015	Keane KN, Calton EK, Cruzat VF, Soares MJ, Newsholme P (2015) The impact of cryopreservation on human peripheral blood leukocyte bioenergetics. Clin Sci (Lond) 128:723–33.	ROUTINE ET		Intact cells	Human	Blood cells
Hasli 2015 Master Thesis	2015	Hasli PR (2015) Characterization of mitochondrial respiration and quality differences in diploid and triploid Atlantic salmon (Salmo salar L.) at 5 °C, 10 °C and 15 °C. Master Thesis:1-147.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue Homogenate	Fishes	Heart Skeletal muscle
Iftikar 2015 Comp Biochem Physiol A Mol Integr Physiol	2015	Iftikar FI, Morash AJ, Cook DG, Herbert NA, Hickey AJ (2015) Temperature acclimation of mitochondria function from the hearts of a temperate wrasse (Notolabrus celidotus). Comp Biochem Physiol A Mol Integr Physiol 184:46-55.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized tissue	Fishes	Heart
Schoettl 2015 Endocrinology	2015	Schöttl T, Kappler L, Braun K, Fromme T, Klingenspor M (2015) Limited mitochondrial capacity of visceral versus subcutaneous white adipocytes in male C57BL/6N mice. Endocrinology 156:923-33.	LEAK ROUTINE OXPHOS ET	N S ROX	Permeabilized cells Isolated mitochondria Intact cells	Mouse	Fat
Mourier 2015 J Cell Biol	2015	Mourier A, Motori E, Brandt T, Lagouge M, Atanassov I, Galinier A, Rappl G, Brodesser S, Hultenby K, Dieterich C, Larsson NG (2015) Mitofusin 2 is required to maintain mitochondrial coenzyme Q levels. J Cell Biol 208:429-42.	LEAK OXPHOS ET	N S Gp Other combinations	Permeabilized cells Isolated mitochondria	Mouse	Heart Fibroblast
Hendricks 2015 Thesis	2015	Hendricks EW (2015) The impact of aging and estrogen therapy on synaptic mitochondrial bioenergetics in an Alzheimer's mouse model. Master Thesis 1-67.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Isolated mitochondria Intact cells	Mouse	Nervous system
Porter 2015 Med Sci Sports Exerc	2015	Porter C, Reidy PT, Bhattarai N, Sidossis LS, Rasmussen BB (2015) Resistance exercise training alters mitochondrial function in human skeletal muscle. Med Sci Sports Exerc 47:1922-31.	LEAK OXPHOS ET	N S NS	Permeabilized tissue	Human	Skeletal muscle
Bowen 2015 Eur J Heart Fail	2015	Bowen TS, Rolim NP, Fischer T, Baekkerud FH, Medeiros A, Werner S, Brønstad E, Rognmo O, Mangner N, Linke A, Schuler G, Silva GJ, Wisløff U, Adams V (2015) Heart failure with preserved ejection fraction induces molecular, mitochondrial, histological, and functional alterations in rat respiratory and limb skeletal muscle. Eur J Heart Fail 17:263-72.	LEAK OXPHOS ET	N NS	Permeabilized tissue	Rat	Skeletal muscle
Vincent 2015 Front Physiol	2015	Vincent G, Lamon S, Gant N, Vincent PJ, MacDonald JR, Markworth JF, Edge JA, Hickey AJ (2015) Changes in mitochondrial function and mitochondria associated protein expression in response to 2-weeks of high intensity interval training. Front Physiol 6:51.	LEAK OXPHOS ET	N S ROX	Permeabilized tissue	Human	Skeletal muscle
Jeger 2015 BioMed Res Internat	2015	Jeger V, Brandt S, Porta F, Jakob SM, Takala J, Djafarzadeh S (2015) Dose response of Endotoxin on hepatocyte and muscle mitochondrial respiration in vitro. BioMed Res Internat Article ID 353074:1-13.	LEAK ROUTINE OXPHOS ET	N S CIV NS ROX	Permeabilized cells Isolated mitochondria Intact cells	Human	Skeletal muscle Liver Other cell lines
Ziak 2015 Mitochondrion	2015	Ziak J, Krajcova A, Jiroutkova K, Nemcova V, Dzupa V, Duska F (2015) Assessing the function of mitochondria in cytosolic context in human skeletal muscle: Adopting high-resolution respirometry to homogenate of needle biopsy tissue samples. Mitochondrion 21:106-12.	LEAK OXPHOS ET	N S NS ROX	Homogenate Isolated mitochondria	Human	Skeletal muscle
Christiansen 2015 J Vet Med Sci	2015	Christiansen LB, Dela F, Koch J, Yokota T (2015) Tissue-specific and substrate-specific mitochondrial bioenergetics in feline cardiac and skeletal muscles. J Vet Med Sci 77:669-75.	LEAK OXPHOS ET	F N S CIV NS Other combinations ROX	Permeabilized tissue	Cat	Heart Skeletal muscle
Torelli 2015 Free Radic Biol Med	2015	Torelli NQ, Ferreira-Júnior JR, Kowaltowski AJ, da Cunha FM (2015) RTG1- and RTG2-dependent retrograde signaling controls mitochondrial activity and stress resistance in Saccharomyces cerevisiae. Free Radic Biol Med 81C:30-7.	LEAK ROUTINE OXPHOS ET	CIV ROX	Isolated mitochondria Intact cells	Saccharomyces cerevisiae
Sheldon 2015 Am J Physiol Gastrointest Liver Physiol	2015	Sheldon RD, Padilla J, Jenkins NT, Laughlin MH, Rector RS (2015) Chronic NOS inhibition accelerates NAFLD progression in an obese rat model. Am J Physiol Gastrointest Liver Physiol 308:G540-9.	LEAK OXPHOS ET	N NS	Isolated mitochondria	Rat	Liver

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