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• MitoPedia: Inhibitors
  210 bytes (21 words) - 16:18, 10 February 2015
• Mitopedia: Inhibitors
  #REDIRECT [[MitoPedia: Inhibitors]]
  35 bytes (3 words) - 00:33, 19 November 2014
• Bioblast Glossary: Inhibitors
  #REDIRECT [[MitoPedia: Inhibitors]]
  35 bytes (3 words) - 16:57, 18 November 2014
• List of inhibitors
  #REDIRECT [[MitoPedia: Inhibitors]]
  35 bytes (3 words) - 17:08, 18 November 2014
• Contamination by hydrophobic inhibitors
  46 bytes (6 words) - 10:07, 29 September 2014
• Lasting effect of EtOH-soluble inhibitors
  46 bytes (6 words) - 11:11, 8 June 2015

Page text matches

• List of inhibitors
  #REDIRECT [[MitoPedia: Inhibitors]]
  35 bytes (3 words) - 17:08, 18 November 2014
• Mitopedia: Inhibitors
  #REDIRECT [[MitoPedia: Inhibitors]]
  35 bytes (3 words) - 00:33, 19 November 2014
• Kopitar-Jerala 2012 Curr Protein Pept Sci
  |title=Kopitar-Jerala N (2012) The role of cysteine proteinases and their inhibitors in the host-pathogen cross talk. Curr Protein Pept Sci 13:767-75. ...n the most recent developments regarding the role of proteinases and their inhibitors in the initiation and regulation of immune responses.
  1 KB (163 words) - 13:48, 29 July 2016
• Degli Esposti 1998 Biochim Biophys Acta
  |title=Degli Esposti M (1998) Inhibitors of NADH-ubiquinone reductase: an overview. Biochim Biophys Acta 1364(2):222 ...complex I. Among commercial products, particular attention is dedicated to inhibitors of pharmacological or toxicological relevance. The compounds that inhibit t
  1 KB (158 words) - 13:55, 12 March 2021
• Fato 2009 Biochim Biophys Acta
  ...Ohnishi T, Lenaz G (2009 ) Differential effects of mitochondrial Complex I inhibitors on production of reactive oxygen species. Biochim Biophys Acta 1787(5):384- ...rease of NADH-DCIP reduction induced by short chain quinones: only Class B inhibitors allow this increase, indicating the presence of a Rotenone-sensitive but St
  2 KB (325 words) - 13:22, 30 November 2018
• Gao 2022 EBioMedicine
  ...ST, Wen Y, Tang TT, Wang B, Liu BC (2022) Cardiorenal protection of SGLT2 inhibitors-Perspectives from metabolic reprogramming. EBioMedicine 83:104215. https:// ...will focus on the current understanding of cardiorenal protection by SGLT2 inhibitors, specifically its relevance to metabolic reprogramming.
  2 KB (205 words) - 08:09, 14 September 2023
• Horseradish peroxidase
  == Known inhibitors == ...8250dat.pdf Sigma-Adrich], citing <ref>Zollner H (1993) Handbook of Enzyme Inhibitors, 2nd ed, Part A:367-8.</ref>: sodium azide, cyanide, L-cystine,dichromate,
  2 KB (209 words) - 15:59, 8 May 2024
• Schiller 2022 Pharmaceuticals (Basel)
  |title=Schiller J, Zickermann V (2022) Binding of natural inhibitors to respiratory complex I. https://doi.org/10.3390/ph15091088 ...detail. In this review, we summarize the state of knowledge of how natural inhibitors bind in the Q reduction site and the Q access pathway and how their inhibit
  1 KB (177 words) - 15:58, 22 March 2023
• Paech 2018a Toxicology
  ...J, Krähenbühl S (2018) Mechanisms of mitochondrial toxicity of the kinase inhibitors ponatinib, regorafenib and sorafenib in human hepatic HepG2 cells. Toxicolo ...a toxicological mechanism of hepatotoxicity associated with certain kinase inhibitors.
  2 KB (330 words) - 14:21, 21 August 2018
• Droese 2011 Mol Pharmacol
  ...L, Brandt U (2011) A common mechanism links differently acting Complex II inhibitors to cardioprotection: modulation of mitochondrial reactive oxygen species pr ...ttenuated ROS generated at Complex I due to reverse electron transfer. All inhibitors showed these ambivalent effects independent of the presence of K(+). These
  2 KB (228 words) - 17:05, 19 February 2018
• MitoPedia: MiP and biochemistry
  ::::» [[MitoPedia: Inhibitors |Inhibitors]]
  1 KB (118 words) - 17:12, 22 December 2020
• Sváb 2021 Antioxidants (Basel)
  ...ADP addition as well as stimulation of respiration upon administration of inhibitors of ATP synthase or ANT, were observed. Qualitatively identical results were
  2 KB (293 words) - 11:45, 2 February 2022
• Declercq 1987 J Biol Chem
  ...the mitochondrial carnitine palmitoyltransferase enzyme system. I. Use of inhibitors. J Biol Chem 262:9812-21. ...nd has the same molecular weight in liver and muscle. It is insensitive to inhibitors where on or off the mitochondrial membrane.
  3 KB (384 words) - 10:30, 6 July 2021
• Skemiene 2020 Biomolecules
  ...R, Borutaite V (2020) Comparison of effects of metformin, phenformin, and inhibitors of mitochondrial complex I on mitochondrial permeability transition and isc ...enone and amobarbital and by MPTP inhibitor cyclosporine A. The latter two inhibitors were protective in adult brain slices as well. Short-term exposure of cultu
  3 KB (349 words) - 21:42, 28 October 2020
• Kalbacova 2003 Cytometry
  ...ý M, Drahota Z, Melková Z (2003) Comparison of the effect of mitochondrial inhibitors on mitochondrial membrane potential in two different cell lines using flow ...e cellular metabolism, viability, and apoptosis. Changes of ΔΨm induced by inhibitors of oxidative phosphorylation characterize
  2 KB (313 words) - 11:57, 9 November 2016
• Satoh 1995 Br J Pharmacol
  ...hihara K (1995) Effects of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on mitochondrial respiration in ischaemic dog hearts. Br J Pharmacol 116:18 ...oronary artery (LAD) in anaesthetized open chest dogs, pretreated with the inhibitors. After 30 min of ischaemia, nonischaemic and ischaemic myocardium were remo
  2 KB (285 words) - 09:12, 16 June 2015
• Strobilurin
  ...sed in agriculture as fungicides. They are part of the larger group of QoI inhibitors, which act to inhibit {''end of Quote'': [http://en.wikipedia.org/wiki/Stro
  498 bytes (64 words) - 02:46, 23 January 2023
• Boukalova Stepana
  |topics=cancer cell metabolism, OXPHOS inhibitors, anti-cancer drugs
  431 bytes (49 words) - 11:11, 4 July 2022
• Rekuviene 2018 Thesis
  |title=Rekuvienė E (2018) Effect of respiratory complex I inhibitors on mitochondrial permeability transition and cell viability during brain is ...of this study is to investigate the effect of respiratory chain complex I inhibitors on regulation of mitochondrial permeability transition pore, mitochondrial
  2 KB (292 words) - 14:20, 5 March 2019
• Meunier 1995 Biochemistry
  |title=Meunier B, Madgwick SA, Reil E, Oettmeier W, Rich PR (1995) New inhibitors of the quinol oxidation sites of bacterial cytochromes bo and bd. Biochemis ...xygen, which is inhibited. It is concluded that the aurachins are powerful inhibitors of the quinol oxidation sites of bacterial cytochromes bo and bd. The effec
  2 KB (368 words) - 12:40, 3 April 2021
• Torres-Quesada 2022 MitoFit Kinase
  ...might predict off-target or identify specific on-target effects of kinase inhibitors. |keywords=Kinases, signaling, mitochondria, kinase inhibitors, cancer, drug off-target effects
  2 KB (312 words) - 13:03, 8 January 2023
• Danylovych 2016 Ukr Biochem J
  ...tonophore, caused decrease in NADH and FAD fluorescence. Moreover, all the inhibitors caused mitochondria swelling. NO donors, e.g. 0.1 mM sodium nitroprusside a |keywords=mitochondrial electron transport chain, NADH, FAD, fluorescence, inhibitors, myometrium of rats
  2 KB (300 words) - 13:18, 14 February 2022
• Corona de la Pena 2017 PLoS One
  ...and heparin (GPIb inhibitors) as well as resveratrol, ATP (calcium-release inhibitors) and PP1 (Tyr-phosphorylation inhibitor) prevented the thrombin-induced pla
  2 KB (286 words) - 19:48, 20 March 2023
• Iqbal 2018 Pathogens
  ...w, we discuss the oxidative phosphorylation pathway and development of its inhibitors in detail.
  2 KB (206 words) - 15:21, 8 October 2023
• Torres-Quesada 2022 BEC
  ...might predict off-target or identify specific on-target effects of kinase inhibitors. |keywords=Kinases, signaling, mitochondria, kinase inhibitors, cancer, drug off-target effects
  3 KB (335 words) - 16:31, 21 January 2024
• Solution protocols
  '''Solution protocols''' contain media, substrates, uncouplers, inhibitors used in [[SUIT|SUIT protocols]], permeabilization agents, etc.
  417 bytes (54 words) - 00:54, 16 April 2024
• Rossato 2014 PLoS One
  ...Catharino RR, Graner E, Castilho RF, Vercesi AE (2014) Fatty acid synthase inhibitors induce apoptosis in non-tumorigenic Melan-A cells associated with inhibitio ...ed by the free radical scavenger N-acetyl-cysteine indicates that the FASN inhibitors induced apoptosis through an oxidative stress-associated mechanism. In comb
  3 KB (404 words) - 11:17, 7 March 2020
• Archer 1993 Circ Res
  ...pulmonary vascular smooth muscle cells during exposure to hypoxia and ETC inhibitors. Hypoxia, rotenone, and antimycin A decreased lung chemiluminescence (-62 +
  2 KB (362 words) - 13:46, 25 April 2022
• Geyer 1951 J Biol Chem
  ...n of rat liver with various labeled fatty acids in the presence of various inhibitors. Of the latter compounds, malonic acid was studied the most intensively.
  2 KB (348 words) - 06:07, 22 March 2023
• Kelly 2010 J Pharmacol Exp Ther
  ...ero M, Edelman A, Fritsch J (2010) Cystic fibrosis transmembrane regulator inhibitors CFTR(inh)-172 and GlyH-101 target mitochondrial functions, independently of ...induced a slight increase. These results support the conclusion that CFTR inhibitors may exert nonspecific effects regarding ROS production, mitochondrial failu
  3 KB (406 words) - 16:00, 9 November 2016
• Kelly 2011 Mitochondrion
  ...en skeletal muscle mitochondria are isolated in the absence of phosphatase inhibitors. We conclude that MDMA treatment of animals increases proton leak in skelet
  2 KB (337 words) - 14:53, 13 November 2017
• El-Mir 2000 J Biol Chem
  ...ide precursor or inhibitors, oxygen radical scavengers, ceramide synthesis inhibitors, or chelation of intra- or extracellular Ca(2+). Because it is established
  2 KB (298 words) - 16:25, 20 November 2023
• Hoel 2017 MiPschool Obergurgl
  ...ltured SH-SY5Y neuroblastoma cells to sub-lethal doses of different OXPHOS inhibitors (Rotenone, Oligomycin, Antimycin A, Myxothiazol) for 72 hours. Our focus wa ...ls of PINK1 and p62, most apparent in the cells exposed to the complex III inhibitors Myxothiazol and Antimycin A. The finding that inhibition of different OXPHO
  2 KB (324 words) - 14:40, 27 March 2018
• Agius 1991 Biochem Pharmacol
  ...ly than the S-enantiomer, both the R- and S-enantiomers are equally potent inhibitors of fatty acid and cholesterol synthesis from acetate in rat hepatocytes. Th
  1 KB (210 words) - 22:51, 5 July 2021
• Hoffman 2009 J Biol Chem
  ...re, we suggest that previous discrepancies in the assignment of effects of inhibitors on ROS may be due to differences in experimental [O₂]. Finally,
  2 KB (325 words) - 21:38, 13 April 2022
• CHNO-fuel substrate
  ...ETS]] at different levels of integration and in the presence or absence of inhibitors acting on specific enzymes which are gate-keepers and control various pathw
  564 bytes (68 words) - 11:41, 3 April 2021
• Jang 2018 J Med Toxicol
  ...ide therapy and gauge severity of disease in poisoning related to cellular inhibitors of public health concern.
  2 KB (302 words) - 14:37, 5 July 2023
• Aya 2022 Eur J Pharmacol
  ...s study was to clarify the mechanisms by which empagliflozin, one of SGLT2 inhibitors, affects heart failure. ...hese findings provide novel mechanisms for the beneficial effects of SGLT2 inhibitors on HF.
  2 KB (323 words) - 16:00, 25 August 2022
• Morota 2009 Exp Neurol
  ...segawa E, Yanagi S, Omi A, Uchino H, Elmér E (2009) Evaluation of putative inhibitors of mitochondrial permeability transition for brain disorders-specificity vs ...and human liver mitochondria, we re-evaluate drugs promoted as potent mPT inhibitors. We address the definition of an mPT inhibitor and present strategies to re
  3 KB (371 words) - 17:34, 25 February 2020
• Hegazy 2022 Biomedicines
  ...S, Elgendy B (2022) Identification of novel mitochondrial pyruvate carrier inhibitors by homology modeling and pharmacophore-based virtual screening. https://doi ...irtual screen of a chemical library. We identified five new non-indole MPC inhibitors, four with IC50 values in the nanomolar range that were up to 7-fold more p
  2 KB (319 words) - 13:39, 5 December 2022
• Hodges 2021 J Biol Chem
  ...o K, Patti GJ, McCommis KS, Finck BN (2021) Mitochondrial pyruvate carrier inhibitors improve metabolic parameters in diet-induced obese mice. J Biol Chem 298:10 ...vide scaffolds that can be used to develop potent and novel classes of MPC inhibitors.
  3 KB (376 words) - 17:19, 22 February 2022
• Torres-Quesada 2022 Abstract Bioblast
  ...might predict off-target or identify specific on-target effects of kinase inhibitors. |keywords=Kinases, signaling, mitochondria, kinase inhibitors, cancer, drug off-target effects
  3 KB (324 words) - 08:43, 28 July 2022
• Gasmi 2021 Arch Toxicol
  ...rshad M, Butnariu M, Menzel A, Bjørklund G (2021) Krebs cycle: activators, inhibitors and their roles in the modulation of carcinogenesis. Arch Toxicol 95:1161-7 ...rogenase as a potential marker of malignancy and estimating activators and inhibitors in cancer treatment.
  2 KB (257 words) - 17:34, 5 October 2023
• Kagawa 1971 J Biol Chem
  ...transfer inhibitors. The ATPase activity was inhibited by energy transfer inhibitors, but stimulated by uncouplers or by the combined action of nigericin and va
  2 KB (236 words) - 13:00, 24 February 2015
• Coupling/pathway control diagram
  ...substrates, e.g. pyruvate and succinate, or [[Electron transfer pathway]] inhibitors, e.g. rotenone) exerts '''pathway control''', then a transition is induced
  2 KB (240 words) - 20:03, 1 January 2021
• Contreras Mostazo 2020 Cancers (Basel)
  ...hat KU812 Parental and ImaR cells viability can be targeted with metabolic inhibitors paving the way to propose novel and promising therapeutic opportunities to ...nic myeloid leukemia, Metabolic reprogramming, Proteomics, Tyrosine kinase inhibitors
  2 KB (322 words) - 23:46, 24 November 2020
• Qu 2018 FASEB J
  ...hibitors, suggesting that the MPTP mediates the antiviral effects of these inhibitors. These findings reveal new insights on HEV-host interactions and provide vi
  2 KB (336 words) - 14:52, 23 February 2020
• Kulkarni 2023 FASEB J
  ...inhibition at higher doses and prolonged incubation times. Neither of the inhibitors could protect mice from collagen-epinephrine-induced pulmonary embolism or
  3 KB (351 words) - 16:03, 18 January 2023
• SUIT-032 O2 mt D109
  ...of liver homogenate is recommended in the washing protocol to bind strong inhibitors.
  2 KB (226 words) - 09:56, 26 January 2024
• Amoedo 2011 PLoS One
  ...nergy metabolism in h460 lung cancer cells: effects of histone deacetylase inhibitors. PLoS One 6:e22264. ...duction. In the present work we showed metabolic reprogramming by means of inhibitors of histone deacetylase (HDACis), sodium butyrate and trichostatin. This tre
  3 KB (426 words) - 16:43, 9 November 2017
• Scavuzzo 2019 J Neurophysiol
  ...lational inhibition. Critical re-evaluation of studies using translational inhibitors to promote the protein synthesis dependent idea of long-term memory is abso
  3 KB (350 words) - 15:31, 15 October 2019
• Barsottini 2020 Commun Biol
  ...levant proteoliposomes. We present structure-activity relationships of AOX inhibitors such as colletochlorin B and analogues which, aided by an MpAOX structural
  2 KB (245 words) - 18:41, 3 June 2020
• Strich 2023 MiPschool Obergurgl
  ...ochondrial Physiology Society|MiPsociety]]Bioenergetic profiling of kinase inhibitors reveals drug off-targer effects in colon cancer cell models ...ted to various human diseases, such as cancer [1]. In recent years, kinase inhibitors have gained recognition by aiming to block single or multiple oncogenic kin
  4 KB (554 words) - 16:07, 28 June 2023
• SUIT-006 02 mt D108
  ...of sample homogenate is recommended in the washing protocol to bind strong inhibitors.
  2 KB (233 words) - 10:43, 26 January 2024
• Becker 1999 Am J Physiol
  ...nium (0.9 +/- 0.1). By contrast, the site IV inhibitor cyanide, as well as inhibitors of xanthine oxidase (allopurinol), nitric oxide synthase (nitro-L-arginine
  2 KB (242 words) - 17:49, 13 April 2022
• Llobet 2015 Dis Model Mech
  ...l DNA replication, such as nucleoside reverse transcriptase inhibitors, or inhibitors of mitochondrial protein synthesis, like ribosomal antibiotics, diminish ad
  2 KB (245 words) - 15:12, 13 November 2017
• Sorby-Adams 2024 Redox Biol
  ...duction in heart, brain, and kidney mitochondria, as well as screening for inhibitors of succinate oxidation with therapeutic potential.
  2 KB (273 words) - 13:31, 13 May 2024
• Billingham 2022 Nat Immunol
  ...ATP levels, as a common metabolite that is diminished by mitochondrial ETC inhibitors. PCr depletion decreased ATP levels and NLRP3 inflammasome activation. Thus
  2 KB (256 words) - 14:56, 4 April 2023
• SUIT-034 O2 mt D111
  ...of liver homogenate is recommended in the washing protocol to bind strong inhibitors.
  2 KB (244 words) - 09:56, 26 January 2024
• Lerchner 2019 Anal Bioanal Chem
  ...ons. Calorimetric measurements under anoxic conditions and with glycolytic inhibitors showed that anaerobic metabolic processes contribute from 30 to 40% to the
  2 KB (266 words) - 12:24, 9 July 2019
• SUIT-033 O2 mt D110
  ...of liver homogenate is recommended in the washing protocol to bind strong inhibitors.
  2 KB (238 words) - 09:57, 26 January 2024
• Murphy 1997 Exp Parasitol
  ...iparum''.Furthermore, salicyclhydroxamic acid, propyl gallate, and related inhibitors of alternative oxidase activities were shown to inhibit the growth of ''P.
  2 KB (261 words) - 10:20, 9 November 2016
• Crofts 2004 Annu Rev Physiol
  ...erapy and agronomy. Recent structural studies have shown how many of these inhibitors bind, and have provided important clues to the mechanism of action and the
  2 KB (299 words) - 22:13, 16 February 2021
• Rodrigues 2013 Abstract MiP2013
  ...rgetics alterations in breast cancer lines induced by histone desacetylase inhibitors. Mitochondr Physiol Network 18.08. ...literature highlighting the various effects caused by histone deacetylase inhibitors (HDACis), which induces accumulation of acetylated substrates, generating p
  4 KB (521 words) - 15:50, 13 November 2017
• Yurista 2020 Cardiovasc Diabetol
  ...But the authors also demonstrated that the sodium-glucose co-transporter 2 inhibitors (SGLT2i) empagliflozin has the capacity to restore mitochondrial function, ...rial fibrillation, Diabetes, Mitochondria, Sodium-glucose co-transporter-2 inhibitors
  2 KB (275 words) - 12:45, 20 January 2020
• Hagenbuchner 2013 Oncogene
  ...nsitize high-stage NB to DNA-damaging drugs. This suggests that glycolysis inhibitors target an 'archilles heel' of Survivin-overexpressing NB and may be highly
  2 KB (271 words) - 14:27, 13 November 2017
• Wu 2022 Front Chem
  ...which MAS can restore the denitrification process inhibited by respiratory inhibitors to a certain extent.
  2 KB (316 words) - 01:58, 19 December 2023
• Ali 2019 MiP2019
  ...e findings, we suggest that combined treatment with PARP and mitochondrial inhibitors may provide novel therapeutic strategy against TNBC.
  2 KB (285 words) - 15:29, 19 August 2019
• Kristian 2007 J Neurochem
  ...with Ca(2+) uptake and mitochondrial swelling. In RBM, the endogenous MPT inhibitors adenosine 5'-diphosphate (ADP) and adenosine 5'-triphosphate (ATP) increase
  2 KB (320 words) - 09:26, 7 May 2020
• Rudnicki 2014 United States Patent Application Publication
  |title=Rudnicki MA, Yin Hang (2014) MICRORNA INHIBITORS. United States Patent Application Publication 1-49.
  814 bytes (104 words) - 15:52, 13 November 2017
• Chabi 2021 Cell Biol Int
  ...bes formation and myogenin expression were blunted with complexes I and II inhibitors while MyoD protein expression was maintained, suggesting an alteration in i
  2 KB (321 words) - 15:51, 19 October 2021
• Tomita 2001 Arthritis Rheum
  ...70 (hsp70) and heme oxygenase 1 (HO-1) increased markedly. The presence of inhibitors of mitochondrial electron transport also increased cellular levels of hsp70
  2 KB (312 words) - 09:04, 17 June 2015
• Coupling-control state
  ...respiration with corresponding rates ''L, R, E'', using membrane-permeable inhibitors of the [[phosphorylation system]] (e.g. [[oligomycin]]) and [[uncoupler]]s
  2 KB (293 words) - 18:58, 7 February 2021
• Kamath 2012 Abstract IOC72
  ...re associated with long-term treatment of nucleoside reverse transcriptase inhibitors (NRTIs) [1]. While mitochondrial toxicity is thought to be a major underlyi ...mitochondrial cardiotoxicity of nucleoside analogue reverse transcriptase inhibitors. J Acquir Immune Defic Syndr 55: 550-557]
  4 KB (539 words) - 11:15, 8 June 2020
• Martell 2023 Acta Neuropathol Commun
  ...t of stem cell-like GBM tumor subpopulations with autophagy and glycolysis inhibitors blocked the induction of senescence while drastically impairing their stemn
  3 KB (447 words) - 15:32, 11 July 2023
• Ma 2020 Sci Rep
  ...e other hand, acted as a partial inhibitor of FAO. As another class of FAO inhibitors that transcriptionally repress FAO genes, antagonists of peroxisome prolife
  2 KB (293 words) - 13:04, 12 September 2023
• Balcarek 2010
  ...mitochondrial cardiotoxicity of nucleoside analogue reverse transcriptase inhibitors. J Acquir Immune Defic Syndr. 55:550-7. ...rm antiretroviral treatment with nucleoside analogue reverse transcriptase inhibitors (NRTI) may result in a cardiomyopathy due to mitochondrial DNA (mtDNA) depl
  2 KB (288 words) - 12:25, 14 October 2015
• Rosenfeld 2010 Abstract IOC60
  ...type and mutant strains, (ii) respiratory inhibitors, and (iii) a panel of inhibitors of NADPH-dependent non-respiratory oxygen consumption pathways.
  2 KB (291 words) - 16:37, 26 March 2018
• De Cavanagh 2008 Exp Gerontol
  ...M, Flores I, Ferder M, Inserra F, Ferder L (2008) Renin-angiotensin system inhibitors protect against age-related changes in rat liver mitochondrial DNA content ...an aging. If the present mitochondrial actions of renin-angiotensin system inhibitors are confirmed in humans they may modify the therapeutic significance of tha
  2 KB (282 words) - 14:49, 20 March 2015
• Friederich-Persson 2013 Abstract MiP2013
  ...itochondria increased with increasing [K+] and was unaffected by K+channel inhibitors.
  2 KB (295 words) - 11:11, 28 April 2017
• Schoenfeld 2011 J Neurochem
  ...not decreased either by inhibitors of the cell membrane NAD(P)H oxidase or inhibitors impairing the PUFA metabolism. (iv) PUFA-induced ROS generation of mitochon
  2 KB (323 words) - 15:07, 9 November 2016
• Michelakis 2002 Circ Res
  ...at isolated arteries, vascular SMCs, and perfused organs. Hypoxia and pETC inhibitors decrease production of AOS and outward K+ current and constrict PAs while i
  2 KB (315 words) - 09:35, 12 April 2022
• Niu 2018 Cancer Metab
  ...tabolic compartmentalization by monitoring the activity of pharmacological inhibitors that cannot be transported into specific cellular compartments. ...to GSK-2837808A until mitochondria are homogenized. This strategy of using inhibitors with selective access to subcellular compartments, which we refer to as tra
  2 KB (329 words) - 11:22, 29 July 2019
• Traufeller 2004 Biochim Biophys Acta
  ...nsported via the acyl-carnitine transporter, too. The combined use of both inhibitors (L-AC and malonyl-CoA) allows the kinetic characterization of CPT I and CPT
  2 KB (350 words) - 10:53, 23 January 2019
• Perevoshchikova 2013 Free Radic Biol Med
  ...inhibitors and the presence of myxothiazol to inhibit complex III. Without inhibitors, respiration and H2O2 production were low unless carnitine or malate was ad
  2 KB (345 words) - 22:02, 3 August 2023
• ISS-Integrated Suction System
  ...meter]]. Media containing living cells or microorganisms, various poisons (inhibitors, uncouplers) and mixtures of proteins and substrates are safely disposed of
  996 bytes (128 words) - 16:59, 14 March 2023
• Bueno 2016 Thesis
  cells previously treated with TMZ on D5 with glycolysis and OXPHOS inhibitors and followed cell number. Results suggest that these inhibitors abrogate TMZ treated
  2 KB (357 words) - 09:47, 28 November 2017
• Tepp 2011 Biochim Biophys Acta
  ...) were 0.38 for ANT and 0.80 for MtCK. In the permeabilized cardiomyocytes inhibitors had to be added in much higher final concentration, and the following value
  2 KB (349 words) - 19:20, 2 September 2013
• Gruenig 2017 Toxicol In Vitro
  ...Felser A, Bouitbir J, Krähenbühl S (2017) The catechol-O-methyltransferase inhibitors tolcapone and entacapone uncouple and inhibit the mitochondrial respiratory |keywords=Apoptosis, COMT inhibitors, Electron transport chain, Necrosis, Uncoupling, Human liver HepaRG cells
  3 KB (332 words) - 11:25, 27 June 2019
• Rodrigues 2012 Abstract IOC72
  Results in the literature show various effects caused by histone deacetylase inhibitors (HDACis), which induce accumulation of acetylated substrates, generating ce ...mplications Schrump DS (2009) Cytotoxicity mediated by histone deacetylase inhibitors in cancer cells: mechanisms and potential clinical implications Clin Cancer
  4 KB (489 words) - 11:16, 8 June 2020
• Reda 2019 Sci Rep
  ...e findings, we suggest that combined treatment with PARP and mitochondrial inhibitors may provide novel therapeutic strategy against TNBC.
  2 KB (331 words) - 10:18, 30 September 2019
• Chinopoulos 2010 FASEB J
  ...lear-targeted luciferases and treated with mitochondrial respiratory chain inhibitors in the presence of glycolytic plus mitochondrial vs. only mitochondrial sub
  2 KB (330 words) - 10:53, 3 April 2022
• Villani 2016 Mol Metab
  ...proved medications for type 2 diabetes. Recent studies indicate that SGLT2 inhibitors may inhibit the growth of some cancer cells but the mechanism(s) remain unc ...ssess the sensitivity of prostate and lung cancer cell growth to the SGLT2 inhibitors. Oxygen consumption, extracellular acidification rate, cellular ATP, glucos
  3 KB (437 words) - 04:17, 12 February 2020
• Prashant S
  :* '''Title of dissertation:''' Mcl-1 inhibitors for the treatment of OSCC
  999 bytes (135 words) - 00:32, 23 May 2017
• Bednarczyk 2014 Abstract IOC96
  ...ltages. The effect was abolished by rotenone, antimycin and cyanide, being inhibitors of respiratory chain. ...class="center" >Schematic of the proposed model and the applied substrates/inhibitors of the respiratory chain.</div> <br>
  3 KB (355 words) - 21:13, 18 March 2018
• Sivertsson 2017 Am J Physiol Renal Physiol
  ...entified as a key player in diabetes, which has stimulated the use of mTOR inhibitors to counter diabetic nephropathy. However, the effect of mTOR inhibition on
  3 KB (348 words) - 17:56, 23 February 2020
• Piericidin
  ...etes with endogenous and partially with exogenous Q for binding sites). CI inhibitors have been divided (''1'') depending of the site of action (functional class
  1 KB (151 words) - 09:28, 2 November 2020
• Pon 2011 Malar J
  ...rganic diacids carrying a 2-hydroxyl/keto group behaved as the most potent inhibitors of ME activity (e.g., oxaloacetate, tartronic acid and oxalate).
  3 KB (370 words) - 10:05, 9 November 2016
• Liemburg-Apers 2015 Biophys J
  ...glycolytic ATP production flux. Both in the absence and presence of OXPHOS inhibitors, GLC was consumed at near maximal rates, meaning that GLC consumption is ra
  3 KB (358 words) - 14:34, 27 March 2018
• Jardim-Messeder 2015 New Phytol
  ...ll cycle genes and the induction of stress-related genes by noncompetitive inhibitors. In conclusion, SDH plays an important role in ROS production, being a dire
  3 KB (370 words) - 17:19, 16 February 2021
• Singh 2016 Mol Neurobiol
  ...atrepirdine, donepezil, and 7-MEOTA were found to be the most potent MAO-A inhibitors. Succinate-induced mitochondrial hydrogen peroxide production was not signi
  3 KB (354 words) - 11:01, 24 June 2019
• Ederer 2018 Int J Mol Sci
  ...system. A growing body of literature argues for a beneficial impact of ACE inhibitors (ACEi) on age-associated metabolic disorders, mediated by cellular changes |keywords=Aging, Angiotensin-converting enzyme inhibitors, Genetic background, Nutrient metabolism, Nutritional stress
  2 KB (334 words) - 09:22, 29 July 2019
• Hatefi 1962 J Biol Chem-XLII
  ...tochrome ''c'' reductase; and IV, cytochrome ''c'' reductase. The specific inhibitors of each complex have been studied. ...tuted systems, both in the presence and the absence of the usual specific inhibitors of the electron transfer system, are essentially the same as those found fo
  3 KB (373 words) - 09:21, 1 May 2024
• Gariani 2016 J Hepatol
  ...to evaluate the therapeutic potential of poly ADP-ribose polymerase (PARP) inhibitors in mouse models of NAFLD. ...nt mouse models of NAFLD confer a protection against its development. PARP inhibitors may therefore represent a novel and practical pharmacological approach for
  3 KB (499 words) - 14:08, 2 August 2017
• Rodrigues 2015 J Cell Biochem
  ...Rumjanek FD, Amoêdo ND (2015) Reciprocal modulation of histone deacetylase inhibitors sodium butyrate and trichostatin a on the energy metabolism of breast cance ...l cells. In the present work we showed metabolic reprogramming by means of inhibitors of histone deacetylase (HDACis), sodium butyrate and trichostatin A in brea
  3 KB (374 words) - 15:50, 13 November 2017
• Sadri 2023 Arch Biochem Biophys
  ...ar N, Yang C, Audi SH, Cowley AW Jr, Dash RK (2023) Effects of ROS pathway inhibitors and NADH and FADH₂ linked substrates on mitochondrial bioenerget ...ate + malate and FADH2-linked substrate succinate followed by additions of inhibitors of different components of the electron transport chain (ETC) and oxidative
  3 KB (423 words) - 22:30, 28 October 2023
• Lee 2005 Am J Physiol Renal Physiol
  ...2+</sup> uniporter (MCU) played a key role in mitochondrial damage: 1) MCU inhibitors (La3+, ruthenium red, Ru360) prevented swelling and cytochrome c release; a
  3 KB (381 words) - 14:56, 24 March 2015
• Virag L
  ...Moreover, the importance of gender issue can not be overstated. E.g. PARP inhibitors (or K.O.?) protect male mice but not females from stroke. We are aware of t
  1 KB (161 words) - 17:21, 12 January 2018
• Muller 2013 Exp Neurol
  ...nted the generation of maximum level of ∆Ψm induced by succinate. The PI3K inhibitors and heated insulin maintained the maximum level of ∆Ψm induced by succin
  3 KB (378 words) - 17:05, 27 March 2018
• Kharechkina 2019 Biochim Biophys Acta Gen Subj
  ...(H) in combination with Mg²⁺, adenine nucleotides (AN), and the inhibitors of AN translocase (ANT), voltage-dependent anion channel (VDAC), and cyclop ...s of NAD(H) and millimolar AN were additive. The conformation-specific ANT inhibitors were unable to cancel the protective effect of NADH even under total ANT in
  3 KB (382 words) - 12:10, 26 July 2019
• Bajeli 2020 Front Cell Infect Microbiol
  ...ese two oxidases, their physiological relevance to mycobacteria, and their inhibitors. Besides these, we also describe the alternative terminal complexes that ar
  3 KB (415 words) - 15:04, 5 November 2023
• Ko 2021 Biomolecules
  ...1 (Drp1) and the Ser637/Ser616 ratio. We then tested whether specific Drp1 inhibitors, Mdivi-1 or Dynasore, affected the dynamic phosphorylation status of Drp1.
  2 KB (344 words) - 11:11, 8 July 2021
• Yang 2023 Cell Death Discov
  ...anced by pleiotropic PARP1. Consequently, the combination of MEK with PARP inhibitors enhances apoptotic cell death ''in vitro'' and ''in vivo'' that occurs thro
  2 KB (350 words) - 17:13, 21 February 2023
• Hroudova 2020 Mol Neurobiol
  ...as fully inhibited by K1053 and K1065; the other tested drugs were partial inhibitors of both MAO-A and MAO-B. The tacrine/7-MEOTA/6-chlorotacrine-trolox heterod |keywords=Alzheimer’s disease, Cholinesterase inhibitors, Electron transport chain complexes, Mitochondrial respiration, Monoamine o
  3 KB (368 words) - 15:10, 20 October 2021
• Reverse electron flow from CII to CI
  ...one in the [[LEAK respiration|LEAK]] state. Addition of I_Q-side inhibitors (ubiquinone-binding side of CI) of [[Complex I |CI]] usually block RET. The
  2 KB (211 words) - 12:20, 25 November 2020
• Komlodi 2014 Abstract MiP2014
  ...rther stimulated by uncouplers. In the simultaneous presence of ET-pathway inhibitors and oligomycin administration of MB stimulates SLP and the formed ATP can c
  4 KB (551 words) - 13:02, 23 January 2019
• Kudin 2004 J Biol Chem
  ...tion site at complex I to be equal to –295 mV. This and the sensitivity to inhibitors suggest that the site of superoxide generation at complex I is most likely
  3 KB (399 words) - 21:39, 13 April 2022
• Schoeckel 2015 Cancer Metab
  ...y of BRAF mutant melanoma cells. As a consequence, the combination of both inhibitors augmented the anti-tumor effect of BAY 87-2243 in a BRAF mutant melanoma mo ...e agent in melanoma and also might be efficacious in combination with BRAF inhibitors in the treatment of patients with BRAF mutant melanoma.
  3 KB (381 words) - 15:07, 9 November 2016
• SUIT-003 O2 ce-pce D020
  ...ility test module is not incorporated into the experiment, [[Complex III]] inhibitors can be used instead of [[rotenone]] to reach [[Residual oxygen consumption| :::- Careful washing is required after the experiment to avoid carry-over of inhibitors and uncoupler.
  3 KB (395 words) - 23:57, 12 April 2021
• Lu 2018 ACS Infect Dis
  ...otoxicity and hERG channel inhibition. Consistent with other reported QcrB inhibitors, TB47 inhibits oxygen consumption only when the alternative oxidase, cytoch
  3 KB (360 words) - 11:03, 11 August 2021
• SUIT-003 O2 ce D012
  ...ability test module is not incorporated to the experiment, [[complex III]] inhibitors can be used to reach [[Residual oxygen consumption| Rox]] instead of [[rote :::- Careful washing is required after the experiment to avoid carry-over of inhibitors and uncoupler.
  3 KB (432 words) - 23:51, 12 April 2021
• Doerrier 2016b Abstract Mito Xmas Meeting Innsbruck
  ...pared to net H₂O₂ production in the absence of these inhibitors [2]. ...on the Amplex red assay more than doubled after application of AF and DNCB inhibitors to the controls. The glutathione and thioredoxin antioxidant system did not
  4 KB (511 words) - 18:41, 10 January 2022
• Pacheco-Velazquez 2018 Mol Pharm
  ...ess (25-65%). The present data support the use of mitochondrially targeted inhibitors for the treatment of TN breast carcinoma.
  3 KB (362 words) - 10:14, 20 July 2018
• Moretti-Almeida 2019 Fungal Genet Biol
  ...ty of Mp-AOX-expressing cells in the presence and absence of potential AOX inhibitors. Together, our results confirm the antioxidant role of Mp-AOX and provide a
  3 KB (412 words) - 12:59, 17 April 2019
• Vizuete 2022 J Neuroinflammation
  ...in fact diverted for the maintenance of the immune response. Accordingly, inhibitors of the glycolytic pathway and Krebs cycle reverted neuroinflammation (reduc
  3 KB (433 words) - 16:42, 7 November 2022
• Zhang 2017 J Am Heart Assoc
  Dipeptidyl peptidase-4 inhibitors can prevent atrial fibrillation by reversing electrophysiological abnormali |keywords=Atrial fibrillation, Dipeptidyl peptidase‐4 inhibitors, Mitochondrial biogenesis, Mitochondrial function
  3 KB (381 words) - 11:58, 27 June 2019
• Cecatto 2018 FEBS J
  ...getics and Ca²⁺ homeostasis, acting as uncouplers and metabolic inhibitors of oxidative phosphorylation, as well as inducers of MPT pore opening, in t
  3 KB (400 words) - 11:13, 3 March 2020
• Loew 1963 Biochim Biophys Acta
  # Respiratory inhibitors acting in the flavin region of the respiratory chain blocked the reaction.
  1 KB (175 words) - 14:34, 24 November 2015
• SUIT-032 NADH mt D078
  ...of liver homogenate is recommended in the washing protocol to bind strong inhibitors.
  3 KB (442 words) - 10:37, 12 January 2024
• Labajova 2006 Gen Physiol Biophys
  ...ized hepatocytes were coupled and responded to the addition of substrates, inhibitors and uncouplers. Ca²⁺-induced Δψm dissipation was caused by MPT
  1 KB (164 words) - 11:14, 18 March 2020
• Boukalova 2020 Biochim Biophys Acta Mol Basis Dis
  ...gs on DHODH biology, the progress made in the development of new, specific inhibitors of DHODH intended for cancer therapy, and the mechanistic insights into the
  1 KB (175 words) - 17:18, 8 October 2023
• SUIT-034 NADH mt D082
  ...of liver homogenate is recommended in the washing protocol to bind strong inhibitors.
  3 KB (454 words) - 16:56, 21 December 2023
• SUIT-033 NADH mt D081
  ...of liver homogenate is recommended in the washing protocol to bind strong inhibitors.
  3 KB (462 words) - 17:44, 4 January 2024
• Hardorp 2024 Bachelor-Thesis
  ...tes which, therefore, was characterized as photodegradation. The effect of inhibitors of the chloroplast electron transfer system on photodegradation remains to
  4 KB (491 words) - 21:13, 30 April 2024
• Karan 2020 Brain Behav Immun Health
  ...ndrial respiratory chain Complexes I, III, IV, and V were used (LPS + Mito-Inhibitors) to acutely perturb mitochondrial function, GC sensitivity was quantified u
  3 KB (391 words) - 00:11, 13 September 2023
• Hagen 2003 Science
  ...h as those involved in glycolysis and angiogenesis. Nitric oxide and other inhibitors of mitochondrial respiration prevent the stabilization of HIF1α during hyp
  1 KB (185 words) - 14:18, 31 May 2019
• SUIT-006 NADH mt D084
  ...of liver homogenate is recommended in the washing protocol to bind strong inhibitors.
  3 KB (462 words) - 17:23, 21 December 2023
• Khalid 2016 Abstract Mito Xmas Meeting Innsbruck
  ...ndrial import and PKCβ has been proposed as S36 kinase. Due to the lack of inhibitors of its oxidoreductase function we pursue a strategy to inhibit p66Shc by in ...kinase lead to JNK1/2, whose involvement was confirmed through the use of inhibitors and JNK1/2-deficient cells. Moreover, expression of a S36E mutant in p66Shc
  3 KB (424 words) - 10:35, 13 December 2016
• Muntane Jordi
  ...roxy acetone phosphate-related ETS capacity using different substrates and inhibitors. ...sidual Oxygen Consumption (ROX) using complex I complex II and complex III inhibitors Proposed Contributions to the Scientific Objectives of the Action The overa
  6 KB (801 words) - 18:34, 16 March 2020
• Cardoso 2023 MiP2023
  ...2k. Multiple protocols were used with sequential titrations of substrates, inhibitors, and uncouplers [1, 2]: N-pool with pyruvate&glutamate&malate, mouse liver ...ply upstream of the Q-junction by using combinations of substrates and ETS-inhibitors in the noncoupled state, the Q-pool became reduced in direct proportion to
  4 KB (495 words) - 16:44, 12 July 2023
• Xue 2019 Sci Rep
  ...u and P-113Tri also block alternative NADH dehydrogenases. Currently, most inhibitors of the mitochondrial complex I are small molecules or artificially-designed
  1 KB (200 words) - 14:25, 8 October 2019
• Doerrier 2017 MiP2017 C1
  ...pared to net H₂O₂ production in the absence of these inhibitors [3]. Fluxes were normalized for mt-protein. .../sub>O₂ flux more than doubled after application of AF and DNCB inhibitors in the controls and after WI. The glutathione and thioredoxin antioxidant s
  5 KB (653 words) - 18:48, 10 January 2022
• Lamberti 2011 Plant Physiol
  ...an intramolecular mechanism. STY8 is inhibited by specific tyrosine kinase inhibitors, although it lacked the ability to phosphorylate tyrosine residues ''in vit
  2 KB (211 words) - 10:16, 9 November 2016
• Iglesias-Gonzalez 2018 MiPschool Tromso E1
  ...rved that complex II is the primary source of ROS ''in vivo'' and that the inhibitors differentially affect the oscillatory patterns of ROS production. Furthermo
  4 KB (509 words) - 05:19, 18 March 2019
• Galemou Yoga 2021 Front Chem
  ...data showed the binding of native Q molecules and short chain analogs and inhibitors in the access pathway and in the Q reduction site, respectively. We here re
  2 KB (216 words) - 16:15, 22 March 2023
• Blanco 2017 Academic Press
  ...A, at complex III; and cyanide, carbon monoxide, and azide, on complex IV. Inhibitors of oxidative phosphorylation include proton and K+ ionophores, which suppre
  4 KB (562 words) - 18:39, 27 August 2023
• O2k-Publications: Inhibitor
  : »[[MitoPedia: Inhibitors]]
  1 KB (186 words) - 11:44, 11 November 2016
• Nardin 2015 Abstract MiPschool London 2015
  ...dification by phosphorylation. A combination of genetic and small molecule inhibitors identified that the CaN-dependent dephosphorylation of these two Parkin res
  2 KB (201 words) - 15:29, 13 November 2017
• Formiga-Jr 2022 J Vis Exp
  ...Amplex Red/Peroxidase and comparing different mitochondrial substrates and inhibitors in saponin-permeabilized nerves, it was possible to detect mitochondrial re
  2 KB (219 words) - 13:37, 2 November 2022
• Roy Chowdhury 2018 J Thorac Oncol
  ...approved for the treatment of B-cell malignancies. We hypothesize that the inhibitors FK866 and idelalisib will alter SCLC mitochondrial bioenergetic profiles an
  3 KB (497 words) - 16:42, 26 March 2019
• Cuperus 2010 Cell Mol Life Sci
  ...ain was not required for ROS production. Co-incubation of fenretinide with inhibitors of different complexes of the respiratory chain suggested that fenretinide-
  2 KB (234 words) - 16:08, 22 October 2023
• Ziak 2015 Mitochondrion
  ...By optimising the amount of muscle and careful titration of substrates and inhibitors we developed a new protocol and compared it to isolated mitochondria. We fo
  1 KB (200 words) - 14:37, 26 March 2018
• Yang 2022 Front Cell Dev Biol
  ...e confirmed that clinical drugs (β-blockers, angiotensin-converting enzyme inhibitors/angiotensin receptor-II blockers) against CVDs have mitochondrial protectiv
  2 KB (220 words) - 18:31, 13 October 2023
• Hatefi 1962 J Biol Chem-XLI
  ...a number of specific metal-chelating compounds are ineffective as inhibitors.
  2 KB (199 words) - 17:16, 16 January 2021
• Koopman 2015 Abstract MiP2015
  ...glycolytic ATP production flux. Both in the absence and presence of OXPHOS inhibitors, GLC was consumed at near maximal rates, meaning that GLC consumption is ra
  3 KB (486 words) - 14:16, 9 November 2016
• Thayer 1975 J Biol Chem
  ...about 6 s and was sensitive to uncouplers or oligomycin but insensitive to inhibitors of electron transport. Lower amounts of ATP were formed by either the pH gr
  2 KB (234 words) - 09:56, 27 November 2015
• Giraldos Jimenez 2016 Thesis
  ...ce of a specific environmental factor: different OXPHOS system xenobiotics inhibitors. The chosen compounds were rotenone (10 nM), antimycin A (10 nM) and oligom
  2 KB (236 words) - 10:02, 28 November 2017
• Hebert-Chatelain 2019b MiP2019
  ...>1</sub>) are powerful regulators of brain physiology and cognition. These inhibitors of synaptic transmission are activated by exo-cannabinoids (such as the psy
  2 KB (235 words) - 09:21, 7 October 2019
• Vidali 2015 Abstract MiP2015
  ...ese compounds could stimulate or reverse the Warburg effect in the RMS. Hh inhibitors were given either locally or systemically. ...o the normal adjacent muscle. Treatment of Ptch^+/- mice with Hh inhibitors was not able to alter the OXPHOS system.
  5 KB (726 words) - 16:12, 4 September 2015
• MitoPedia: Oroboros QM
  ::::## [[Solution protocols]]: media, substrates, uncouplers, inhibitors used in SUIT protocols, permeabilization agents, etc.
  2 KB (222 words) - 06:12, 19 July 2022
• Yu 2023 Antioxidants (Basel)
  ...tochondrial division inhibitor-1 (Mdivi-1) and other mitochondrial fission inhibitors, as well as certain commonly used drugs for metabolic diseases. This review
  2 KB (251 words) - 09:54, 24 October 2023
• Crispim 2019 MitoFit Preprint Arch EA
  ...nd consequently for the pyrimidine's biosynthesis. In this sense, possible inhibitors of the ubiquinone biosynthesis pathway would be candidates by stimulating t
  4 KB (546 words) - 08:28, 8 January 2023
• Zoccarato 2011 J Bioenerg Biomembr
  ...etoacetate, and is higher at 0.5 mM acetoacetate. We conclude that several inhibitors of H(2)O(2) release act jointly and concentration dependently to rapidly se
  2 KB (206 words) - 10:46, 3 April 2022
• Mahalaxmi 2022 Toxicol In Vitro
  ...ng the mitochondrial activity in the presence of mitochondrial substrates, inhibitors and uncouplers. Apart from the specific effects of these molecules on mitoc
  2 KB (268 words) - 13:18, 5 December 2022
• Pesout MiP2010
  ...nylyl cyclase - PKG - mtKATP - ROS). The basis for this conclusion is that inhibitors of this pathway do not block cardioprotection when perfused to bracket the ...alosomes allowed us to probe the signalling cascade from ADOR to PKG using inhibitors. Signalosomes were activated by brief preincubation with 2 µM H2O2. When p
  4 KB (594 words) - 16:08, 15 February 2016
• Han 2017 Cell Rep
  ...t to induce ROS production in activated or fertilized eggs. Using chemical inhibitors, we identified mitochondria as the major source of fertilization-induced RO
  2 KB (233 words) - 06:44, 15 September 2018
• Steady state
  === After addition of inhibitors === ...ady_state_O2flux_01.png | '''Figure 6'''. Inhibition by rotenone (or other inhibitors, ''e.g.'' [[Antimycin A]]) may require a long time until a new steady respi
  8 KB (1,115 words) - 03:00, 23 January 2023
• Ghelli 1997 J Biochem
  ...les. NADH addition to particles in which ubiquinol oxidation is blocked by inhibitors of other respiratory complexes generates oxonol signals corresponding to me
  2 KB (254 words) - 16:41, 7 November 2016
• Krishnathas 2017 Med Chem Comm
  ...ct on the respiratory chain complexes II–IV. Similar to established Q-site inhibitors, EVP4593 elicits the release of reactive oxygen species at the flavin site
  2 KB (232 words) - 13:49, 4 June 2018
• Gong 2005 Am J Physiol Cell Physiol
  ...hyloxalylglycine. The inhibitory effect of mitochondrial respiratory chain inhibitors and oligomycin on hypoxic HIF-1alpha content was pronounced in cells expose
  2 KB (255 words) - 16:58, 31 May 2019
• Liu 2009 J Biomed Sci
  Methods: Using fluorescent dyes for ROS detection and mitochondrial inhibitors of known specificities, we studied ROS production under three conditions wh
  2 KB (260 words) - 23:33, 23 April 2023
• Letellier 1992 Pediatr Res
  ...ization of muscle fibers by saponin by allowing respiratory substrates and inhibitors to reach the mitochondria. In this way, the mitochondria may be studied ins
  2 KB (249 words) - 19:24, 17 April 2022
• Teh 2019 Mol Cancer Ther
  ...Respiratory capacity and reserve predict cell sensitivity to mitochondria inhibitors: mechanism-based markers to identify metformin-responsive cancers. Mol Canc
  2 KB (255 words) - 04:25, 12 February 2020
• Joshi 2022 Biomolecules
  ...TRAP1: structural dynamics, interactome, role in metabolic regulation, and inhibitors. Biomolecules 12:880. https://doi.org/10.3390/biom12070880
  2 KB (272 words) - 15:25, 5 October 2023
• Goetzman 2011 Prog Mol Biol Transl Sci
  ...d oxidation in the mouse are discussed, in particular the various chemical inhibitors that have been used successfully in vivo.
  2 KB (276 words) - 16:16, 29 October 2023
• Polajnar 2013 Biol Chem
  ...an stefins and cystatins are physiologically important cysteine proteinase inhibitors, acting as a first line of defense against undesirable proteolysis. Mutatio
  2 KB (283 words) - 13:43, 29 July 2016
• Sottocasa 1967 J Cell Biol
  ...or ferricyanide by a reaction that is insensitive to the respiratory chain inhibitors, antimycin A, amytal, and rotenone, and is not coupled to phosphorylation.
  2 KB (277 words) - 12:09, 28 May 2015
• Chmielewska 2011 Pharmacol Rep
  ...red by calcium ionophore A23187 treatment. Application of two BKCa channel inhibitors, paxilline and iberiotoxin, abolished this cytoprotective effect. At concen
  2 KB (260 words) - 15:33, 12 August 2013
• Kielley 1951 J Biol Chem
  ...ic acid during the oxidation of α-ketoglutarate in the absence of inhibitors such as fluoride, and show very low dephosphorylating activities.
  2 KB (287 words) - 11:30, 15 June 2015
• Copsey 2021 Sci Rep
  ...he PL system has also been employed in dose-response assays with novel AOX inhibitors. Such information is critical for the future development of novel treatment
  2 KB (255 words) - 09:22, 30 July 2021
• SUIT-003 O2 ce D039
  :::- Careful washing is required after the experiment to avoid carry-over of inhibitors and uncoupler.
  2 KB (253 words) - 14:47, 23 March 2021
• Sander 2022 Rev Med Virol
  ...atitis C virus, human immunodeficiency virus and influenza virus, with ROS inhibitors has shown a decrease in both pathogenesis and viral replication both in vit
  2 KB (265 words) - 14:08, 15 October 2023
• Nunn 2022 Biomedicines
  ...mic these by enhancing mitochondrial function, perhaps in combination with inhibitors that quell the inflammatory response.
  2 KB (269 words) - 11:50, 9 July 2023
• Starkov 2003 J Neurochem
  ...r physiologically realistic conditions in the absence of respiratory chain inhibitors. This study used Amplex Red fluorescence measurements of H2O2 to test the h
  2 KB (281 words) - 10:07, 4 April 2022
• Yamamoto 2018 Arch Biochem Biophys
  .... The permeabilization by PEIs were insensitive to permeability-transition inhibitors, indicating that PEI-induced permeabilization was not attributed to permeab
  2 KB (287 words) - 11:25, 6 August 2018
• Labajova 2006 Anal Biochem
  ...ansmitochondrial cybrids, HeLa G and BSC-40) after addition of substrates, inhibitors, and uncoupler of respiratory chain. Our system can be successfully used fo
  2 KB (259 words) - 11:16, 18 March 2020
• Dos Santos 2013 Bio Open
  ...th higher levels of UCP3 and ANT, the effects of activator (palmitate) and inhibitors (carboxyatractyloside and GDP) on mitochondrial parameters were similar in
  2 KB (281 words) - 17:49, 9 November 2017
• Chretien 2017 bioRxiv
  ...d primary skin fibroblasts. This differential was abolished by respiratory inhibitors or in cells lacking mitochondrial DNA, but enhanced by expressing thermogen
  2 KB (252 words) - 09:32, 14 June 2017
• Schroedl 2002 Am J Physiol Lung Cell Mol Physiol
  ...or this model comes from the observation that cells treated with complex I inhibitors, such as rotenone, or cells that lack mitochondrial DNA (rho(0)-cells) fail
  2 KB (258 words) - 21:32, 13 April 2022
• Zacharovova 2005 Transplant Proc
  ...hondrial function could be assessed after addition of specific respiration inhibitors or stimulators.
  2 KB (253 words) - 16:36, 13 November 2017
• Shen 2021 Cells
  ...rove the prognosis of cancer. However, the therapeutic window of metabolic inhibitors used alone or in combination may be rather narrow due to cytotoxicity to no
  2 KB (293 words) - 18:48, 8 October 2023
• Fontaine 1998 J Biol Chem
  ...not inhibit respiration. Our results define a new structural class of pore inhibitors and may open new perspectives for the pharmacological modulation of the PTP
  2 KB (239 words) - 22:17, 16 February 2021
• SUIT-023 O2 ce D053
  :::* The concentrations of inhibitors used in this protocol have been optimised for the specific case of the micr
  2 KB (247 words) - 12:45, 23 March 2021
• Hroudova 2012 Toxicol Lett
  ...s in the range of 0.07 to 0.46mmol/l. Partial inhibition was found for all inhibitors. Differences between individual drugs with similar physicochemical properti
  2 KB (275 words) - 14:40, 13 November 2017
• Grefte 2014 Abstract MiP2014
  ...A) or in the presence of the CIII inhibitor [[antimycin A]] (Ama). For all inhibitors, the lowest concentration that fully inhibited myoblast O2 consumption (100
  4 KB (565 words) - 16:30, 23 February 2015
• Bociaga-Jasik 2013 Pharmacol Rep
  |keywords=HIV-associated lipodystrophy, Protease inhibitors, Adipocyte, Oxidative stress, Mitochondrial toxicity, Apoptosis, Gene Expre
  2 KB (262 words) - 21:08, 18 March 2018
• Siebels 2013 Biochim Biophys Acta
  ...es ROS at subsaturating succinate concentrations in the presence of Q-site inhibitors like atpenin A5 or when a further downstream block of the respiratory chain
  2 KB (278 words) - 10:39, 27 March 2018
• Honzik 2006 Placenta
  ...d by one-electron acceptor, potassium ferricyanide and it was depressed by inhibitors of mGPDH and by cytochrome c. Our results indicate that mGPDH should be con
  2 KB (256 words) - 14:30, 26 March 2018
• Rodrigues 2014 Abstract MiP2014
  ...s as 2-DOG and iodocetamide, but were quasi-insensitive to respiratory the inhibitors rotenone and antimycin A. These results indicate that SCC9, LN1 and LN2 pri
  4 KB (603 words) - 15:24, 20 October 2017
• Amoedo 2013 Biosci Rep
  ...em amenable to new forms of treatment by highlighting possible targets for inhibitors. In this respect, a case study describing the effect of a metabolite analog
  2 KB (303 words) - 15:34, 22 February 2018
• Curtabbi 2023 Redox Biol
  ...studies focus on inhibiting complex I at the Q-site, little is known about inhibitors targeting other sites within the complex. In this study, we demonstrate tha
  2 KB (279 words) - 15:35, 3 January 2024
• Beutner 2014 PLoS One
  ...onally more mature; ETC activity and OXPHOS are coupled and respond to ETC inhibitors. In addition, the assembly of highly efficient respiratory supercomplexes c
  2 KB (308 words) - 23:11, 23 April 2023
• Herbst 2017 Appl Physiol Nutr Metab
  ...ddition of either low-concentration α-cyano-4-hydroxycinnamate or UK-5099, inhibitors of mitochondrial pyruvate transport. Mitochondrial respiration was comparab
  2 KB (289 words) - 15:13, 11 October 2018
• SUIT-022 O2 ce D051
  :::* The concentrations of inhibitors used in this protocol have been optimised for the specific case of the micr
  2 KB (263 words) - 12:46, 23 March 2021
• Aisenberg 1961 Academic Press
  :::## Metabolic inhibitors of glycolysis
  2 KB (322 words) - 11:27, 23 September 2021
• Drahota 2002 J Bioenerg Biomembr
  ...GP-dependent antimycin A-insensitive oxygen uptake, which was prevented by inhibitors of mitochondrial GP dehydrogenase (mGPDH) or by coenzyme Q(CoQ). GP-depende
  2 KB (267 words) - 19:07, 1 April 2018
• Read 2021 Redox Biol
  ...Fe-S clusters are also among the binding sites of classical mitochondrial inhibitors, such as rotenone, and play an important role in the production of mitochon
  2 KB (271 words) - 17:59, 2 April 2023
• SUIT-003 AmR ce D059
  ::- Careful washing is required after the experiment to avoid carry-over of inhibitors and uncoupler.
  2 KB (309 words) - 13:44, 7 July 2020
• Kampjut 2019 Nature
  .... Our results are relevant to the development of currently unavailable NNT inhibitors, which may have therapeutic potential in ischaemia reperfusion injury, meta
  2 KB (310 words) - 17:38, 20 January 2023
• Boxma 2005 Nature
  ...d complex II, were identified. The N. ovalis hydrogenosome is sensitive to inhibitors of mitochondrial complex I and produces succinate as a major metabolic end
  2 KB (295 words) - 14:35, 27 March 2018
• Vasington 1962 J Biol Chem
  Respiratory inhibitors such as Amytal, antimycin A, cyanide, and azide inhibit Ca<sup>++<
  3 KB (351 words) - 11:23, 28 May 2015
• Skalska 2008 Biochim Biophys Acta
  ...olished by 200 nM charybdotoxin or 50 nM iberiotoxin, which are well-known inhibitors of large conductance, calcium-activated potassium channels (BK(Ca) channel)
  2 KB (271 words) - 12:07, 7 October 2015
• Alves 2018 MiPschool Tromso E2
  ...d invasive BC cells to the combined treatment with combined mTOR and SIRT1 inhibitors, this is a first assessment of the metabolic and bioenergetics profile of t
  5 KB (660 words) - 18:01, 23 February 2020
• Hughey 2011 J Vis Exp
  ...PHOS. Additionally, troubleshooting advice as well as specific substrates, inhibitors and uncouplers that may be used to determine mitochondria function at speci
  2 KB (278 words) - 11:37, 27 February 2013
• Dawson 1993 Am J Physiol
  ...oxyl radical formation, delayed cell killing after each of the respiratory inhibitors. Anoxia also delayed cell killing during chemical hypoxia. However, during
  2 KB (288 words) - 16:31, 3 February 2022
• Pan 2007 Mol Cell Biol
  ...HIF-1α accumulation in vivo. Furthermore, cells treated with mitochondrial inhibitors, such as rotenone and myxothiazol, provided direct evidence that PHDs remai
  2 KB (285 words) - 16:06, 31 May 2019
• Verschoor 2010 PLoS One
  ...ion. Ets-1 over-expression also caused increased sensitivity to glycolytic inhibitors, as well as growth inhibition in a glucose-depleted culture environment. Co
  2 KB (298 words) - 16:25, 13 November 2017
• Labieniec 2011 Int J Mol Sci
  ...2k according to experimental protocol including respiratory substrates and inhibitors. The results revealed that RAG protects the heart against diabetes-associat
  2 KB (303 words) - 11:22, 23 January 2019
• Peruzzo 2016 Abstract Mito Xmas Meeting Innsbruck
  ...d all these effects, indicating specificity. Since membrane permeant Kv1.3 inhibitors are characterized by poor water solubility, in order to increase their bioa
  2 KB (264 words) - 17:19, 14 December 2016
• Gaviraghi 2019 Anal Biochem
  ...ess to mitochondria was not limited. This was confirmed by using selective inhibitors for specific mitochondrial substrates. Additionally, mitochondria revealed
  2 KB (292 words) - 14:51, 15 May 2019
• Chacko 2013 Lab Invest
  ...st, neutrophils were essentially unresponsive to mitochondrial respiratory inhibitors indicating that they have a minimal requirement for oxidative phosphorylati
  2 KB (298 words) - 12:27, 16 September 2021
• Rosca 2011 Biochim Biophys Acta
  ...ave similar effects on oxidative phosphorylation? The usage of phosphatase inhibitors revealed a specific decrease in complex I-supported respiration with glutam
  2 KB (303 words) - 09:12, 16 June 2015
• Different O2 fluxes in left and right chamber
  ::::* Hydrophobic inhibitors, see [[MiPNet19.03 O2k-cleaning and ISS]].
  2 KB (341 words) - 18:56, 6 November 2019
• Sharpley 2006 J Biol Chem
  ...lass of complex I inhibitor clearly distinct from the many ubiquinone site inhibitors. No evidence for increased superoxide production by zinc-inhibited complex
  2 KB (327 words) - 04:53, 15 October 2023
• Quinlan 2013 Redox Biol
  ...ria oxidizing a variety of conventional substrates in the absence of added inhibitors: succinate; glycerol 3-phosphate; palmitoylcarnitine plus carnitine; or glu
  2 KB (317 words) - 10:01, 23 August 2021
• Pecinova 2017 MiP2017
  ...l lines as ones with high content and activity of mGPDH. Using novel mGPDH inhibitors (metformin, phenformin, alpha tocopheryl succinate and iGP-1) we targeted g
  2 KB (284 words) - 08:17, 21 February 2020
• Kuznetsov 2012 Biochem J
  ...skeleton structures by intracellular proteases. Therefore the use of their inhibitors is strongly advised at the permeabilization step with careful washing of fi
  2 KB (321 words) - 12:17, 28 April 2015
• Saillan-Barreau 2008 J Acquir Immune Defic Syndr
  ...luate the effects of various protease and nucleoside reverse transcriptase inhibitors in this model. We tested the effect of drugs on triglyceride accumulation a
  2 KB (286 words) - 15:54, 13 November 2017
• Black 2014 Antimicrob Agents Chemother
  ...implications of inhibiting drug extrusion, through the use of efflux pump inhibitors, are also discussed.
  2 KB (338 words) - 19:06, 14 October 2023
• Dang 2014 Plant Cell
  ...in pgrl1, including higher sensitivity of photosynthesis to mitochondrial inhibitors, increased light-dependent O2 uptake, and increased amounts of flavodiiron
  2 KB (290 words) - 15:13, 8 August 2023
• Alvarez-Fischer 2013 J Neurochem
  ...(ii) that it also potentiates the effects of other mitochondrial complex I inhibitors such as rotenone. On a mechanistic level, we show that probenecid is able t
  2 KB (305 words) - 14:12, 12 October 2017
• Fernandez-Vizarra 2013 Abstract IOC80
  ...easurements in basal conditions and on exposure to specific substrates and inhibitors. This first characterization will provide key information to then continue
  2 KB (300 words) - 10:40, 9 November 2016
• Jones 2010 Biochim Biophys Acta
  ...ess substrates. To dissect specific deficiencies in the respiratory chain, inhibitors for each respiratory chain complex were used to isolate their contributions
  2 KB (304 words) - 14:38, 20 March 2015
• Korge 2015 Biochim Biophys Acta
  ...ns from their reduced flavoprotein to O2 when electron flow is impaired by inhibitors or because of limited availability of their natural electron acceptors, GSS
  2 KB (304 words) - 17:08, 3 February 2022
• SUIT-024 O2 ce-pce D056
  :::+ Different combinations of substrates and inhibitors can be used depending on the specific aims, ''e.g.'': PGM, PM, GM, MnaPM or
  2 KB (276 words) - 12:36, 25 November 2020
• King 2009 Biochemistry
  ...by an additional, non-energy-transducing pathway (which is insensitive to inhibitors such as rotenone and piericidin A). Here, we show that inhibitor-insensitiv
  2 KB (320 words) - 11:58, 5 November 2023
• Boyle 2015 Abstract MiP2015
  ...This will be further investigated using additional permeant and impermeant inhibitors of the Kv1.3 channel.
  2 KB (309 words) - 09:14, 1 February 2017
• Chen 2022 Am J Physiol Cell Physiol
  ...down under the physiological conditions of low ADP or low Po2. The common inhibitors used for studying the ETC components, ΔpH, and ΔΨ are indicated in brick ...are the source of hydroxyl radical production induced by •O2−. The common inhibitors used for studying the ETC components, ΔpH, and ΔΨ are indicated in brick
  5 KB (754 words) - 03:39, 11 November 2023
• SUIT-006
  :::+ Different combinations of substrates and inhibitors (X) can be used depending on the specific aims, e.g.: PGM, PM, GM, MnaPM or :::+ The combinations of substrates for one ET-pathway state with inhibitors for other pathways provide the best coupling-control protocols for one spec
  8 KB (1,169 words) - 13:08, 13 December 2023
• Schirris 2015 Cell Metab
  ...ral statin lactones reduced respiratory capacity and appeared to be strong inhibitors of mitochondrial complex III (CIII) activity, up to 84% inhibition. The lac
  2 KB (278 words) - 14:36, 27 March 2018
• Ziabreva 2010 Glia
  ...ave not been examined. We determine the ''in vitro'' impact of established inhibitors of mitochondrial respiratory chain Complex IV or cytochrome c oxidase on ol
  2 KB (312 words) - 13:14, 19 March 2015
• SUIT-003 O2 ce D062
  :::- Careful washing is required after the experiment to avoid carry-over of inhibitors and uncoupler.
  2 KB (302 words) - 12:37, 25 November 2020
• Viall 2013 J Autoimmun
  ...control antibodies, were rapidly internalised by the syncytiotrophoblast. Inhibitors of endocytosis or the low-density lipoprotein receptor (LDLR) family, but n
  2 KB (307 words) - 12:56, 25 February 2020
• Parrino 2000 J Exp Biol
  ...on of sulfide-stimulated respiration and ATP production by the complex III inhibitors myxothiazol and antimycin A, respectively, suggests that electrons enter th
  2 KB (305 words) - 10:08, 9 November 2016
• Zelenka 2016 Oxid Med Cell Longev
  ...om Gunn rats showed decreased expression of senescence markers, cell cycle inhibitors p21 and p16. Mitochondria from aged Gunn rats showed higher respiration and
  2 KB (306 words) - 10:45, 17 August 2022
• SUIT-003 O2 ce-pce D018
  :::- Careful washing is required after the experiment to avoid carry-over of inhibitors and uncoupler.
  2 KB (309 words) - 23:56, 12 April 2021
• Kunz 1999 Brain Res
  ...to be unrelated to spontaneous activity since it was not sensitive to the inhibitors of the sodium–potassium ATPase ouabain and of the mitochondrial adenine n
  2 KB (306 words) - 12:48, 26 March 2015
• Wisniewski 1995 Eur J Biochem
  ...= 4) and 0.09 ? 0.03 (n = 3) using inhibitor titrations with the specific inhibitors oligomycin, carboxyatractyloside, mersalyl, rotenone and cyanide, respectiv
  2 KB (278 words) - 10:43, 23 January 2019
• Di Noia 2014 J Biol Chem
  ...both carriers was saturable and inhibited by mercurial compounds and other inhibitors of mitochondrial carriers to various degrees. In confirmation of their iden
  2 KB (335 words) - 16:42, 3 May 2024
• SUIT-003 AmR ce D058
  :::- Careful washing is required after the experiment to avoid carry-over of inhibitors and uncoupler.
  2 KB (328 words) - 16:06, 8 June 2020

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