Oroboros Ecosystem Agenda 2021 Archive

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Oroboros Ecosystem Agenda 2021 Archive

Mitochondria and Cell Research - the Oroboros Ecosystem
» Current Oroboros Ecosystem Agenda

Last week

2021 Week 7
  • Feb-15 Mo International Childhood Cancer Day
O2k-Publications in the MiPMap Glucocorticoids induce apoptosis via repressed mitochondrial respiration and altered expression of mt-transporters in childhood acute lymphoblastic leukemia
from the O2k-Network »DE Regensburg Renner-Sattler K« and »AT Innsbruck Gnaiger E«
  • Eberhart K, Rainer J, Bindreither D, Ritter I, Gnaiger E, Kofler R, Oefner PJ, Renner K (2011) Glucocorticoid-induced alterations in mitochondrial membrane properties and respiration in childhood acute lymphoblastic leukemia. Biochim Biophys Acta 1807:719-25. »Bioblast link«

  • Feb-16 Tu

  • Feb-17 We
O2k-Open SupportInfo: improve Improve preparation of permeabilized muscle fibers

The application of high-resolution respirometry in permeabilized muscle fibers provides a sensitive diagnostic tool for the analysis of mitochondrial (dys)function in small biopsy samples.
- »O2k-Videosupport: Fiber permeabilization« 
- »Doerrier 2018 Methods Mol Biol« 
- communicated by »Doerrier Carolina« and »Tindle-Solomon Lisa«

  • Feb-18 Th

  • Feb-19 Fr

Feb 2021

 2021 Week 5
  • Feb-01 Mo

  • Feb-02 Tu
O2k-Open SupportInfo: improve DatLab error messages: What do they mean and how to solve them?

- » DatLab error messages« 
- communicated by »Garcia-Souza Luiz F« and »Tindle-Solomon Lisa«

  • Feb-03 We

  • Feb-04 Th
O2k-Publications in the MiPMap Could inhibitors of Dihydroorotate-dehydrogenase be anti-cancer agents?
from the O2k-Network »CZ Prague Neuzil J« »AU Queensland Neuzil J« »NL Nijmegen Koopman WJ« »AU Sydney Stocker R« »AU Queensland Peart J«
  • Bajzikova M, Kovarova J, Coelho AR, Boukalova S, Oh S, Rohlenova K, Svec D, Hubackova S, Endaya B, Judasova K, Bezawork-Geleta A, Kluckova K, Chatre L, Zobalova R, Novakova A, Vanova K, Ezrova Z, Maghzal GJ, Magalhaes Novais S, Olsinova M, Krobova L, An YJ, Davidova E, Nahacka Z, Sobol M, Cunha-Oliveira T, Sandoval-Acuña C, Strnad H, Zhang T, Huynh T, Serafim TL, Hozak P, Sardao VA, Koopman Werner JH, Ricchetti M, Oliveira PJ, Kolar F, Kubista M, Truksa J, Dvorakova-Hortova K, Pacak K, Gurlich R, Stocker R, Zhou Y, Berridge MV, Park S, Dong L, Rohlena J, Neuzil J (2019) Reactivation of dihydroorotate dehydrogenase-driven pyrimidine biosynthesis restores tumor growth of respiration-deficient cancer cells. Cell Metab 29:399-416. »Bioblast link«

  • Feb-05 Fr

2021 Week 6
  • Feb-08 Mo
O2k-Open SupportInfo: improve Do you know how to properly insert the ISS-tip into the O2k-chamber?

With the stirrer bar still rotating, insert the ISS-tip to the bottom of the O2k-Chamber, so that it points away from you.
- »MiPNet19.03 O2k-cleaning and ISS: Section 2« 
- communicated by »Doerrier Carolina«, »Cecatto Cristiane« and »Komlodi Timea«

  • Feb-10 We
O2k-Publications in the MiPMap Approved FAO inhibitor Trimetazidine restricts tumor growth in oxidative lung carcinomas
from the O2k-Network »FR Bordeaux Rossignol R« 
  • Amoedo ND, Sarlak S, Obre E, Esteves P, Bégueret H, Kieffer Y, Rousseau B, Dupis A, Izotte J, Bellance N, Dard L, Redonnet-Vernhet I, Punzi G, Rodrigues MF, Dumon E, Mafhouf W, Guyonnet-Dupérat V, Gales L, Palama T, Bellvert F, Dugot-Senan N, Claverol S, Baste JM, Lacombe D, Rezvani HR, Pierri CL, Mechta-Grigoriou F, Thumerel M, Rossignol R (2021) Targeting the mitochondrial trifunctional protein restrains tumor growth in oxidative lung carcinomas. J Clin Invest 131:e133081. »Bioblast link«

  • Feb-11 Th

  • Feb-12 Fr

  • Feb-13 Sa

  • Feb-14 Su Donor Day
O2k-Publications in the MiPMap Preservation solutions are superior to cardioplegic solutions for prolonged cold storage of the heart
from the O2k-Network »AT Innsbruck Gnaiger E« and »AT Innsbruck Oroboros«
  • Schneeberger S, Kuznetsov AV, Seiler R, Renz O, Meusburger H, Mark W, Brandacher G, Margreiter R, Gnaiger E (2008) Mitochondrial ischemia-reperfusion injury of the transplanted rat heart: improved protection by preservation versus cardioplegic solutions. Shock 30:365-71. »Bioblast link«

Jan 2021

  • Jan-01 Fr
Happy New Year!
 2021 Week 1
  • Jan-04 Mo
The Oroboros office is enjoying a break from December 24th to January 6th.

  • Jan-05 Tu

  • Jan-06 We

  • Jan-07 Th
Oroboros Instruments is pleased to be a collaborator on the CureMILS project that has recently been approved for EJP-RD funding.

Led by O2k-Network member, Alessandro Prigione, the project aims to employ a novel approach to enable drug discovery of Mitochondrial DNA (mtDNA)-associated Leigh syndrome (MILS).

- Read more »CureMILS«

  • Jan-08 Fr
O2k-brief repository Liver mitochondrial adaptation in a mouse model of NAFLD induced by a Western-style diet
from the O2k-Network »CZ Hradec Kralove Cervinkova Z«
  • Staňková P, Kučera O, Peterová E, Lotková H, Maseko TE, Nožičková K, Červinková Z (2020) Adaptation of mitochondrial substrate flux in a mouse model of nonalcoholic fatty liver disease. Int J Mol Sci 21:E1101. »Bioblast link«

2021 Week 2
  • Jan-11 Mo
O2k-Open SupportInfo: improve Are you a beginner or need a refresher on using SUIT protocols with DatLab7.4?

- » O2k-Videosupport: How to perform an experiment with a SUIT DL-Protocol« and » Run DL-Protocol/Set O2 limit in DatLab « 
- communicated by »Komlodi Timea« and Schmitt Sabine«

  • Jan-13 We
O2k-Publications in the MiPMap Positive effect of regular physical activity on mitochondrial respiration in burnout syndrome
from the O2k-Network »CH Basel Eckert A«
  • Brand S, Ebner K, Mikoteit T, Lejri I, Gerber M, Beck J, Holsboer-Trachsler E, Eckert A (2020) Influence of regular physical activity on mitochondrial activity and symptoms of burnout-an interventional pilot study. J Clin Med 9:E667.»Bioblast link«

  • Jan-14 Th

  • Jan-15 Fr
2021 Week 3
  • Jan-18 Mo

  • Jan-19 Tu
O2k-Publications in the MiPMap Complex III is essential in mitochondrial electron transfer system maturation and supercomplex formation
from the O2k-Network »US FL Miami Moraes CT«
  • Protasoni M, Pérez-Pérez R, Lobo-Jarne T, Harbour ME, Ding S, Peñas A, Diaz F, Moraes CT, Fearnley IM, Zeviani M, Ugalde C, Fernández-Vizarra E (2020) Respiratory supercomplexes act as a platform for complex III-mediated maturation of human mitochondrial complexes I and IV. EMBO J 39:e102817. »Bioblast link«

  • Jan-20 We
Gnaiger 2020 BEC MitoPathways A quote from MitoPathways Chapter 3. Normalization:

Respiratory OXPHOS capacity P in human skeletal muscle ranges from 60 to 160 pmol∙s­-1∙mg­-1 based on wet muscle mass of permeabilized fibers. By comparison, mass-specific electron transfer capacity E is approximately 25 pmol∙s-1∙mg-1 in platelets and senescent fibroblasts and 40 to 80 pmol∙s-1∙mg-1 in PBMC, HEK, CEM, HUVEC, and young fibroblasts. ― Are these values comparable? - »Gnaiger 2020 BEC MitoPathways«.

  • Jan-21 Th
Measuring ATP production with Magnesium Green – which sample preparations work?

Magnesium Green (MgG) can be used with mitochondrial preparations: isolated mitochondria, tissue homogenates, and permeabilized cells and tissues.
- »MgG« and »Publications MgG« 
- communicated by »Cardoso Luiza« and »Komlodi Timea«

  • Jan-22 Fr
2021 Week 4
  • Jan-25 Mo

  • Jan-27 We
O2k-Publications in the MiPMap Cell-permeable succinate prodrug NV118 improves statin-induced mitochondrial dysfunction in human platelets
from the O2k-Network »RO Timisoara Muntean DM« and »SE Lund Elmer E«
  • Avram VF, Chamkha I, Åsander-Frostner E, Ehinger JK, Timar RZ, Hansson MJ, Muntean DM, Elmér E (2021) Cell-permeable succinate rescues mitochondrial respiration in cellular models of statin toxicity. Int J Mol Sci 22:424. »Bioblast link«

  • Jan-28 Th
Gnaiger 2020 BEC MitoPathways A quote from MitoPathways Chapter 6. Convergent electron transfer at the Q-junction:

The concept on convergent electron transfer at the Q-junction (ETS) challenges conventional OXPHOS analysis based on the ETC terminology and a way of thinking about the mitochondrial ‘electron transfer chain’ - »Gnaiger 2020 BEC MitoPathways«.

  • Jan-29 Fr
MitoFit pdf SUIT protocols with Magnesium Green™ (MgG) can be used to study respiration and ATP production P»

MgG dye does not affect respiration of cardiac isolated mitochondria.

  • Cardoso LHD, Doerrier C, Gnaiger E (2021) Magnesium Green for fluorometric measurement of ATP production does not interfere with mitochondrial respiration. MitoFit Preprints 2021.1. doi:10.26124/mitofit:2021-0001.

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